Heather Patisaul

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

ENVIRONMENTAL HEALTH, 21(SUPPL 1).

Advancing the science on chemical classes

[Review of ]. ENVIRONMENTAL HEALTH, 21(SUPPL 1).

Developmental nicotine exposure and masculinization of the rat preoptic area

NEUROTOXICOLOGY, 89, 41–54.

Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model

NEUROTOXICOLOGY, 91, 140–154.

Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters

Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.

Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles

TOXICS, 10(5).

Virtual Issue: Neurotoxicology

Sombers, L. A., & Patisaul, H. B. (2022, August 3). ACS CHEMICAL NEUROSCIENCE, Vol. 13, pp. 2238–2239.

Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers

ENVIRONMENTAL HEALTH PERSPECTIVES, 129(10).

Endocrine disruption and reproductive disorders: impacts on sexually dimorphic neuroendocrine pathways

[Review of ]. REPRODUCTION, 162(5), F111–F130.

FireMaster (R) 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster

HORMONES AND BEHAVIOR, 134.

Interactions of the estrous cycle, novelty, and light on female and male rat open field locomotor and anxiety-related behaviors

PHYSIOLOGY & BEHAVIOR, 228.

Introduction to sex differences in neurotoxic effects

NEUROTOXICOLOGY AND TERATOLOGY, Vol. 83.

Neural correlates of mating system diversity: oxytocin and vasopressin receptor distributions in monogamous and non-monogamous Eulemur

SCIENTIFIC REPORTS, 11(1).

Neurotoxicity of Ortho-Phthalates: Recommendations for Critical Policy Reforms to Protect Brain Development in Children

AMERICAN JOURNAL OF PUBLIC HEALTH, 111(4), 687–695.

Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture

ENDOCRINOLOGY, 162(8).

Transcriptomic, proteomic, and metabolomic analyses identify candidate pathways linking maternal cadmium exposure to altered neurodevelopment and behavior

SCIENTIFIC REPORTS, 11(1).

Achieving CLARITY on bisphenol A, brain and behaviour

[Review of ]. JOURNAL OF NEUROENDOCRINOLOGY, 32(1).

Analysis of neurotransmitters in rat placenta exposed to flame retardants using IR-MALDESI mass spectrometry imaging

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(15), 3745–3752.

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

NATURE REVIEWS ENDOCRINOLOGY, 16(1), 45–57.

Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies

REPRODUCTIVE TOXICOLOGY, 98, 29–60.

Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(7).

Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain

TOXICOLOGICAL SCIENCES, 176(1), 203–223.

Metabotropic glutamate receptor subtype 5 (mGlu(5)) is necessary for estradiol mitigation of light-induced anxiety behavior in female rats

PHYSIOLOGY & BEHAVIOR, 214.

Temporal and bidirectional influences of estradiol on voluntary wheel running in adult female and male rats

HORMONES AND BEHAVIOR, 120.

The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study

[Review of ]. ENDOCRINOLOGY, 161(5).

PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation

ENDOCRINOLOGY, 160(11), 2748–2758.

Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study

NEUROTOXICOLOGY, 74, 139–148.

Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats

NEUROTOXICOLOGY, 75, 136–147.

Animal models of endocrine disruption

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 32(3), 283–297.

CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems

Basic & Clinical Pharmacology & Toxicology, 10(S3), 14–31.

EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain

ENDOCRINE CONNECTIONS, 7(2), 305–324.

Endocrine disruptors and the developing immune system

Current Opinion in Toxicology, 10, 31–36.

Environmental Mechanisms of Neurodevelopmental Toxicity

Current Environmental Health Reports, 5(1), 145–157.

IR-MALDESI mass spectrometry imaging of underivatized neurotransmitters in brain tissue of rats exposed to tetrabromobisphenol A

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410(30), 7979–7986.

Individual Variation in Social Behaviours of Male Lab-reared Prairie voles (Microtus ochrogaster) is Non-heritable and Weakly Associated with V1aR Density

Scientific Reports, 8(1), 1396.

Introduction to the special issue on endocrine disrupting chemicals and behavior

Barrett, E. S., & Patisaul, H. B. (2018, May). HORMONES AND BEHAVIOR, Vol. 101, pp. 1–2.

Neurodevelopmental and neurological effects of chemicals associated with unconventional oil and natural gas operations and their potential effects on infants and children

[Review of ]. REVIEWS ON ENVIRONMENTAL HEALTH, 33(1), 3–29.

Novel unconditioned prosocial behavior in prairie voles (Microtus ochrogaster) as a model for empathy

BMC Research Notes, 11(1).

Nucleus accumbens core medium spiny neuron electrophysiological properties and partner preference behavior in the adult male prairie vole, Microtus ochrogaster

Journal of Neurophysiology, 119(4), 1576–1588.

Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study

NEUROTOXICOLOGY, 65, 207–220.

The NIEHS TaRGET II Consortium and environmental epigenomics

The NIEHS TaRGET II Consortium and environmental epigenomics

Nature Biotechnology, 36(3), 225–227.

Chemical Contributions to Neurodevelopmental Disorders

Policy Insights from the Behavioral and Brain Sciences, 4(2), 123–130.

Effects of perinatal bisphenol A exposure on the volume of sexually-dimorphic nuclei of juvenile rats: A CLARITY-SPA consortium study

NEUROTOXICOLOGY, 63, 33–42.

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Frontiers in Endocrinology, 8.

Endocrine disrupting chemicals and behavior: Re-evaluating the science at a critical turning point

Barrett, E. S., & Patisaul, H. B. (2017, November). HORMONES AND BEHAVIOR, Vol. 96, pp. A1–A6.

Environmental endocrine disruption of brain and behavior

Hormones, Brain and Behavior, Vol 5: Development of Hormone-Behavior Relationships, 3rd Edition, 63–88.

Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats

SCIENTIFIC REPORTS, 7.

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

ACS Chemical Neuroscience, 8(2), 272–280.

Assessment of sex specific endocrine disrupting effects in the prenatal and pre-pubertal rodent brain

Rebuli, M. E., & Patisaul, H. B. (2016, June). JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol. 160, pp. 148–159.

Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours

Proceedings of the Nutrition Society, 76(2), 130–144.

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

Endocrinology, 157(10), 3856–3872.

Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

HORMONES AND BEHAVIOR, 84, 121–126.

Sex differences in microglial colonization and vulnerabilities to endocrine disruption in the social brain

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 238, 39–46.

Transplacental and Lactational Transfer of Firemaster (R) 550 Components in Dosed Wistar Rats

TOXICOLOGICAL SCIENCES, 153(2), 246–257.

Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies

ENDOCRINOLOGY, 156(3), 911–922.

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

TOXICOLOGICAL SCIENCES, 148(2), 341–354.

Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring

REPRODUCTIVE TOXICOLOGY, 58, 282–294.

A Novel Model for Neuroendocrine Toxicology: Neurobehavioral Effects of BPA Exposure in a Prosocial Species, the Prairie Vole (Microtus ochrogaster)

ENDOCRINOLOGY, 155(10), 3867–3881.

In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components

Toxicology Letters, 228(2), 93–102.

Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

TOXICOLOGICAL SCIENCES, 140(1), 190–203.

Sex-specific Esr2 mRNA expression in the rat hypothalamus and amygdala is altered by neonatal bisphenol A exposure

Cao, J., Joyner, L., Mickens, J. A., Leyrer, S. M., & Patisaul, H. B. (2014, April). REPRODUCTION, Vol. 147, pp. 537–554.

Soy but not bisphenol A (BPA) induces hallmarks of polycystic ovary syndrome (PCOS) and related metabolic co-morbidities in rats

REPRODUCTIVE TOXICOLOGY, 49, 209–218.

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II

CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.

Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster ® 550

Environmental Health Perspectives, 122(9), 963–969.

Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity

EPIGENETICS, 8(11), 1128–1132.

Designing endocrine disruption out of the next generation of chemicals

Green Chemistry, 15(1), 181–198.

Designing endocrine disruption out of the next generation of chemicals

Green Chem., 15(1), 181–198.

Effects of environmental endocrine disruptors and phytoestrogens on the Kisspeptin system

Kisspeptin Signaling in Reproductive Biology, 784, 455–479.

Prenatal Bisphenol A Exposure Alters Sex-Specific Estrogen Receptor Expression in the Neonatal Rat Hypothalamus and Amygdala

TOXICOLOGICAL SCIENCES, 133(1), 157–173.

Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation

NEUROTOXICOLOGY, 36, 55–62.

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster®550 in Rats: An Exploratory Assessment

Journal of Biochemical and Molecular Toxicology, 27(2), 124–136.

Anxiogenic Effects of Developmental Bisphenol A Exposure Are Associated with Gene Expression Changes in the Juvenile Rat Amygdala and Mitigated by Soy

PLOS ONE, 7(9).

Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A

BIOLOGY OF REPRODUCTION, 87(2).

Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems

[Review of ]. JOURNAL OF NEUROENDOCRINOLOGY, 24(1), 144–159.

Infertility in the Southern White Rhino: Is Diet the Source of the Problem?

Patisaul, H. B. (2012, April). ENDOCRINOLOGY, Vol. 153, pp. 1568–1571.

Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis

Biology of Sex Differences, 3(1), 2.

Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus

NeuroToxicology, 33(1), 23–36.

Reproductive consequences of developmental phytoestrogen exposure

REPRODUCTION, 143(3), 247–260.

Sex-specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala

Journal of Comparative Neurology, 521(2), 465–478.

Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 333(2), 151–159.

Endocrine Disruption of Brain Sexual Differentiation by Developmental PCB Exposure

ENDOCRINOLOGY, 152(2), 581–594.

Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness

Hormones and Behavior, 60(2), 185–194.

Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat

REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.

On the Need for a National (US) Research Program to Elucidate the Potential Risks to Human Health and the Environment Posed by Contaminants of Emerging Concern

Novak, P. J., Arnold, W. A., Blazer, V. S., Halden, R. U., Klaper, R. D., Kolpin, D. W., … Swackhamer, D. L. (2011, May 1). ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol. 45, pp. 3829–3830.

Sexually dimorphic expression of hypothalamic estrogen receptors α and β and kiss1 in neonatal male and female rats

The Journal of Comparative Neurology, 519(15), 2954–2977.

The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat

NEUROTOXICOLOGY, 32(1), 38–49.

Assessing Risks from Bisphenol A Evaluating human health risks from endocrine disruptors' such as BPA is difficult, but animal studies suggest trouble is afoot

AMERICAN SCIENTIST, 98(1), 30–39.

Neuroendocrine disruption: Historical roots, current progress, questions for the future

Gore, A. C., & Patisaul, H. B. (2010, October). FRONTIERS IN NEUROENDOCRINOLOGY, Vol. 31, pp. 395–399.

The pros and cons of phytoestrogens

[Review of ]. FRONTIERS IN NEUROENDOCRINOLOGY, 31(4), 400–419.

Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats

NeuroToxicology, 30(3), 350–357.

Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior

Frontiers in Behavioral Neuroscience, 3, 10.

Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons

BIOLOGY OF REPRODUCTION, 81(4), 690–699.

Neonatal agonism of ERα masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis

Behavioural Brain Research, 196(2), 317–322.

Progesterone and medroxyprogesterone acetate differentially regulate α4 subunit expression of GABAA receptors in the CA1 hippocampus of female rats

Physiology & Behavior, 97(1), 58–61.

Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats

HORMONES AND BEHAVIOR, 55(2), 319–328.

Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus

[Review of ]. NEUROTOXICOLOGY, 29(6), 988–997.

Influence of endocrine active compounds on the developing rodent brain

Brain Research Reviews, 57(2), 352–362.

Neonatal exposure to endocrine active compounds or an ERβ agonist increases adult anxiety and aggression in gonadally intact male rats

Hormones and Behavior, 53(4), 580–588.

Sex Differences in Serotonergic But Not γ-Aminobutyric Acidergic (GABA) Projections to the Rat Ventromedial Nucleus of the Hypothalamus

Endocrinology, 149(1), 397–408.

Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A

NEUROTOXICOLOGY, 28(1), 1–12.

Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV☆

Neurotoxicology and Teratology, 28(1), 111–118.

Dietary Soy Supplements Produce Opposite Effects on Anxiety in Intact Male and Female Rats in the Elevated Plus-Maze.

Behavioral Neuroscience, 119(2), 587–594.

Phytoestrogen Action in the Adult and Developing Brain

Journal of Neuroendocrinology, 17(1), 57–64.

A soy supplement and tamoxifen inhibit sexual behavior in female rats

Hormones and Behavior, 45(4), 270–277.

Dietary Phytoestrogens

In Endocrine Disruptors (pp. 135–173).

Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus

Brain Research, 978(1-2), 185–193.

Oxytocin, But Not Oxytocin Receptor, is Regulated by Oestrogen Receptor β in the Female Mouse Hypothalamus

Journal of Neuroendocrinology, 15(8), 787–793.

Genistein Affects ERβ- But Not ERα-Dependent Gene Expression in the Hypothalamus

Endocrinology, 143(6), 2189–2197.

Neurobehavioral actions of coumestrol and related isoflavonoids in rodents

Neurotoxicology and Teratology, 24(1), 47–54.

Coumestrol Antagonizes Neuroendocrine Actions of Estrogen via the Estrogen Receptor α

Experimental Biology and Medicine, 226(4), 301–306.

Cross-species and interassay comparisons of phytoestrogen action.

Environmental Health Perspectives, 109(suppl 1), 5–20.

Soy Isoflavone Supplements Antagonize Reproductive Behavior and Estrogen Receptor α- and β-Dependent Gene Expression in the Brain*

Endocrinology, 142(7), 2946–2952.

Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17β-estradiol and the phytoestrogen, coumestrol

Molecular Brain Research, 67(1), 165–171.