Hayley L. Dirscherl

Works (3)

Updated: July 5th, 2023 15:43

2015 journal article

A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant

Immunogenetics, 67(9), 501–513.

By: H. Dirscherl n & J. Yoder n 

author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Chromosome Mapping; Chromosome Walking; Evolution, Molecular; Female; Gene Expression Profiling; Genotype; Genotyping Techniques; Haplotypes / genetics; Histocompatibility Antigens Class I / classification; Histocompatibility Antigens Class I / genetics; Male; Molecular Sequence Data; Polymorphism, Genetic / genetics; Zebrafish / genetics; Zebrafish / immunology
TL;DR: Two MHC class I U lineage genes are described that map to chromosome 22 in zebrafish and are likely to play a nonclassical role as they lack conservation of key peptide binding residues, display limited polymorphic variation, and exhibit tissue-specific expression. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

The MHC class I genes of zebrafish

Developmental & Comparative Immunology, 46(1), 11–23.

By: H. Dirscherl n, S. McConnell *, J. Yoder n  & J. de Jong *

author keywords: Immunity; Multigene families; Haplotype; Polymorphism; Histocompatibility; MHC
MeSH headings : Animals; Genes, MHC Class I; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Major Histocompatibility Complex; Phylogeny; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR: This review examines the polygenic, polymorphic, and haplotypic diversity of the zebrafish MHC class I genes, discussing known and postulated functional differences between the different class I lineages. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish

Immunogenetics, 66(3), 185–198.

By: H. Dirscherl n & J. Yoder n 

author keywords: Teleost; MHC class I; Evolution; Polymorphism; Haplotype
MeSH headings : Alleles; Amino Acid Sequence; Animals; Chromosome Mapping; DNA, Complementary; Gene Expression; Gene Expression Regulation; Gene Order; Genes, MHC Class I; Genetic Linkage; Genetic Loci; Haplotypes; Molecular Sequence Data; Phylogeny; Polymorphism, Genetic; Sequence Alignment; Transcription, Genetic; Ubiquitination; Zebrafish / classification; Zebrafish / genetics; Zebrafish / immunology
TL;DR: It is reported that neither of the Z transcripts previously described match the current genome assembly and these transcripts are classified as additional gene loci and a gene nomenclature system for the Z genes consistent with MHC nomenClature in other species and with the zebrafish gene nonymclature guidelines is presented. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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