Hailey Young

College of Sciences

Works (4)

Updated: June 21st, 2025 05:01

2025 article

Oxidative Couplings of N-Aryl Peptides in Organic Solvent: Preventing Amino Acid Side Chain Loss

McKinney, K. C., Warner, E. J. T., Young, H. A., Gage, S. C., & Proulx, C. (2025, June 6). Organic Letters, Vol. 6.

By: K. McKinney n, E. Warner n, H. Young n, S. Gage n & C. Proulx n 

topics (OpenAlex): Chemical Synthesis and Analysis; Radical Photochemical Reactions; Sulfur-Based Synthesis Techniques
Sources: Web Of Science, NC State University Libraries
Added: June 16, 2025

2022 article

On-resin Cα-functionalization of N-arylglycinyl peptides with boronic acids

Young, H. A., & Proulx, C. (2022, January 1). Organic & Biomolecular Chemistry, Vol. 5.

By: H. Young n & C. Proulx n 

MeSH headings : Boronic Acids / chemistry; Catalysis; Peptides / chemistry
topics (OpenAlex): Chemical Synthesis and Analysis; Fluorine in Organic Chemistry
TL;DR: A late-stage α-C-H functionalization reaction of resin-bound, electron-rich N-aryl peptides with boronic acid nucleophiles under mild conditions is reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2019 article

N-Arylation of Amino Acid Esters to Expand Side Chain Diversity in Ketoxime Peptide Ligations

Young, H. A., Guthrie, Q. A. E., & Proulx, C. (2019, December 3). The Journal of Organic Chemistry, Vol. 85, pp. 1748–1755.

By: H. Young n, Q. Guthrie n & C. Proulx n 

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Peptidase Inhibition and Analysis
TL;DR: Palladium-catalyzed N-arylations of amino acid tert-butyl esters using 4-bromo-N,N-dimethylaniline as a coupling partner are reported, increasing the scope of Cα-substitution in ketoxime peptides. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020

2019 article

Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides

Guthrie, Q. A. E., Young, H. A., & Proulx, C. (2019, January 1). Chemical Science, Vol. 10, pp. 9506–9512.

By: Q. Guthrie n, H. Young n & C. Proulx n 

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications
TL;DR: Ketoxime peptides are readily accessible from oxidative couplings between N-aryl peptides and alkoxyamines under catalyst-free conditions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 18, 2019

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