@article{carrell_michael d. o'connell_jacobsen_pomeroy_hayes_reeves_2017, title={A facilitated diffusion mechanism establishes the Drosophila Dorsal gradient}, volume={144}, ISSN={["1477-9129"]}, DOI={10.1242/dev.155549}, abstractNote={The transcription factor NF-κB plays an important role in the immune system, apoptosis, and inflammation. Dorsal, a Drosophila homolog of NF-κB, patterns the dorsal-ventral axis in the blastoderm embryo. During this stage, Dorsal is sequestered outside the nucleus by the IκB homolog Cactus. Toll signaling on the ventral side breaks the Dorsal/Cactus complex, allowing Dorsal to enter the nucleus to regulate target genes. Fluorescent data show that Dorsal accumulates on the ventral side of the syncytial blastoderm. Here we use both modeling and experiment to show that this accumulation is due to facilitated diffusion, or shuttling, of Dorsal/Cactus complex. We also show that active Toll receptors are limiting in wildtype embryos, which is a key factor in explaining global Dorsal gradient formation. Our results suggest that shuttling is necessary for viability of embryos from mothers with compromised dorsal levels. Therefore, Cactus not only has the primary role of regulating Dorsal nuclear import, but also a secondary role in shuttling. Given that this mechanism has been found in other, independent systems, we suggest it may be more prevalent than previously thought.}, number={23}, journal={DEVELOPMENT}, author={Carrell, Sophia N. and Michael D. O'Connell and Jacobsen, Thomas and Pomeroy, Amy E. and Hayes, Stephanie M. and Reeves, Gregory T.}, year={2017}, month={Dec}, pages={4450–4461} }
 @article{jermusyk_murphy_reeves_2016, title={Analyzing negative feedback using a synthetic gene network expressed in the Drosophila melanogaster embryo}, volume={10}, journal={BMC Systems Biology}, author={Jermusyk, A. A. and Murphy, N. P. and Reeves, G. T.}, year={2016} }
 @article{carrell_reeves_2015, title={Imaging the dorsal-ventral axis of live and fixed Drosophila melanogaster embryos}, volume={1189}, journal={Tissue morphogenesis: methods and protocols}, author={Carrell, S. N. and Reeves, G. T.}, year={2015}, pages={63–78} }
 @article{o'connell_reeves_2015, title={The presence of nuclear cactus in the early Drosophila embryo may extend the dynamic range of the dorsal gradient}, volume={11}, number={4}, journal={PLoS Computational Biology}, author={O'Connell, M. D. and Reeves, G. T.}, year={2015} }
 @article{trisnadi_altinok_stathopoulos_reeves_2013, title={Image analysis and empirical modeling of gene and protein expression}, volume={62}, number={1}, journal={Methods}, author={Trisnadi, N. and Altinok, A. and Stathopoulos, A. and Reeves, G. T.}, year={2013}, pages={68–78} }
 @article{garcia_nahmad_reeves_stathopoulos_2013, title={Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo}, volume={381}, number={1}, journal={Developmental Biology}, author={Garcia, M. and Nahmad, M. and Reeves, G. T. and Stathopoulos, A.}, year={2013}, pages={286–299} }
 @article{reeves_trisnadi_truong_nahmad_katz_stathopoulos_2012, title={Dorsal-ventral gene expression in the Drosophila embryo reflects the dynamics and precision of the dorsal nuclear gradient}, volume={22}, number={3}, journal={Developmental Cell}, author={Reeves, G. T. and Trisnadi, N. and Truong, T. V. and Nahmad, M. and Katz, S. and Stathopoulos, A.}, year={2012}, pages={544–557} }
 @article{mcmahon_reeves_supatto_stathopoulos_2010, title={Mesoderm migration in Drosophila is a multi-step process requiring FGF signaling and integrin activity.}, volume={137}, journal={Development }, author={McMahon, A. and Reeves, G. T. and Supatto, W. and Stathopoulos, A.}, year={2010}, pages={2167–2175} }
 @article{reeves_fraser_2009, title={Biological systems from an engineer's point of view}, volume={7}, number={1}, journal={PLoS Biology}, author={Reeves, G. T. and Fraser, S. E.}, year={2009}, pages={0032–0035} }
 @article{reeves_stathopoulos_2009, title={Graded dorsal and differential gene regulation in the Drosophila embryo}, volume={1}, number={4}, journal={Cold Spring Harbor Perspectives in Biology}, author={Reeves, G. T. and Stathopoulos, A.}, year={2009}, pages={566–577} }
 @article{liberman_reeves_stathopoulos_2009, title={Quantitative imaging of the dorsal nuclear gradient reveals limitations to threshold-dependent patterning in Drosophila}, volume={106}, number={52}, journal={Proceedings of the National Academy of Sciences of the United States of America}, author={Liberman, L. M. and Reeves, G. T. and Stathopoulos, A.}, year={2009}, pages={22317–22322, S22317/1–S22317/2} }
 @article{goentoro_reeves_kowal_martinelli_schupbach_shvartsman_2006, title={Quantifying the gurken morphogen gradient in Drosophila oogenesis}, volume={11}, number={2}, journal={Developmental Cell}, author={Goentoro, L. A. and Reeves, G. T. and Kowal, C. P. and Martinelli, L. and Schupbach, T. and Shvartsman, S. Y}, year={2006}, pages={263–272} }
 @article{reeves_muratov_schupbach_shvartsman_2006, title={Quantitative models of developmental pattern formation}, volume={11}, number={3}, journal={Developmental Cell}, author={Reeves, G. T. and Muratov, C. B. and Schupbach, T. and Shvartsman, S. Y}, year={2006}, pages={289–300} }
 @article{reeves_kalifa_klein_lemmon_shvartsman_2005, title={Computational analysis of EGFR inhibition by Argos}, volume={284}, number={2}, journal={Developmental Biology}, author={Reeves, G. T. and Kalifa, R. and Klein, D. E. and Lemmon, M. A. and Shvartsman, S. Y.}, year={2005}, pages={523–535} }
 @article{klein_nappi_reeves_shvartsman_lemmon_2004, title={Argos inhibits epidermal growth factor receptor signalling by ligand sequestration}, volume={430}, number={7003}, journal={Nature}, author={Klein, D. E. and Nappi, V. M. and Reeves, G. T. and Shvartsman, S. Y. and Lemmon, M. A.}, year={2004}, pages={1040–1044} }
 @article{pilyugin_reeves_narang_2004, title={Predicting stability of mixed microbial cultures from single species experiments: 1. Phenomenological model}, volume={192}, journal={Mathematical Biosciences}, author={Pilyugin, S. S. and Reeves, G. T. and Narang, A}, year={2004}, pages={85–109} }
 @article{pilyugin_reeves_narang_2004, title={Predicting stability of mixed microbial cultures from single species experiments: 2. Physiological model.}, volume={192}, journal={Mathematical Biosciences}, author={Pilyugin, S. S. and Reeves, G. T. and Narang, A.}, year={2004}, pages={111–136} }
 @article{reeves_narang_pilyugin_2003, title={Growth of mixed cultures on mixtures of substitutable substrates: The operating diagram for a structured model.}, volume={226}, number={2}, journal={Journal of Theoretical Biology}, author={Reeves, G. T. and Narang, A. and Pilyugin, S. S}, year={2003}, pages={143–157} }
 @article{shoemaker_reeves_gupta_pilyugin_egli_narang_2003, title={The dynamics of single-substrate continuous cultures: The role of transport enzymes.}, volume={223}, number={3}, journal={Journal of Theoretical Biology}, author={Shoemaker, J. and Reeves, G. T. and Gupta, S. and Pilyugin, S. S. and Egli, T. and Narang, A.}, year={2003}, pages={307–322} }