Garrison Allen

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Updated: July 5th, 2023 14:22

2021 journal article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).

By: M. Foley n, S. O'Flaherty n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n , C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
TL;DR: It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2021

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