Gabrielle M. Hochu

Works (3)

Updated: April 23rd, 2025 19:47

2016 article

Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody

Wang, C., Ye, Y., Hochu, G. M., Sadeghifar, H., & Gu, Z. (2016, March 21). Nano Letters.

By: C. Wang n, Y. Ye n, G. Hochu n, H. Sadeghifar  n & Z. Gu n

author keywords: Anti-PD-1; cancer immunotherapy; microneedle patch; melanoma; drug delivery
MeSH headings : Animals; Antibodies, Neoplasm / immunology; Antibodies, Neoplasm / pharmacology; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Immunotherapy / instrumentation; Immunotherapy / methods; Mice; Needles; Programmed Cell Death 1 Receptor / immunology; Skin Neoplasms / immunology; Skin Neoplasms / pathology; Skin Neoplasms / therapy
topics (OpenAlex): Immunotherapy and Immune Responses; Advancements in Transdermal Drug Delivery; Monoclonal and Polyclonal Antibodies Research
TL;DR: It is found that a single administration of the MN patch induces robust immune responses in a B16F10 mouse melanoma model compared to MN without degradation trigger or intratumoral injection of free aPD1 with the same dose. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors

Ye, Y., Wang, J., Hu, Q., Hochu, G. M., Xin, H., Wang, C., & Gu, Z. (2016, September 6). ACS Nano.

By: Y. Ye n, J. Wang n, Q. Hu  n, G. Hochu n, H. Xin n, C. Wang n, Z. Gu n

author keywords: drug delivery; immunotherapy; anti-PD1; IDO; microneedle
MeSH headings : Animals; Cell Cycle Checkpoints / drug effects; Drug Delivery Systems; Immunosuppression Therapy; Immunotherapy / methods; Indoleamine-Pyrrole 2,3,-Dioxygenase / therapeutic use; Melanoma / therapy; Programmed Cell Death 1 Receptor / therapeutic use; Skin Neoplasms / therapy; Tumor Microenvironment
topics (OpenAlex): Immunotherapy and Immune Responses; Advancements in Transdermal Drug Delivery; Cancer Immunotherapy and Biomarkers
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

Sun, W., Ji, W., Hu, Q., Yu, J., Wang, C., Qian, C., … Gu, Z. (2016, April 29). Biomaterials.

By: W. Sun n, W. Ji  n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
MeSH headings : Cell Death / drug effects; Cell Line, Tumor; Cell Membrane / metabolism; Cytokines / administration & dosage; DNA / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans; Hydrodynamics; Liposomes; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nickel / chemistry; Particle Size; Phosphatidylcholines / chemistry; Phospholipases A2 / metabolism; TNF-Related Apoptosis-Inducing Ligand / pharmacology
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Dendrimers and Hyperbranched Polymers
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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