Huixuan Liang

Works (4)

Updated: July 12th, 2023 21:15

2013 journal article

Neural development is dependent on the function of specificity protein 2 in cell cycle progression

DEVELOPMENT, 140(3), 552–561.

By: H. Liang n, G. Xiao n, H. Yin n, S. Hippenmeyer *, J. Horowitz n & H. Ghashghaei  n

author keywords: Neurogenesis; Neural stem cells; Neural progenitors; Sp2; Cell cycle; M phase; Mouse
MeSH headings : Animals; Brain / cytology; Brain / embryology; Brain / metabolism; Cell Count; Cell Cycle; Cell Proliferation; Crosses, Genetic; Embryo Implantation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Eye Proteins / genetics; Eye Proteins / metabolism; Female; Genetic Markers; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Homologous Recombination; Intermediate Filament Proteins / genetics; Intermediate Filament Proteins / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nestin; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis; Neurons / cytology; Neurons / metabolism; PAX6 Transcription Factor; Paired Box Transcription Factors / genetics; Paired Box Transcription Factors / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Sp2 Transcription Factor / genetics; Sp2 Transcription Factor / metabolism; Stem Cell Niche; Transplantation Chimera / embryology; Transplantation Chimera / metabolism
TL;DR: It is demonstrated that neural stem cells and intermediate neural progenitor cells (NPCs) employ a zinc-finger transcription factor specificity protein 2 (Sp2) as a cell cycle regulator in two temporally and spatially distinct progenitors domains. (via Semantic Scholar)
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Added: August 6, 2018

2011 journal article

Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb

JOURNAL OF NEUROSCIENCE, 31(25), 9368–9382.

By: B. Jacquet n, N. Muthusamy n, L. Sommerville n, G. Xiao n, H. Liang n, Y. Zhang *, M. Holtzman *, H. Ghashghaei  n

MeSH headings : Animals; Forkhead Transcription Factors / metabolism; Mice; Mice, Knockout; Neurogenesis / physiology; Neurons / physiology; Olfactory Bulb / embryology; Olfactory Bulb / physiology; Prosencephalon / embryology; Prosencephalon / physiology
TL;DR: For the first time, this study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods. (via Semantic Scholar)
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Added: August 6, 2018

2009 journal article

Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors

GENE THERAPY, 16(8), 1021–1033.

By: B. Jacquet n, M. Patel*, M. Iyengar n, H. Liang n, B. Therit n, R. Salinas-Mondragon, C. Lai *, J. Olsen*, E. Anton*, H. Ghashghaei  n

author keywords: adult neural stem cells; adult neurogenesis; lentivirus; EIAV; olfactory bulb; neuronal migration
MeSH headings : Adult Stem Cells / physiology; Animals; Brain / cytology; Brain / physiology; Cell Differentiation; Cell Movement; Cell Proliferation; Defective Viruses; Gene Transfer Techniques; Genetic Vectors; Infectious Anemia Virus, Equine / genetics; Mice; Neural Stem Cells / physiology; Neurogenesis; Neurons / physiology; Olfactory Bulb / cytology; Stem Cell Niche / genetics; Transduction, Genetic
TL;DR: It is shown that a replication-incompetent Equine Infectious Anemia Virus (EIAV) is highly suitable for stable and persistent gene transfer to adult neural stem cells and ishighly suitable for discovery and assessment of mechanisms that regulate proliferation, migration and differentiation in the postnatal brain. (via Semantic Scholar)
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2009 journal article

FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain

DEVELOPMENT, 136(23), 4021–4031.

By: B. Jacquet n, R. Salinas-Mondragon, H. Liang n, B. Therit n, J. Buie n, M. Dykstra n, K. Campbell*, L. Ostrowski*, S. Brody*, H. Ghashghaei  n

author keywords: Subventricular zone; Adult stem cell niche; Ependymal cells; Astrocytes; FoxJ1; Mouse
MeSH headings : Animals; Astrocytes / cytology; Astrocytes / metabolism; Astrocytes / ultrastructure; Brain / cytology; Brain / metabolism; Cell Differentiation / physiology; Cells, Cultured; Ependyma / cytology; Ependyma / metabolism; Ependyma / ultrastructure; Fluorescent Antibody Technique, Direct; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Expression; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Knockout; Neuroglia / cytology; Neuroglia / physiology; Neuroglia / ultrastructure
TL;DR: It is suggested that time- and cell-specific expression of FoxJ1 in the brain acts on an array of target genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the adult stem cell niche. (via Semantic Scholar)
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Added: August 6, 2018

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