@article{cash_prevost_wagner_comins_2014, title={Studies toward the Total Synthesis of Dihydrolycolucine. Preparation of AB and CEF Ring Fragments}, volume={79}, ISSN={["0022-3263"]}, DOI={10.1021/jo500878v}, abstractNote={A strategy for the synthesis of the lycopodium alkaloid dihydrolycolucine (1) has been investigated. Synthetic routes were developed based on N-acylpyridinium salt chemistry to prepare target fragments 3 and 4 that could ultimately converge to the natural product. Key reactions include IMDA cycloadditions and retro-Mannich ring-openings to form both the AB and the EF ring fragments. The ring C precursor was prepared using pyridine substitution and directed lithiation chemistry. A Suzuki cross-coupling of rings C and EF led to the CEF ring fragment. Initial attempts at closure of the seven-membered D ring were unsuccessful.}, number={12}, journal={JOURNAL OF ORGANIC CHEMISTRY}, author={Cash, Brandon M. and Prevost, Natacha and Wagner, Florence F. and Comins, Daniel L.}, year={2014}, month={Jun}, pages={5740–5745} } @article{wagner_comins_2007, title={Recent advances in the synthesis of nicotine and its derivatives}, volume={63}, ISSN={["0040-4020"]}, DOI={10.1016/j.tet.2007.04.100}, abstractNote={This review covers developments in the synthesis of nicotine and derivatives published mainly from 1996 to 2006.}, number={34}, journal={TETRAHEDRON}, author={Wagner, Florence F. and Comins, Daniel L.}, year={2007}, month={Aug}, pages={8065–8082} } @article{wagner_comins_2006, title={Expedient five-step synthesis of SIB-1508Y from natural nicotine}, volume={71}, ISSN={["0022-3263"]}, DOI={10.1021/jo0616052}, abstractNote={Altinicline (SIB-1508Y), an anti-Parkinson's agent, was prepared in five steps from natural nicotine in 32% overall yield via a regioselective substitution of the pyridine ring of (S)-nicotine.}, number={22}, journal={JOURNAL OF ORGANIC CHEMISTRY}, author={Wagner, Florence F. and Comins, Daniel L.}, year={2006}, month={Oct}, pages={8673–8675} } @article{wagner_comins_2006, title={Regioselective 5-, 4-, and 2-substitution of (S)-6-chloronicotine and 4-substitution of (S)-5-chloronicotine}, volume={2006}, ISSN={["1099-0690"]}, DOI={10.1002/ejoc.200600415}, abstractNote={A variety of novel 2-, 4-, and 5-substituted 6-chloronicotine and 4-substituted 5-chloronicotine derivatives have been synthesized in a regioselective manner in moderate to high yield from (S)-6-chloronicotine and (S)-5-chloronicotine, respectively. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)}, number={16}, journal={EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}, author={Wagner, Florence F. and Comins, Daniel L.}, year={2006}, month={Aug}, pages={3562–3565} } @article{wagner_comins_2006, title={Six-step synthesis of (S)-brevicolline from (S)-nicotine}, volume={8}, ISSN={["1523-7060"]}, DOI={10.1021/ol061334h}, abstractNote={[reaction: see text] A six-step synthesis of (S)-brevicolline from (S)-nicotine is reported. Regioselective trisubstitution of the pyridine ring of nicotine, followed by successive Suzuki cross-coupling and Buchwald amination reactions, afforded the enantiopure beta-carboline alkaloid, brevicolline.}, number={16}, journal={ORGANIC LETTERS}, author={Wagner, Florence F. and Comins, Daniel L.}, year={2006}, month={Aug}, pages={3549–3552} }