Greer Kaylie Arthur

Works (8)

Updated: July 5th, 2023 15:37

2022 article

Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling

Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). ALLERGY, Vol. 12.

By: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

Contributors: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

author keywords: asthma; IgE; mast cells
MeSH headings : Animals; Humans; Mice; Basophils / metabolism; Cell Degranulation; Exons; Hypersensitivity / metabolism; Mast Cells / metabolism; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction
TL;DR: It is reported that targeting FcεRIβ with exon‐skipping oligonucleotides eliminates IgE‐mediated degranulation in mouse MCs, but equivalent targeting in human MCs was not effective at reducing degranulations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 25, 2022

2022 journal article

Regulation of Trafficking and Signaling of the High Affinity IgE Receptor by Fc epsilon RI beta and the Potential Impact of Fc epsilon RI beta Splicing in Allergic Inflammation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(2).

By: G. Arthur n & G. Cruse n 

Contributors: G. Arthur n & G. Cruse n 

author keywords: mast cell; IgE receptor; Fc epsilon RI beta; antisense therapy; allergy; asthma; exon skipping
MeSH headings : Alternative Splicing; Animals; Biomarkers; Cell Degranulation / genetics; Cell Degranulation / immunology; Disease Susceptibility; Gene Expression Regulation; Humans; Hypersensitivity / diagnosis; Hypersensitivity / etiology; Hypersensitivity / metabolism; Hypersensitivity / therapy; Mast Cells / immunology; Mast Cells / metabolism; RNA Splicing; Receptors, IgE / chemistry; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction; Structure-Activity Relationship
TL;DR: The characteristic role of FcεRIβ in both trafficking and signaling of the F cεRI receptor complex, the specificity to IgE-mediated activation pathways, and the preferential expression in mast cells and basophils makes Fc�RIβ an excellent, but challenging, candidate for therapeutic strategies in allergy and asthma, if targeting can be realized. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 7, 2022

2021 journal article

Does Irrigation with Treated and Untreated Wastewater Increase Antimicrobial Resistance in Soil and Water: A Systematic Review

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(21), 11046.

By: S. Slobodiuk n, C. Niven n , G. Arthur n, S. Thakur n  & A. Ercumen n 

author keywords: antimicrobial resistance; resistance genes; resistant bacteria; persistent organic pollutants; wastewater irrigation; wastewater reuse; water scarcity; water insecurity; untreated municipal wastewater; treated municipal wastewater
MeSH headings : Agricultural Irrigation; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Bacterial Agents / pharmacology; Drug Resistance, Bacterial; Genes, Bacterial; Humans; Soil; Wastewater / analysis; Water
TL;DR: It is demonstrated that irrigation with untreated wastewater increases AMR in soil and call for precautionary action by field workers, their families, and consumers when untreated wastewater is used to irrigate crops. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: December 13, 2021

2021 journal article

Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms

MOLECULAR THERAPY, 30(1), 295–310.

By: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

Contributors: D. Snider n, G. Arthur n, G. Falduto *, A. Olivera *, L. Ehrhardt-Humbert n, E. Smith n, C. Smith n, D. Metcalfe *, G. Cruse n 

MeSH headings : Humans; Mast Cells / metabolism; Mast Cells / pathology; Mastocytosis / genetics; Mastocytosis / pathology; Mastocytosis / therapy; Proto-Oncogene Proteins c-kit / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptor Protein-Tyrosine Kinases / metabolism
TL;DR: It is proposed that the innovative approach, which employs well-tolerated, chemically stable oligonucleotides to target KIT expression through unconventional pathways, has potential as a KIT-targeted therapeutic alone, or in combination with agents thattarget KIT signaling, in the treatment of K IT-associated malignancies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 7, 2022

2020 journal article

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation

TISSUE ENGINEERING PART A, 27(15-16), 1008–1022.

By: E. Ozpinar n , A. Frey  n, G. Arthur n, C. Mora-Navarro  n, A. Biehl  n, D. Snider  n, G. Cruse n , D. Freytes n

Contributors: E. Ozpinar n , A. Frey  n, G. Arthur n, C. Mora-Navarro  n, A. Biehl  n, D. Snider  n, G. Cruse n , D. Freytes n

author keywords: extracellular matrix; mast cell; allergy; metabolism
MeSH headings : Animals; Cell Differentiation; Collagen; Extracellular Matrix; Humans; Hydrogels; Mast Cells; Swine
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 11, 2020

2018 article

Exon Skipping of Fc epsilon RI beta for Allergic Diseases

EXON SKIPPING AND INCLUSION THERAPIES: METHODS AND PROTOCOLS, Vol. 1828, pp. 503–518.

By: G. Arthur n & G. Cruse n 

Contributors: G. Arthur n & G. Cruse n 

author keywords: Mast cell; Allergic diseases; Allergic inflammation; Fc epsilon RI; Exon skipping
MeSH headings : Anaphylaxis; Animals; Calcium / metabolism; Calcium Signaling; Cell Degranulation / immunology; Exons; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Hypersensitivity / genetics; Hypersensitivity / immunology; Mast Cells / immunology; Mast Cells / metabolism; Mice; Oligonucleotides, Antisense / administration & dosage; Oligonucleotides, Antisense / genetics; RNA Splicing; Receptors, IgE / genetics; Transfection
TL;DR: The methods of exon skipping in mast cells and the assays used to examine the responses of mast cells in vitro and in vivo are described and a novel application to alter receptor trafficking and dampen allergic inflammation is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2019

2017 journal article

Big data meets materials science: Training the future generation

American Ceramic Society Bulletin, 96(6), 40–44.

By: E. Dickey  & G. Arthur

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Exon skipping of Fc epsilon RI beta eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(49), 14115–14120.

By: G. Cruse n , Y. Yin *, T. Fukuyama n, A. Desai*, G. Arthur n, W. Baumer  n, M. Beaven*, D. Metcalfe *

Contributors: G. Cruse n , Y. Yin *, T. Fukuyama n, A. Desai*, G. Arthur n, W. Bäumer  n, M. Beaven*, D. Metcalfe *

author keywords: mast cell; allergy; IgE receptor; oligonucleotides; dermatitis
MeSH headings : Animals; Calcium / metabolism; Cell Degranulation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / biosynthesis; Dermatitis, Allergic Contact / therapy; Disease Models, Animal; Female; Humans; Mast Cells / drug effects; Mast Cells / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotides, Antisense / pharmacology; Oligonucleotides, Antisense / therapeutic use; Passive Cutaneous Anaphylaxis / genetics; RNA Splicing / drug effects; Receptors, IgE / genetics; Receptors, IgE / metabolism
TL;DR: An innovative approach for targeting mast cells in vitro and in vivo is described using antisense oligonucleotide-mediated exon skipping of the β-subunit of the high-affinity IgE receptor (FcεRIβ) to eliminate surface high-Affinity Ig E receptor expression and function, rendering mast cells unresponsive to IgE-mediated activation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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