Haleigh Conley

College of Veterinary Medicine

Works (5)

Updated: March 29th, 2024 05:01

2024 journal article

MARCKS Inhibition Alters Bovine Neutrophil Responses to <i>Salmonella</i> Typhimurium

BIOMEDICINES, 12(2).

By: H. Conley n, C. Brown n, T. Westerman*, J. Elfenbein* & M. Sheats  n

author keywords: neutrophils; Salmonella; MARCKS; respiratory burst; migration; phagocytosis
TL;DR: This study demonstrates that MARCKS inhibition attenuated STm-induced neutrophil adhesion and chemotaxis and enhanced neutrophil phagocytosis and respiratory burst in response to STm, the first report describing the role of MARCKS protein in neutrophil antibacterial responses. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024

2023 journal article

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in & beta;(2)-integrin activation and signaling. CELL ADHESION & MIGRATION, 17(1), 1–16.

By: H. Conley n, R. Till n, A. Berglund n, S. Jones n  & M. Sheats  n

author keywords: Beta2-integrin; ICAM-1; MARCKS; neutrophils; outside-in; >
MeSH headings : Alanine; CD18 Antigens / metabolism; Neutrophils; Peptides / pharmacology; Signal Transduction; Myristoylated Alanine-Rich C Kinase Substrate / antagonists & inhibitors
TL;DR: MANS treatment significantly attenuated ICAM-1/Mn2+-stimulated static adhesion, cell spreading andβ2-integrin clustering, suggesting a role for MARCKS function in outside-in β2-Integrin activation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2023

2023 journal article

Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst

JOURNAL OF IMMUNOTOXICOLOGY, 20(1).

By: D. Phelps* , A. Palekar, H. Conley*, G. Ferrero, J. Driggers*, K. Linder*, S. Kullman n , D. Reif n  ...

author keywords: Innate immunity; neutrophils; per- and polyfluoroalkyl substances (PFAS); reactive oxygen species; zebrafish
MeSH headings : Animals; Humans; Zebrafish; Neutrophils; Reactive Oxygen Species; Respiratory Burst; Fluorocarbons / toxicity; Alkanesulfonic Acids / toxicity; Environmental Pollutants
TL;DR: This report is the first to demonstrate that these PFASs suppress neutrophil function and support the utility of employing zebrafish larvae and a human cell line as screening tools to identify chemicals that may suppress human immune function. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2023

2023 review

Targeting Neutrophil beta(2)-Integrins: A Review of Relevant Resources, Tools, and Methods

[Review of ]. BIOMOLECULES, 13(6).

By: H. Conley n & M. Sheats  n

author keywords: neutrophils; beta(2)-integrins; CD18; CD11; ICAM-1; innate immune cells
MeSH headings : Humans; Neutrophils / metabolism; CD18 Antigens / metabolism; Inflammation / metabolism; Signal Transduction / physiology; Cell Adhesion / physiology
TL;DR: A detailed review of resources, tools, experimental methods, and in vivo models that have been and will continue to be utilized to investigate the vitally important cell surface receptors, neutrophil β2-integrins are provided. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 28, 2023

2021 journal article

Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques

FRONTIERS IN IMMUNOLOGY, 12.

By: J. Pollara *, M. Tay *, R. Edwards*, D. Goodman*, A. Crowley *, R. Edwards *, D. Easterhoff *, H. Conley* ...

author keywords: phagocytosis; Fc Receptor; rhesus macaques; antibody function; IgG3
MeSH headings : Amino Acid Sequence; Animals; Antibody-Dependent Cell Cytotoxicity / immunology; Biomarkers; HIV Infections / immunology; HIV Infections / virology; Humans; Immunoglobulin G / immunology; Immunoglobulin Isotypes / chemistry; Immunoglobulin Isotypes / genetics; Immunoglobulin Isotypes / immunology; Leukocytes, Mononuclear / immunology; Leukocytes, Mononuclear / metabolism; Macaca mulatta; Neutrophils / immunology; Neutrophils / metabolism; Phagocytes / immunology; Phagocytes / metabolism; Phagocytosis / immunology; Receptors, IgG / genetics; Receptors, IgG / metabolism; Simian Acquired Immunodeficiency Syndrome / immunology; Simian Acquired Immunodeficiency Syndrome / virology; Species Specificity
TL;DR: It is found that for both human and RM phagocytes, ADP activity of antibodies targeting the CD4 binding site was greatest when mediated byhuman IgG3, followed by RM and human IgG1, and there is functional homology between antibody and FcRs from these two species for ADP. (via Semantic Scholar)
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Source: Web Of Science
Added: June 10, 2021

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