Hailey Young

College of Sciences

Works (3)

Updated: July 5th, 2023 15:05

2022 article

On-resin C alpha-functionalization of N-arylglycinyl peptides with boronic acids

Young, H. A., & Proulx, C. (2022, May 19). ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 5.

By: H. Young n & C. Proulx n

MeSH headings : Boronic Acids / chemistry; Catalysis; Peptides / chemistry
TL;DR: A late-stage α-C-H functionalization reaction of resin-bound, electron-rich N-aryl peptides with boronic acid nucleophiles under mild conditions is reported. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 13, 2022

2020 journal article

N-Arylation of Amino Acid Esters to Expand Side Chain Diversity in Ketoxime Peptide Ligations

JOURNAL OF ORGANIC CHEMISTRY, 85(3), 1748–1755.

By: H. Young n, Q. Guthrie n & C. Proulx n

TL;DR: Palladium-catalyzed N-arylations of amino acid tert-butyl esters using 4-bromo-N,N-dimethylaniline as a coupling partner are reported, increasing the scope of Cα-substitution in ketoxime peptides. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 16, 2020

2019 journal article

Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides

CHEMICAL SCIENCE, 10(41), 9506–9512.

By: Q. Guthrie n, H. Young n & C. Proulx n

TL;DR: Ketoxime peptides are readily accessible from oxidative couplings between N-aryl peptides and alkoxyamines under catalyst-free conditions. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 18, 2019

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