Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature - Tandrup, Tobias; Lo Leggio, Leila; Meilleur, Flora (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2023)
Keywords: lytic polysaccharide mono-oxygenases; Lentinus similis AA9_A; copper metalloenzymes; protonation states; neutron crystallography

Neutron Scattering in the Biological Sciences: Techniques And Applications - Meilleur, Flora (JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2023)

Structural analysis and functional evaluation of the disordered ß-hexosyltransferase region from Hamamotoa (Sporobolomyces) singularis - Dagher, Suzanne F.; Vaishnav, Asmita; Stanley, Christopher B.; Meilleur, Flora; Edwards, Brian F. P.; Bruno-Barcena, Jose M. (FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023)
Keywords: disorder; expression; kinetics; mutagenesis; transglycosylation; Hamamotoa singularis

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase - Schroder, Gabriela C.; William B. O'Dell; Webb, Simon P.; Agarwal, Pratul K.; Meilleur, Flora (CHEMICAL SCIENCE, 2022)

Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding - Tandrup, Tobias; Muderspach, Sebastian J.; Banerjee, Sanchari; Santoni, Gianluca; Ipsen, Johan O.; Hernandez-Rollan, Cristina; Norholm, Morten H. H.; Johansen, Katja S.; Meilleur, Flora; Lo Leggio, Leila (IUCRJ, 2022)

Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature - Moreno-Chicano, Tadeo; Carey, Leiah M.; Axford, Danny; Beale, John H.; Doak, R. Bruce; Duyvesteyn, Helen M. E.; Ebrahim, Ali; Henning, Robert W.; Monteiro, Diana C. F.; Myles, Dean A.; Owada, Shigeki; Sherrell, Darren A.; et al. (IUCRJ, 2022)
Keywords: serial femtosecond crystallography; serial synchrotron crystallography; neutron crystallography; XFELs; room temperature; metalloenzymes

Mapping H+ in the Nanoscale (A(2)C(4))(2)-Ag-8 Fluorophore - David, Fred; Setzler, Caleb; Sorescu, Alexandra; Lieberman, Raquel L.; Meilleur, Flora; Petty, Jeffrey T. (JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2022)

Teaching and Education highlighted - Dawe, Louise N.; Manuel Garcia-Ruiz, Juan; Hadju, Janos; McIntyre, Garry J.; Meilleur, Flora; Stephenson, Lisa (JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2022)
Keywords: teaching; education

The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition - Sacco, Michael Dominic; Hu, Yanmei; Gongora, Maura Verenice; Meilleur, Flora; Kemp, Michael Trent; Zhang, Xiujun; Wang, Jun; Chen, Yu (CELL RESEARCH, 2022)

The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature - Correy, Galen J.; Kneller, Daniel W.; Phillips, Gwyndalyn; Pant, Swati; Russi, Silvia; Cohen, Aina E.; Meigs, George; Holton, James M.; Gahbauer, Stefan; Thompson, Michael C.; Ashworth, Alan; Coates, Leighton; et al. (SCIENCE ADVANCES, 2022)

Capture of activated dioxygen intermediates at the copper-active site of a lytic polysaccharide monooxygenase - Schröder, Gabriela C.; O'Dell, William B.; Webb, Simon P.; Agarwal, Pratul K.; Meilleur, Flora (2021)

Metalloprotein catalysis: structural and mechanistic insights into oxidoreductases from neutron protein crystallography - Schroeder, Gabriela C.; Meilleur, Flora (ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2021)
Keywords: neutron protein crystallography; X-ray diffraction; metalloproteins; enzymatic mechanisms; protonation; radiation damage

Preliminary results of neutron and X-ray diffraction data collection on a lytic polysaccharide monooxygenase under reduced and acidic conditions - Schroder, Gabriela C.; William B. O'Dell; Swartz, Paul D.; Meilleur, Flora (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2021)
Keywords: lytic polysaccharide monooxygenases; Neurospora crassa; neutron protein crystallography; reduction; protonation; enzymatic mechanism.

A beginner’s guide to neutron macromolecular crystallography - Meilleur, Flora (The Biochemist, 2020)

Dynamic nuclear polarization enhanced neutron crystallography: Amplifying hydrogen in biological crystals - Pierce, Joshua; Cuneo, Matthew J.; Jennings, Anna; Li, Le; Meilleur, Flora; Zhao, Jinkui; Myles, Dean A. A. (NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, 2020)

IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor - Meilleur, Flora; Kovalevsky, Andrey; Myles, Dean A. A. (NEUTRON CRYSTALLOGRAPHY IN STRUCTURAL BIOLOGY, 2020)

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures - Schroeder, Gabriela C.; Meilleur, Flora (JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2020)

A prototype system for dynamically polarized neutron protein crystallography - Pierce, J.; Crow, L.; Cuneo, M.; Edwards, M.; Herwig, K. W.; Jennings, A.; Jones, A.; Li, L.; Meilleur, F.; Myles, D. A. A.; Robertson, L.; Standaert, R.; et al. (NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2019)
Keywords: Polarized target; Dynamic nuclear polarization; Protein crystallography; Neutron scattering

Neutron and X-ray analysis of the Fenna-Matthews-Olson photosynthetic antenna complex from Prosthecochloris aestuarii - Lu, Xun; Selvaraj, Brinda; Ghimire-Rijal, Sudipa; Orf, Gregory S.; Meilleur, Flora; Blankenship, Robert E.; Cuneo, Matthew J.; Myles, Dean A. A. (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2019)
Keywords: neutron crystallography; photosynthesis; hydrogen; site energy; neutron diffraction; Fenna-Matthews-Olson protein; Prosthecochloris aestuarii

Titration of ionizable groups in proteins using multiple neutron data sets from a single crystal: application to the small GTPase Ras - Knihtila, Ryan; Volmar, Alicia Y.; Meilleur, Flora; Mattos, Carla (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2019)
Keywords: in crystallo titration; neutron crystallography; pK(a); protonation; radiation damage

A suite-level review of the neutron single-crystal diffraction instruments at Oak Ridge National Laboratory - Coates, L.; Cao, H. B.; Chakoumakos, B. C.; Frontzek, M. D.; Hoffmann, C.; Kovalevsky, A. Y.; Liu, Y.; Meilleur, F.; Santos, A. M.; Myles, D. A. A.; Wang, X. P.; Ye, F. (REVIEW OF SCIENTIFIC INSTRUMENTS, 2018)

Modulating Enzyme Activity by Altering Protein Dynamics with Solvent - Duff, Michael R., Jr; Borreguero, Jose M.; Cuneo, Matthew J.; Ramanathan, Arvind; He, Junhong; Kamath, Ganesh; Chennubhotla, S. Chakra; Meilleur, Flora; Howell, Elizabeth E.; Herwig, Kenneth W.; Myles, Dean A. A.; Agarwal, Pratul K. (Biochemistry, 2018)

Neutron scattering in the biological sciences: progress and prospects - Ashkar, Rana; Bilheux, Hassina Z.; Bordallo, Heliosa; Briber, Robert; Callaway, David J. E.; Cheng, Xiaolin; Chu, Xiang-Qiang; Curtis, Joseph E.; Dadmun, Mark; Fenimore, Paul; Fushman, David; Gabel, Frank; et al. (ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2018)
Keywords: neutron scattering; biological systems; structure and dynamics

Next-generation diamond cell and applications to single-crystal neutron diffraction - Haberl, Bianca; Dissanayake, Sachith; Wu, Yan; Myles, Dean A. A.; Santos, Antonio M.; Loguillo, Mark; Rucker, Gerald M.; Armitage, Douglas P.; Cochran, Malcolm; Andrews, Katie M.; Hoffmann, Christina; Cao, Huibo; et al. (REVIEW OF SCIENTIFIC INSTRUMENTS, 2018)

Structural investigation of cellobiose dehydrogenase IIA: Insights from small angle scattering into intra- and intermolecular electron transfer mechanisms - Bodenheimer, Annette M.; ODell, William B.; Oliver, Ryan C.; Qian, Shuo; Stanley, Christopher B.; Meilleur, Flora (BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2018)
Keywords: Intramolecular electron transfer (IaET); Intermolecular electron transfer (IeET); Redox complex; Oxidative cellulose degradation; Small-angle scattering; Modeling

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities - Meilleur, Flora; Coates, Leighton; Cuneo, Matthew J.; Kovalevsky, Andrey; Myles, Dean A. A. (CRYSTALS, 2018)
Keywords: neutron; crystallography; macromolecules; Laue diffraction; hydrogen; proton; deuteration

An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase - Golden, Emily; Yu, Li-Juan; Meilleur, Flora; Blakeley, Matthew P.; Duff, Anthony P.; Karton, Amir; Vrielink, Alice (Scientific Reports, 2017)

Crystallization of a fungal lytic polysaccharide monooxygenase expressed from glycoengineered Pichia pastoris for X-ray and neutron diffraction - William B. O'Dell; Swartz, Paul D.; Weiss, Kevin L.; Meilleur, Flora (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2017)
Keywords: lytic polysaccharide monooxygenases; Pichia pastoris; glycoengineering; neutron proteincrystallography

Innentitelbild: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. 3/2017) - O'Dell, William B.; Agarwal, Pratul K.; Meilleur, Flora (Angewandte Chemie, 2017)

Neutron crystallographic studies of T4 lysozyme at cryogenic temperature - Li, Le; Shukla, Shantanu; Meilleur, Flora; Standaert, Robert F.; Pierce, Josh; Myles, Dean A. A.; Cuneo, Matthew J. (PROTEIN SCIENCE, 2017)
Keywords: T4-lysozyme; neutron; structure; X-ray; hydrogen

Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type - Hiromoto, Takeshi; Meilleur, Flora; Shimizu, Rumi; Shibazaki, Chie; Adachi, Motoyasu; Tamada, Taro; Kuroki, Ryota (PROTEIN SCIENCE, 2017)
Keywords: lysozyme; hydrolysis; perdeuteration; neutron crystallography

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase - William B. O'Dell; Agarwal, Pratul K.; Meilleur, Flora (ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017)
Keywords: copper; oxidoreductases; oxygen activation; polysaccharide monooxygenases; protein structures

Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase - O'Dell, William B.; Agarwal, Pratul K.; Meilleur, Flora (Angewandte Chemie, 2017)

Structural studies of Neurospora crassa LPMO9D and redox partner CDHIIA using neutron crystallography and small-angle scattering - Bodenheimer, Annette M.; William B. O'Dell; Stanley, Christopher B.; Meilleur, Flora (CARBOHYDRATE RESEARCH, 2017)
Keywords: Polysaccharide monooxygenases; Cellobiose dehydrogenases; Neutron diffraction; Neutron scattering; X-ray induced photoreduction

Crystal structures of wild-type Trichoderma reesei Cel7A catalytic domain in open and closed states - Bodenheimer, Annette M.; Meilleur, Flora (FEBS LETTERS, 2016)
Keywords: Cel7A; cellulase; closed state; processivity; product-binding site; Trichoderma reesei

Detection of Mycoplasma haemocanis, Mycoplasma haematoparvum, Mycoplasma suis and other vector-borne pathogens in dogs from Córdoba and Santa Fé, Argentina - Mascarelli, Patricia E.; Tartara, Gustavo P.; Pereyra, Norma B.; Maggi, Ricardo G. (Parasites & Vectors, 2016)
Keywords: Dogs; Babesia vogeli; Anaplasma phagocytophilum; Anaplasma platys; Ehrlichia canis; Mycoplasma haemocanis; Mycoplasma haematoparvum; Mycoplasma suis; Bartonella spp.; Argentina

Inside Cover: Oxygen Activation at the Active Site of a Fungal Lytic Polysaccharide Monooxygenase (Angew. Chem. Int. Ed. 3/2017) - O'Dell, William B.; Agarwal, Pratul K.; Meilleur, Flora (Angewandte Chemie International Edition, 2016)

Neutron protein crystallography: A complementary tool for locating hydrogens in proteins - William B. O'Dell; Bodenheimer, Annette M.; Meilleur, Flora (ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2016)
Keywords: Neutron; Crystallography; Hydrogen; Enzyme; Protonation; Water

Crystal structure and thermal expansion of a CsCe2Cl7 scintillator - Zhuravleva, M.; Lindsey, A.; Chakoumakos, B.C.; Custelcean, R.; Meilleur, F.; Hughes, R.W.; Kriven, W.M.; Melcher, C.L. (Journal of Solid State Chemistry, 2015)
Keywords: X-ray diffraction; Crystal structure; Thermal expansion; Scintillator; Crystal growth

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate - Knihtila, Ryan; Holzapfel, Genevieve; Weiss, Kevin; Meilleur, Flora; Mattos, Carla (JOURNAL OF BIOLOGICAL CHEMISTRY, 2015)

Production and characterization of recombinant perdeuterated cholesterol oxidase - Golden, Emily; Attwood, Paul V.; Duff, Anthony P.; Meilleur, Flora; Vrielink, Alice (ANALYTICAL BIOCHEMISTRY, 2015)
Keywords: Flavoenzyme; Perdeuteration; Thermal stability; Protein expression; Enzyme kinetics; Protein structure

Crystallization and preliminary X-ray diffraction analysis of Hypocrea jecorina Cel7A in two new crystal forms - Bodenheimer, A.M.; Cuneo, M.J.; Swartz, P.D.; He, J.; O'Neill, H.M.; Myles, D.A.; Evans, B.R.; Meilleur, Flora; Section, F. (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2014)

Neutron structure of the cyclic glucose-bound xylose isomerase E186Q mutant - Munshi, P.; Snell, E.H.; Woerd; Mj, Judge; Ra, Myles; Da, Ren; Z, Meilleur; F, Acta Crystallographica Section; D. (ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2014)

ORNL hosts the participants of the 4thNeutrons in Structural Biology Workshop and the IMAGINE single crystal neutron diffractometer first external users - Meilleur, Flora (Neutron News, 2014)

Refinement of macromolecular structures against neutron data with SHELXL2013 - Gruene, Tim; Hahn, Hinrich W.; Luebben, Anna V.; Meilleur, Flora; Sheldrick, George M. (JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2014)

The Neutrons in Structural Biology Workshop celebrates its 5th edition - Meilleur, Flora (Neutron News, 2014)

Neutron Scattering Techniques and Applications in Structural Biology - Ankner, John F.; Heller, William T.; Herwig, Kenneth W.; Meilleur, Flora; Myles, Dean A.A. (Current Protocols in Protein Science, 2013)

New insight into the structure of RNA in red clover necrotic mosaic virus and the role of divalent cations revealed by small-angle neutron scattering - Martin, Stanton L.; He, Lilin; Meilleur, Flora; Guenther, Richard H.; Sit, Tim L.; Lommel, Steven A.; Heller, William T. (ARCHIVES OF VIROLOGY, 2013)

The IMAGINE instrument: first neutron protein structure and new capabilities for neutron macromolecular crystallography. - Meilleur, F.; Munshi, P.; Robertson, L.; Stoica, A.D.; Crow, L.; Kovalevsky, A.; Koritsanszky, T.; Chakoumakos, B.C.; Blessing, R.; Myles, D.A.; Section, D. (Biological crystallography, 2013)

Third School on the Applications of Neutron Scattering Techniques in Structural Biology, Oak Ridge, TN - Meilleur, Flora (Neutron News, 2013)

Conformational Changes in Sindbis Virus Induced by Decreased pH Are Revealed by Small-Angle Neutron Scattering - He, Lilin; Piper, Amanda; Meilleur, Flora; Hernandez, Raquel; Heller, William T.; Brown, Dennis T. (JOURNAL OF VIROLOGY, 2012)

Neutron protein crystallography at ultra-low (< 15 K) temperatures - Myles, Dean A. A.; Dauvergne, Francois; Blakeley, Matthew P.; Meilleur, Flora (JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2012)
Keywords: neutron protein crystallography; flash cooling; cryocrystallography

Open Conformation of Ezrin Bound to Phosphatidylinositol 4,5-Bisphosphate and to F-actin Revealed by Neutron Scattering - Jayasundar, Jayant James; Ju, Jeong Ho; He, Lilin; Liu, Dazhi; Meilleur, Flora; Zhao, Jinkui; Callaway, David J. E.; Bu, Zimei (JOURNAL OF BIOLOGICAL CHEMISTRY, 2012)

Rapid visualization of hydrogen positions in protein neutron crystallographic structures - Munshi, P.; Chung, S.L.; Blakeley, M.P.; Weiss, K.L.; Myles, D.A.; Meilleur, Flora; Section, D. (ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2012)

Molecular and Serological Diagnosis of Bartonella Infection in 61 Dogs from the United States - Pérez, C.; Maggi, R.G.; Diniz, P.P.V.P.; Breitschwerdt, E.B. (Journal of Veterinary Internal Medicine, 2011)
Keywords: Bacteria; BAPGM; Bartonella; Blood culture

Redox-Promoting Protein Motions in Rubredoxin - Borreguero, Jose M.; He, Junhong; Meilleur, F.; Weiss, Kevin L.; Brown, Craig M.; Myles, Dean A.; Herwig, Kenneth W.; Agarwal, Pratul K. (JOURNAL OF PHYSICAL CHEMISTRY B, 2011)

Scattering functions of Platonic solids - Li, Xin; Shew, Chwen-Yang; He, Lilin; Meilleur, Flora; Myles, Dean A. A.; Liu, Emily; Zhang, Yang; Smith, Gregory S.; Herwig, Kenneth W.; Pynn, Roger; Chen, Wei-Ren (JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2011)

Crystallization and preliminary X-ray diffraction analysis of red clover necrotic mosaic virus - Martin, S.L.; Guenther, R.H.; Sit, T.L.; Swartz, P.D.; Meilleur, Flora; Lommel, S.A.; Rose, Robert; Section, F. (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2010)
Keywords: red clover necrotic mosaic virus; dianthoviruses; viruses

The Structure of Sindbis Virus Produced from Vertebrate and Invertebrate Hosts as Determined by Small-Angle Neutron Scattering - He, Lilin; Piper, Amanda; Meilleur, Flora; Myles, Dean A. A.; Hernandez, Raquel; Brown, Dennis T.; Heller, William T. (JOURNAL OF VIROLOGY, 2010)

Unambiguous determination of H-atom positions: comparing results from neutron and high-resolution X-ray crystallography - Gardberg, A.S.; Castillo, Del; Ar, Weiss; Kl, Meilleur; F, Blakeley; Mp, Myles; Da, Acta Crystallographica Section; D. (ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2010)

Deuterium Labeling for Neutron Structure-Function-Dynamics Analysis - Meilleur, Flora; Weiss, Kevin L.; Myles, Dean A.A. (Micro and Nano Technologies in Bioanalysis, 2009)
Keywords: Protein; Membrane; Nucleic acid; Deuterium labeling; Cell culture; Over-expression; Deuterium exchange; Crystallography; Reflectometry; Small angle scattering; Contrast variation

Erratum to “New sources and instrumentation for neutrons in biology” [Chem. Phys. 345 (2008) 133–151] - Teixeira, S.C.M.; Zaccai, G.; Ankner, J.; Bellissent-Funel, M.C.; Bewley, R.; Blakeley, M.P.; Callow, P.; Coates, L.; Dahint, R.; Dalgliesh, R.; Dencher, N.A.; Forsyth, V.T.; et al. (Chemical Physics, 2008)

New sources and instrumentation for neutrons in biology - Teixeira, S. C. M.; Zaccai, G.; Ankner, J.; Bellissent-Funel, M. C.; Bewley, R.; Blakeley, M. P.; Callow, P.; Coates, L.; Dahint, R.; Dalgliesh, R.; Dencher, N. A.; Forsyth, V. T.; et al. (CHEMICAL PHYSICS, 2008)
Keywords: neutron scattering; neutron crystallography; small angle neutron scattering; reflectometry; inelastic neutron scattering; quasi-elastic neutron scattering; proteins; membranes; macromolecular structure and dynamics

New sources and instrumentation for neutrons in biology (vol 345, pg 133, 2008) - Teixeira, S. C. M.; Zaccai, G.; Ankner, J.; Bellissent-Funel, M. C.; Bewley, R.; Blakeley, M. P.; Callow, P.; Coates, L.; Dahint, R.; Dalgliesh, R.; Dencher, N. A.; Forsyth, V. T.; et al. (Chemical Physics, 2008)

Preliminary neutron crystallographic analysis of selectively CH3-protonated deuterated rubredoxin from Pyrococcus furiosus - Weiss, K.L.; Meilleur, Flora; Blakeley, M.P.; Myles, D.A.; Section, F. (ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2008)

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase. - Blakeley, MP; Ruiz, F; Cachau, R; Hazemann, I; Meilleur, F; Mitschler, A; Ginell, S; Afonine, P; Ventura, ON; Cousido-Siah, A; Haertlein, M; Joachimiak, A; et al. (Proceedings of the National Academy of Sciences of the United States of America, 2008)
Keywords: enzymatic mechanism; helium cooling; subatomic resolution crystallography; x-ray plus neutrons joint refinement

Expression, purification, assay, and crystal structure of perdeuterated human arginase I - Di Costanzo, Luigi; Moulin, Martine; Haertlein, Michael; Meilleur, Flora; Christianson, David W. (ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007)

A preliminary neutron diffraction study of rasburicase, a recombinant urate oxidase enzyme, complexed with 8-azaxanthin. - Budayova-Spano, M.; Bonneté, F.; Ferté, N.; El Hajji, M.; Meilleur, F.; Blakeley, M.P.; Castro, B.; Section, F. (Structural biology and crystallization communications, 2006)

A quasi-Laue neutron crystallographic study of d-xylose isomerase - Meilleur, Flora; Snell, Edward H.; Woerd, Mark J.; Judge, Russell A.; Myles, Dean A. A. (European Biophysics Journal, 2006)

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase-inhibitor complex. - Blakeley, MP; Mitschler, A; Hazemann, I; Meilleur, F; Myles, DA; Podjarny, A (European biophysics journal : EBJ, 2006)

Neutron Laue macromolecular crystallography - Meilleur, Flora; Myles, Dean A. A.; Blakeley, Matthew P. (European Biophysics Journal, 2006)

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase. - Hazemann, I.; Dauvergne, M.T.; Blakeley, M.P.; Meilleur, F.; Haertlein, M.; Van Dorsselaer, A.; Mitschler, A.; Myles, D.A.; Podjarny, A.; Section, D. (Biological crystallography, 2005)

Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate. - Bennett, B.C.; Meilleur, F.; Myles, D.A.; Howell, E.E.; Dealwis, C.G.; Section, D.; crystallography, Biological (2005)

Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam. - Meilleur, F.; Dauvergne, M.T.; Schlichting, I.; Myles, D.A.; Section, D. (Biological crystallography, 2005)

Structural Stability and Dynamics of Hydrogenated and Perdeuterated Cytochrome P450cam (CYP101)† - Meilleur, Flora; Contzen, Jörg; Myles, Dean A. A.; Jung, Christiane (Biochemistry, 2004)

Interplay of intrinsic and environmental effects on the magnetic properties of free radicals issuing from H-atom addition to cytosine. - Adamo, C; Heitzmann, M; Meilleur, F; Rega, N; Scalmani, G; Grand, A; Cadet, J; Barone, V (Journal of the American Chemical Society, 2001)