Works (11)

Updated: July 5th, 2023 15:59

2021 journal article

Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase

BIOCHEMISTRY, 60(4), 324–345.

By: G. Buhrman n, P. Enriquez n, L. Dillard n, H. Baer n, V. Truong n, A. Grunden n, R. Rose n

co-author countries: United States of America 🇺🇸
MeSH headings : Bacteria / enzymology; Bacterial Proteins / chemistry; Carbon-Nitrogen Ligases / chemistry; Crystallography, X-Ray; Enzyme Stability; Hot Temperature; Protein Domains; Structure-Activity Relationship
Sources: Web Of Science, ORCID
Added: January 20, 2021

2015 journal article

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

STRUCTURE, 23(3), 505–516.

By: S. Fetics n, H. Guterres*, B. Kearney n, G. Buhrman n, B. Ma*, R. Nussinov*, C. Mattos n

co-author countries: Israel 🇮🇱 United States of America 🇺🇸
MeSH headings : Allosteric Regulation; Catalytic Domain; Crystallography, X-Ray; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation, Missense; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Protein Structure, Secondary; Proto-Oncogene Proteins c-raf / chemistry; Proto-Oncogene Proteins p21(ras) / chemistry; Proto-Oncogene Proteins p21(ras) / genetics
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs

Immunogenetics, 68(3), 205–217.

By: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸

Contributors: S. Friedenberg n, G. Buhrman n, L. Chdid n, N. Olby n, T. Olivry n, J. Guillaumin*, T. O’Toole*, R. Goggs* ...

author keywords: Canine; Immune-mediated disease; Dog leukocyte antigen; Major histocompatibility complex class Ib
MeSH headings : Alleles; Amino Acid Substitution; Animals; Autoimmune Diseases / genetics; Autoimmune Diseases / immunology; Binding Sites; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Exons; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Immune System Diseases / veterinary; Meta-Analysis as Topic; Models, Molecular; Peptides / chemistry; Peptides / metabolism; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation; Reproducibility of Results; Structure-Activity Relationship
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition

BIOCHEMISTRY, 51(31), 6114–6126.

By: G. Holzapfel n, G. Buhrman n & C. Mattos n

co-author countries: United States of America 🇺🇸
MeSH headings : Acetates / metabolism; Acetates / pharmacology; Allosteric Regulation / drug effects; Allosteric Site / drug effects; Calcium Compounds / metabolism; Calcium Compounds / pharmacology; Catalytic Domain; Dithioerythritol / metabolism; Dithioerythritol / pharmacology; Dithiothreitol / metabolism; Dithiothreitol / pharmacology; Enzyme Stability / drug effects; Guanosine Triphosphate / metabolism; Guanylyl Imidodiphosphate / chemistry; Hydrolysis; Isoenzymes / chemistry; Isoenzymes / metabolism; Models, Molecular; Polyethylene Glycols / pharmacology; Protein Structure, Secondary; Small Molecule Libraries / metabolism; Small Molecule Libraries / pharmacology; Solutions; Solvents / chemistry; Solvents / pharmacology; ras Proteins / chemistry; ras Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331.

By: G. Buhrman*, V. Kumar, M. Cirit n, J. Haugh n & C. Mattos*

co-author countries: United States of America 🇺🇸
MeSH headings : Allosteric Regulation; Allosteric Site; Animals; Guanosine Triphosphate / metabolism; Kinetics; Mice; Mutation, Missense; NIH 3T3 Cells; Protein Conformation; Protein Stability; Signal Transduction; raf Kinases / metabolism; ras Proteins / genetics; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features

BIOCHEMISTRY, 50(14), 2907–2918.

By: S. Biswas n, G. Buhrman n, K. Gagnon*, C. Mattos n, B. Brown n & E. Maxwell n

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Animals; Binding Sites / genetics; Circular Dichroism; Crystallography, X-Ray; Giardia lamblia / metabolism; Humans; Methyltransferases / chemistry; Methyltransferases / metabolism; Models, Molecular; Molecular Sequence Data; Molecular Weight; Phylogeny; Protein Binding; Protein Stability; Protein Structure, Secondary; Protein Structure, Tertiary; Protozoan Proteins / chemistry; Protozoan Proteins / genetics; Protozoan Proteins / metabolism; RNA / genetics; RNA / metabolism; Ribonucleoproteins, Small Nucleolar / chemistry; Ribonucleoproteins, Small Nucleolar / classification; Ribonucleoproteins, Small Nucleolar / metabolism; Sequence Homology, Amino Acid; Temperature
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Functional Analysis of a Novel Motif Conserved across Geminivirus Rep Proteins

JOURNAL OF VIROLOGY, 85(3), 1182–1192.

By: T. Nash n, M. Dallas n, M. Reyes n, G. Buhrman n, J. Ascencio-Ibanez n & L. Hanley-Bowdoin n

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; DNA Helicases / genetics; DNA Helicases / metabolism; DNA, Viral / metabolism; Geminiviridae / enzymology; Geminiviridae / genetics; Geminiviridae / physiology; Molecular Sequence Data; Mutation, Missense; Plant Diseases / virology; Protein Binding; Sequence Alignment; Tobacco / virology; Trans-Activators / genetics; Trans-Activators / metabolism; Viral Proteins / genetics; Viral Proteins / metabolism; Virulence; Virus Replication
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(11), 4931–4936.

By: G. Buhrman n, G. Holzapfel*, S. Fetics* & C. Mattos*

co-author countries: United States of America 🇺🇸
author keywords: GTPase; Raf; calcium; intrinsic hydrolysis
MeSH headings : Acetates / pharmacology; Allosteric Regulation / drug effects; Allosteric Site; Biocatalysis / drug effects; Calcium / metabolism; Calcium Compounds / pharmacology; Catalytic Domain; Crystallography, X-Ray; Enzyme Stability / drug effects; Glutamine / metabolism; Hydrogen Bonding / drug effects; Hydrolysis / drug effects; Hydroxyl Radical / metabolism; Magnesium / metabolism; Models, Molecular; Protein Structure, Tertiary; Structure-Activity Relationship; ras Proteins / chemistry; ras Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf

STRUCTURE, 15(12), 1618–1629.

By: G. Buhrman n, G. Wink n & C. Mattos n

co-author countries: United States of America 🇺🇸
MeSH headings : Catalysis; Crystallography, X-Ray; Guanosine Triphosphate / metabolism; Hydrolysis; Models, Molecular; Mutation; Protein Conformation; raf Kinases / metabolism; ras Proteins / chemistry; ras Proteins / genetics
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond

BIOCHEMISTRY, 44(14), 5307–5316.

By: G. Buhrman n, B. Parker n, J. Sohn n, J. Rudolph n & C. Mattos n

co-author countries: United States of America 🇺🇸
MeSH headings : Binding Sites; Catalytic Domain; Cell Cycle Proteins / chemistry; Cell Cycle Proteins / metabolism; Crystallization; Disulfides / chemistry; Models, Molecular; Oxidation-Reduction; Protein Conformation; cdc25 Phosphatases / chemistry; cdc25 Phosphatases / metabolism
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Organic solvents order the dynamic switch II in Ras crystals

STRUCTURE, 11(7), 747–751.

By: G. Buhrman n, V. Serrano n & C. Mattos n

co-author countries: United States of America 🇺🇸
MeSH headings : Crystallization; Guanosine Triphosphate / analogs & derivatives; Guanosine Triphosphate / chemistry; Organic Chemicals / chemistry; Solvents / chemistry; ras Proteins / chemistry
Source: Web Of Science
Added: August 6, 2018