Works (3)
Updated: February 19th, 2024 08:11
2019 journal article
Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle
FOOD AND CHEMICAL TOXICOLOGY, 126, 285–294.
author keywords: Physiologically based pharmacokinetic (PBPK) model; Withdrawal interval; Florfenicol; Florfenicol amine; Cattle
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; China; Chromatography, High Pressure Liquid; Drug Administration Routes; Drug Residues / analysis; Drug Residues / metabolism; Drug Residues / pharmacokinetics; Kidney / drug effects; Liver / drug effects; Models, Biological; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / analysis; Thiamphenicol / metabolism; Thiamphenicol / pharmacokinetics
TL;DR:
A population physiologically based pharmacokinetic (PBPK) model to predict the concentrations of FF and its metabolite, florfenicol amine, in cattle after four different routes of administration, and to calculate and compare the withdrawal intervals (WDIs) with approved withdrawal times based on different marker residues and their MRLs or tolerances.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 15, 2019
2018 journal article
Pharmacokinetics of minocycline in crucian carp (Carassius auratus) after intravenous and oral administration
AQUACULTURE RESEARCH, 49(8), 2782–2787.
author keywords: bioavailability; crucian carp; minocycline; oral administration; pharmacokinetic
TL;DR:
It was shown that minocycline was slowly but relatively completely absorbed, extensively distributed, and slowly eliminated in crucian carp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Pharmacokinetics of orbifloxacin in crucian carp (Carassius auratus) after intravenous and intramuscular administration
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(4), 599–604.
author keywords: bioavailability; crucian carp; intramuscular injection; orbifloxacin; pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Ciprofloxacin / administration & dosage; Ciprofloxacin / analogs & derivatives; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Goldfish / blood; Goldfish / metabolism; Half-Life; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary
TL;DR:
It was shown that orbifloxacin was completely but relatively slowly absorbed, extensively distributed, and slowly eliminated in crucian carp, and an orbif loxacins dosage of 10 mg/kg administered intravenously or intramuscularly would be expected to successfully treat crucian fish infected by strains with MIC values ≤0.5 μg/ml.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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