Works (187)

Updated: April 22nd, 2024 05:51

2024 article

Comparison of the Backbone Dynamics of Dehaloperoxidase-Hemoglobin Isoenzymes

Gonzalez-Delgado, J. M., Thompson, P. M., Andralojc, W., Gdaniec, Z., Ghiladi, R. A., & Franzen, S. (2024, April 2). JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 4.

By: J. Gonzalez-Delgado n, P. Thompson n, W. Andralojc*, Z. Gdaniec*, R. Ghiladi n & S. Franzen n

Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 article

Decomposition of 2,4-dihalophenols by dehaloperoxidase activity and spontaneous reaction with hydrogen peroxide

Aktar, M. S., Hill, R., Holbert, W., & Franzen, S. (2024, March). JOURNAL OF INORGANIC BIOCHEMISTRY, Vol. 252.

By: M. Aktar n, R. Hill n, W. Holbert n & S. Franzen n

author keywords: Peroxidase; Hydroxylation; Xenobiotic; Halogenated phenol; Halogenated quinone; Singular value decomposition
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 26, 2024

2023 journal article

Comparative study of the binding and activation of 2,4-dichlorophenol by dehaloperoxidase A and B

JOURNAL OF INORGANIC BIOCHEMISTRY, 247.

By: M. Aktar n, V. Serrano n, R. Ghiladi n & S. Franzen n

author keywords: Peroxidase; 4-dichlorophenol; electron transfer; Activation energy; Enzyme kinetics; Solvent effect
TL;DR: Comparison of the binding and reactivity of the substrate 2,4-dichlorophenol (DCP) in the isoforms DHPA and B contributes to the studies of DHP as a naturally occurring bioremediation enzyme capable of oxidizing a wide range of environmental pollutants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2023 journal article

The divergent pH dependence of substrate turnover in dehaloperoxidases A and B

JOURNAL OF INORGANIC BIOCHEMISTRY, 238.

By: N. Madhuresh n, H. Nguyen n & S. Franzen n

author keywords: Oxidation; Mass spectrometry; Reaction mechanism; Marine; Chlorinated molecules; Stopped-flow
MeSH headings : Animals; Hemoglobins / chemistry; Polychaeta; Peroxidases / metabolism; Peroxidase / chemistry; Hydrogen-Ion Concentration
TL;DR: As pH was lowered, DHP-A appeared to have a higher peroxidase activity than D HP-B, an unprecedented result, and the fact that there are multiple processes contributing to both kinetics and yield of TCP oxidation complicates interpretation of these data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 9, 2023

2022 article

Classical Model of Surface Enhanced Infrared Absorption (SEIRA) Spectroscopy

Gao, Y., Aspnes, D. E., & Franzen, S. (2022, January 10). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 1.

By: Y. Gao n, D. Aspnes n & S. Franzen n

TL;DR: This study generalizes the interactions of plasmons with molecules by considering the N2O asymmetric stretch SEIRA signal on a Dy doped CdO (CdO:Dy) film, which has tunable plasmon dispersion curves throughout the near-and mid-infrared that can interact directly with vibrational absorption transitions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2021 journal article

A new inhibition mechanism in the multifunctional catalytic hemoglobin dehaloperoxidase as revealed by the DHP A(V59W) mutant: A spectroscopic and crystallographic study

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 25(7-8), 756–771.

By: M. Thompson*, M. Shay*, V. Serrano n, R. Dumarieh n, R. Ghiladi n & S. Franzen n

author keywords: Peroxidase; hemoglobin; structure-function; tryptophan; inhibition
TL;DR: The data reveal a new mechanism of DHP inhibition, namely a shift towards a non-reactive form by OH that is strongly stabilized (presumably through H-bonding interactions) by the presence of W59 in the distal cavity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 23, 2021

2020 journal article

Classical Correlation Model of Resonance Raman Spectroscopy

JOURNAL OF PHYSICAL CHEMISTRY A, 124(44), 9177–9186.

By: Y. Gao n, D. Aspnes n & S. Franzen n

TL;DR: A classical correlation model based on forces instead of potentials is developed and applied to resonance Raman scattering to provide a foundation for further advances in understanding the effects of fields and vibronic perturbations on the optical properties of materials by a simple, yet versatile, description. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 journal article

Critical Test of the Interaction of Surface Plasmon Resonances with Molecular Vibrational Transitions

JOURNAL OF PHYSICAL CHEMISTRY A, 124(9), 1744–1753.

By: E. Sachet*, D. Aspnes n, J. Maria n & S. Franzen n

TL;DR: The results show that interactions of infrared SPPs with molecular vibrations are in the weak coupling limit, and that enhancements comparable those reported for noble metals are achievable. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2018 review

As good as gold and better: conducting metal oxide materials for mid-infrared plasmonic applications

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY C, 6(31), 8326–8342.

By: H. Khamh n, E. Sachet n, K. Kelly n, J. Maria n & S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2018 journal article

Dynamics of dehaloperoxidase-hemoglobin A derived from NMR relaxation spectroscopy and molecular dynamics simulation

JOURNAL OF INORGANIC BIOCHEMISTRY, 181, 65–73.

By: J. Zhao n, M. Xue*, D. Gudanis*, H. Gracz n, G. Findenegg*, Z. Gdaniec*, S. Franzen n

author keywords: Multifunctional-enzyme; Peroxidase; Peroxygenase; Protein dynamics; Model-free analysis
MeSH headings : Algorithms; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / metabolism; Histidine / chemistry; Histidine / genetics; Histidine / metabolism; Kinetics; Ligands; Models, Molecular; Molecular Dynamics Simulation; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / metabolism; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Polychaeta / enzymology; Protein Conformation; Protein Folding; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Xenon / chemistry; Xenon / metabolism
TL;DR: A study of the protein backbone dynamics of DHP using heteronuclear NMR relaxation methods and molecular dynamics simulations to address the role of protein dynamics in switching from one function to another. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Bindings of NO, CO, and O-2 to multifunctional globin type dehaloperoxidase follow the 'sliding scale rule'

Biochemical Journal (London, England : 1984), 474, 3485–3498.

By: G. Wu, J. Zhao, S. Franzen & A. Tsai

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Bindings of NO, CO, and O2 to multifunctional globin type dehaloperoxidase follow the ‘sliding scale rule’

Bindings of NO, CO, and O2 to multifunctional globin type dehaloperoxidase follow the ‘sliding scale rule.’ Biochemical Journal, 474(20), 3485–3498.

By: G. Wu*, J. Zhao n, S. Franzen n & A. Tsai*

MeSH headings : Carbon Monoxide / metabolism; Globins / metabolism; Hemoglobins / metabolism; Nitric Oxide / metabolism; Oxygen / metabolism; Peroxidases / metabolism
TL;DR: The present study provides useful insights into the rationale for DHP to function both as mono-oxygenase and oxidase, and is the first example of a globin peroxidase shown to follow the 'sliding scale rule' hypothesis in gaseous ligand discrimination. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: February 18, 2020

2017 journal article

Interaction of Azole-Based Environmental Pollutants with the Coelomic Hemoglobin from Amphitrite ornata: A Molecular Basis for Toxicity

Biochemistry, 56(17), 2294–2303.

By: N. McCombs n, T. Moreno-Chicano*, L. Carey n, S. Franzen n, M. Hough* & R. Ghiladi n

Contributors: N. McCombs n, T. Moreno-Chicano*, L. Carey n, S. Franzen n, M. Hough* & R. Ghiladi n

MeSH headings : Amino Acid Motifs; Animals; Benzimidazoles / chemistry; Benzimidazoles / metabolism; Benzimidazoles / toxicity; Catalytic Domain; Computational Biology; Environmental Pollutants / chemistry; Environmental Pollutants / metabolism; Environmental Pollutants / toxicity; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / toxicity; Fungicides, Industrial / chemistry; Fungicides, Industrial / metabolism; Fungicides, Industrial / toxicity; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Imidazoles / chemistry; Imidazoles / metabolism; Imidazoles / toxicity; Indazoles / chemistry; Indazoles / metabolism; Indazoles / toxicity; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / metabolism; Kinetics; Ligands; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Pesticides / chemistry; Pesticides / metabolism; Pesticides / toxicity; Polychaeta / enzymology; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Triazoles / chemistry; Triazoles / metabolism; Triazoles / toxicity
TL;DR: The results demonstrate a new mechanism by which azole pollutants can potentially disrupt hemoglobin function, thereby improving the understanding of their impact on infaunal organisms in marine and aquatic environments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Vibrational spectroscopy of the double complex salt Pd(NH3)4(ReO4)2, a bimetallic catalyst precursor

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 173, 618–624.

By: S. Thompson n, H. Lamb n, B. Delley* & S. Franzen n

author keywords: FTIR; Raman; DMol(3); Double complex salt; Tetraamminepalladium (II) complex; Perrhenate
TL;DR: The infrared (IR) and Raman spectra of tetraamminepalladium(II) perrhenate and several related compounds are presented and good agreement is observed between ab initio calculations and experimental spectra. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2016 journal article

Multi-functional hemoglobin dehaloperoxidases

Heme Peroxidases, (4), 218–244.

By: S. Franzen, R. Ghiladi, L. Lebioda & J. Dawson

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Near-Infrared Optical Extinction of Indium Tin Oxide Structures Prepared by Nanosphere Lithography

ACS PHOTONICS, 3(10), 1993–1999.

By: M. Kang, M. Losego*, E. Sachet*, J. Maria* & S. Franzen*

author keywords: localized surface plasmon resonance; epsilon-near-zero mode; metamaterial; nanosphere lithography
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Steered molecular dynamics study of inhibitor binding in the internal binding site in dehaloperoxidase-hemoglobin

BIOPHYSICAL CHEMISTRY, 211, 28–38.

author keywords: Binding pathway; Potential of mean force; Protein-ligand interaction; Michaelis-menten kinetics; Steered molecular dynamics; Jarzynski equality
MeSH headings : Binding Sites; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Phenols / chemistry; Phenols / pharmacology
TL;DR: The binding free energy of 4-bromophenol (4-BP), an inhibitor that binds in the internal binding site in dehaloperoxidase-hemoglobin (DHP) was calculated using Molecular Dynamics methods combined with pulling or umbrella sampling and the effects of systematic changes in the pulling speed, pulling force constant and restraint force constant on the calculated potential of mean force (PMF) are presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

The quadrapolar character of the Markovnikov reaction transition state

CHEMICAL PHYSICS, 464, 46–54.

By: S. Franzen n, K. Cochran n, J. Weng n, L. Bartolotti* & B. Delley*

author keywords: Nudged elastic band; Intrinsic reaction coordinate; Transition state; Fukui function; Softness; Regioselectivity
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Aerobic oxidation of beta-isophorone by tetraphenylporphYrin catalysts in pyridine solution

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 410, 110–120.

By: E. Burns n, T. Huang n, W. Weare n, L. Bartolotti*, X. Wang*, J. Yao*, H. Li*, S. Franzen n

author keywords: Density functional theory; Resonance; Raman spectroscopy; Selectivity; Radical; High performance liquid chromatography
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Distinct Enzyme-Substrate Interactions Revealed by Two Dimensional Kinetic Comparison between Dehaloperoxidase-Hemoglobin and Horseradish Peroxidase

JOURNAL OF PHYSICAL CHEMISTRY B, 119(40), 12828–12837.

By: J. Zhao n, C. Lu* & S. Franzen n

MeSH headings : Hemoglobins / metabolism; Horseradish Peroxidase / metabolism; Kinetics; Oxidation-Reduction; Peroxidases / metabolism; Substrate Specificity
TL;DR: DHP is a tortoise, a slow but steady enzyme that wins the evolutionary race against the HRP-type of peroxidase, which is a hare, initially rapid, but flawed for this application because of the protein denaturation under the conditions of the experiment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Dysprosium-doped cadmium oxide as a gateway material for mid-infrared plasmonics

Nature Materials, 14(4), 414–420.

By: E. Sachet n, C. Shelton n, J. Harris n, B. Gaddy n, D. Irving n, S. Curtarolo*, B. Donovan*, P. Hopkins* ...

TL;DR: This work shows that CdO:Dy is a model system for intrinsic and extrinsic manipulation of defects affecting electrical, optical and thermal properties, that oxide conductors are ideal candidates for plasmonic devices and that the defect engineering approach for property optimization is generally applicable to other conducting metal oxides. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2015 journal article

Measurement of Internal Substrate Binding in Dehaloperoxidase-Hemoglobin by Competition with the Heme-Fluoride Binding Equilibrium

JOURNAL OF PHYSICAL CHEMISTRY B, 119(7), 2827–2838.

By: J. Zhao n, J. Moretto n, P. Le n & S. Franzen n

MeSH headings : Amino Acids / chemistry; Animals; Anions / chemistry; Binding Sites; Binding, Competitive; Fluorides / chemistry; Halogenation; Heme / chemistry; Hemoglobins / chemistry; Hydrogen Bonding; Hydrogen-Ion Concentration; Indoles / chemistry; Peroxidases / chemistry; Phenols / chemistry; Polychaeta; Protein Binding; Spectrum Analysis
TL;DR: 2, 4-dibromophenol (2,4-DBP) is identified as the tightest binding substrate discovered thus far, with approximately 20-fold tighter binding affinity than that of 4-bromophenols (4-BP), a known internally binding inhibitor in DHP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

A Model for the Flexibility of the Distal Histidine in Dehaloperoxidase-Hemoglobin A Based on X-ray Crystal Structures of the Carbon Monoxide Adduct

BIOCHEMISTRY, 53(15), 2474–2482.

By: J. Zhao n, V. Serrano n & S. Franzen n

MeSH headings : Amino Acid Sequence; Carbon Monoxide / chemistry; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Hemoglobin A / chemistry; Hemoglobins / chemistry; Histidine / chemistry; Molecular Sequence Data; Peroxidases / chemistry; Protein Conformation
TL;DR: The X-ray crystallographic structure of the carbonmonoxy complex (DHPCO) is reported, supporting the modified hypothesis suggesting a competition between the strength of interactions with heme ligand and the heme propionates as the factors that determine the conformation of the distal histidine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Controlling enantioselectivity of esterase in asymmetric hydrolysis of aryl prochiral diesters by introducing aromatic interactions

Biotechnology and Bioengineering, 111(9), 1729–1739.

By: F. Guo*, S. Franzen*, L. Ye*, J. Gu* & H. Yu*

author keywords: enantioselectivity; esterase; rational design; aromatic interactions; molecular dynamics simulation
MeSH headings : Escherichia coli / enzymology; Escherichia coli / genetics; Esterases / genetics; Esterases / metabolism; Hydrolysis; Rhodobacter sphaeroides / enzymology; Rhodobacter sphaeroides / genetics; Substrate Specificity
TL;DR: The successful engineering of the enantioselectivity in two different proteins toward four different substrates suggests that the introduction of aromatic interactions is a generally applicable strategy in the control of enantiOSElectivity toward aryl substrates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2014 journal article

Correlation of Heme Binding Affinity and Enzyme Kinetics of Dehaloperoxidase

BIOCHEMISTRY, 53(44), 6863–6877.

By: P. Le n, J. Zhao n & S. Franzen n

MeSH headings : Animals; Heme / chemistry; Hemoglobins / chemistry; Kinetics; Peroxidases / chemistry; Polychaeta / enzymology; Protein Binding; Protein Denaturation; Thermodynamics
TL;DR: Thermal denaturation and heme transfer experiments from DHP to HSMb further support the hypothesis that the binding of halophenols to DHP facilitates the removal of the heme, and Kinetic studies verified that DHP B has a catalytic efficiency ∼5-6 times greater than that of DHP A but showed an increased level of substrate inhibition in DHPB for both 2,4,6-TCP and 2, 4, 6-TBP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Dynamics of Multifunctional Dehaloperoxidase Hemoglobin

Biophysical Journal, 106(2), 662a.

By: S. Franzen n, J. Zhao n & H. Gracz n

TL;DR: Time-resolved X-ray crystallography reveals ballistic motion of carbon monoxide to the only internal Xe-binding site and rapid escape from the protein, both features that are consistent with the open architecture of the distal pocket. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2014 journal article

Highly Efficient Fluorescent Interstrand Photo-crosslinking of DNA Duplexes Labeled with 5-Fluoro-4-thio-2 '-O-methyluridine

CHEMBIOCHEM, 15(14), 2045–2049.

By: J. Nowak-Karnowska*, Z. Chebib*, J. Milecki*, S. Franzen n & B. Skalski*

author keywords: enzymatic digestion; fluorescence; fluorothiouridine; interstrand photo-crosslinking; oligonucleotides
MeSH headings : Base Sequence; Cross-Linking Reagents / chemistry; DNA / chemistry; DNA, Complementary / chemistry; Fluorescent Dyes / chemistry; Molecular Dynamics Simulation; Oligonucleotides / chemistry; Photochemistry; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR: The identity of the thymidine that participates in the photo‐crosslinking reaction as well as the diastereomeric structures of the crosslinks are revealed and the proposed pathways of interstrand photo‐Crosslinking are supported by experiments with isotopically labeled oligonucleotide constructs and visualized by means of molecular dynamics simulations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Peroxygenase and Oxidase Activities of Dehaloperoxidase-Hemoglobin from Amphitrite ornata

Journal of the American Chemical Society, 136(22), 7914–7925.

By: D. Barrios n, J. D’Antonio n, N. McCombs n, J. Zhao n, S. Franzen n, A. Schmidt n, L. Sombers n, R. Ghiladi n

Contributors: D. Barrios n, . J. D'Antonio, N. McCombs n, J. Zhao n, S. Franzen n, A. Schmidt n, L. Sombers n, R. Ghiladi n

MeSH headings : Animals; Catalytic Domain; Hemoglobins / chemistry; Hemoglobins / metabolism; Indoles / chemistry; Indoles / metabolism; Mixed Function Oxygenases / metabolism; Models, Molecular; Oxidoreductases / metabolism; Oxygen / chemistry; Oxygen Consumption; Oxygen Radioisotopes; Polychaeta / enzymology; Protein Conformation
TL;DR: The marine globin dehaloperoxidase‐hemoglobin (DHP) from Amphitrite ornata was found to catalyze the H2O2‐dependent oxidation of monohaloindoles, a previously unreported class of substrate for DHP, and non‐enzymatic and anaerobic controls suggest a novel oxidase activity for D HP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2014 journal article

Photochemistry of 6-amino-2-azido, 2-amino-6-azido and 2,6-diazido analogues of purine ribonucleosides in aqueous solutions

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 13(3), 563–573.

By: K. Komodzinski*, J. Lepczynska*, Z. Gdaniec*, L. Bartolotti*, B. Delley*, S. Franzen n, B. Skalski*

MeSH headings : 2-Aminopurine / analogs & derivatives; 2-Aminopurine / chemistry; Absorption; Adenosine / analogs & derivatives; Adenosine / chemistry; Azides / chemistry; Chromatography, High Pressure Liquid; Computer Simulation; Kinetics; Light; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Oxidation-Reduction; Oxygen / chemistry; Photochemical Processes; Ribonucleosides / chemistry; Solvents / chemistry; Spectrum Analysis; Ultraviolet Rays; Water / chemistry
TL;DR: The role of the 2-amino group in regulating the competition between these pathways was elucidated in order to explain how the striking difference in reactivity under irradiation arises from the greater spin density on the 6-nitreno-9-methyl-9 H -purin-2-amine, which essentially eliminates the barrier to oxidation observed in 6-Nitreno -9- methyl-9H -purine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Self-Assembley of Dehaloperoxidase-Hemoglobin Probed by Backbone Dynamics using NMR Relaxation Experiments and Molecular Dynamics Simulation

Biophysical Journal, 106(2), 466a.

By: J. Zhao n, M. Xue*, H. Gracz n & S. Franzen n

TL;DR: The dynamic pattern of DHP monomer shows that the μs-ms slow motions experiencing by residues in the dimer interface are primarily responsible for association between each monomers, which leads to the unique autoreduction phenomenon in DHP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2014 journal article

The coupling of tautomerization to hydration in the transition state on the pyrimidine photohydration reaction path

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 16(37), 20164–20174.

By: S. Franzen n, B. Skalski*, L. Bartolotti* & B. Delley*

MeSH headings : Cytosine / chemistry; Pyrimidines / chemistry; Quantum Theory; Thermodynamics; Thymine / chemistry; Uridine / chemistry; Water / chemistry
TL;DR: Comparison of calculations with previous computational and experimental work suggests that a hot ground state formed by the rapid internal conversion of pyrimidines has sufficient energy to permit crossover from the common form to the tautomeric form of the pyrimidine at the transition state. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Catalytic efficiency of dehaloperoxidase A is controlled by electrostatics - application of the vibrational Stark effect to understand enzyme kinetics

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 430(3), 1011–1015.

By: G. Schkolnik, T. Utesch, J. Zhao*, S. Jiang*, M. Thompson*, M. Mroginski, P. Hildebrandt, S. Franzen*

author keywords: Vibrational Stark effect; Hemoglobin; 4-mercaptobenzonitrile; Enzyme kinetics; Electric field
MeSH headings : Animals; Catalysis; Kinetics; Mutation; Peroxidase / chemistry; Peroxidase / genetics; Peroxidases / chemistry; Peroxidases / genetics; Polychaeta / enzymology; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Static Electricity; Vibration
TL;DR: By labeling the protein with 4-mercaptobenzonitrile (MBN), a Stark probe molecule, this work provides further evidence that the diffusion control of the catalytic process arises from the electrostatic repulsion between the enzyme and the negatively charged substrate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Comment on 'Cooperativity between two selected RNA Pdases in the synthesis of Pd nanoparticles' by J. L. Rouge et al., J. Mater. Chem., 2010, 20, 8394-8398

JOURNAL OF MATERIALS CHEMISTRY B, Vol. 1, pp. 6339–6341.

By: S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Crystals: The Formation of Pd Nanocrystals from Pd2(dba)3Microcrystals (Part. Part. Syst. Charact. 3/2013)

Particle & Particle Systems Characterization, 30(3), 298–298.

By: S. Chung*, D. Leonard n, V. Altoe*, S. Aloni*, J. De Yoreo* & S. Franzen n

Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2013 journal article

Functional Consequences of the Open Distal Pocket of Dehaloperoxidase-Hemoglobin Observed by Time-Resolved X-ray Crystallography

BIOCHEMISTRY, 52(45), 7943–7950.

By: J. Zhao n, V. Srajer* & S. Franzen n

MeSH headings : Binding Sites; Carbon Monoxide / chemistry; Carbon Monoxide / metabolism; Crystallography, X-Ray / methods; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism
TL;DR: Using time-resolved X-ray crystallography, a bifunctional dehaloperoxidase-hemoglobin (DHP) is contrasted with previously studied examples of myoglobin and hemoglobin to understand the functional role of the distal pocket of globins. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Kinetic Study of the Inhibition Mechanism of Dehaloperoxidase-Hemoglobin A by 4-Bromophenol

JOURNAL OF PHYSICAL CHEMISTRY B, 117(28), 8301–8309.

By: J. Zhao n & S. Franzen n

MeSH headings : Crystallography, X-Ray; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Hemoglobins / chemistry; Kinetics; Mixed Function Oxygenases / antagonists & inhibitors; Mixed Function Oxygenases / chemistry; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Phenols / pharmacology; Protein Binding / drug effects
TL;DR: Two new species have been identified during the reaction of 4-BP bound form of DHP in the transient-state kinetic experiment by using Singular Value Decomposition (SVD) and global-fitting analysis, and an inhibitor bound intermediate that possesses blue-shifted Soret band and a double peaked Q-band is observed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Mid-infrared surface plasmon resonance in zinc oxide semiconductor thin films

Applied Physics Letters, 102(5), 051111.

By: E. Sachet n, M. Losego n, J. Guske n, S. Franzen n & J. Maria n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Role of Polarity of the Distal Pocket in the Control of Inhibitor Binding in Dehaloperoxidase-Hemoglobin

BIOCHEMISTRY, 52(13), 2218–2227.

By: A. Plummer n, M. Thompson* & S. Franzen n

MeSH headings : Animals; Binding Sites; Crystallography, X-Ray; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / metabolism; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Phenols / metabolism; Point Mutation; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / genetics; Polychaeta / metabolism; Protein Binding; Substrate Specificity
TL;DR: Kinetic assays and resonance Raman indicate that the peroxidase activity of the L100T and L100F mutants is increased compared to that of native DHP in the presence of 4-bromophenol (4-BP), suggesting a reduction in the inhibitor binding constant. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Structural and Kinetic Study of an Internal Substrate Binding Site in Dehaloperoxidase-Hemoglobin A from Amphitrite ornata

BIOCHEMISTRY, 52(14), 2427–2439.

By: J. Zhao n, V. Serrano n, J. Zhao n, P. Le n & S. Franzen n

MeSH headings : 2-Propanol / chemistry; Animals; Crystallography, X-Ray; Dimethyl Sulfoxide / chemistry; Hemoglobins / chemistry; Hemoglobins / metabolism; Kinetics; Methanol / chemistry; Models, Molecular; Peroxidases / chemistry; Peroxidases / metabolism; Phenols / chemistry; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / metabolism; Protein Conformation
TL;DR: The X-ray crystal structure is consistent with the presence of an internal active site above the heme α-edge, in which the substrate would be oxidized in two consecutive steps inside the enzyme, followed by attack by H2O via a water channel in the protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

The Formation of Pd Nanocrystals from Pd2(dba)3Microcrystals

Particle & Particle Systems Characterization, 30(3), 280–286.

By: S. Chung*, D. Leonard n, V. Altoe*, S. Aloni*, J. De Yoreo* & S. Franzen n

author keywords: palladium; microcrystals; nanocrystals; transmission electron microscopy; thermal annealing
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2013 journal article

The Regulatory Implications of Hydroquinone for the Multifunctional Enzyme Dehaloperoxidase-Hemoglobin from Amphitrite ornata

JOURNAL OF PHYSICAL CHEMISTRY B, 117(47), 14615–14624.

By: J. Zhao n, J. Zhao n & S. Franzen n

MeSH headings : Animals; Chlorophenols / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Peroxide / metabolism; Hydroquinones / metabolism; Models, Molecular; Multifunctional Enzymes / chemistry; Multifunctional Enzymes / metabolism; Oxidation-Reduction; Peroxidases / chemistry; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / metabolism
TL;DR: Light is shed on understanding the difference between substrate and inhibitor binding sites and regulatory implication for the peroxidase and oxygen-transporter functions in DHP, and the reversible reactions between ferric/oxyferrous DHP A and H2Q/1,4-BQ are shown to involve a proton-coupled electron transfer (PCET) mechanism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

The role of T56 in controlling the flexibility of the distal histidine in dehaloperoxidase-hemoglobin from Amphitrite ornata

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834(10), 2020–2029.

By: S. Jiang*, I. Wright, P. Swartz* & S. Franzen*

author keywords: Enzyme kinetics; Catalytic efficiency; Hemichrome; Resonance Raman; Molecular dynamics
MeSH headings : Animals; Biocatalysis; Heme / chemistry; Hemoglobins / chemistry; Hemoglobins / genetics; Histidine / chemistry; Histidine / genetics; Iron / chemistry; Kinetics; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Peroxidases / chemistry; Peroxidases / genetics; Polychaeta / chemistry; Polychaeta / enzymology; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics; Threonine / chemistry; Threonine / genetics
TL;DR: It is confirmed that subtle changes in the conformation of H55 affect the catalytic efficiency of DHP, and a balance of enzymatic rate and protein stability with respect to hemichrome formation appears to be optimum in wild type DHP (WT-DHP). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

A Resonance Raman Enhancement Mechanism for Axial Vibrational Modes in the Pyridine Adduct of Myoglobin Proximal Cavity Mutant (H93G)

The Journal of Physical Chemistry B, 116(35), 10514–10521.

By: S. Franzen n, D. Brown n, J. Gaff n & B. Delley*

MeSH headings : Amino Acid Substitution; Heme / chemistry; Mutation; Myoglobin / chemistry; Myoglobin / genetics; Myoglobin / metabolism; Pyridines / chemistry; Spectrum Analysis, Raman
TL;DR: The observation that the pyridine ring breathing mode and the symmetric ring stretching modes are enhanced under these conditions is explained by a computational approach that shows that coupling of the π-system of the heme with the p-orbitals of the p Pyridine is analogous toπ-backbonding in diatomic ligand adducts of heme proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2012 journal article

Infrared surface plasmon resonance of AZO-Ag-AZO sandwich thin films

OPTICS EXPRESS, 20(21), 23215–23226.

By: J. Guske n, J. Brown*, A. Welsh* & S. Franzen n

MeSH headings : Light; Materials Testing; Membranes, Artificial; Scattering, Radiation; Silver / chemistry; Surface Plasmon Resonance / methods; Zinc Oxide / chemistry
TL;DR: Near-infrared surface plasmon resonance (SPR) spectra were collected of thin multilayer films of aluminum-doped zinc oxide / silver / AZO on BK-7 glass in the Kretschmann configuration in air, indicating an inhibition of metal island formation for Ag deposited on AZO. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Nonphotochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2Occurs by a Radical Mechanism

The Journal of Physical Chemistry B, 116(5), 1666–1676.

By: S. Franzen*, K. Sasan, B. Sturgeon*, B. Lyon*, B. Battenburg*, H. Gracz*, R. Dumariah, R. Ghiladi*

Contributors: S. Franzen*, K. Sasan, B. Sturgeon*, B. Lyon*, B. Battenburg*, H. Gracz*, R. Dumariah, R. Ghiladi*

MeSH headings : Animals; Benzoquinones / chemistry; Benzoquinones / metabolism; Catalysis; Chlorophenols / metabolism; Hydrogen Peroxide / metabolism; Peroxidases / metabolism; Polychaeta / enzymology; Polychaeta / metabolism
TL;DR: The control experiments and precedents in studies of other peroxidases lead to the conclusion that hydroxylation will be observed following any process that leads to the formation of the 2,6-DCQ at pH > 7, regardless of the catalyst used in the2,4, 6-TCP oxidation reaction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Photoaddition of 5-Bromouracil to Uracil in Oligonucleotides Leading to 5,5 '-Bipyrimidine-Type Adducts: Mechanism of the Photoreaction

JOURNAL OF ORGANIC CHEMISTRY, 77(24), 11362–11367.

By: J. Lepczynska*, K. Komodzinski*, J. Milecki*, R. Kierzek*, Z. Gdaniec*, S. Franzen n, B. Skalski*

MeSH headings : Bromouracil / chemistry; Oligonucleotides / chemistry; Photochemical Processes
TL;DR: The results indicate that the primary photochemical process in all of these compounds involves the formation of an intermediate cyclobutane phodoadduct composed of (Br)U and U, which undergoes further photochemically and thermally induced transformations to 5,5'-bipyrimidine type adducts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Resonance Raman enhancement of pyridine on Ag clusters

Chemical Physics, 397(1), 34–41.

By: J. Gaff* & S. Franzen*

author keywords: Surface-enhanced Raman spectroscopy; Charge transfer; Adsorption; Nanoparticle; Time correlator
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2012 journal article

Study of the electrostatic effects of mutations on the surface of dehaloperoxidase-hemoglobin A

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 420(4), 733–737.

By: J. Zhao n, J. Rowe n, J. Franzen n, C. He* & S. Franzen n

author keywords: Surface mutation; Electrostatic interaction; Isoelectric focusing; Ionic strength effect; Enzyme kinetics
MeSH headings : Animals; Hemoglobin A / chemistry; Hemoglobin A / genetics; Mutagenesis; Mutation; Peroxidases / chemistry; Peroxidases / genetics; Polychaeta / enzymology; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Static Electricity
TL;DR: The electrostatic nature of substrate binding was further confirmed by the result that kinetic assays of DHP A were affected by ionic strength, and isoelectric focusing gel study showed that D HP A has a slight negative charge pH 7, consistent with the kinetic observations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

The Role of the Distal Histidine in H2O2 Activation and Heme Protection in both Peroxidase and Globin Functions

The Journal of Physical Chemistry B, 116(40), 12065–12077.

By: J. Zhao n, V. de Serrano n, R. Dumarieh n, M. Thompson n, R. Ghiladi n & S. Franzen n

Contributors: J. Zhao n, V. De Serrano n, R. Dumarieh n, M. Thompson n, R. Ghiladi n & S. Franzen n

MeSH headings : Biocatalysis; Chlorophenols / chemistry; Chlorophenols / metabolism; Heme / chemistry; Heme / metabolism; Hemoglobin A / chemistry; Hemoglobin A / metabolism; Histidine / chemistry; Histidine / genetics; Histidine / metabolism; Hydrogen Peroxide / chemistry; Hydrogen Peroxide / metabolism; Models, Molecular; Molecular Structure; Mutation; Oxidation-Reduction; Peroxidases / chemistry; Peroxidases / metabolism; Quinones / chemistry; Quinones / metabolism
TL;DR: The distal histidine mutations of dehaloperoxidase-hemoglobin A to aspartate (H55D) and asparagine and H55N have been prepared to study the role played by the distal Histidine in both activation and protection against oxidation by radicals in heme proteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 journal article

The dehaloperoxidase paradox

Biochimica Et Biophysica Acta (BBA) - Proteins and Proteomics, 1824(4), 578–588.

By: S. Franzen n, M. Thompson n & R. Ghiladi n

Contributors: S. Franzen n, M. Thompson n & R. Ghiladi n

author keywords: Peroxidase; Competitive inhibition; Hemoglobin; Phenol; Marine; Enzyme
MeSH headings : Amino Acid Motifs; Amino Acid Substitution; Animals; Enzyme Inhibitors / chemistry; Free Radicals / chemistry; Heme / chemistry; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / genetics; Humans; Hydrogen-Ion Concentration; Isoenzymes / antagonists & inhibitors; Isoenzymes / chemistry; Isoenzymes / genetics; Kinetics; Models, Molecular; Oxidation-Reduction; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / genetics; Phenols / chemistry; Protein Binding
TL;DR: The unresolved aspects of the reaction scheme that leads to the apparent paradox of Amphitrite ornata are explored in the context of control of reactivity radical pathways and reactivity by the motion of the distal histidine, H55, which is coupled to the binding of substrate and inhibitor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 journal article

Thin-layer spectroelectrochemistry of the Fe(III)/Fe(II) redox reaction of dehaloperoxidase-hemoglobin

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 668, 37–43.

By: . Edward L. D'Antonio, E. Bowden n & S. Franzen n

author keywords: Dehaloperoxidase; Hemoglobin; Fe(III)/Fe(II) reduction potential; Gibbs free energy analysis; Distal histidine conformation; Redox thermodynamic square scheme
TL;DR: A thermodynamic cycle that links the conformational change to electron transfer is shown to be consistent with a positive shift in reduction potential if the open conformation is differentially favored by the Fe(II) state, a proposal that is supported by the available crystallographic data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Vibrational Stark Effect of the Electric-Field Reporter 4-Mercaptobenzonitrile as a Tool for Investigating Electrostatics at Electrode/SAM/Solution Interfaces

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13(6), 7466–7482.

By: G. Schkolnik*, J. Salewski*, D. Millo*, I. Zebger*, S. Franzen n & P. Hildebrandt*

author keywords: interfaces; self-assembled monolayer; electrode; vibrational Stark effect; surface enhanced Raman; surface enhanced infrared; potential of zero-charge
MeSH headings : Electrochemical Techniques; Electrodes; Models, Chemical; Nitriles / chemistry; Static Electricity; Sulfhydryl Compounds / chemistry
TL;DR: The present electrostatic model consistently explains the electric field strengths for MBN SAMs on Ag and Au as well as for thiophenol and mercaptohexanoic acid SAMs with MBN incorporated as a VSE reporter. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

5-Fluoro-4-thiouridine phosphoramidite: New synthon for introducing photoaffinity label into oligodeovnucleotides

BIOORGANIC & MEDICINAL CHEMISTRY, 19(20), 6098–6106.

By: J. Milecki*, J. Nowak*, B. Skalski* & S. Franzen n

author keywords: Photocrosslink; 5-Fluoro-4-thiouridine; Oligonucleotides; Phosphoramidite
MeSH headings : Oligodeoxyribonucleotides / chemical synthesis; Oligodeoxyribonucleotides / chemistry; Oligonucleotides / chemical synthesis; Oligonucleotides / chemistry; Organophosphorus Compounds / chemical synthesis; Organophosphorus Compounds / chemistry; Photoaffinity Labels / chemical synthesis; Photoaffinity Labels / chemistry; Thiouridine / analogs & derivatives; Thiouridine / chemical synthesis; Thiouridine / chemistry
TL;DR: The synthesis of phosphoramidite of 5-fluoro-4-thio-2'-O-methyluridine of 4-triazolyl as the 4-(2-cyanoethyl)thio derivative and t-butyldimethyl silyl for 2' and 3' hydroxyl protection prevented unwanted side reactions during oligonucleotide synthesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 review

A comparison of peptide and folate receptor targeting of cancer cells: from single agent to nanoparticle

[Review of ]. EXPERT OPINION ON DRUG DELIVERY, 8(3), 281–298.

By: S. Franzen n

author keywords: antibody; caveolar uptake; cell-penetrating peptide; clathrin-mediated endocytosis; colloid; cytokine; dendrimer; endosomolytic peptide; hormone; liposome; macropinocytosis; phage display; poly(ethylene glycol) polymer
MeSH headings : Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacology; Drug Delivery Systems / methods; Folic Acid Transporters / metabolism; Humans; Nanoparticles; Neoplasms / drug therapy; Receptors, Peptide / metabolism
TL;DR: This review describes how the coupling chemistry and surface charge effects of peptide labeling in nanoparticle drug delivery strategies have proved difficult to control, resulting in many studies that use folate instead. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Analysis of RNA-Mediated Materials Synthesis Using Magnetic Selection

JOURNAL OF PHYSICAL CHEMISTRY C, 115(19), 9335–9343.

By: S. Franzen n & D. Leonard*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Characterizing the Molecular Order of Phosphonic Acid Self-Assembled Monolayers on Indium Tin Oxide Surfaces

LANGMUIR, 27(19), 11883–11888.

By: M. Losego*, J. Guske*, A. Efremenko*, J. Maria* & S. Franzen*

MeSH headings : Membranes, Artificial; Molecular Structure; Organophosphonates / chemical synthesis; Organophosphonates / chemistry; Particle Size; Surface Properties; Tin Compounds / chemistry
TL;DR: Results indicate that long-chain SAMs are more highly ordered, and have a smaller tilt angle, than short- Chain SAMs, and surprisingly, the 1-octadecyl phosphonic acids maintain their order as the lateral grain dimensions of the ITO surface shrink to ∼50 nm. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Decay of Compound ES in Dehaloperoxidase-Hemoglobin

Biophysical Journal, 100(3), 194a.

TL;DR: A kinetic model of the experimental data suggests that formation of Compound RH or the Tyr38 radical are two alternative routes ofcompound ES decay, a product of safe termination of the two oxidizing equivalents of H2O2 when no substrate is available. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2011 journal article

Degradation of sulfide by dehaloperoxidase-hemoglobin from Amphitrite ornata

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 16(4), 611–619.

By: F. Nicoletti*, M. Thompson n, S. Franzen n & G. Smulevich*

author keywords: Sulfide; Dehaloperoxidase-hemoglobin; Resonance Raman; Detoxification; Oxygen
MeSH headings : Animals; Binding Sites; Biocatalysis; Hemoglobins / metabolism; Models, Molecular; Oxidation-Reduction; Peroxidase / metabolism; Polychaeta / chemistry; Polychaeta / enzymology; Sulfides / metabolism
TL;DR: This proposed new function for DHP relies on the highly flexible distal His55 for deprotonation of the bound hydrogen sulfide, similar to H2O2 activation of the peroxidase function, and provides further support for the importance of the flexibility of the distal He55 in this novel globin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Dehaloperoxidase-Hemoglobin from Amphitrite ornata Is Primarily a Monomer in Solution

JOURNAL OF PHYSICAL CHEMISTRY B, 115(14), 4266–4272.

By: M. Thompson n, S. Franzen n, M. Davis n, R. Oliver* & J. Krueger*

MeSH headings : Animals; Crystallography, X-Ray; Dimerization; Hemoglobins / chemistry; Peroxidases / chemistry; Polychaeta / enzymology; Polychaeta / metabolism; Protein Conformation; Scattering, Small Angle; Solutions / chemistry; X-Ray Diffraction
TL;DR: DHP A is primarily monomeric in solution, but with a detectable level of dimer (~10%), under all conditions studied up to a protein concentration of 3.0 mM, which is likely 10-100-fold lower than the K(d) for dimer formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Determination of the Solubility Limit of Tris(dibenzylideneacetone) dipalladium(0) in Tetrahydrofuran/Water Mixtures

JOURNAL OF CHEMICAL EDUCATION, 88(5), 619–623.

By: S. Franzen n

author keywords: Upper-Division Undergraduate; Laboratory instruction; Physical Chemistry; Hands-On Learning/Manipulatives; Computer-Based Learning; Solutions/Solvents; Thermodynamics; Nanotechnology; Colloids; UV-Vis Spectroscopy
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Distal Histidine Flexibility as the Key to the Reactivity of Dehaloperoxidase-Hemoglobin

Biophysical Journal, 100(3), 222a.

By: M. Thompson & S. Franzen*

TL;DR: The recent discovery of an internal inhibitor binding site, in the distal pocket, clearly establishes the peroxidase function and suggests that thedistal histidine (H55) plays the central role in both function switching and activation of DHPs A&B. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2011 journal article

Effect of H55D Mutation on Kinetics and Structure of Dehaloperoxidase-Hemoglobin A

Biophysical Journal, 100(3), 221a.

By: J. Zhao, V. de Serrano, R. Dumarieh, M. Thompson & S. Franzen*

TL;DR: The H55D mutant has been prepared to mimic the H64D mutant of Sperm Whale myoglobin, which has the highest peroxidase activity of any myoglobin mutant studied to date, and shows inhibition by 4-bromophenol in the oxidation of TCP, which is substantiated by the X-ray crystal structure of 4-BP bound to the internal inhibitor binding site observed in wild type DHP A and B. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2011 journal article

Functional Consequences of the Creation of an Asp-His-Fe Triad in a 3/3 Globin

Biochemistry, 50(44), 9664–9680.

By: E. D’Antonio n, J. D’Antonio n, V. de Serrano n, H. Gracz n, M. Thompson n, R. Ghiladi n, E. Bowden n, S. Franzen n

Contributors: E. Dantonio n, J. Dantonio n, V. De Serrano n, H. Gracz n, M. Thompson n, R. Ghiladi n, E. Bowden n, S. Franzen n

MeSH headings : Animals; Aspartic Acid / chemistry; Aspartic Acid / genetics; Catalytic Domain / genetics; Crystallography, X-Ray; Electrochemistry; Globins / chemistry; Globins / genetics; Helminth Proteins / chemistry; Helminth Proteins / genetics; Histidine / chemistry; Histidine / genetics; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Polychaeta / enzymology; Polychaeta / genetics; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman
TL;DR: The results suggest that the proximal charge relay in peroxidases regulate the redox potential of the heme Fe but that the trans effect is a carefully balanced property that can both activate H( 2)O(2) and attract ligation by the distal histidine. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Making Substrates Out of Inhibitors: Distal Cavity Mutations in Dehaloperoxidase from Amphitrite Ornata

Biophysical Journal, 100(3), 222a.

By: A. Plummer, M. Thompson & S. Franzen*

TL;DR: Blocking internal binding in DHP may be the key to effectively enable DHP to function as a peroxidase on the full range of halogenated phenols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2011 journal article

Mass Spectrometric Detection of Targeting Peptide Bioconjugation to Red clover necrotic mosaic virus

BIOCONJUGATE CHEMISTRY, 22(10), 1970–1982.

By: R. Wang, D. Lockney*, M. Goshe* & S. Franzen*

MeSH headings : Amino Acid Sequence; Capsid / chemistry; Cross-Linking Reagents / chemistry; Drug Delivery Systems; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Peptides / chemistry; Tombusviridae / chemistry
TL;DR: Results show that heterobifunctional linkers may not be the most efficient method for attachment of peptides to plant virus capsids, and maleimide peptides were used to conjugate with the virus in a one-step reaction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Molecular Activation by Peroxidases

Biophysical Journal, 100(3), 221a.

By: K. Sasan & S. Franzen*

TL;DR: The effect of alternative activation using peroxy acids, such as meta-chloroperoxybenzoic acid, is probed to test the role played by activation and electron transfer in the formation of products by the dual function hemoglobin-dehaloperoxidase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2011 journal article

Mutagenesis Study on the Conformation of Distal Histidine in Dehaloperoxidase-Hemoglobin

Biophysical Journal, 100(3), 221a.

By: S. Jiang & S. Franzen*

TL;DR: Molecular dynamics simulations, Resonance Raman spectroscopy, X-ray crystallography and other methods will be presented to understand how a change in the Thr56 position affects the both the conformation of His55 and peroxidase activity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2011 journal article

Oxidative dechlorination of halogenated phenols catalyzed by two distinct enzymes: Horseradish peroxidase and dehaloperoxidase

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 505(1), 22–32.

By: L. Szatkowski*, M. Thompson n, R. Kaminski*, S. Franzen n & A. Dybala-Defratyka*

author keywords: Dehaloperoxidase; Horseradish peroxidase; Chlorine kinetic isotope effects; QM/MM; Halophenols; Oxidation
MeSH headings : Animals; Armoracia / enzymology; Halogenation; Halogens / metabolism; Horseradish Peroxidase / metabolism; Kinetics; Models, Molecular; Oxidation-Reduction; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology
TL;DR: It is concluded that two sequential one electron oxidations of the halogenated phenol substrate leads to a cationic intermediate that strongly resembles a Meisenheimer intermediate - a commonly formed reactive complex during nucleophilic aromatic substitution reactions especially in the case of arenes carrying electron withdrawing groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Revisiting the Peroxidase Oxidation of 2,4,6-Trihalophenols: ESR Detection of Radical Intermediates

CHEMICAL RESEARCH IN TOXICOLOGY, 24(11), 1862–1868.

By: B. Sturgeon*, B. Battenburg*, B. Lyon* & S. Franzen n

MeSH headings : Animals; Benzoquinones / chemistry; Benzoquinones / metabolism; Biocatalysis; Biochemistry; Chlorophenols / chemistry; Chlorophenols / metabolism; Electron Spin Resonance Spectroscopy; Free Radicals; Horseradish Peroxidase / metabolism; Horses; Myoglobin / metabolism; Oxidation-Reduction; Solutions
TL;DR: Evidence is presented for the transient 2,4,6-trichlorophenoxyl radical intermediate (TCP•), which exists free in solution, i.e., is not enzyme associated and best explained as a 1-electron peroxidase oxidation of TCP to form TCP•, followed by enzyme-independent radical reactions leading to the 2-electrons oxidized product. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Structural evidence for stabilization of inhibitor binding by a protein cavity in the dehaloperoxidase-hemoglobin from Amphitrite ornata

Biopolymers, 98(1), 27–35.

By: V. de Serrano n & S. Franzen n

MeSH headings : Animals; Crystallography, X-Ray; Hemoglobins; Peroxidases; Polychaeta; Protein Conformation
TL;DR: It is shown that the origin of the stronger binding by a larger para-halogen substituent coincides structurally with a Xe-binding cavity (Xe1) characterized structurally by X-ray crystallography. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2011 journal article

The Red clover necrotic mosaic virus Capsid as a Multifunctional Cell Targeting Plant Viral Nanoparticle

BIOCONJUGATE CHEMISTRY, 22(1), 67–73.

By: D. Lockney n, R. Guenther n, L. Loo n, W. Overton n, R. Antonelli n, J. Clark n, M. Hu n, C. Luft n, S. Lommel n, S. Franzen n

MeSH headings : Amino Acid Sequence; Biological Availability; Biological Transport; Capsid / chemistry; Capsid / metabolism; Doxorubicin / chemistry; Doxorubicin / pharmacokinetics; Fluorescent Dyes / chemistry; HeLa Cells; Humans; Models, Molecular; Nanoparticles / chemistry; Peptides / chemistry; Peptides / metabolism; Plants / virology; Protein Conformation; Surface Properties; Tombusviridae
TL;DR: It is shown that targeting peptides (less than 16 amino acids) can be conjugated to the capsid using the heterobifunctional chemical linker sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Ab Initio Calculation of Resonance Raman Cross Sections Based on Excited State Geometry Optimization

JOURNAL OF PHYSICAL CHEMISTRY A, 114(43), 11681–11690.

By: J. Gaff n, S. Franzen n & B. Delley*

MeSH headings : Amino Acids, Aromatic / chemistry; Chlorine Compounds / chemistry; Cycloheptanes / chemistry; Molecular Structure; Nitrates / chemistry; Oxides / chemistry; Quantum Theory; Skatole / chemistry; Spectrum Analysis, Raman; Stilbenes / chemistry; Temperature; Toluene / chemistry
TL;DR: This method permits significant gains in the efficiency of calculating resonance Raman cross sections from first principles and, consequently, permits extension to large systems (>50 atoms). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Block the Inhibitor Binding Site in the Interior of Dehaloperoxidase from Amphitrite Ornata

Biophysical Journal, 98(3), 641a.

By: M. Thompson n, J. Parnell n & S. Franzen n

TL;DR: Using resonance Raman spectroscopy, it is demonstrated that the apparent dissociation constants of the para-halogenated phenols mimic the trend observed in the X-ray crystal structures and suggest that a few amino acids surrounding the hydrophobic cavity regulate internal binding of the inhibitor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2010 journal article

Compound ES of Dehaloperoxidase Decays via Two Alternative Pathways Depending on the Conformation of the Distal Histidine

Journal of the American Chemical Society, 132(49), 17501–17510.

By: M. Thompson n, S. Franzen n, R. Ghiladi n, B. Reeder n & D. Svistunenko n

Contributors: M. Thompson n, S. Franzen n, R. Ghiladi n, B. Reeder n & D. Svistunenko n

MeSH headings : Animals; Electron Spin Resonance Spectroscopy; Free Radicals / metabolism; Heme / chemistry; Heme / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Histidine / chemistry; Histidine / metabolism; Hydrogen Peroxide / metabolism; Kinetics; Models, Molecular; Molecular Conformation; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / chemistry; Polychaeta / enzymology; Polychaeta / metabolism; Protein Conformation
TL;DR: A kinetic model of the experimental data suggests that formation of Compound RH and formation of the Tyr38 radical are two alternative routes ofcompound ES decay, a product of safe termination of the two oxidizing equivalents of H2O2 when no substrate is available. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2010 journal article

Determination of Separate Inhibitor and Substrate Binding Sites in the Dehaloperoxidase−Hemoglobin fromAmphitrite ornata,

Biochemistry, 49(6), 1199–1206.

By: M. Davis, B. Bobay* & S. Franzen*

MeSH headings : Animals; Benzomorphans; Binding Sites; Catalytic Domain; Chlorophenols / chemistry; Chlorophenols / metabolism; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrocarbons, Halogenated / chemistry; Magnetic Resonance Spectroscopy; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Phenols / chemistry; Phenols / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Substrate Specificity
TL;DR: DHP A possesses the ability to bind halophenols in a distinct, internal distal binding pocket, and data herein suggest a distinction between inhibitor (monohalogenated phenol) and substrate (trihalogenated Phenol) binding locations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2021

2010 review

Expanding the catalytic repertoire of ribozymes and deoxyribozymes beyond RNA substrates

[Review of ]. Current Opinion in Molecular Therapeutics, 12(2), 223–232.

By: S. Franzen

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Experimental and Computational Study of the Monomer-Dimer Equilibrium in Dehaloperoxidase from Amphitrite Ornata

Biophysical Journal, 98(3), 640a.

By: S. Franzen n, V. de Serrano n, R. Oliver* & J. Krueger*

TL;DR: Small angle X-ray scattering (SAXS) and molecular dynamics simulations are used to develop a systematic approach to characterization of monomer-multimer equilibria based SAXS andX-ray crystallography data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2010 journal article

Internal Binding of Halogenated Phenols in Dehaloperoxidase-Hemoglobin Inhibits Peroxidase Function

BIOPHYSICAL JOURNAL, 99(5), 1586–1595.

By: M. Thompson n, M. Davis n, V. Serrano n, F. Nicoletti*, B. Howes*, G. Smulevich*, S. Franzen n

MeSH headings : Animals; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Halogenation; Hemoglobins / chemistry; Hemoglobins / metabolism; Iodobenzenes / chemistry; Iodobenzenes / metabolism; Iodobenzenes / pharmacology; Kinetics; Models, Molecular; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Spectrum Analysis, Raman
TL;DR: It is demonstrated that DHP has a unique two-site competitive binding mechanism in which the internal and external binding sites communicate through two conformations of the distal histidine of the enzyme, resulting in nonclassical competitive inhibition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Kinetic Analysis of a Naturally Occurring Bioremediation Enzyme: Dehaloperoxidase-Hemoglobin from Amphitrite ornata

JOURNAL OF PHYSICAL CHEMISTRY B, 114(43), 13823–13829.

By: H. Ma n, M. Thompson n, J. Gaff n & S. Franzen n

MeSH headings : Animals; Biodegradation, Environmental; Biological Products / chemistry; Biological Products / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Kinetics; Models, Molecular; Peroxidase / chemistry; Peroxidase / metabolism; Polychaeta / enzymology; Protein Conformation; Quantum Theory; Temperature
TL;DR: The analysis suggests a dominant role for diffusion in the kinetics of DHP, and density function theory (DFT) calculations were used to address the fate of phenoxy radical intermediates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

New Insights into the Role of Distal Histidine Flexibility in Ligand Stabilization of Dehaloperoxidase-Hemoglobin from Amphitrite ornata

BIOCHEMISTRY, 49(9), 1903–1912.

By: F. Nicoletti*, M. Thompson n, B. Howes*, S. Franzen n & G. Smulevich*

MeSH headings : Animals; Enzyme Stability; Ferric Compounds / chemistry; Hemoglobins / antagonists & inhibitors; Hemoglobins / chemistry; Hemoglobins / metabolism; Histidine / chemistry; Ligands; Magnetic Resonance Spectroscopy; Peroxidases / antagonists & inhibitors; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Protein Binding; Protein Conformation; Spectrophotometry; Spectrum Analysis, Raman; Substrate Specificity
TL;DR: The two conformations of His55 in equilibrium at room temperature provide a level of control that permits the distal histidine to act as both the acid-base catalyst in the peroxidase mechanism and the stabilizing amino acid for exogenous heme-coordinated ligands. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Photoinduced Fluorescent Cross-Linking of 5-Chloro- and 5-Fluoro-4-thiouridines with Thymidine

JOURNAL OF ORGANIC CHEMISTRY, 75(3), 621–626.

By: B. Skalski*, K. Taras-Goslinska*, A. Dembska*, Z. Gdaniec* & S. Franzen n

MeSH headings : Cross-Linking Reagents; Crystallography, X-Ray; Models, Molecular; Molecular Sequence Data; Photochemistry; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Thymidine / chemistry
TL;DR: Two highly fluorescent, thermally stable diastereomeric photoadducts, 3a,b, are formed when either 5-chloro-4-thiouridine, 1, or 5-fluoro- 4-thaviouridine, 2, are photoexcited with 366 nm UV light in the presence of thymidine (T). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Picosecond primary structural transition of the heme is retarded after nitric oxide binding to heme proteins

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(31), 13678–13683.

By: S. Kruglik*, B. Yoo, S. Franzen n, M. Vos, J. Martin & M. Negrerie

author keywords: time-resolved Raman spectroscopy; allostery; structural dynamics
MeSH headings : Allosteric Regulation; Heme / chemistry; Heme / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen Bonding; Kinetics; Mutation; Myoglobin / chemistry; Myoglobin / genetics; Myoglobin / metabolism; Nitric Oxide / chemistry; Nitric Oxide / metabolism; Protein Binding; Time Factors
TL;DR: It is found that the heme response and iron motion do not follow the kinetics of NO rebinding, and this observed phenomenon constitutes the primary structural transition in heme proteins induced by NO binding. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Spectroscopic and Mechanistic Investigations of Dehaloperoxidase B fromAmphitrite ornata

Biochemistry, 49(31), 6600–6616.

By: J. D’Antonio n, E. D’Antonio n, M. Thompson n, E. Bowden n, S. Franzen n, T. Smirnova n, R. Ghiladi n

Contributors: . J. D'Antonio, . E.L. D'Antonio n, M. Thompson n, E. Bowden n, S. Franzen n, T. Smirnova n, R. Ghiladi n

MeSH headings : Animals; Cloning, Molecular; Halogenation; Hemoglobins; Iron; Kinetics; Oxidation-Reduction; Oxygen / metabolism; Peroxidases / genetics; Peroxidases / metabolism; Polychaeta / enzymology; Spectrum Analysis
TL;DR: A novel reaction pathway is demonstrated in which the products of the oxidative dehalogenation of trihalophenols (dihaloquinones) are themselves capable of inducing formation of oxyferrous DHP B, and an updated catalytic cycle for DHP is proposed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2010 journal article

Structure of dehaloperoxidase B at 1.58 angstrom resolution and structural characterization of the AB dimer from Amphitrite ornata

Acta Crystallographica. Section D, Biological Crystallography, 66, 529–538.

By: V. Serrano, J. D'Antonio, S. Franzen & R. Ghiladi

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

X-ray structure of the metcyano form of dehaloperoxidase from Amphitrite ornata: Evidence for photoreductive dissociation of the iron-cyanide bond

Acta Crystallographica. Section D, Biological Crystallography, 66, 770–782.

By: V. Serrano, M. Davis, J. Gaff, Q. Zhang, Z. Chen, E. D'Antonio, E. Bowden, R. Rose, S. Franzen

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

A role for hydrophobicity in a DielsAlder reaction catalyzed by pyridyl-modified RNA

NUCLEIC ACIDS RESEARCH, 37(9), 3074–3082.

By: K. Gagnon n, S. Ju n, M. Goshe n, E. Maxwell n & S. Franzen n

MeSH headings : Anthracenes / metabolism; Base Sequence; Catalysis; Ethylene Glycols / metabolism; Hydrophobic and Hydrophilic Interactions; Lactones; Molecular Sequence Data; Nucleic Acid Conformation; Pyridines / chemistry; RNA / chemistry; RNA / metabolism; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Sesquiterpenes
TL;DR: It is shown that DA_TR96, the most active member of the DA22 RNA sequence family, which was selected with pyridyl-modified nucleotides, accelerates a cycloaddition reaction between anthracene and maleimide derivatives with high turnover, and suggests a key role for the hydrophobic effect in the catalytic mechanism. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Characterization of Dehaloperoxidase Compound ES and Its Reactivity with Trihalophenols†

Biochemistry, 48(5), 995–1005.

By: J. Feducia n, R. Dumarieh n, L. Gilvey n, T. Smirnova n, S. Franzen n & R. Ghiladi n

Contributors: J. Feducia n, R. Dumarieh n, L. Gilvey n, T. Smirnova n, S. Franzen n & R. Ghiladi n

MeSH headings : Animals; Binding Sites; Chlorophenols / chemistry; Chlorophenols / metabolism; Crystallography, X-Ray; Cytochrome-c Peroxidase / chemistry; Cytochrome-c Peroxidase / metabolism; Electron Transport Complex IV / chemistry; Electron Transport Complex IV / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology
TL;DR: It is demonstrated that the first detectable intermediate following the addition of hydrogen peroxide to ferric DHP contains both a ferryl heme and a tyrosyl radical, analogous to Compound ES of cytochrome c peroxidase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2009 journal article

Conductive oxide thin films: Model systems for understanding and controlling surface plasmon resonance

Journal of Applied Physics, 106(2), 024903.

By: M. Losego n, A. Efremenko n, C. Rhodes n, M. Cerruti n, S. Franzen n & J. Maria n

UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2009 journal article

Conductive thin film multilayers of gold on glass formed by self-assembly of multiple size gold nanoparticles

THIN SOLID FILMS, 517(24), 6803–6808.

By: R. Gerber n, D. Leonard* & S. Franzen n

author keywords: Colloidal self-assembly; Atomic force microscopy; Selected area diffraction; Gold nanoparticles
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Different Modes of Binding of Mono-, Di-, and Trihalogenated Phenols to the Hemoglobin Dehaloperoxidase from Amphitrite ornata

BIOCHEMISTRY, 48(10), 2164–2172.

By: M. Davis n, H. Gracz n, F. Vendeix n, V. Serrano n, A. Somasundaram n, S. Decatur n, S. Franzen n

MeSH headings : Animals; Binding Sites / physiology; Catalysis; Catalytic Domain / physiology; Heme / chemistry; Hemoglobins / chemistry; Hemoglobins / genetics; Hemoglobins / metabolism; Hydrocarbons, Halogenated / chemistry; Hydrocarbons, Halogenated / metabolism; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Phenols / chemistry; Phenols / metabolism; Polychaeta / enzymology; Polychaeta / genetics; Potassium Cyanide / chemistry; Protein Binding / physiology; Protein Conformation; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Substrate Specificity
TL;DR: The most soluble trihalogenated phenol acts as a highly soluble structural analogue to the native substrate 2,4,6-tribromophenol, and to improve the understanding of substrate binding, the most soluble substrate analogues are compared. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Distal histidine conformational flexibility in dehaloperoxidase from Amphitrite ornata

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 65, 34–40.

By: Z. Chen n, V. Serrano n, L. Betts* & S. Franzen n

MeSH headings : Animals; Crystallization; Crystallography, X-Ray; Heme Oxygenase (Decyclizing) / chemistry; Heme Oxygenase (Decyclizing) / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Histidine / chemistry; Histidine / metabolism; Iodobenzenes / chemistry; Iodobenzenes / metabolism; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Protein Binding; Protein Conformation; Solvents
TL;DR: It is reported that the distal histidine, His55, exhibits conformational flexibility in the deoxy form and is consequently observed in two solvent-exposed conformations more than 9.5 A away from the heme, analogous to the open conformation of sperm whale myoglobin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Excited-State Geometry Method for Calculation of the Absolute Resonance Raman Cross Sections of the Aromatic Amino Acids

JOURNAL OF PHYSICAL CHEMISTRY A, 113(18), 5414–5422.

By: J. Gaff n & S. Franzen n

MeSH headings : Amino Acids, Aromatic / chemistry; Cresols / chemistry; Electrons; Proteins / chemistry; Skatole / chemistry; Spectrum Analysis, Raman; Toluene / chemistry
TL;DR: The role played by substituents on the aromatic ring that decrease vibronic activity to a level that permits application of the time correlator is discussed and indicates that the L(a),(b) states are Franck-Condon active in the aromatic molecules studied. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Intrinsic Limitations on the vertical bar E vertical bar(4) Dependence of the Enhancement Factor for Surface-Enhanced Raman Scattering

JOURNAL OF PHYSICAL CHEMISTRY C, 113(15), 5912–5919.

By: S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Is Pd-2(DBA)(3) a Feasible Precursor for the Synthesis of Pd Nanoparticles?

JOURNAL OF PHYSICAL CHEMISTRY C, 113(29), 12706–12714.

By: D. Leonard n & S. Franzen n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Plasmonic phenomena in indium tin oxide and ITO-Au hybrid films

OPTICS LETTERS, 34(18), 2867–2869.

By: S. Franzen n, C. Rhodes n, M. Cerruti n, R. Gerber n, M. Losego n, J. Maria n, D. Aspnes n

TL;DR: The observation of surface-plasmon resonances in indium tin oxide (ITO) thin films is complemented with the effects of hybrid ITO/Au conducting layers where charge densities can be tuned. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Resonance Raman Probes of the Internal Binding Pocket of Dehaloperoxidase from Amphitrite ornata

Biophysical Journal, 96(3), 437a.

By: M. Thompson n, M. Davis n & S. Franzen n

TL;DR: DHP clearly demonstrates the importance of the hydrophobic cavity as an inherent selector for substrates entering the distal pocket by making use of the cavity-halogen hydrophilic interaction concomitantly preventing non- Halogenated substrates from binding. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2009 journal article

Spectroscopic Probes of the Reactive Intermediates of Dehaloperoxidase from Amphitrite ornata

Biophysical Journal, 96(3), 437a.

By: R. Ghiladi n, R. Dumarieh n, M. Thompson n, Z. Wang n, T. Smirnova n & S. Franzen n

TL;DR: While unreactive toward further oxidation, Compound RH can be reduced and subsequently bind dioxygen, generating oxyferrous DHP, which may represent the catalytic link between the peroxidase and oxygen-transport activities in this bifunctional protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2009 journal article

Structural Probes Of Reactive Intermediates Of Dehaloperoxidase From Amphitrite ornata

Biophysical Journal, 96(3), 558a.

By: S. Franzen n, V. de Serrano n, M. Davis n & M. Thompson n

TL;DR: The structure and function of DHP is discussed using X-ray crystallography and nuclear magnetic resonance (NMR) to discuss the large differences between DHP function and hemoglobin function despite the strong structural similarities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2009 journal article

Substrate binding triggers a switch in the iron coordination in dehaloperoxidase from Amphitrite Ornate

Biophysical Journal, 96(3), 437a.

By: T. Smirnova n, M. Davis n, R. Weber & S. Franzen n

TL;DR: Hyperfine sublevel correlation spectroscopic analysis of the ferric form of DHP was carried out to characterize effects of the substrate 2,4,6-trifluorophenol (TFP) binding on the iron coordination in order to elucidate molecular mechanisms responsible for switching the protein function from a globin to a peroxidase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2009 review

Targeting cancer with 'smart bombs': equipping plant virus nanoparticles for a 'seek and destroy' mission

[Review of ]. NANOMEDICINE, 4(5), 575–588.

By: S. Franzen n & S. Lommel n

author keywords: biodegradable; capsid; chemotherapy; colloid; nanoparticle plant virus; receptor-mediated endocytosis; reticuloendothelial system
MeSH headings : Endocytosis; Humans; Liposomes; Micelles; Nanoparticles; Neoplasms / drug therapy; Plant Viruses
TL;DR: The structural uniformity, cargo capacity, responsive behavior and ease of manufacturing of plant virus nanoparticles are unique properties that suggest they have a wider role to play in targeted therapy, and they are considered to have the most promise to address these complex phenomena. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Characterization of monolayer formation on aluminum-doped zinc oxide thin films

LANGMUIR, 24(2), 433–440.

By: C. Rhodes n, S. Lappi n, D. Fischer n, S. Sambasivan n, J. Genzer n & S. Franzen n

MeSH headings : Aluminum / chemistry; Spectrum Analysis / methods; Zinc Oxide / chemistry
TL;DR: The characterization of the SAM deposition onto the AZO thin film reveals a range of possible applications for this conducting metal oxide. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Conformational Dynamics Associated with Photodissociation of CO from Dehaloperoxidase Studied Using Photoacoustic Calorimetry

BIOCHEMISTRY, 47(44), 11510–11517.

By: J. Miksovska n, S. Horsa n, M. Davis n & S. Franzen n

MeSH headings : Animals; Calorimetry / methods; Carbon Monoxide / chemistry; Catalytic Domain; Hemoglobins / chemistry; Hemoglobins / metabolism; Hemoglobins / radiation effects; Models, Molecular; Peroxidases / chemistry; Peroxidases / metabolism; Peroxidases / radiation effects; Photochemistry; Polychaeta / enzymology; Protein Conformation; Spectrophotometry; Thermodynamics
TL;DR: The dynamics and energetics of conformational changes observed for dissociation of a ligand from DHP differ significantly from those measured previously for photodissociation of CO from the structural homologue myoglobin, suggesting that structural dynamics in DHP are fine-tuned to enhance the peroxidase function of this protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Dependence of plasmon polaritons on the thickness of indium tin oxide thin films

Journal of Applied Physics, 103(9), 093108.

By: C. Rhodes n, M. Cerruti n, A. Efremenko n, M. Losego n, D. Aspnes n, J. Maria n, S. Franzen n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 journal article

Determinants of Substrate Internalization in the Distal Pocket of Dehaloperoxidase Hemoglobin of Amphitrite ornata

BIOCHEMISTRY, 47(49), 12985–12994.

By: K. Nienhaus n, E. Nickel n, M. Davis n, S. Franzen n & G. Nienhaus n

MeSH headings : Animals; Binding Sites; Crystallography, X-Ray; Hemoglobins / chemistry; Hemoglobins / metabolism; Hydrogen-Ion Concentration; Ligands; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Protein Conformation; Spectroscopy, Fourier Transform Infrared; Substrate Specificity
TL;DR: The results on wild-type DHP and its variants indicate that halophenols and a diatomic ligand can indeed simultaneously be present in the distal pocket if thedistal histidine is in the low-pH conformation, in which its side chain is swung out of the Distal pocket. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Factors determining the efficacy of nuclear delivery of antisense oligonucleotides by gold nanoparticles

BIOCONJUGATE CHEMISTRY, 19(5), 1009–1016.

By: Y. Liu & S. Franzen n

MeSH headings : Alternative Splicing; Biotinylation; Cell Nucleus / chemistry; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Colloids / chemistry; Endocytosis / drug effects; Endosomes / chemistry; Endosomes / drug effects; Endosomes / metabolism; Genetic Vectors / chemistry; Genetic Vectors / metabolism; Gold / chemistry; Gold / metabolism; HeLa Cells; Humans; Lipids / chemistry; Lipids / pharmacology; Metal Nanoparticles / chemistry; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / pharmacology; RNA, Messenger / genetics; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Sulfhydryl Compounds / chemistry; Thionucleotides / chemistry; Thionucleotides / metabolism; Thionucleotides / pharmacology; beta-Thalassemia / genetics
TL;DR: It is concluded that sequestration of cargo from the harsh conditions of the endosome is a desirable strategy for cell-targeting nanoparticles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Infusion of dye molecules into Red clover necrotic mosaic virus

CHEMICAL COMMUNICATIONS, (1), 88–90.

By: L. Loo n, R. Guenther n, S. Lommel n & S. Franzen n

MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / metabolism; Coloring Agents / analysis; Coloring Agents / metabolism; Doxorubicin / metabolism; Microscopy, Electron, Transmission; Tombusviridae / chemistry; Tombusviridae / metabolism; Tombusviridae / ultrastructure
TL;DR: The Red clover necrotic mosaic virus capsid is utilized to package and release molecules through reversible depletion and re-addition of divalent cations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Interfacial and solvent effects govern the formation of tris(dibenzylidenacetone)dipalladium(0) microstructures

LANGMUIR, 24(15), 7803–7809.

By: D. Leonard n, M. Cerruti n, G. Duscher n & S. Franzen n

TL;DR: The formation of a majority of rods or hexagonal platelets in solution was shown to be determined by the ratio of THF to H(2)O in the solvent, whereas supersaturation effects and interfacial surface tension played a major role in creating the shape of particles formed upon evaporation of Pd(2)(DBA)(3) droplets on a surface. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Investigation of hexadecanethiol self-assembled monolayers on cadmium tin oxide thin films

THIN SOLID FILMS, 516(8), 1838–1842.

By: C. Rhodes, S. Brewer*, J. Folmer & S. Franzen*

author keywords: plasma frequency; surface plasmon; conducting thin film; Fourier-transform infrared spectroscopy
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 patent

Nanoparticle delivery vehicle

Washington, DC: U.S. Patent and Trademark Office.

By: S. Franzen, D. Feldheim, A. Tkachenko, M. Godek, J. Ryan & M. Anderson

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Substrate binding triggers a switch in the iron coordination in dehaloperoxidase from Amphitrite ornata: HYSCORE experiments

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(7), 2128-+.

By: T. Smirnova n, R. Weber n, M. Davis n & S. Franzen n

MeSH headings : Animals; Electron Spin Resonance Spectroscopy; Ferric Compounds / chemistry; Ferric Compounds / metabolism; Heme / chemistry; Heme / metabolism; Hemoglobins / chemistry; Hemoglobins / metabolism; Iron / chemistry; Iron / metabolism; Models, Molecular; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Protein Binding; Spectrum Analysis / methods; Water / chemistry; Water / metabolism
TL;DR: Continuous wave EPR spectra show that heme iron of DHP at pH 6.0 exists in the high spin state, consistent with a water molecule being the sixth ligand in the iron coordination, and highlights the proposed role of the substrate as a trigger for the switch from hemoglobin to peroxidase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Surface plasmon polaritons and screened plasma absorption in indium tin oxide compared to silver and gold

JOURNAL OF PHYSICAL CHEMISTRY C, 112(15), 6027–6032.

By: S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

An infrared spectroscopic study of the conformational transition of elastin-like polypeptides

BIOPHYSICAL JOURNAL, 93(7), 2429–2435.

By: V. Serrano n, W. Liu* & S. Franzen n

MeSH headings : Computer Simulation; Elastin / chemistry; Models, Chemical; Models, Molecular; Normal Distribution; Peptides / chemistry; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Salts / chemistry; Sodium Chloride / chemistry; Spectrophotometry, Infrared / methods; Spectroscopy, Fourier Transform Infrared; Temperature
TL;DR: To correlate the spectroscopic observations with structure a density function theory model was created that captures the essential hydrogen bonding and packing of the beta-spiral structure proposed for elastin andElastin-like polypeptides. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Cellular uptake of gold nanoparticles passivated with BSA-SV40 large T antigen conjugates

ANALYTICAL CHEMISTRY, 79(23), 9150–9159.

By: J. Ryan n, K. Overton n, M. Speight n, C. Oldenburg n, L. Loo n, W. Robarge n, S. Franzen n, D. Feldheim n

MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Cell Nucleus / metabolism; Gold / chemistry; HeLa Cells; Humans; Metal Nanoparticles; Reproducibility of Results; Serum Albumin, Bovine / metabolism; Subcellular Fractions / metabolism
TL;DR: The ICP-OES and nuclear fractionation techniques reported here are valuable tools that can add important quantitative information to optical and electron imaging methods such as VEC-DIC and transmission electron microscopy regarding the fate of nanoparticles in cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Detection of DNA hybridization on indium tin oxide surfaces

SENSORS AND ACTUATORS B-CHEMICAL, 125(2), 574–580.

By: S. Moses n, S. Brewer n, S. Kraemer n, R. Fuierer n, L. Lowe n, C. Agbasi n, M. Sauthier n, S. Franzen n

author keywords: thermography; electrochemistry; Fourier-transform infrared; nanoparticle detection; strippingvoltarnmetry
TL;DR: CV was used to successfully detect DNA hybridization for nanoparticle concentrations as low as 10 pM when using the gold nanoparticles bound to an ITO electrode as catalysts for the electrochemical oxidation of FeCl2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Encapsidation of nanoparticles by Red Clover Necrotic Mosaic Virus

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(36), 11111–11117.

By: L. Loo n, R. Guenther n, S. Lommel n & S. Franzen n

MeSH headings : Biocompatible Materials; Capsid / physiology; Capsid Proteins / genetics; Capsid Proteins / metabolism; Cobalt / chemistry; Ferric Compounds / chemistry; Gold / chemistry; Nanoparticles / chemistry; Nanotechnology; Quantum Dots; Tombusviridae / physiology; Virus Assembly
TL;DR: Covalent linkage of the OAS to nanoparticles directs RNA-dependent encapsidation and demonstrates that foreign cargo can be packaged into RCNMV virions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Influence of indium-tin oxide surface structure on the ordering and coverage of carboxylic acid and thiol monolayers

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 40(14), 4212–4221.

By: M. Cerruti n, C. Rhodes n, M. Losego n, A. Efremenko n, J. Maria n, D. Fischer*, S. Franzen n, J. Genzer n

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Probing protein adsorption onto mercaptoundecanoic acid stabilized gold nanoparticles and surfaces by quartz crystal microbalance and zeta-potential measurements

LANGMUIR, 23(11), 6053–6062.

By: E. Kaufman n, J. Belyea n, M. Johnson n, Z. Nicholson n, J. Ricks n, P. Shah n, M. Bayless n, T. Pettersson n ...

MeSH headings : Adsorption; Animals; Biosensing Techniques; Cattle; Coated Materials, Biocompatible / chemistry; Cytochromes c / chemistry; Electrochemistry; Fatty Acids / chemistry; Gold / chemistry; Hydrogen-Ion Concentration; In Vitro Techniques; Metal Nanoparticles / chemistry; Myoglobin / chemistry; Proteins / chemistry; Quartz; Serum Albumin, Bovine / chemistry; Surface Properties
TL;DR: The observation of stable BSA complexes on MUA/AuNPs at the isoelectric point by zeta-potential measurements demonstrates that BSA can sterically stabilize MUA /AuNP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 patent

Single pass attenuated total reflection fourier transform infrared microscopy apparatus and method for identifying protein secondary structure, surface charge and binding affinity

Washington, DC: U.S. Patent and Trademark Office.

By: S. Franzen & S. Lappi

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers

ANALYTICAL CHEMISTRY, 79(6), 2221–2229.

By: Y. Liu, M. Shipton n, J. Ryan n, E. Kaufman n, S. Franzen n & D. Feldheim n

MeSH headings : Amino Acid Sequence; Endocytosis; Gold / chemistry; HeLa Cells; Humans; Molecular Structure; Molecular Weight; Nanoparticles / chemistry; Peptides / chemical synthesis; Peptides / chemistry; Polyethylene Glycols / chemistry; Spectrometry, Fluorescence; Sulfhydryl Compounds / chemistry
TL;DR: The assembly of poly(ethylene glycol) (PEG) and mixed peptide/PEG monolayers on gold nanoparticle surfaces is described to provide useful cues in the assembly of stable peptides/gold nanoparticle bioconjugates capable of being internalized into cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

The pH dependence of the activity of dehaloperoxidase from Amphitrite ornata

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1774(1), 121–130.

By: S. Franzen n, L. Gilvey n & J. Belyea n

author keywords: peroxidase; Fourier-transform infrared spectroscopy; X-ray crystallography; enzyme kinetics
MeSH headings : Animals; Crystallography, X-Ray; Hemoglobins / metabolism; Hydrogen-Ion Concentration; Kinetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared
TL;DR: A study of the pH dependence of the activity of DHP reveals a substantial difference in mechanism, and other known peroxidases, which oxidize substrates at the heme edge are discussed by comparison. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

The role of selection pressure in RNA-mediated evolutionary materials synthesis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(49), 15340–15346.

By: S. Franzen n, M. Cerruti n, D. Leonard n & G. Duscher n

MeSH headings : Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Transmission; Palladium / chemistry; RNA / chemistry
TL;DR: This study rigorously test the assumptions, procedures, and results of the only published example of an RNA-mediated evolutionary materials synthesis, and concludes that RNA selections should not be carried out in binary solvent systems, such as tetrahydrofuran (THF) and water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 63, 1094–1101.

By: V. Serrano n, Z. Chen n, M. Davis n & S. Franzen n

MeSH headings : Animals; Binding Sites; Crystallography, X-Ray / methods; Cysteine / chemistry; Escherichia coli / metabolism; Heme / chemistry; Hemoglobins / chemistry; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Conformation; Peroxidases / chemistry; Polychaeta / metabolism; Protein Conformation; Recombinant Proteins / chemistry; Serine / chemistry
TL;DR: Hydrogen-bonding interaction between His55 and the bound diatomic oxygen molecule provides new insight into the catalytic activation of H(2)O(2), which is essential for peroxidase activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Controlled encapsidation of gold nanoparticles by a viral protein shell

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(14), 4502–4503.

By: L. Loo n, R. Guenther n, V. Basnayake n, S. Lommel n & S. Franzen n

MeSH headings : Capsid Proteins / chemistry; Capsid Proteins / genetics; DNA, Viral / chemistry; DNA, Viral / genetics; Gold / chemistry; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; RNA, Viral / chemistry; RNA, Viral / genetics; Tombusviridae / chemistry; Tombusviridae / genetics
TL;DR: Covalent linkage of the OAS to Au functions as a trigger for specific encapsidation and demonstrates that foreign cargo can be packaged into Red clover necrotic mosaic virus virions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Gold and silica-coated gold nanoparticles as thermographic labels for DNA detection

ANALYTICAL CHEMISTRY, 78(10), 3282–3288.

By: M. Cerruti n, M. Sauthier n, D. Leonard n, D. Liu n, G. Duscher n, D. Feldheim n, S. Franzen n

MeSH headings : DNA / analysis; DNA / chemistry; Gold / chemistry; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Structure; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Polylysine / chemistry; Silicon Dioxide / chemistry; Temperature; Thermography
TL;DR: The infrared emissivity of Au and silica-coated Au nanoparticles (Au NPs) deposited on indium tin oxide substrates was investigated and differences in temperature before and after laser irradiation were found to be directly proportional to the number of particles present on the slide and to the laser power used in the experiment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Hydrophobic distal pocket affects NO-heme geminate recombination dynamics in dehaloperoxidase and H64V myoglobin

JOURNAL OF PHYSICAL CHEMISTRY B, 110(29), 14483–14493.

By: S. Franzen*, A. Jasaitis, J. Belyea*, S. Brewer*, R. Casey, A. MacFarlane, R. Stanley, M. Vos, J. Martin*

MeSH headings : Amino Acid Substitution; Animals; Heme / chemistry; Hemoglobins / chemistry; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Chemical; Myoglobin / chemistry; Nitric Oxide / chemistry; Peroxidases / chemistry; Polychaeta / enzymology; Protein Conformation; Time Factors
TL;DR: A comparison between the more rapid rate constant of the slow geminate phase in DHP-NO and horse heart myoglobin or sperm whale myoglobin suggests that protein interactions with photolyzed NO are weaker in D HP than in the wild-type MbNOs, consistent with the hydrophobic distal pocket of DHP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Nanoscale Structural and Chemical Characterization of Silica Coated Gold Nanoparticles Using STEM 3D Imaging and EELS

Microscopy and Microanalysis, 12(S02), 602–603.

By: D. Leonard n, K. Jarausch*, M. Cerruti n, G. Duscher n, S. Franzen n & D. Feldheim n

TL;DR: Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006 about the design and application of nanofiltration membranes for selective separation of Na6(CO3)(SO4) from Na2SO4. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 7, 2020

2006 journal article

Proximal cavity, distal histidine, and substrate hydrogen-bonding mutations modulate the activity of Amphitrite ornata dehaloperoxidase

BIOCHEMISTRY, 45(30), 9085–9094.

By: S. Franzen n, J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n, S. Lommel n

Contributors: S. Franzen n, J. Belyea n, L. Gilvey n, M. Davis n, C. Chaudhary n, T. Sit n, S. Lommel n

MeSH headings : Animals; Binding Sites / genetics; Hemoglobins; Histidine / chemistry; Histidine / genetics; Hydrogen Bonding; Mutagenesis, Site-Directed; Peroxidases / chemistry; Peroxidases / genetics; Peroxidases / metabolism; Phenylalanine / genetics; Polychaeta / enzymology; Polychaeta / genetics; Substrate Specificity / genetics; Tyrosine / genetics; Valine / genetics
TL;DR: The role of tyrosine 38 (Y38), which hydrogen bonds to the hydroxyl group of the substrate, was probed and it was suggested that abolishing this hydrogen bond may open a pathway for the escape of the one-electron product, the phenoxy radical leading to polymeric products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

Resonance Raman study of ferric heme adducts of dehaloperoxidase from Amphitrite ornata

BIOCHEMISTRY, 45(48), 14275–14284.

By: J. Belyea n, C. Belyea n, S. Lappi n & S. Franzen n

MeSH headings : Animals; Heme / chemistry; Heme / metabolism; Hydrogen Bonding; Iron / chemistry; Iron / metabolism; Ligands; Models, Molecular; Molecular Conformation; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Porphyrins / chemistry; Spectrum Analysis, Raman
TL;DR: The Raman data provide the first direct measurement of the effect of axial ligation on the heme iron in DHP, in which a strongly hydrogen-bonded backbone carbonyl (>C=O) polarizes the proximal histidine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Role of heme iron coordination and protein structure in the dynamics and geminate rebinding of nitric oxide to the H93G myoglobin mutant - Implications for nitric oxide sensors

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(15), 10389–10398.

By: M. Negrerie, S. Kruglik, J. Lambry, M. Vos, J. Martin & S. Franzen n

MeSH headings : Animals; Cattle; Heme / chemistry; Humans; Imidazoles / chemistry; Iron / chemistry; Kinetics; Ligands; Models, Chemical; Models, Molecular; Mutation; Myoglobin / chemistry; Myoglobin / genetics; Nitric Oxide / chemistry; Nitrogen / chemistry; Protein Binding; Protein Conformation; Proteins / chemistry; Spectrophotometry; Spectrum Analysis, Raman; Time Factors
TL;DR: The data show that the iron coordination state or the heme iron out-of-plane motion are not at the origin of the bi-exponential kinetics, which depends upon the protein structure, and that the 4-coordinate state favors the fast phase of NO geminate rebinding. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Spectroscopic study of substrate binding to the carbonmonoxy form of dehaloperoxidase from Amphitrite ornata

JOURNAL OF PHYSICAL CHEMISTRY B, 110(26), 13264–13276.

By: K. Nienhaus n, P. Deng n, J. Belyea n, S. Franzen n & G. Nienhaus n

MeSH headings : Animals; Models, Molecular; Peroxidases / chemistry; Peroxidases / metabolism; Polychaeta / enzymology; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Substrate Specificity
TL;DR: The dynamics of substrate binding in DHP are explored using Fourier transform infrared spectroscopy and flash photolysis to identify a number of discrete conformations at the active site that are involved in promotion of substrate and cosubstrate entry and exit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Surface plasmon resonance in conducting metal oxides

JOURNAL OF APPLIED PHYSICS, 100(5).

By: C. Rhodes n, S. Franzen n, J. Maria n, M. Losego n, D. Leonard n, B. Laughlin n, G. Duscher n, S. Weibel

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 patent

Surface plasmon resonance systems and methods having a variable charge density layer

Washington, DC: U.S. Patent and Trademark Office.

By: S. Franzen & S. Brewer

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Testing Bridge-Mediated Differences in Dinuclear Valence Tautomeric Behavior

Inorganic Chemistry, 45(11), 4461–4467.

By: S. Bin-Salamon n, S. Brewer n, E. Depperman n, S. Franzen n, J. Kampf n, M. Kirk n, R. Kumar n, S. Lappi n ...

TL;DR: The results highlight the necessity of studying both crystalline and amorphous samples to distinguish the effects of intrinsic electronic structure and intermolecular forces on valence tautomeric behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

Transcription inhibition using oligonucleotide-modified gold nanoparticles

BIOCONJUGATE CHEMISTRY, 17(5), 1178–1183.

By: C. Agbasi-Porter n, J. Ryman-Rasmussen n, S. Franzen n & D. Feldheim n

MeSH headings : Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gold / chemistry; Gold / metabolism; Humans; Metal Nanoparticles / chemistry; Oligonucleotides / chemistry; Oligonucleotides / metabolism; Promoter Regions, Genetic; Transcription, Genetic; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR: The competitive binding and inhibition of T7 RNA polymerase due to specific interactions on the nanoparticle surface represents a transcription factor decoy approach in a model system and provides a basis for determining the accessibility of binding sites on nanoparticle surfaces for applications involving cell targeting or the use of nanoparticles as binding agents in solution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Detection of adsorption of Ru(II) and Os(II) polypyridyl complexes on gold and silver nanoparticles by single-photon counting emission measurements

JOURNAL OF PHYSICAL CHEMISTRY B, 109(2), 804–810.

MeSH headings : Adsorption; Gold / chemistry; Metal Nanoparticles / chemistry; Organometallic Compounds / chemistry; Osmium / chemistry; Pyridines / chemistry; Ruthenium / chemistry; Sensitivity and Specificity; Silver / chemistry; Surface Properties; Time Factors; Tomography, Emission-Computed / methods
TL;DR: The results demonstrate that time-resolved spectroscopy provides a rapid method for the measurement of surface binding of labeled molecules on metallic nanoparticles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomain

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(46), 16662–16667.

author keywords: protein folding; Fourier transform IR; temperature jump; diffusion collision
MeSH headings : Kinetics; Microfilament Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Folding; Spectroscopy, Fourier Transform Infrared; Temperature
TL;DR: Equilibrium Fourier transform infrared (FTIR) and temperature-jump (T-jump) IR spectroscopic techniques were used to study the thermodynamics and kinetics of the unfolding and folding of the villin headpiece helical subdomain (HP36), a small three-helix protein. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Enzyme function of the globin dehaloperoxidase from Amphitrite ornata is activated by substrate binding

BIOCHEMISTRY, 44(48), 15637–15644.

By: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n, S. Lommel n, S. Franzen n

Contributors: J. Belyea n, L. Gilvey n, M. Davis n, M. Godek n, T. Sit n, S. Lommel n, S. Franzen n

MeSH headings : Animals; Cloning, Molecular; Enzyme Activation; Escherichia coli / enzymology; Escherichia coli / genetics; Globins / metabolism; Hemoglobins; Hydrogen Peroxide / metabolism; Peroxidases / antagonists & inhibitors; Peroxidases / genetics; Peroxidases / metabolism; Phenols / metabolism; Polychaeta / enzymology; Protein Binding; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism
TL;DR: The present study shows that, unlike other known peroxidases, DHP activity requires the addition of substrate, TBP, prior to the cosubstrate, peroxide. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2005 journal article

Hairpin folding dynamics: The cold-denatured state is predisposed for rapid refolding

BIOCHEMISTRY, 44(30), 10406–10415.

By: R. Dyer n, S. Maness n, S. Franzen n, R. Fesinmeyer n, K. Olsen n & N. Andersen n

MeSH headings : Circular Dichroism; Cold Temperature; Hot Temperature; Humans; Hydrogen Bonding; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Peptides / chemistry; Propanols / chemistry; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thermodynamics
TL;DR: The acceleration of the folding rate of MrH3a in 8% HFIP is interpreted as a direct consequence of the collapsed conformations of the cold-denatured state, and there may be some reduction of the loop search cost when starting from theCold denaturation state, since this state may have some of the stabilizing cross-strand interactions already formed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Investigation of the electrical and optical properties of iridium oxide by reflectance FTIR spectroscopy and density functional theory calculations

Chemical Physics, 313(1-3), 25–31.

By: S. Brewer n, D. Wicaksana n, J. Maria n, A. Kingon n & S. Franzen n

author keywords: plasmon frequency; conductivity; metal oxide; band gap
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2005 journal article

Probing BSA binding to citrate-coated gold nanoparticles and surfaces

LANGMUIR, 21(20), 9303–9307.

By: S. Brewer n, W. Glomm n, M. Johnson n, M. Knag n & S. Franzen n

TL;DR: The interaction of bovine serum albumin with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance measurements, respectively, to determine the surface charge and coverage, suggesting that BSA binding to gold nanoparticles and gold surfaces occurs by an electrostatic mechanism when citrate is present. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Solvatochromism of a novel betaine dye derived from purine

JOURNAL OF PHYSICAL CHEMISTRY A, 109(5), 759–766.

By: A. Masternak n, G. Wenska n, J. Milecki n, B. Skalski n & S. Franzen n

MeSH headings : Betaine / chemistry; Coloring Agents / chemical synthesis; Coloring Agents / chemistry; Hydrogen-Ion Concentration; Models, Molecular; Molecular Structure; Purines / chemistry; Spectrum Analysis
TL;DR: A novel solvatochromic betaine dye has been synthesized from xanthosine and characterized spectroscopically by UV-vis in a broad range of solvents and has the potential application as a polarity probe for application in RNA oligonucleotides. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Supramolecular control of valence-tautomeric equilibrium on nanometer-scale gold clusters

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(15), 5328–5329.

By: S. Bin-Salamon n, S. Brewer n, S. Franzen n, D. Feldheim n, S. Lappi n & D. Shultz n

TL;DR: The results show that surface confinement attenuates both DeltaH degrees and DeltaS degrees, and attribute these changes to a reduced accessible molecular surface area. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

The origin of stark splitting in the initial photoproduct state of MbCO

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(1), 40–41.

By: K. Nienhaus n, J. Olson n, S. Franzen n & G. Nienhaus n

MeSH headings : Carbon Monoxide / chemistry; Carbon Monoxide / metabolism; Heme / chemistry; Heme / metabolism; Hydrogen Bonding; Models, Molecular; Myoglobin / chemistry; Myoglobin / metabolism; Photolysis; Spectroscopy, Fourier Transform Infrared
TL;DR: F Fourier transform infrared (FTIR) spectroscopy and density functional theory (DFT) calculations were used to interpret the effects of the electrostatic environment on the B state bands. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

CO vibration as a probe of ligand dissociation and transfer in myoglobin

PHYSICAL REVIEW LETTERS, 93(1).

By: T. Polack, J. Ogilvie, S. Franzen*, M. Vos, M. Joffre, J. Martin, A. Alexandrou

MeSH headings : Biophysical Phenomena; Biophysics; Carbon Monoxide / chemistry; Carbon Monoxide / metabolism; Heme / chemistry; Heme / metabolism; Ligands; Models, Chemical; Myoglobin / chemistry; Myoglobin / metabolism; Photochemistry; Vibration
TL;DR: Density-functional calculations demonstrate that indeed vibrational frequency and absorption strength are not linearly coupled and that the absorption strength varies in a slower manner due to charge transfer from the heme iron to CO. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Calculation of the electronic and optical properties of indium tin oxide by density functional theory

CHEMICAL PHYSICS, 300(1-3), 285–293.

By: S. Brewer n & S. Franzen n

author keywords: transparent conducting oxide; plasma frequency; charge carrier density
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Cellular trajectories of peptide-modified gold particle complexes: Comparison of nuclear localization signals and peptide transduction domains

BIOCONJUGATE CHEMISTRY, 15(3), 482–490.

By: A. Tkachenko, H. Xie n, Y. Liu, D. Coleman n, J. Ryan n, W. Glomm n, M. Shipton n, S. Franzen n, D. Feldheim n

MeSH headings : 3T3 Cells; Animals; Biological Transport, Active / physiology; Cell Line, Tumor; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Gene Products, tat / chemistry; Gold / chemistry; Gold / pharmacokinetics; HeLa Cells; Humans; Macromolecular Substances; Mice; Nuclear Localization Signals / drug effects; Nuclear Localization Signals / metabolism; Peptides / chemistry; Peptides / pharmacokinetics; Protein Structure, Tertiary / physiology; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Temperature; Transduction, Genetic
TL;DR: Video-enhanced color differential interference contrast microscopy and transmission electron microscopy indicated that transport of nanoparticles into the cytoplasm and nucleus depends on peptide sequence and cell line, and cellular uptake of Tat PTD peptide-gold nanoparticle conjugates was temperature dependent, suggesting an endosomal pathway of uptake. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Characterization of single- and double-stranded DNA on gold surfaces

LANGMUIR, 20(25), 11134–11140.

By: S. Moses n, S. Brewer n, L. Lowe n, S. Lappi n, L. Gilvey n, M. Sauthier n, R. Tenent n, D. Feldheim n, S. Franzen n

MeSH headings : DNA / chemistry; Gold / chemistry; Surface Properties; Temperature; Time Factors
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Covalent attachment of a nickel nitrilotriacetic acid group to a germanium attenuated total reflectance element

LANGMUIR, 20(4), 1184–1188.

By: B. Smith n, S. Lappi n, S. Brewer n, S. Dembowy n, J. Belyea n & S. Franzen n

TL;DR: The surface of a germanium internal reflectance element (IRE) was modified to bind 6X-histidine (his)-tagged biomolecules and binding of his-tagged biotin to nickel nitrilotriacetic acid (Ni-NTA) was observed by ATR-FT-IR spectroscopy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Efficiency and pattern of UV pulse laser-induced RNA-RNA cross-linking in the ribosome

NUCLEIC ACIDS RESEARCH, 32(4), 1518–1526.

By: T. Shapkina n, S. Lappi*, S. Franzen* & P. Wollenzien*

MeSH headings : Base Sequence; Escherichia coli / genetics; Lasers; Molecular Sequence Data; Photons; Purine Nucleosides / radiation effects; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / radiation effects; Ribosomes / radiation effects; Ultraviolet Rays
TL;DR: Cross- linking frequencies obtained with one laser pulse are more correlated to internucleotide distances than arefrequency obtained with transilluminator irradiation, probably due to intensity-dependent photoreversal. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Eigenvector mapping: a method for discerning solvent effects on vibrational spectra

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy., 60(02-Jan), 357–370.

By: S. Lappi n & S. Franzen*

MeSH headings : Adenine / chemistry; Hydrogen Bonding; Models, Molecular; Solvents; Spectrophotometry / methods; Spectrophotometry, Infrared / methods; Spectroscopy, Fourier Transform Infrared / methods; Spectrum Analysis, Raman / methods; Statistics as Topic / methods; Water / chemistry
TL;DR: The improvement in the fit between matrix isolation data and a model of adenine with a single water was not as dramatic as the fit seen for the polycrystalline data, but the fact that a single hydrogen-bonded water shifted the spectra of the model to a closer fit than that of isolatedAdenine is important. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2004 journal article

Infrared detection of a phenylboronic acid terminated alkane thiol monolayer on gold surfaces

LANGMUIR, 20(13), 5512–5520.

By: S. Brewer n, A. Allen n, S. Lappi n, T. Chasse n, K. Briggman n, C. Gorman n, S. Franzen n

Contributors: S. Brewer n, A. Allen n, S. Lappi n & . al.

MeSH headings : Alkanes / chemistry; Boron / chemistry; Boronic Acids / chemistry; Esters / chemistry; Gold / chemistry; Infrared Rays; Molecular Structure; Spectrophotometry, Infrared; Sulfhydryl Compounds / chemistry; Vibration
TL;DR: Polarization modulation infrared reflectance absorption spectroscopy and IRRAS have been used to characterize the formation of a self-assembled monolayer of N-(3-dihydroxyborylphenyl)-11-mercaptoundecanamide (abbreviated PBA) on a gold surface and the subsequent binding of various sugars to the PBA adlayer through the phenylboronic acid moiety to form aphenylboronate ester. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Infrared spectra of (H2O)-O-16, (H2O)-O-18 and D2O in the liquid phase by single-pass attenuated total internal reflection spectroscopy

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 60(11), 2611–2619.

By: S. Lappi n, B. Smith n & S. Franzen n

author keywords: IR; attenuated total reflection; (H2O)-O-16; (H2O)-O-18; (D2O)-O-16; density functional theory calculations
MeSH headings : Deuterium Oxide / chemistry; Oxygen Isotopes / chemistry; Spectroscopy, Fourier Transform Infrared; Water / chemistry
TL;DR: DFT calculation of the vibrational spectrum of liquid water was conducted on seven model systems and the nine-water PBC model was found to give a good fit to the experimental line shapes and a difference is observed in the broadening of the water bending and stretching vibrations indicative of a difference in the rate of pure dephasing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Regulating the fluorescence intensity of an anthracene boronic acid system: a B-N bond or a hydrolysis mechanism?

BIOORGANIC CHEMISTRY, 32(6), 571–581.

By: W. Ni n, G. Kaur*, G. Springsteen n, B. Wang* & S. Franzen n

author keywords: anthracene-based fluorescent boronic acid; B-N bond; PET
MeSH headings : Anthracenes / chemistry; Boron / chemistry; Boron Compounds / chemistry; Boronic Acids / chemistry; Carbohydrates / chemistry; Fluorescence; Hydrogen-Ion Concentration; Hydrolysis; Nitrogen / chemistry
TL;DR: This work suggests a possible alternative mechanism for the fluorescence change upon the formation of a boronic acid (1a) complex with diols, which results in the protonation of the amine nitrogen if the reactions are carried out in a protic solvent such as water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

The mechanism of beta-hairpin formation

BIOCHEMISTRY, 43(36), 11560–11566.

By: R. Dyer n, S. Maness n, E. Peterson n, S. Franzen n, R. Fesinmeyer n & N. Andersen n

MeSH headings : Amino Acid Sequence; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Sequence Data; Peptides / chemical synthesis; Peptides / chemistry; Protein Folding; Protein Structure, Secondary; Proteins / chemical synthesis; Proteins / chemistry; Spectroscopy, Fourier Transform Infrared; Thermodynamics
TL;DR: This work explores the fundamental processes of folding in two linear peptides that form beta-hairpin structures, having a stabilizing hydrophobic cluster connected by loops of differing lengths, and finds a substantial acceleration of the folding rate when the connecting loop is made shorter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

A quantitative theory and computational approach for the vibrational Stark effect

JOURNAL OF CHEMICAL PHYSICS, 119(2), 851–858.

By: S. Brewer n & S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Density functional calculation of a potential energy surface for alkane thiols on Au(111) as function of alkane chain length

CHEMICAL PHYSICS LETTERS, 381(3-4), 315–321.

By: S. Franzen n

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Laser-induced temperature jump electrochemistry on gold nanoparticle-coated electrodes

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(47), 14258–14259.

By: L. Lowe n, S. Brewer n, S. Kramer n, R. Fuierer n, G. Qian n, C. Agbasi-Porter n, S. Moses n, S. Franzen n, D. Feldheim n

MeSH headings : DNA, Single-Stranded / analysis; DNA, Single-Stranded / chemistry; Electrochemistry / methods; Electrodes; Gold / chemistry; Indium / chemistry; Lasers; Nanotechnology; Particle Size; Surface Plasmon Resonance; Temperature; Thermography / methods
TL;DR: Laser-induced temperature jumps at gold nanoparticle-coated indium tin oxide (ITO) electrodes in contact with electrolyte solutions have been measured using temperature-sensitive redox probes and an infrared charge-coupled device. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Multifunctional gold nanoparticle-peptide complexes for nuclear targeting

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125(16), 4700–4701.

By: A. Tkachenko, H. Xie n, D. Coleman n, W. Glomm n, J. Ryan n, M. Anderson n, S. Franzen n, D. Feldheim n

MeSH headings : Amino Acid Sequence; Cell Nucleus / metabolism; Gold / chemistry; Gold / pharmacokinetics; Humans; Molecular Sequence Data; Nanotechnology / methods; Oligopeptides / chemistry; Oligopeptides / pharmacokinetics; Particle Size; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Tumor Cells, Cultured
TL;DR: The ability of peptide-modified gold nanoparticles to target the nucleus of HepG2 cells was explored and nuclear targeting was more efficient when the two signals were attached to nanoparticles as separate short pieces versus one long peptide. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides

BIOPHYSICAL JOURNAL, 84(6), 3874–3882.

By: S. Maness n, S. Franzen n, A. Gibbs*, T. Causgrove* & R. Dyer*

MeSH headings : Kinetics; Nanotechnology / methods; Peptides / chemistry; Peptides, Cyclic / chemistry; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared / methods; Temperature
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

New paradigm for design of high-spin organic molecules: The mechanism of spin-dependent delocalization in exchange-coupled, mixed-valent organic species

JOURNAL OF PHYSICAL CHEMISTRY A, 107(21), 4292–4299.

By: S. Franzen n & D. Shultz n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Study of polymer glasses by modulated differential scanning calorimetry in the undergraduate physical chemistry laboratory

JOURNAL OF CHEMICAL EDUCATION, 80(7), 813–818.

By: J. Folmer n & S. Franzen n

UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Study of the mechanism of electron-transfer quenching by boron-nitrogen adducts in fluorescent sensors

JOURNAL OF PHYSICAL CHEMISTRY B, 107(47), 12942–12948.

By: S. Franzen n, W. Ni n & B. Wang n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

A theoretical explanation for quantum yield failure in bacterial photosynthetic reaction centers

CHEMICAL PHYSICS, 276(2), 115–127.

By: S. Franzen n & R. Stanley*

TL;DR: The model provides a mechanism for a reduction of the quantum yield and an explanation for the lack of a concomitant increase in either prompt or delayed fluorescence and predicts an effect on the intersystem crossing rate constant. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

An electrostatic model for the frequency shifts in the carbonmonoxy stretching band of myoglobin: Correlation of hydrogen bonding and the Stark tuning rate

Journal of the American Chemical Society, 124(44), 13271–13281.

By: S. Franzen

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

Carbonmonoxy rebinding kinetics in H93G myoglobin: Separation of proximal and distal side effects

JOURNAL OF PHYSICAL CHEMISTRY B, 106(17), 4533–4542.

By: S. Franzen n

TL;DR: Thermodynamic analysis based on microscopic reversibility shows that the effect of proximal adducts on equilibrium constant for the intrinsic CO binding to heme iron, KCO, is 15 times larger than the effect on the equilibrium c... (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Center for Synchrotron Biosciences' U2B beamline: an international resource for biological infrared spectroscopy

JOURNAL OF SYNCHROTRON RADIATION, 9(2002 Jul), 189–197.

By: N. Marinkovic*, R. Huang*, P. Bromberg*, M. Sullivan*, J. Toomey*, L. Miller*, E. Sperber*, S. Moshe* ...

author keywords: infrared spectroscopy; microscopy; biological imaging; bone; protein folding; nucleic acid dynamics
MeSH headings : Bone and Bones / chemistry; Brain Mapping / instrumentation; Epilepsy / pathology; Hippocampus / chemistry; Humans; Osteoporosis / pathology; Purine Nucleosides / chemistry; Spectrophotometry, Infrared / instrumentation; Spectrophotometry, Infrared / methods; Synchrotrons / instrumentation; Temperature; X-Ray Diffraction / instrumentation
TL;DR: A number of synchrotron IR microscopy experiments that have been performed in the mid-IR spectral range, including time-resolved protein-folding studies in the microsecond time regime, IR imaging of neurons, bone and other biological tissues, as well as imaging of samples of interest in the chemical and environmental sciences are summarized. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Density functional analysis of anharmonic contributions to adenine matrix isolation spectra

JOURNAL OF PHYSICAL CHEMISTRY A, 106(47), 11446–11455.

By: S. Lappi n, W. Collier n & S. Franzen n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Detection of DNA hybridization on gold surfaces by polarization modulation infrared reflection absorption spectroscopy

LANGMUIR, 18(11), 4460–4464.

By: S. Brewer n, S. Anthireya n, S. Lappi n, D. Drapcho n & S. Franzen n

TL;DR: Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) was used to detect DNA hybridization on gold surfaces and contained absorptive features indicative of DNA arising from the phosphodiester backbone and the purine and pyrimidine rings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Experimental observation of anharmonic coupling of the heme-doming and iron-ligand out-of-plane vibrational modes confirmed by density functional theory

JOURNAL OF PHYSICAL CHEMISTRY B, 106(44), 11641–11646.

By: S. Franzen n, K. Fritsch n & S. Brewer n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Formation of thiolate and phosphonate adlayers on indium-tin oxide: Optical and electronic characterization

Langmuir, 18(18), 6857–6865.

By: S. Brewer, D. Brown & S. Franzen

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

Heme charge-transfer band III is vibronically coupled to the soret band

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124(24), 7146–7155.

By: S. Franzen n, S. Wallace-Williams n & A. Shreve n

MeSH headings : Animals; Cold Temperature; Heme / chemistry; Horses; Myoglobin / chemistry; Spectroscopy, Near-Infrared; Spectrum Analysis, Raman / methods
TL;DR: The results show that band III is vibronically coupled to the Soret band, and the coupling of band III to modes with strong rhombic distortion of the heme macrocycle calls into question the hypothesis that the axial iron out-of-plane displacement is primarily responsible for the structure-dynamics correlations observed in myoglobin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Indium tin oxide plasma frequency dependence on sheet resistance and surface adlayers determined by reflectance FTIR spectroscopy

JOURNAL OF PHYSICAL CHEMISTRY B, 106(50), 12986–12992.

By: S. Brewer n & S. Franzen n

Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Nanoparticle Layers Assembled through DNA Hybridization:  Characterization and Optimization

Langmuir, 18(5), 1825–1830.

By: M. Sauthier n, R. Carroll n, C. Gorman n & S. Franzen n

Contributors: