@misc{kaur_narayanan_garg_sachdev_matai_2022, title={Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing}, volume={5}, ISSN={["2576-6422"]}, DOI={10.1021/acsabm.2c00035}, abstractNote={Skin tissue wound healing proceeds through four major stages, including hematoma formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling. These four steps significantly overlap with each other and are aided by various factors such as cells, cytokines (both anti- and pro-inflammatory), and growth factors that aid in the neo-tissue formation. In all these stages, advanced biomaterials provide several functional advantages, such as removing wound exudates, providing cover, transporting oxygen to the wound site, and preventing infection from microbes. In addition, advanced biomaterials serve as vehicles to carry proteins/drug molecules/growth factors and/or antimicrobial agents to the target wound site. In this review, we report recent advancements in biomaterials-based regenerative strategies that augment the skin tissue wound healing process. In conjunction with other medical sciences, designing nanoengineered biomaterials is gaining significant attention for providing numerous functionalities to trigger wound repair. In this regard, we highlight the advent of nanomaterial-based constructs for wound healing, especially those that are being evaluated in clinical settings. Herein, we also emphasize the competence and versatility of the three-dimensional (3D) bioprinting technique for advanced wound management. Finally, we discuss the challenges and clinical perspective of various biomaterial-based wound dressings, along with prospective future directions. With regenerative strategies that utilize a cocktail of cell sources, antimicrobial agents, drugs, and/or growth factors, it is expected that significant patient-specific strategies will be developed in the near future, resulting in complete wound healing with no scar tissue formation.}, number={5}, journal={ACS APPLIED BIO MATERIALS}, author={Kaur, Gurvinder and Narayanan, Ganesh and Garg, Deepa and Sachdev, Abhay and Matai, Ishita}, year={2022}, month={Apr}, pages={2069–2106} }
 @misc{narayanan_shen_matai_sachdev_boy_tonelli_2022, title={Cyclodextrin-based nanostructures}, volume={124}, ISSN={["1873-2208"]}, url={https://publons.com/publon/50714719/}, DOI={10.1016/j.pmatsci.2021.100869}, abstractNote={Cyclodextrins (CDs) are a unique class of molecules that are naturally available via degradation of starchy molecules. Their toroidal structure and abundant presence of hydroxyl groups have given scientists exceptional leverage resulting in synthesizing novel molecules for applications ranging from food packaging, controlled release of small molecules, antibacterial coating, agriculture, and air and water filtration. With the advent of nanotechnology, CDs have positioned itself in a variety of forms such as their ability to act as capping/reducing agents for metallic nanoparticles, or form stable nanofibers or nanoparticles or nano micelles, which can be subsequently utilized for sophisticated applications. In this review, we summarize researches on the presence of CDs in various aspects of nanotechnology ranging from nanoparticles, nanorods, nanomicelles, to nanofibers. In addition, through this review, we provide state-of-the-art applications that are being carried out using these nanostructures.}, journal={PROGRESS IN MATERIALS SCIENCE}, author={Narayanan, Ganesh and Shen, Jialong and Matai, Ishita and Sachdev, Abhay and Boy, Ramiz and Tonelli, Alan E.}, year={2022}, month={Feb} }
 @article{tonelli_narayanan_gurarslan_2018, title={Host-Guest Polymer Complexes}, volume={10}, ISSN={["2073-4360"]}, DOI={10.3390/polym10080911}, abstractNote={n/a}, number={8}, journal={POLYMERS}, author={Tonelli, Alan E. and Narayanan, Ganesh and Gurarslan, Alper}, year={2018}, month={Aug} }
 @article{narayanan_caydamli_tekinalp_matai_boy_chung_shen_gupta_tonelli_2018, title={Thermal, mechanical, and topographical evaluation of nonstoichiometric alpha-cyclodextrin/poly(epsilon-caprolactone) pseudorotaxane nucleated poly(epsilon-caprolactone) composite films}, volume={56}, ISSN={["1099-0488"]}, DOI={10.1002/polb.24741}, abstractNote={ABSTRACT}, number={22}, journal={JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS}, publisher={Wiley}, author={Narayanan, Ganesh and Caydamli, Yavuz and Tekinalp, Halil and Matai, Ishita and Boy, Ramiz and Chung, Ching-Chang and Shen, Jialong and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2018}, month={Nov}, pages={1529–1537} }
 @article{narayanan_tekbudak_caydamli_dong_krause_2017, title={Accuracy of electrospun fiber diameters: The importance of sampling and person-to-person variation}, volume={61}, ISSN={["1873-2348"]}, DOI={10.1016/j.polymertesting.2017.04.017}, abstractNote={Potential sampling errors (regional variation) on an electrospun mat were explored and person-to-person (analyst affect) variation in image analysis of the fiber diameter were investigated via detailed statistical analyses. Scanning electron microscope (SEM) samples were prepared from the vertical midline of a single non-woven mat of electrospun polyethylene oxide. Thirteen analysts with identical training and instructions measured the diameters of the nanofibers from the six SEM images and statistical analyses were performed on the resulting data. The fiber diameters were significantly different in the lower region than the upper and center regions. Furthermore, the fiber diameters in the lower region—from micrographs taken only millimeters apart—were statistically different demonstrating a statistically significant regional variation in the sample. Furthermore, statistically significant variation between the analysts also was observed, with the average fiber diameter ranging from 166 nm to 276 nm.}, journal={POLYMER TESTING}, author={Narayanan, Ganesh and Tekbudak, Merve Yasemin and Caydamli, Yavuz and Dong, Ju and Krause, Wendy E.}, year={2017}, month={Aug}, pages={240–248} }
 @article{narayanan_boy_gupta_tonelli_2017, title={Analytical techniques for characterizing cyclodextrins and their inclusion complexes with large and small molecular weight guest molecules}, volume={62}, ISSN={["1873-2348"]}, url={https://doi.org/10.1016/j.polymertesting.2017.07.023}, DOI={10.1016/j.polymertesting.2017.07.023}, abstractNote={Cyclodextrins are oligosaccharides that have truncated cone like structures, making them capable of forming non-covalent bonds with a large variety of molecules (especially hydrophobic molecules). Additionally, as the outer rims of their truncated cones are lined with several hydroxyl groups, secondary interactions with and functionalization of these hydroxyl groups are also possible. Current techniques available to analyze and characterize these interactions, although somewhat limited, can be accomplished by judicious selection of analytical tools. However, for emerging applications, the currently utilized techniques summarized in this review may not be sufficient. The purpose of this review is to provide an overview, including their possible limitations, of current techniques commonly employed to investigate such interactions. In view of CD-based materials for emerging applications, wherever possible, analytical tools used for these studies are also discussed.}, journal={POLYMER TESTING}, publisher={Elsevier BV}, author={Narayanan, Ganesh and Boy, Ramiz and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2017}, month={Sep}, pages={402–439} }
 @article{narayanan_chung_aguda_boy_hartman_mehraban_gupta_tonelli_2016, title={Correlation of the stoichiometries of poly-(epsilon-caprolactone) and alpha-cyclodextrin pseudorotaxanes with their solution rheology and the molecular orientation, crystallite size, and thermomechanical properties of their nanofibers}, volume={6}, ISSN={["2046-2069"]}, DOI={10.1039/c6ra23536k}, abstractNote={Pseudorotaxane nanofibers based on biomedical polymers, such as poly(ε-caprolactone) (PCL), and α-cyclodextrins (α-CD) open new horizons for a variety of biomedical applications.}, number={112}, journal={RSC ADVANCES}, publisher={Royal Society of Chemistry (RSC)}, author={Narayanan, Ganesh and Chung, Ching-Chang and Aguda, Remil and Boy, Ramiz and Hartman, Matthew and Mehraban, Nahid and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2016}, pages={111326–111336} }
 @article{narayanan_aguda_hartman_chung_boy_gupta_tonelli_2016, title={Fabrication and Characterization of Poly(epsilon-caprolactone)/alpha-Cyclodextrin Pseudorotaxane Nanofibers}, volume={17}, ISSN={["1526-4602"]}, DOI={10.1021/acs.biomac.5b01379}, abstractNote={Multifunctional scaffolds comprising neat poly(ε-caprolactone) (PCL) and α-cyclodextrin pseudorotaxanated in α-cyclodextrin form have been fabricated using a conventional electrospinning process. Thorough in-depth characterizations were performed on the pseudorotaxane nanofibers prepared from chloroform (CFM) and CFM/dimethylformamide (DMF) utilizing scanning electron microscopy (SEM), transmission electron microscopy (TEM), rheology, differential scanning calorimetry (DSC), thermogravimetric analyses (TGA), wide-angle X-ray diffraction (WAXD), and Instron tensile testing. The results indicate the nanofibers obtained from chloroform retain the rotaxanated structure; while those obtained from CFM/DMF had significantly dethreaded during electrospinning. As a consequence, the nanowebs obtained from CFM showed higher moduli and lower elongations at break compared to neat PCL nanowebs and PCL/α-CD nanowebs electrospun from CFM/DMF.}, number={1}, journal={BIOMACROMOLECULES}, publisher={American Chemical Society (ACS)}, author={Narayanan, Ganesh and Aguda, Remil and Hartman, Matthew and Chung, Ching-Chang and Boy, Ramiz and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2016}, month={Jan}, pages={271–279} }
 @article{boy_narayanan_chung_kotek_2016, title={Novel cellulose-collagen blend biofibers prepared from an amine/salt solvent system}, volume={92}, ISSN={["1879-0003"]}, url={https://doi.org/10.1016/j.ijbiomac.2016.08.010}, DOI={10.1016/j.ijbiomac.2016.08.010}, abstractNote={Cellulose/collagen biofibers were produced from ethylene diamine/potassium thiocyanate binary solvent system, with methanol as a coagulant. The dynamic viscosity of the solutions decreased with the gradual increase in the collagen content up to 40%. The elemental analysis showed incorporation of collagen into cellulose matrix, thereby demonstrating some degree of interaction with the cellulose matrix. The chemical and thermal analysis further revealed an intermolecular interaction between cellulose and the protein and improved thermal stability, respectively. Furthermore, the electron microscopy images mostly exhibited fibrillar morphology with no visible phase separation, indicating compatibility between the two phases. Moreover, biofibers containing higher cellulose content showed higher crystallinity, tensile, and birefringence properties of the composite fibers.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, publisher={Elsevier BV}, author={Boy, Ramiz and Narayanan, Ganesh and Chung, Ching-Chang and Kotek, Richard}, year={2016}, month={Nov}, pages={1197–1204} }
 @article{narayanan_ormond_gupta_tonelli_2015, title={Efficient wound odor removal by -cyclodextrin functionalized poly (epsilon-caprolactone) nanofibers}, volume={132}, ISSN={["1097-4628"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84940895893&partnerID=MN8TOARS}, DOI={10.1002/app.42782}, abstractNote={ABSTRACT}, number={45}, journal={JOURNAL OF APPLIED POLYMER SCIENCE}, author={Narayanan, Ganesh and Ormond, Bryan R. and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2015}, month={Dec} }
 @article{narayanan_gupta_tonelli_2015, title={Enhanced mechanical properties of poly (epsilon-caprolactone) nanofibers produced by the addition of non-stoichiometric inclusion complexes of poly (epsilon-caprolactone) and alpha-cyclodextrin}, volume={76}, DOI={10.1016/j.polymer.2015.08.045}, abstractNote={A unique nanofibrous structure consisting of poly (ε-caprolactone) (PCL) and non-stoichiometric α-cyclodextrin-poly (ε-caprolactone) inclusion complexes [(n-s)-PCL-α-CD-ICs] was produced by electrospinning. For electrospinning experiments, stoichiometric ratios of the (n-s)-PCL-α-CD-ICs, their percentage loading, and the concentration of the PCL solutions were varied. With their partially un-included guest PCL chain portions, the effects of the (n-s)-PCL-α-CD-ICs on the thermal behavior and mechanical properties of the PCL nanofibers have been investigated. SEM indicated that at lower PCL concentrations (12%), loading of up to 15% (n-s)-PCL-α-CD-ICs resulted in bead-free fibers. However, at 14% PCL concentration, bead-free fibers were obtained only until 10% loading; beyond this loading, some beads were observed. DSC analyses indicated, compared to neat PCL nanowebs, there were significant increases in the melting and the crystallization temperatures of the PCL/(n-s)-PCL-α-CD-IC nanowebs. Absence of water loss and enhanced thermal stability of α-CDs was observed by TGA analyses, which indicated the presence of α-CDs threaded by PCL chains. Mechanical properties of the composite webs indicated, with the addition of the ICs, the tensile modulus and ultimate tensile strength of the composite fibers increased significantly (200–400% for the modulus) over those of neat PCL or uncomplexed PCL/α-CD nanofibers. At the same time, their extensions at break were reduced by factors of ∼ (2–3). With better mechanical and stiffness properties, these novel nanocomposite fibers, which are non-toxic, but biodegradable and biocompatible, would be potential candidates as scaffolds for various applications.}, journal={Polymer}, author={Narayanan, G. and Gupta, B. S. and Tonelli, A. E.}, year={2015}, pages={321–330} }
 @article{narayanan_gupta_tonelli_2014, title={Poly(epsilon-caprolactone) Nanowebs Functionalized with alpha- and gamma-Cyclodextrins}, volume={15}, ISSN={["1526-4602"]}, DOI={10.1021/bm501158w}, abstractNote={The effects of alpha- and gamma-cyclodextrins (α- and γ-CDs) on the thermal and crystal nucleation behavior of electrospun poly(ε-caprolactone) (PCL) nanofibers have been investigated. PCL/CD composite nanofibers were obtained for the first time by electrospinning the mixture from chloroform/N,N-dimethylformamide (60:40). Scanning electron microscopy analyses indicated that neat PCL nanofibers have an average diameter of 400 nm, which increases with the addition of CDs. The presence of CDs on or in the electrospun PCL fibers in the electrospun mats was investigated using Fourier transform infrared spectroscopy, thermogravimetric analysis, and wide-angle X-ray diffraction analysis. Differential scanning calorimetry showed that the PCL/CD composite fibers exhibit higher crystallization temperatures and sharper crystallization exotherms with increased CD loading, indicating the ability of CDs to nucleate PCL crystallization. Water contact angle (WCA) measurements indicate an inverse relationship between WCA and α- or γ-CD concentration up to 30% loading. Phenolphthalein absorption tests were performed to study the kinetics of their inclusion complex (IC) formation with CDs. Unexpectedly, γ-CD-functionalized nanowebs performed better than α-CD. This might be because at elevated loadings some α-CDs may have threaded over PCL chains and formed ICs, whereas γ-CD did not. With their encapsulation capabilities and their lowered hydrophobicity, PCL/CD composite fibers might have potential uses in medical applications, in particular as wound odor absorbants in dressings, because it is well known that CDs can form ICs with these odorants, thereby effectively removing them.}, number={11}, journal={BIOMACROMOLECULES}, author={Narayanan, Ganesh and Gupta, Bhupender S. and Tonelli, Alan E.}, year={2014}, month={Nov}, pages={4122–4133} }