Guillaume Robichaud

Works (8)

Updated: July 30th, 2023 20:20

2015 journal article

Analysis of trace fibers by IR-MALDESI imaging coupled with high resolving power MS

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407(3), 813–820.

By: K. Cochran n, J. Barry n, G. Robichaud n & D. Muddiman n 

author keywords: Mass spectrometry imaging; Forensic science; Trace evidence; Polarity switching imaging; MALDESI
TL;DR: IR-MALDESI was used as a source for mass spectrometry imaging (MSI) of a dyed nylon fiber cluster and single fiber to yield more quantitative structural information about the dye and polymer that can be used for more conclusive comparisons. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 377, 448–455.

By: J. Barry n, M. Groseclose *, G. Robichaud n, S. Castellino * & D. Muddiman n 

author keywords: MALDI; IR-MALDESI; Mass spectrometry imaging; Drug distribution
TL;DR: The detection of lapatinib as well as several of its metabolites in liver tissue was determined by MSI using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) coupled to high resolving power Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

IR-MALDESI Mass Spectrometry Imaging of Biological Tissue Sections Using Ice as a Matrix

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(3), 319–328.

By: G. Robichaud n, J. Barry n & D. Muddiman n 

author keywords: Mass spectrometry imaging; IR-MALDESI; Tissue ablation; Shadowgraphy
MeSH headings : Animals; Brain / cytology; Brain Chemistry; Histocytological Preparation Techniques / methods; Ice; Mice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: With a better understanding of the fundamentals of ablation dynamics and a systematic approach to explore the experimental space, it was possible to improve ion abundance by nearly one order of magnitude. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Mapping Antiretroviral Drugs in Tissue by IR-MALDESI MSI Coupled to the Q Exactive and Comparison with LC-MS/MS SRM Assay

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(12), 2038–2047.

By: J. Barry n, G. Robichaud n, M. Bokhart n, C. Thompson *, C. Sykes*, A. Kashuba *, D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; LC-MS/MS; Drug distribution
MeSH headings : Adenine / analogs & derivatives; Adenine / analysis; Adenine / chemistry; Adenine / pharmacokinetics; Anti-Retroviral Agents / analysis; Anti-Retroviral Agents / chemistry; Anti-Retroviral Agents / pharmacokinetics; Cervix Uteri / chemistry; Cervix Uteri / metabolism; Chromatography, Liquid / methods; Deoxycytidine / analogs & derivatives; Deoxycytidine / analysis; Deoxycytidine / chemistry; Deoxycytidine / pharmacokinetics; Emtricitabine; Female; Histocytochemistry; Humans; Molecular Imaging / methods; Organophosphonates / analysis; Organophosphonates / chemistry; Organophosphonates / pharmacokinetics; Pyrrolidinones / analysis; Pyrrolidinones / chemistry; Pyrrolidinones / pharmacokinetics; Raltegravir Potassium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry / methods; Tenofovir; Tissue Distribution
TL;DR: An agreement between the average intensities from the imaging experiment and the absolute quantities for each drug was observed and this correlation between these two techniques serves as a prerequisite to quantitative IR-MALDESI MSI. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Imaging Source Coupled to a FT-ICR Mass Spectrometer

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 24(1), 92–100.

By: G. Robichaud n, J. Barry n, K. Garrard  n & D. Muddiman n 

author keywords: FTMS; Mass spectrometry imaging; Infrared laser; MALDESI; Atmospheric pressure
MeSH headings : Animals; Atmospheric Pressure; Brain Chemistry; Fourier Analysis; Lipids / analysis; Lipids / chemistry; Lung / chemistry; Mice; Molecular Imaging / methods; Myocardium / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: This work introduces here a versatile source for MALDESI imaging analysis coupled to a hybrid LTQ-FT-ICR mass spectrometer, offering single shot or multi-shot capability per pixel with full control over the laser repetition rate and mass Spectrometer scanning cycle. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

MSiReader: An Open-Source Interface to View and Analyze High Resolving Power MS Imaging Files on Matlab Platform

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 24(5), 718–721.

By: G. Robichaud n, K. Garrard n, J. Barry n & D. Muddiman n 

author keywords: Mass spectrometry imaging; Software; High mass resolving power; FT-ICR-MS; Open-source
MeSH headings : Algorithms; Computational Biology; Image Processing, Computer-Assisted / methods; Internet; Mass Spectrometry / methods; Software; User-Computer Interface
TL;DR: MSiReader is introduced, a free open source application to read and analyze high resolution MSI data from the most common MSi data formats and is built on the Matlab platform and includes a large selection of data analysis tools and features. (via Semantic Scholar)
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9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Mass Recalibration of FT-ICR Mass Spectrometry Imaging Data Using the Average Frequency Shift of Ambient Ions

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 24(7), 1137–1145.

By: J. Barry n, G. Robichaud n & D. Muddiman n 

author keywords: Mass spectrometry imaging; FT-ICR MS; Mass calibration; MALDESI; MMA
MeSH headings : Animals; Brain / anatomy & histology; Brain Chemistry; Calibration; Cyclotrons; Fourier Analysis; Infrared Rays; Ions; Mass Spectrometry / methods; Mass Spectrometry / statistics & numerical data; Mice; Molecular Imaging / methods; Molecular Imaging / statistics & numerical data; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Electrospray Ionization / statistics & numerical data; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / statistics & numerical data
TL;DR: A calibration method is applied based on the observed cyclotron frequency shift of ions found in the ambient laboratory environment, polydimethylcyclosiloxanes (PDMS) to achieve part per billion mass accuracy with relatively high precision for an infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI dataset. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Design, modeling, fabrication, and evaluation of the air amplifier for improved detection of biomolecules by electrospray ionization mass spectrometry

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 300(2-3), 99–107.

By: G. Robichaud n, R. Dixon n, A. Potturi n, D. Cassidy n, J. Edwards n , A. Sohn n, T. Dow n, D. Muddiman n 

author keywords: Air amplifier; Electrospray ionization; Modeling; Detection limits
TL;DR: A computer simulation that accurately portrays actual conditions and the results from these simulations are corroborated by the experimental data is developed, which can be used to predict outcomes from future designs resulting in a design process that is efficient in terms of financial cost and time. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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