George Logan Draughn

Works (3)

Updated: July 5th, 2023 15:40

2019 article

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis

Milton, M. E., Draughn, G. L., Bobay, B. G., Stowe, S. D., Olson, A. L., Feldmann, E. A., … Cavanagh, J. (2019, September 5). Journal of Molecular Biology.

By: M. Milton *, G. Draughn n, B. Bobay n, S. Stowe n, A. Olson n, E. Feldmann n, R. Thompson*, K. Myers n ...

author keywords: Biofilms; Bacillus subtilis; Transcriptional regulation; NMR solution structure
MeSH headings : Amino Acid Sequence / genetics; Bacillus subtilis / genetics; Bacillus subtilis / ultrastructure; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / ultrastructure; Biofilms / growth & development; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / genetics; DNA-Binding Proteins / ultrastructure; Gene Expression Regulation, Bacterial / genetics; Molecular Docking Simulation; Mutation / genetics; Protein Binding / genetics; Protein Conformation
topics (OpenAlex): Bacterial Genetics and Biotechnology; Bacterial biofilms and quorum sensing; Bacteriophages and microbial interactions
TL;DR: This work presents the first full-length structural model of tetrameric SinR using a hybrid approach combining high-resolution solution NMR, chemical crosslinking, mass spectrometry, and molecular docking, and provides an evidence-based mechanism that confirms how disruption of the SinR tetramer by SinI regulates gene expression. (via Semantic Scholar)
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Source: Web Of Science
Added: February 27, 2020

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2015 article

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

Stowe, S., Thompson, R., Peng, L., Su, Z., Blackledge, M., Draughn, G., … Cavanagh, J. (2015, April 23). Current Drug Delivery.

By: S. Stowe*, R. Thompson*, L. Peng*, Z. Su*, M. Blackledge*, G. Draughn*, W. Coe, E. Johannes* ...

author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
topics (OpenAlex): Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing; Antimicrobial agents and applications
TL;DR: A model is proposed that describes how the structure of RA-2AI allows it to insert itself into and disrupt the fluidity of the membrane, creating an opportunity for increased molecular permeability. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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