Works (4)

Updated: July 5th, 2023 15:47

2013 journal article

A Transgenerational Endocrine Signaling Pathway in Crustacea

PLoS ONE, 8(4), e61715.

By: G. LeBlanc n, Y. Wang n, C. Holmes n, G. Kwon n & E. Medlock n

Ed(s): B. He

MeSH headings : Amino Acid Sequence; Animals; Cloning, Molecular; Crustacea / drug effects; Crustacea / metabolism; Daphnia / drug effects; Daphnia / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Fatty Acids, Unsaturated / pharmacology; Female; Fertility; Genes, Reporter; Life Cycle Stages / drug effects; Ligands; Luciferases / metabolism; Male; Molecular Sequence Data; Population Density; Pyridines / pharmacology; Sex Determination Processes / drug effects; Sex Ratio; Signal Transduction / drug effects; Transcription Factors / chemistry
TL;DR: Results reveal likely components to a hormone/receptor signaling pathway in a crustacean that orchestrates transgenerational modifications to important population metrics (sex ratios, fecundity of females) and how these signaling processes can facilitate population sustainability under normal conditions or threaten sustainability when perturbed by environmental chemicals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Regulation and dysregulation of vitellogenin mRNA accumulation in daphnids (Daphnia magna)

AQUATIC TOXICOLOGY, 101(2), 351–357.

By: B. Hannas n, Y. Wang n, S. Thomson n, G. Kwon n, H. Li n & G. LeBlanc n

author keywords: Vitellogenin; Water flea; Biomarker; Ecdysteroids; Estrogens; Endocrine disruption
MeSH headings : Animals; Cadmium / toxicity; Daphnia / drug effects; Daphnia / genetics; Daphnia / metabolism; Ecdysteroids / toxicity; Ecdysterone / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Gene Expression / drug effects; Heterocyclic Compounds / toxicity; Polycyclic Compounds / toxicity; RNA, Messenger / metabolism; Vitellogenins / genetics; Vitellogenins / metabolism; Xenobiotics / toxicity
TL;DR: Results indicate that ecdysteroids are suppressors of vitellogenin gene expression and that viteLLogenin mRNA levels can be elevated or suppressed in daphnids by xenobiotics that elicit antiecdysteroidal or ecdystersoidal activity, respectively. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Tributyltin Synergizes with 20-Hydroxyecdysone to Produce Endocrine Toxicity

TOXICOLOGICAL SCIENCES, 123(1), 71–79.

By: Y. Wang n, G. Kwon n, H. Li n & G. LeBlanc n

author keywords: chemical mixtures; models; synergy; invertebrate; ecdysteroid; nuclear receptor; retinoid X receptor; ecdysteroid receptor
MeSH headings : Animals; Cells, Cultured; Daphnia; Dose-Response Relationship, Drug; Drug Synergism; Ecdysterone / metabolism; Ecdysterone / toxicity; Female; Gene Expression / drug effects; Molting / drug effects; Receptors, Steroid / genetics; Receptors, Steroid / metabolism; Retinoid X Receptors / genetics; Retinoid X Receptors / metabolism; Signal Transduction; Trialkyltin Compounds / toxicity; Water Pollutants, Chemical / toxicity
TL;DR: Results demonstrate that xenobiotics, such as tributyltin, can interact with RXR to influence gene expression regulated by the heterodimeric partner to RXR. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex

BMC Genomics, 10.

By: S. Thomson, W. Baldwin, Y. Wang, G. Kwon & G. LeBlanc

Source: NC State University Libraries
Added: August 6, 2018

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