Gabrielle M. Hochu

Works (3)

Updated: July 5th, 2023 15:39

2016 journal article

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

NANO LETTERS, 16(4), 2334–2340.

By: C. Wang n, Y. Ye n, G. Hochu n, H. Sadeghifar  n & Z. Gu n

author keywords: Anti-PD-1; cancer immunotherapy; microneedle patch; melanoma; drug delivery
MeSH headings : Animals; Antibodies, Neoplasm / immunology; Antibodies, Neoplasm / pharmacology; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Immunotherapy / instrumentation; Immunotherapy / methods; Mice; Needles; Programmed Cell Death 1 Receptor / immunology; Skin Neoplasms / immunology; Skin Neoplasms / pathology; Skin Neoplasms / therapy
TL;DR: It is found that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

ACS NANO, 10(9), 8956–8963.

By: Y. Ye n, J. Wang n, Q. Hu  n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

BIOMATERIALS, 96, 1–10.

By: W. Sun n, W. Ji  n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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