Gilad Fefer

Works (9)

Updated: April 13th, 2024 05:01

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.

By: C. Colon  n, P. Early n, K. Munana n , N. Olby n , C. Mariani n , S. Mancini n, G. Fefer n, Z. Li * ...

author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2023 journal article

A novel task of canine olfaction for use in adult and senior pet dogs

SCIENTIFIC REPORTS, 13(1).

By: M. Khan n, A. Mondino  n, K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
TL;DR: A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.

By: M. Salzman *, N. Merten *, W. Panek n , G. Fefer n, A. Mondino  n, H. Westermeyer n , M. Gruen n , N. Olby n , F. Mowat n

author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
TL;DR: Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 journal article

Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs

ANIMALS, 13(24).

By: G. Templeton n, G. Fefer n, B. Case n, J. Roach *, M. Azcarate-Peril *, M. Gruen n , B. Callahan n , N. Olby n 

author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
TL;DR: The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 journal article

Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs

FRONTIERS IN VETERINARY SCIENCE, 9.

By: M. Khan n, A. Mondino  n, K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
TL;DR: The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 journal article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

FRONTIERS IN VETERINARY SCIENCE, 10.

By: A. Mondino  n, M. Khan n, B. Case n, G. Fefer n, W. Panek n , M. Gruen n , N. Olby n 

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

By: G. Fefer n, M. Khan n, W. Panek n , B. Case n, M. Gruen n  & N. Olby n 

author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
TL;DR: Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022

2022 journal article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

JOURNAL OF ALZHEIMERS DISEASE, 87(3), 1367–1378.

By: G. Fefer n, W. Panek n , M. Khan n, M. Singer n, H. Westermeyer n , F. Mowat n, D. Murdoch *, B. Case n, N. Olby n , M. Gruen n 

author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
TL;DR: It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 journal article

Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs

FRONTIERS IN VETERINARY SCIENCE, 8.

By: J. Hoel n, G. Templeton n, G. Fefer n, B. Case n, A. Shah n, M. Gruen n , N. Olby n 

author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
TL;DR: It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

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