Works (24)
Updated: April 4th, 2024 09:02
2023 review
Development and Delivery of a Hands-On Short Course in Adeno-Associated Virus Manufacturing to Support Growing Workforce Needs in Gene Therapy
[Review of ]. HUMAN GENE THERAPY, 34(7-8), 259–272.
author keywords: viral vectors; AAV; gene therapy; biomanufacturing; training; short course
MeSH headings : Humans; Dependovirus / genetics; Genetic Therapy; Commerce; Genetic Vectors / genetics
TL;DR:
The design of the course, the backgrounds of the nearly 80 students who have participated in the seven offerings held since March 2019, and feedback from the course participants are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 19, 2023
2023 chapter
Digital Twins in Pilot Scale Fermentation: Non-Linear State Estimation for Improving Induction Timing
In Computer Aided Chemical Engineering (pp. 2637–2642).
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2023
2023 article
Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates
WENNING, C. H. U., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, February 21). (Vol. 2). Vol. 2.
doi.org (repository)
Source: ORCID
Added: February 22, 2023
2023 article
Peptide ligands for the affinity purification of adeno-associated viruses from HEK 293 cell lysates
Chu, W., Shastry, S., Barbieri, E., Prodromou, R., Greback-Clarke, P., Smith, W., … Menegatti, S. (2023, July 12). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 7.
author keywords: adeno-associated virus; affinity chromatography; HEK 293 lysate; peptide ligands; virus purification
MeSH headings : Humans; Dependovirus / genetics; HEK293 Cells; Ligands; Peptides / genetics; Peptides / metabolism; Amino Acid Sequence; Genetic Vectors
TL;DR:
Peptide ligands that selectively capture AAVs and release them under mild conditions are introduced, affording high recovery, high recovery of host cell proteins (HCPs), and high transduction activity of the purified viruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 7, 2023
2023 article
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
Shastry, S., WENNING, C. H. U., Barbieri, E., Greback-Clarke, P., Smith, W., Cummings, C., … Menegatti, S. (2023, May 23).
Source: ORCID
Added: May 23, 2023
2023 article
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography
Shastry, S., Chu, W., Barbieri, E., Greback-Clarke, P., Smith, W. K., Cummings, C., … Menegatti, S. (2023, September 28). BIOTECHNOLOGY JOURNAL, Vol. 9.
author keywords: adeno-associated virus; affinity chromatography; gene therapy; peptide ligands; transduction activity
TL;DR:
This study introduces a cohort of peptide ligands that mimic the biorecognition activity of the AAV receptor (AAVR) and anti-AAV antibody A20, enable product elution under near-physiological conditions (pH 6.0) and grant extended reusability by withstanding multiple regenerations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023
2022 article
A direct comparison between membrane adsorber and packed column chromatography performance (vol 1612, 460629, 2020)
Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2022, March 15). JOURNAL OF CHROMATOGRAPHY A, Vol. 1666.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022
2022 article
Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries
Fahr, S., Pena-Benavides, S. A., Thiel, L., Sengoba, C., Karacasulu, K., Ihling, N., … Roh, K. (2022, August 19). INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, Vol. 61.
Contributors: S. Fahr *, S. Pena-Benavides *, L. Thiel *, C. Sengoba*, K. Karacasulu *, N. Ihling *, J. Sosa-Hernandez *, n
TL;DR:
This work designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA that can produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 14, 2022
2021 book
Sources: ORCID, Crossref, NC State University Libraries
Added: October 16, 2022
2020 journal article
A direct comparison between membrane adsorber and packed column chromatography performance
JOURNAL OF CHROMATOGRAPHY A, 1612.
author keywords: Chromatography; Membrane adsorber; Packed column; Binding capacity; Productivity
MeSH headings : Adsorption; Anion Exchange Resins; Chromatography, Ion Exchange / methods; Proteins / isolation & purification; Serum Albumin, Bovine / isolation & purification
TL;DR:
The comparison was performed using anion exchange media with the same ligand immobilized on the adsorbing surface, namely the strong Q quaternary ammonium group, R-CH2-N+-(CH3)3, and bovine serum albumin as a model protein to confirm the better performance of membrane chromatography at high flow rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 10, 2020
2020 journal article
Recycled eggshells as precursors for iron-impregnated calcium oxide catalysts for partial oxidation of methane
BIORESOURCES AND BIOPROCESSING, 7(1).
author keywords: Eggshell; Iron; Methane; Catalyst; Partial oxidation
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2020
2020 journal article
Valorization of Eggshell Waste into Supported Copper Catalysts for Partial Oxidation of Methane
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, 14(1), 61–70.
author keywords: Eggshell; Copper; Catalyst; Methane; Partial oxidation
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 9, 2019
2016 journal article
A Life Cycle Approach to Education and Training for the Biopharmaceutical Industry
Chemical Engineering Education. https://journals.flvc.org/cee/article/view/88298
Source: ORCID
Added: October 16, 2022
2015 journal article
Calcined eggshell as an inexpensive catalyst for partial oxidation of methane
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 57, 123–128.
author keywords: Catalyst; Eggshell; Hydrocarbons; Methane oxidation
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Comprehensive Hands-on Training for Influenza Vaccine Manufacturing: A WHO-BARDA-BTEC Partnership for Global Workforce Development
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 42(5), 414–419.
author keywords: workforce development; developing countries vaccine manufacturers; influenza vaccine; global vaccine capacity-building; active learning; cGMP manufacturing
MeSH headings : Capacity Building / methods; Education, Continuing / methods; Humans; Influenza Vaccines / biosynthesis; Influenza Vaccines / immunology; Internet; Program Development / methods; Reproducibility of Results; Technology, Pharmaceutical / education; Technology, Pharmaceutical / methods; United States; United States Dept. of Health and Human Services; World Health Organization
TL;DR:
The Biomanufacturing Training and Education Center at North Carolina State University has addressed the need for training for staff supporting operations within vaccine production facilities by developing and delivering a comprehensive training program, consisting of three courses: Fundamentals of cGMP Influenza Vaccine Manufacturing, Advanced Upstream Processes for Influenza vaccine Manufacturing, and Advanced Downstream processeses for influenza vaccine Manufacturing.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
From Process Development to Manufacturing: Lab-intensive Courses in Downstream Bioprocessing
Chemical Engineering Education. https://journals.flvc.org/cee/article/view/83365
Source: ORCID
Added: October 16, 2022
2014 journal article
Value-addition of methane via selective catalytic oxidation
Biofuels, 5(2), 175–188.
Contributors: G. Karoshi n, P. Kolar n, S. Shah n & n
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: ORCID
Added: October 16, 2022
1995 journal article
Gas separations in hollow-fiber adsorbers
AIChE Journal, 41(6), 1413–1425.
Contributors: * , J. Parker * & E. Cussler *
Source: ORCID
Added: October 16, 2022
1989 journal article
SEGREGATION AND CHEMICAL CONVERSION AT OIL-WATER INTERFACE
CHEMICAL ENGINEERING SCIENCE, 44(1), 171–177.
Contributors: S. Ganesan, P. Lloyd, * & P. Lim*
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018
Employment
Updated: October 14th, 2022 08:05
2019 - present
North Carolina State University Raleigh, North Carolina, US
Executive Director
Biomanufacturing Training and Education Center
Education
Updated: October 14th, 2022 08:07
1987 - 1992
University of Minnesota Minneapolis, MN, US
PhD
Chemical Engineering
1982 - 1986
North Carolina State University Raleigh, North Carolina, US
BS
Chemical Engineering
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