George Varghese P J

College of Engineering

Works (7)

Updated: August 2nd, 2025 05:03

2025 article

A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy

Zhao, K., Chen, P., Wang, Z., George, V. P. J., Liu, J., & Hu, J. (2025, April 7). Biomaterials Advances, Vol. 174.

By: K. Zhao n, P. Chen n, Z. Wang n, V. George n, J. Liu n  & J. Hu n 

author keywords: Minimally invasive procedure; Embolic agent; Fluorescence imaging; Photothermal therapy
topics (OpenAlex): Innovative Microfluidic and Catalytic Techniques Innovation; Surface Modification and Superhydrophobicity; Micro and Nano Robotics
Sources: Web Of Science, NC State University Libraries
Added: April 28, 2025

2025 article

Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance

Chen, P., Jernigan, S., Zhao, K., George, V. P. J., Saha, M., Kim, C., … Hu, J. (2025, January 1). Biomaterials Science, Vol. 7.

By: P. Chen n, S. Jernigan n, K. Zhao n, V. George n, M. Saha n, C. Kim *, A. Arzani *, G. Buckner n, J. Hu n 

MeSH headings : Microspheres; Alginates / chemistry; Embolization, Therapeutic / methods; Tantalum / chemistry; Humans; Animals; Cell Survival / drug effects; Mice; Contrast Media / chemistry; Phantoms, Imaging
topics (OpenAlex): Vascular Malformations Diagnosis and Treatment; Tribology and Lubrication Engineering; Vascular Malformations and Hemangiomas
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 21, 2025

2024 article

An Investigation on the Effect of Contrast Agents in the Chitosan-Nanoclay Shear Thinning Hydrogel for Trans-Catheter Arterial Embolization

Varghese, P. J. G., Chen, P., Zhao, K., Saha, M., & Hu, J. (2024, July 10). JOM, Vol. 7.

By: P. Varghese n, P. Chen n, K. Zhao n, M. Saha n & J. Hu n 

topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Intracranial Aneurysms: Treatment and Complications; Vascular Procedures and Complications
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 15, 2024

2024 article

Characterization of an Injectable Chitosan Hydrogel for the Tunable, Localized Delivery of Immunotherapeutics

Mantooth, S. M., Hancock, A. M., Thompson, P. M., George, V. P. J., Meritet, D. M., Vrabel, M. R., … Zaharoff, D. A. (2024, January 19). ACS Biomaterials Science & Engineering, Vol. 10, pp. 905–920.

By: S. Mantooth n, A. Hancock n , P. Thompson n , V. George n, D. Meritet n, M. Vrabel  n, J. Hu n , D. Zaharoff n

author keywords: hydrogel; chitosan; immunotherapy; intratumoral
MeSH headings : Humans; Chitosan; Hydrogels / chemistry; Injections; Neoplasms
topics (OpenAlex): Nanoparticle-Based Drug Delivery; 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications
TL;DR: The goal of the present work was to construct a novel, injectable hydrogel that could be tuned for localized immunotherapy delivery and displayed several clinically important features, including injectability, biocompatibility, and imageability. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2024

2024 article

Chitosan‐nanoclay embolic material for catheter‐directed arterial embolization

George, V. P. J., Zhao, K., Chen, P., & Hu, J. (2024, January 16). Journal of Biomedical Materials Research Part A, Vol. 1.

By: V. George n, K. Zhao n, P. Chen n & J. Hu n 

author keywords: embolic agent; hydrogel; minimally invasive procedure; rheology; transcatheter injectability
MeSH headings : Chitosan; Embolization, Therapeutic; Hydrogels; Injections; Catheters
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Intracranial Aneurysms: Treatment and Complications; Vascular Malformations Diagnosis and Treatment
TL;DR: A gel embolic agent comprising chitosan nanofibers and nanoclay with excellent catheter injectability and tunable mechanical properties for embolization is introduced with the potential for transcatheter embolization of vascular malformation and malignant/benign tumors. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 26, 2024

2024 article

Developing a transcatheter injectable nanoclay- alginate gel for minimally invasive procedures

Zhao, K., George, V. P. J., Chen, P., & Hu, J. (2024, February 3). Journal of the Mechanical Behavior of Biomedical Materials/Journal of Mechanical Behavior of Biomedical Materials, Vol. 152.

By: K. Zhao n, V. George n, P. Chen n & J. Hu n 

author keywords: Minimally invasive procedure; Gel embolic agent; Shear -thinning; Transcatheter injectability
MeSH headings : Animals; Alginates; Catheters; Gastropoda; Gels; Minimally Invasive Surgical Procedures
topics (OpenAlex): Intracranial Aneurysms: Treatment and Complications; Botulinum Toxin and Related Neurological Disorders; Electrospun Nanofibers in Biomedical Applications
TL;DR: Overall, NC/alginate gel exhibited excellent stability and tunable injectability by optimizing the composition of each component, highlighting the gel's potential as a robust embolic agent for a wide range of minimally invasive procedures. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 4, 2024

2024 article

Mechanical investigation of a Tandem embolization-visualization system for minimally invasive procedures

Chen, P., George, V. P. J., Zhao, K., & Hu, J. (2024, September 11). Journal of the Mechanical Behavior of Biomedical Materials/Journal of Mechanical Behavior of Biomedical Materials, Vol. 160.

By: P. Chen n, V. George n, K. Zhao n & J. Hu n 

author keywords: Transcatheter arterial embolization; Embolic agent; Calcium-alginate microsphere; Indocyanine green; Fluorescence imaging; Tunable mechanical property
MeSH headings : Mechanical Phenomena; Embolization, Therapeutic; Microspheres; Materials Testing; Alginates / chemistry; Minimally Invasive Surgical Procedures; Hemolysis / drug effects; Indocyanine Green / chemistry; Calcium Chloride / chemistry; Rheology; Humans; Animals
topics (OpenAlex): Peripheral Artery Disease Management; Coronary Interventions and Diagnostics; Angiogenesis and VEGF in Cancer
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2024

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