@misc{hamedi_moradi_hudson_tonelli_king_2022, title={Chitosan based bioadhesives for biomedical applications: A review}, volume={282}, ISSN={["1879-1344"]}, DOI={10.1016/j.carbpol.2022.119100}, abstractNote={Due to the promising properties of chitosan for biomedical engineering applications like biodegradability, biocompatibility, and non-toxicity, it is one of the most interesting biopolymers in this field. Therefore, Chitosan and its derivatives have attracted great attention in vast variety of biomedical applications. In the current paper, different types of chitosan-based bioadhesives including passive and active and their different types of external stimuli response structure such as thermo, pH and Light responsive systems are discussed. Different bioadhesives mechanisms with chitosan as an adhesive agent or main polymer component and some examples were also presented. Chitosan based bioadhesives and their potential biomedical applications in drug delivery systems, suture less surgery, wound dressing and hemostatic are also discussed. The results confirmed wound healing, hemostatic and bioadhesion capabilities of the chitosan bioadhesives and its great potential for biomedical applications.}, journal={CARBOHYDRATE POLYMERS}, author={Hamedi, Hamid and Moradi, Sara and Hudson, Samuel M. and Tonelli, Alan E. and King, Martin W.}, year={2022}, month={Apr} }
 @article{hamedi_moradi_tonelli_2023, title={External Stimuli Responsive Nanofibers in Biomedical Engineering}, volume={291}, ISBN={["978-3-031-31405-6", "978-3-031-31402-5"]}, ISSN={["1436-5030"]}, DOI={10.1007/12_2022_121}, abstractNote={Nanofiber technology has attracted great attention in many research and applications area because of its unique physicochemical properties and characteristics such as high surface area compared to bulk material. This property provides better cell adhesion and drug and protein loading. In addition, their fabrication from a wide range of polymers with different properties makes them excellent candidates for smart delivery systems. In this chapter, first different external stimuli-responsive nanofibers such as thermo-, magnet-, pH-, electrically-, biomolecule-, and multi-responsive are explained. Then their biomedical applications such as wound dressings, drug delivery systems, cell scaffolds, and diagnosis are discussed.}, journal={ELECTROSPUN POLYMERIC NANOFIBERS}, author={Hamedi, Hamid and Moradi, Sara and Tonelli, Alan E.}, year={2023}, pages={287–311} }
 @article{wang_hamedi_zhang_el-shafei_brown_gluck_king_2022, title={Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh}, volume={5}, ISSN={2576-6422 2576-6422}, url={http://dx.doi.org/10.1021/acsabm.2c00695}, DOI={10.1021/acsabm.2c00695}, abstractNote={A hernia is a pathological condition caused by a defect or opening in the muscle wall, which leads to organs pushing through the opening or defect. Hernia recurrence, seroma, persistent pain, tissue adhesions, and wound infection are common complications following hernia repair surgery. Infection after hernia mesh implantation is the third major complication leading to hernia recurrence. In order to reduce the incidence of late infections, we developed a polypropylene mesh with antibacterial properties. In this study, knitted polypropylene meshes were exposed to radio-frequency plasma to activate their surfaces. The antibacterial monomer diallyldimethylammonium chloride (DADMAC) was then grafted onto the mesh surface using pentaerythritol tetraacrylate as the cross-linker since it is able to engage all four functional groups to form a high-density cross-linked network. The subsequent antibacterial performance showed a 2.9 log reduction toward Staphylococcus aureus and a 0.9 log reduction for Escherichia coli.}, number={12}, journal={ACS Applied Bio Materials}, publisher={American Chemical Society (ACS)}, author={Wang, Ziyu and Hamedi, Hamid and Zhang, Fan and El-Shafei, Ahmed and Brown, Ashley C. and Gluck, Jessica M. and King, Martin W.}, year={2022}, month={Nov}, pages={5645–5656} }
 @misc{moradi_hamedi_tonelli_king_2021, title={Chitosan/Graphene Oxide Composite Films and Their Biomedical and Drug Delivery Applications: A Review}, volume={11}, ISSN={["2076-3417"]}, DOI={10.3390/app11177776}, abstractNote={The healing of wounds is still a challenging clinical problem for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings that can accelerate the wound healing process with minimal side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity, and antibacterial activities of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review paper discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems.}, number={17}, journal={APPLIED SCIENCES-BASEL}, author={Moradi, Sara and Hamedi, Hamid and Tonelli, Alan E. and King, Martin W.}, year={2021}, month={Sep} }
 @article{moradi_barati_tonelli_hamedi_2021, title={Effect of clinoptilolite on structure and drug release behavior of chitosan/thyme oil gamma-Cyclodextrininclusion compound hydrogels}, volume={138}, ISSN={["1097-4628"]}, DOI={10.1002/app.49822}, abstractNote={AbstractChitosan‐based hydrogels involving γ‐cyclodextrin inclusion compounds of thyme oil were prepared by freeze–thaw cycling method. Clinoptilolite as a natural zeolite was added to investigate its effects on the structural, mechanical, and drug release behaviors of the hydrogels. Zeolite compressed the structure and improved mechanical properties, which decreased swelling values. Release of thyme oil in prepared hydrogels were investigated by UV spectroscopy and drug release mechanism was evaluated by applying various mathematical methods. Rates of water vapor transmission of the samples were calculated as 2247–2998 g m−2 day−1 which are all in the range of an ideal wound dressing. Hydrogels with clinoptilolite had slower drug release (from 56% to 24% for hydrogels containing zeolite 1%) in comparison with that of without zeolite. Based on MTT assay, samples were low‐toxic. Obtained results suggest that drug loaded hydrogels can be applied in biomedical field including drug delivery systems and wound dressings.}, number={6}, journal={JOURNAL OF APPLIED POLYMER SCIENCE}, author={Moradi, Sara and Barati, Abolfazl and Tonelli, Alan E. and Hamedi, Hamid}, year={2021}, month={Feb} }
 @article{moradi_barati_tonelli_hamedi_2020, title={Chitosan-based hydrogels loading with thyme oil cyclodextrin inclusion compounds: From preparation to characterization}, volume={122}, ISSN={["1873-1945"]}, DOI={10.1016/j.eurpolymj.2019.109303}, abstractNote={Hydrogels, based on polysaccharides such as chitosan have found various applications as drug delivery carriers. Three different preparations of pH sensitive chitosan/polyvinyl alcohol hydrogels containing inclusion compounds of thyme oil with methyl-β-, hydroxypropyl-β- and γ-cyclodextrin were developed by using a controlled, bio-compatible and low cost method based on freeze-thaw cycling. The structures and morphology of the hydrogels were characterized by FTIR, optical and scanning electron microscopy. Stable hydrogels of chitosan and polyvinyl alcohol had good mechanical properties and swelling ratios. The water vapor transmission rates of the hydrogels were all in the range of an ideal wound dressing. Encapsulation and release of thyme oil-cyclodextrin inclusion compounds (TM-CD-ICs) in the hydrogels were detected and followed by UV spectroscopy and different mathematical models were applied for evaluating the drug release mechanisms. Hydrogels loaded with TM-CD-ICs had slower and more controlled drug release. The antibacterial activity of the samples was studied by counting the number of surviving both gram-negative and gram-positive bacteria in a broth medium and the results showed antibacterial activity of all prepared hydrogels, especially those containing TM-γCD-ICs. The MTT assay indicated more cell viability of TM-γCD-ICs hydrogels in comparison with those containing β-cyclodextrin inclusion compounds (TM-βCD-ICs hydrogels). Cell attachment study showed great biocompatibility of TM-γCD-ICs hydrogels. Finally, the modified hydrogels can be used in different biomedical applications, such as wound dressings for improving the wound healing process and in drug delivery systems.}, journal={EUROPEAN POLYMER JOURNAL}, author={Moradi, Sara and Barati, Aboulfazl and Tonelli, Alan E. and Hamedi, Hamid}, year={2020}, month={Jan} }
 @article{hamedi_moradi_tonelli_hudson_2019, title={Preparation and Characterization of Chitosan-Alginate Polyelectrolyte Complexes Loaded with Antibacterial Thyme Oil Nanoemulsions}, volume={9}, ISSN={["2076-3417"]}, DOI={10.3390/app9183933}, abstractNote={Biomedical industries are attempting to utilize natural materials, as they are bio-compatible, non-toxic, and show bioactive properties, like antimicrobial activity. In this study, natural polyelectrolyte complexed chitosan/alginate films (PECs) were prepared via a casting/solvent evaporation technique, and their characteristics and drug release properties were investigated. PEC films made with two different overall polymer contents, 0.4 and 1 w/v%, were loaded with thyme oil nanoemulsion as drug carrier. The structure of the films was studied by FTIR and optical and scanning electron microscopy. Prepared PEC films had good mechanical and water vapor permeability properties. Release of the thyme oil from the pH-sensitive PEC films (TM-PEC) was detected and followed by UV spectroscopy. The results indicated that the drug release rate of TM-PEC films was the fastest when the chitosan content was 1 %w/v, and various mathematical models were analyzed for investigating the drug release mechanism. Antibacterial tests were performed by counting the number of surviving gram-negative and gram-positive bacteria. The in vitro test indicated the limitation Escherichia coli (E. coli) and Staphylococcus aureus (S.aureus) growth in the presence of TM-PEC films. The MTT test showed more cell viability of the TM-PEC film in comparison with that of the PEC film without TM. Based on the measured physical and antibacterial properties, the chitosan–alginate PEC films loaded with antibacterial essential oils can be considered for biomedical applications, such as wound dressings or controlled release systems.}, number={18}, journal={APPLIED SCIENCES-BASEL}, author={Hamedi, Hamid and Moradi, Sara and Tonelli, Alan E. and Hudson, Samuel M.}, year={2019}, month={Sep} }
 @article{moradi_barati_salehi_tonelli_hamedi_2019, title={Preparation and characterization of chitosan based hydrogels containing cyclodextrin inclusion compounds or nanoemulsions of thyme oil}, volume={68}, ISSN={["1097-0126"]}, DOI={10.1002/pi.5899}, abstractNote={AbstractHydrogels derived from natural polysaccharides are ideal scaffolds for use in biomedical applications. pH‐sensitive polyvinyl alcohol and chitosan hydrogels containing inclusion compounds of thyme oil (TM) with host methyl‐β‐cyclodextrin (MβCD) and hydroxypropyl‐β‐cyclodextrin (HβCD) and TM nanoemulsion (TM‐nano) were prepared via controlled, biocompatible and low cost freeze–thaw method. The structure of the hydrogels was characterized by Fourier transform IR spectroscopy and optical and scanning electron microscopy. The physicochemical properties of the hydrogels such as gel fraction, swelling ratio and tensile properties were measured. The water vapor transmission rate of the hydrogels indicated that they can maintain a moist environment over the wound bed. Encapsulation and release of antibacterial TM from the hydrogels were determined by UV spectroscopy. In all cases, hydrogels with lower amounts of TM evidenced slower and more controlled release. Different kinetic models were applied for evaluating the drug release mechanism. The antibacterial activity of the samples was studied by counting the number of both Gram‐negative and Gram‐positive bacteria surviving in a broth medium and the results proved the antibacterial activity of all prepared hydrogels. The results of an MTT (3‐(4,5‐dimethylthiazol‐2yl)‐2,5‐diphenyltetrazolium bromide) assay indicated more cell viability of TM‐nano hydrogels in comparison with those of TM‐βCD inclusion compounds. Cell attachment observations also showed great biocompatibility of TM‐nano hydrogels. The prepared hydrogels, especially those containing TM‐nano, might be used as potential wound dressings to improve the wound healing process. © 2019 Society of Chemical Industry}, number={11}, journal={POLYMER INTERNATIONAL}, author={Moradi, Sara and Barati, Abolfazl and Salehi, Ehsan and Tonelli, Alan E. and Hamedi, Hamid}, year={2019}, month={Nov}, pages={1891–1902} }