Gilad Fefer

Works (14)

Updated: April 25th, 2025 19:46

2025 journal article

Case Report: Presumed cerebral salt wasting syndrome in a 10-week-old German Shorthaired Pointer

Frontiers in Veterinary Science, 12.

By: E. Jackson n, G. Fefer n, K. Muñana n  & B. Hansen n

author keywords: canine; skull fracture; hyponatremia; traumatic brain injury; hypovolemia
topics (OpenAlex): Electrolyte and hormonal disorders; Apelin-related biomedical research; Diet and metabolism studies; Renal function and acid-base balance; Gastroesophageal reflux and treatments
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 9, 2025

2024 article

Cross-sectional and longitudinal analysis of health-related quality of life (HRQoL) in senior and geriatric dogs

Mondino, A., Yang, C.-C., Simon, K. E., Fefer, G., Robertson, J., Gruen, M. E., & Olby, N. J. (2024, September 4). (J. S. Suchodolski, Ed.). PLoS ONE, Vol. 19.

By: A. Mondino n , C. Yang n, K. Simon n, G. Fefer n, J. Robertson* , M. Gruen n , N. Olby n 

Ed(s): J. Suchodolski n

MeSH headings : Animals; Dogs; Quality of Life; Cross-Sectional Studies; Longitudinal Studies; Male; Aging / physiology; Female; Surveys and Questionnaires; Longevity / physiology
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
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3. Good Health and Well-being (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 8, 2024

2024 article

Establishing a clinically applicable frailty phenotype screening tool for aging dogs

Russell, K. J., Mondino, A., Fefer, G., Griffith, E., Saker, K., Gruen, M. E., & Olby, N. J. (2024, September 25). Frontiers in Veterinary Science, Vol. 11.

By: K. Russell n, A. Mondino n , G. Fefer n, E. Griffith n , K. Saker n, M. Gruen n , N. Olby n 

author keywords: frailty; canine frailty; frailty phenotype; geriatric; aging dogs
topics (OpenAlex): Frailty in Older Adults; Health Systems, Economic Evaluations, Quality of Life; Nutrition and Health in Aging
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colón, C., Early, P., Muñana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). Journal of Veterinary Pharmacology and Therapeutics, Vol. 3.

By: C. Colón n, P. Early n, K. Muñana n , N. Olby n , C. Mariani n , S. Mancini n, G. Fefer n, Z. Li * ...

author keywords: analgesia; canine; ketamine; novel; veterinary
MeSH headings : Animals; Dogs; Ketamine / pharmacokinetics; Ketamine / administration & dosage; Ketamine / analogs & derivatives; Ketamine / blood; Male; Injections, Subcutaneous / veterinary; Female; Analgesics / pharmacokinetics; Analgesics / administration & dosage; Analgesics / blood; Area Under Curve; Half-Life
topics (OpenAlex): Treatment of Major Depression; Veterinary Pharmacology and Anesthesia; Anesthesia and Sedative Agents
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 article

Surgical management of a lumbar far lateral intervertebral disc extrusion in a cat

Fefer, G., Bynum, L., & Early, P. (2024, July 1). Journal of Feline Medicine and Surgery Open Reports.

By: G. Fefer n, L. Bynum n & P. Early n

author keywords: Foraminotomy; foraminal; intervertebral disc extrusion; lameness; surgery
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Veterinary Oncology Research
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Source: Web Of Science
Added: August 14, 2024

2024 article

Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan

Yang, C.-C., Yap, P.-T., Wu, Y., Zidan, N., Fefer, G., Nelson, N. C., … Olby, N. J. (2024, August 5). Scientific Reports, Vol. 14.

By: C. Yang n, P. Yap *, Y. Wu *, N. Zidan n, G. Fefer n, N. Nelson n , M. Gruen n , N. Olby n 

author keywords: Age-related hearing loss; Central presbycusis; Canine; Diffusion tensor imaging
MeSH headings : Animals; Dogs; Diffusion Tensor Imaging / methods; Auditory Pathways / physiopathology; Auditory Pathways / diagnostic imaging; Presbycusis / physiopathology; Presbycusis / diagnostic imaging; Male; Female; Evoked Potentials, Auditory, Brain Stem / physiology; Longevity; Aging / physiology; White Matter / diagnostic imaging; White Matter / physiopathology; White Matter / pathology; Anisotropy
topics (OpenAlex): Advanced Neuroimaging Techniques and Applications; Congenital gastrointestinal and neural anomalies; Hearing, Cochlea, Tinnitus, Genetics
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2024

2023 article

A novel task of canine olfaction for use in adult and senior pet dogs

Khan, M. Z., Mondino, A., Russell, K., Case, B., Fefer, G., Woods, H., … Gruen, M. (2023, February 8). Scientific Reports, Vol. 13.

By: M. Khan n, A. Mondino n , K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Animal Behavior and Welfare Studies
TL;DR: A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 19, 2023

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). Documenta Ophthalmologica, Vol. 6.

By: M. Salzman *, N. Merten *, W. Panek n , G. Fefer n, A. Mondino n , H. Westermeyer n , M. Gruen n , N. Olby n , F. Mowat n

author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
topics (OpenAlex): Retinal Development and Disorders; Olfactory and Sensory Function Studies; Retinal Diseases and Treatments
TL;DR: Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Longitudinal Analysis of Canine Oral Microbiome Using Whole Genome Sequencing in Aging Companion Dogs

Templeton, G. B., Fefer, G., Case, B. C., Roach, J., Azcarate-Peril, M. A., Gruen, M. E., … Olby, N. J. (2023, December 14). Animals, Vol. 13.

By: G. Templeton n, G. Fefer n, B. Case n, J. Roach *, M. Azcarate-Peril *, M. Gruen n , B. Callahan n , N. Olby n 

author keywords: oral; microbiome; canine cognitive dysfunction syndrome; Alzheimer's disease
topics (OpenAlex): Gut microbiota and health; Oral microbiology and periodontitis research; Probiotics and Fermented Foods
TL;DR: The importance of defining the oral microbiota in aged dogs with a view to understanding potential therapeutic targets is shown, with an increased fungal and bacterial alpha diversity in aging dogs over time and nearly universal oral dysbiosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs

Khan, M. Z., Mondino, A., Russell, K., Case, B., Fefer, G., Woods, H., … Gruen, M. E. (2023, January 4). Frontiers in Veterinary Science, Vol. 9.

By: M. Khan n, A. Mondino n , K. Russell n, B. Case n, G. Fefer n, H. Woods n, N. Olby n , M. Gruen n 

author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Neuroendocrine regulation and behavior
TL;DR: The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W. K., Gruen, M. E., & Olby, N. J. (2023, June 15). Frontiers in Veterinary Science, Vol. 10.

By: A. Mondino n , M. Khan n, B. Case n, G. Fefer n, W. Panek n , M. Gruen n , N. Olby n 

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

Relationship between hearing, cognitive function, and quality of life in aging companion dogs

Fefer, G., Khan, M. Z., Panek, W. K., Case, B., Gruen, M. E., & Olby, N. J. (2022, August 6). Journal of Veterinary Internal Medicine, Vol. 8.

By: G. Fefer n, M. Khan n, W. Panek n , B. Case n, M. Gruen n  & N. Olby n 

author keywords: canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; presbycusis
MeSH headings : Aging; Animals; Cognition; Dementia / epidemiology; Dog Diseases; Dogs; Hearing; Humans; Pets; Presbycusis / epidemiology; Presbycusis / veterinary; Prospective Studies; Quality of Life
topics (OpenAlex): Human-Animal Interaction Studies; Ear Surgery and Otitis Media; Hearing Loss and Rehabilitation
TL;DR: Presbycusis negatively alters owner‐pet interactions and is associated with poor executive performance and owner‐assessed dementia severity, and in multivariate analysis, higher CADES score was associated with worse hearing. (via Semantic Scholar)
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1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 22, 2022

2022 article

Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population

Fefer, G., Panek, W. K., Khan, M. Z., Singer, M., Westermeyer, H. D., Mowat, F. M., … Gruen, M. E. (2022, April 15). Journal of Alzheimer s Disease.

By: G. Fefer n, W. Panek n , M. Khan n, M. Singer n, H. Westermeyer n , F. Mowat n, D. Murdoch *, B. Case n, N. Olby n , M. Gruen n 

author keywords: Blood biomarkers; canine cognitive dysfunction syndrome; CCDS; cognitive testing; dementia; neurofilament light chain; NfL
MeSH headings : Aging; Animals; Biomarkers; Cognitive Dysfunction / diagnostic imaging; Dogs; Humans; Neuropsychological Tests; Surveys and Questionnaires
topics (OpenAlex): Human-Animal Interaction Studies; Neuroinflammation and Neurodegeneration Mechanisms; Gut microbiota and health
TL;DR: It is suggested that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 article

Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs

Hoel, J. A., Templeton, G. B., Fefer, G., Case, B. C., Shah, A., Gruen, M. E., & Olby, N. J. (2021, December 23). Frontiers in Veterinary Science, Vol. 12.

By: J. Hoel n, G. Templeton n, G. Fefer n, B. Case n, A. Shah n, M. Gruen n , N. Olby n 

author keywords: Canine Cognitive Dysfunction Syndrome; cognitive testing; dementia; executive function; attention; cognitive impairment
topics (OpenAlex): Human-Animal Interaction Studies; Neuroendocrine regulation and behavior; Primate Behavior and Ecology; Veterinary Medicine and Surgery
TL;DR: It is concluded that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

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