Works (15)

Updated: April 5th, 2024 01:23

2006 journal article

Dermatological effects of chronic exposure to 7,12-dimethylbenz[a]anthracene (DMBA) or N-methyl-N-nitrosoguanidine (MNNG) in swine

CUTANEOUS AND OCULAR TOXICOLOGY, 25(2), 103–119.

By: N. Monteiro-Riviere n, A. Inman n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n

Contributors: N. Monteiro-Riviere n, A. Inman n, V. Hedgpeth n, B. Mosteller n & J. Piedrahita n

author keywords: DMBA; MNNG; skin cancer; swine
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Analysis of Variance; Animals; Cocarcinogenesis; Female; Methylnitronitrosoguanidine / toxicity; Neoplasms, Radiation-Induced; Skin / drug effects; Skin / radiation effects; Skin Neoplasms / chemically induced; Swine; Ultraviolet Rays
TL;DR: The findings show that although chronic exposure to MNNG and DMBA, with or without UVB exposure, caused severe to mild dermatopathological changes, neither resulted in the development of skin carcinomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Expression and localization of hypoxia inducible factor-1 alpha mRNA in the porcine ovary

Canadian Journal of Veterinary Research, 69(3), 215–222.

By: U. Boonyaprakob, J. Gadsby, V. Hedgpeth, P. Routh & G. Almond

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Cloning of pig prostaglandin F-2 alpha(FP) receptor cDNA and expression of its mRNA in the corpora lutea

Reproduction (Cambridge, England), 125(1), 53–64.

By: U. Boonyaprakob*, J. Gadsby*, V. Hedgpeth*, P. Routh* & G. Almond*

TL;DR: It is demonstrated that FPr is expressed in pig corpora lutea throughout the oestrous cycle and that upregulation of the FPr mRNA occurs when the corporaLutea becomes sensitive to PGF(2alpha). (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Expression and localization of vascular endothelial growth factor and its receptors in pig corpora lutea during the oestrous cycle

Reproduction (Cambridge, England), 126(3), 393–405.

By: U. Boonyaprakob*, J. Gadsby*, V. Hedgpeth*, P. Routh* & G. Almond*

MeSH headings : Animals; Blotting, Northern / methods; Corpus Luteum / chemistry; Corpus Luteum / physiology; Estrous Cycle / physiology; Female; Follicular Phase / physiology; In Situ Hybridization / methods; Luteal Phase / physiology; RNA, Messenger / analysis; Receptors, Vascular Endothelial Growth Factor / genetics; Swine / physiology; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor Receptor-1 / genetics; Vascular Endothelial Growth Factor Receptor-2 / genetics
TL;DR: Data indicate that the VEGF system may be involved in the regulation of luteal vasculature throughout the lifespan of the corpus luteum, and variations in the expression of V EGFR-1 and VEGFR-2 mRNAs indicate that differential regulation of expression of the V EGF receptors may play a role in the control of VEGf-mediated vascular growth at different phases of development and maturation of the pig corpus lutenum. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2003 journal article

Insulin-like growth factor (IGF)-I and IGF binding proteins-2,-3,-4,-5 in porcine corpora lutea during the estrous cycle; evidence for inhibitory actions of IGFBP-3

DOMESTIC ANIMAL ENDOCRINOLOGY, 25(2), 183–197.

By: Z. Ge*, E. Miller*, W. Nicholson*, V. Hedgpeth* & J. Gadsby*

author keywords: IGF-I; IGFBP-3; progesterone; corpus luteum; pig
MeSH headings : Animals; Blotting, Western / veterinary; Corpus Luteum / chemistry; Corpus Luteum / metabolism; Estrous Cycle / metabolism; Female; Insulin-Like Growth Factor Binding Protein 3 / metabolism; Insulin-Like Growth Factor Binding Proteins / analysis; Insulin-Like Growth Factor Binding Proteins / metabolism; Insulin-Like Growth Factor I / analysis; Insulin-Like Growth Factor I / metabolism; Progesterone / metabolism; Radioimmunoassay / veterinary; Swine / physiology
TL;DR: It is concluded that IGFBP-3 inhibits IGF-I actions in the porcine CL in the estrous cycle and inhibited the steroidogenic actions of IGF, but had no significant actions alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle

REPRODUCTION, 125(2), 241–249.

By: E. Miller*, Z. Ge*, V. Hedgpeth* & J. Gadsby*

TL;DR: IGF-I has steroidogenic actions only on 'young' (days 4-7) pig corpora lutea; endogenous IGF-I and IGFBP are insufficient to modulate progesterone secretion in vitro; and the steroidsogenic actions of IGF- I are mediated via PI-3-kinase. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Alteration of activation, growth, and atresia of bovine preantral follicles by long-term treatment of cows with estradiol and recombinant bovine somatotropin

BIOLOGY OF REPRODUCTION, 65(2), 581–586.

By: R. Cushman n, J. DeSouza n, V. Hedgpeth n & J. Britt n

author keywords: apoptosis; estradiol; follicle; growth hormone; ovary
MeSH headings : Animals; Apoptosis; Cattle / physiology; Drug Implants; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Follicular Atresia / drug effects; Human Growth Hormone / administration & dosage; Human Growth Hormone / pharmacology; Immunohistochemistry; Ovarian Follicle / chemistry; Ovarian Follicle / drug effects; Ovarian Follicle / physiology; Proliferating Cell Nuclear Antigen / analysis
TL;DR: E2 induced activation of follicles, bST enhanced survival, and the combination lowered atresia, as well as the combination of bST + E2 decreased apoptosis as shown by decreased fluorescence intensity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Effect of long-term treatment with recombinant bovine somatotropin and estradiol on hormone concentrations and ovulatory response of superovulated cattle

THERIOGENOLOGY, 55(7), 1533–1547.

By: R. Cushman n, J. DeSouza n, V. Hedgpeth n & J. Britt n

author keywords: cattle; follicle; superovulation; growth hormone; estradiol
MeSH headings : Animals; Body Weight; Cattle / physiology; Drug Implants; Estradiol / administration & dosage; Estradiol / blood; Female; Follicle Stimulating Hormone / pharmacology; Follicular Fluid / chemistry; Growth Hormone / administration & dosage; Growth Hormone / blood; Hormones / blood; Insulin-Like Growth Factor I / analysis; Ovulation / drug effects; Recombinant Proteins / administration & dosage; Superovulation
TL;DR: It is concluded that long-term treatment with bST and E2 may interact to enhance follicular development and ovulatory response to FSH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

The effect of early postnatal treatment with a gonadotropin-releasing hormone agonist on the developmental profiles of testicular steroid hormones in the intact male pig

Journal of Animal Science, 79(4), 1003–1010.

By: P. Sinclair*, E. Squires*, J. Raeside*, J. Britt n & V. Hedgpeth n

MeSH headings : Adipose Tissue / chemistry; Androstenes / analysis; Animals; Dehydroepiandrosterone Sulfate / analysis; Leuprolide / pharmacology; Male; Organ Size / drug effects; Random Allocation; Submandibular Gland / chemistry; Swine / growth & development; Testis / growth & development; Testis / metabolism; Testosterone / blood
TL;DR: The results of these studies indicate that daily administration of a GnRH agonist significantly decreased testicular development and steroidogenesis only during treatment, but testis growth and steroidsogenesis had returned to control levels by 60 d of age in male pigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 journal article

Evaluation of numbers of microscopic and macroscopic follicles in cattle selected for twinning

Journal of Animal Science, 78(6), 1564–1567.

By: R. Cushman n, V. Hedgpeth n, S. Echternkamp* & J. Britt n

MeSH headings : Animals; Breeding; Cattle / anatomy & histology; Cattle / genetics; Cattle / physiology; Female; Ovarian Follicle / anatomy & histology; Ovary / anatomy & histology; Pregnancy; Pregnancy, Multiple / physiology; Surface Properties; Twins
TL;DR: It is concluded that ovaries of Control and Twinner cows do not differ in the number of primordial follicles or in thenumber of follicles activated into the growing pool; however,Twinner cows are able to maintain more growing follicles at the secondary and subsequent stages of development. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2000 journal article

Influence of vitamin A injection before mating on oocyte development, follicular hormones, and ovulation in gilts fed high-energy diets

Journal of Animal Science, 78(6), 1598–1607.

By: S. Whaley n, V. Hedgpeth n, C. Farin n, N. Martus n, F. Jayes n & J. Britt n

MeSH headings : Animal Feed; Animals; Dinoprost / metabolism; Embryonic and Fetal Development / drug effects; Energy Metabolism; Estradiol / metabolism; Female; Follicle Stimulating Hormone / blood; Granulosa Cells / drug effects; Granulosa Cells / metabolism; Insulin-Like Growth Factor I / metabolism; Luteinizing Hormone / blood; Oocytes / drug effects; Oocytes / growth & development; Ovulation / drug effects; Progesterone / metabolism; Sexual Behavior, Animal / drug effects; Swine / metabolism; Vitamin A / pharmacology
TL;DR: Evidence is provided that vitamin A may influence embryonic development by advancing resumption of meiosis and altering follicular hormonal environment during follicle maturation and treatment with vitamin A in vivo did not affect LH-stimulated or unstimulated secretion of progesterone by granulosa cells in vitro. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

Superovulatory response of one ovary is related to the micro- and macroscopic population of follicles in the contralateral ovary of the cow

BIOLOGY OF REPRODUCTION, 60(2), 349–354.

By: R. Cushman n, J. DeSouza n, V. Hedgpeth n & J. Britt n

MeSH headings : Animals; Cattle / physiology; Corpus Luteum / physiology; Female; Follicle Stimulating Hormone / pharmacology; Ovarian Follicle / anatomy & histology; Ovarian Follicle / drug effects; Ovariectomy; Superovulation
TL;DR: It is concluded that superovulatory response in cattle is related positively to the pools of primordial and growing follicles in the bovine ovary. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Technical note: Use of slow-release estradiol and prostaglandin F-2 alpha to induce pseudopregnancy and control estrus in gilts

Journal of Animal Science, 77(11), 2883–2885.

By: R. Cushman n, P. Davis n, U. Boonyaprakob n, V. Hedgpeth n, P. Burns & J. Britt n

MeSH headings : Animals; Delayed-Action Preparations; Dinoprost / administration & dosage; Dinoprost / pharmacology; Estradiol / administration & dosage; Estradiol / pharmacology; Estrus / drug effects; Female; Pseudopregnancy / chemically induced; Swine
TL;DR: It is concluded that a single injection of SRE2 can induce pseudopregnancy and that the CL can be regressed with PGF2alpha, providing a simple method for controlling estrus in gilts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

Use of an ovarian biopsy to predict surface follicle numbers on the bovine ovary.

Biology of Reproduction, 60(1999), 107.

By: J. Britt, R. Cushman, V. Hedgpeth & D. Shaw

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Evidence that injection of vitamin A before mating may improve embryo survival in gilts fed normal or high-energy diets

Journal of Animal Science, 75(4), 1071–1077.

By: S. Whaley n, V. Hedgpeth n & J. Britt n

MeSH headings : Animals; Aromatase / analysis; Diet / veterinary; Embryo, Mammalian / drug effects; Embryo, Mammalian / enzymology; Embryo, Mammalian / physiology; Embryonic and Fetal Development / drug effects; Embryonic and Fetal Development / physiology; Energy Intake / physiology; Estradiol / blood; Female; Gestational Age; Injections / methods; Injections / veterinary; Litter Size / drug effects; Ovulation / physiology; Pregnancy; Pregnancy, Animal / physiology; Progesterone / blood; Swine / blood; Swine / embryology; Swine / physiology; Vitamin A / administration & dosage; Vitamin A / pharmacology
TL;DR: Injecting vitamin A before estrus restored embryo survival to normal levels in gilts fed high-energy diets, and this may be attributable to decreased variation in size of embryos. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

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