Henry S. Marr

Works (37)

Updated: April 5th, 2024 04:24

2023 journal article

A practical protocol to prepare paraffin-embedded whole tick histology sections

TICKS AND TICK-BORNE DISEASES, 14(4).

By: T. Yang  n, E. LaDouceur, W. Baumgartner*, H. Marr n, M. Karounos n, J. Robertson n , N. Whitehurst n, L. Miller n, A. Birkenheuer n 

MeSH headings : Animals; Humans; Fixatives; Paraffin Embedding; Ixodes; Tick-Borne Diseases
TL;DR: A feasible protocol to prepare high quality paraffin-embedded whole tick histology sections is described that uses commonly available tools, reagents and standard histologic equipment and should allow any investigator to easily make adjustments to this protocol as needed based on their experimental goals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 24, 2023

2023 journal article

Cytauxzoon felis in salivary glands of Amblyomma americanum

TICKS AND TICK-BORNE DISEASES, 14(1).

By: T. Yang  n, M. Reichard *, J. Thomas*, L. Miller n, H. Marr n, M. Karounos n, A. Bell n, A. Birkenheuer n 

author keywords: Cytauxzoon felis; Sporozoites; In situ hybridization; Tick; Salivary glands
MeSH headings : Cats; Animals; Amblyomma; Microscopy, Electron, Transmission; Salivary Glands
TL;DR: The first direct visualization of any developing stage of C. felis within the tick host has been visualized microscopically, and it is believed that sporozoites in tick salivary glands (SG) have similar potential for cytauxzoonosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2023 journal article

Transmission of Cytauxzoon felis by injection of Amblyomma americanum salivary glands

PARASITOLOGY INTERNATIONAL, 95.

By: T. Yang  n, M. Reichard *, J. Thomas*, H. Marr n, M. Karounos n, J. Hyatt*, C. Miller *, A. Birkenheuer n 

author keywords: Feline; Cytauxzoon felis; Sporozoite; Ticks; Salivary glands
MeSH headings : Animals; Cats; Amblyomma; Ixodidae / parasitology; Protozoan Infections, Animal / parasitology; Ticks / parasitology; Piroplasmida / physiology; Felis; Cat Diseases
TL;DR: This study validates the feasibility of collecting infectious sporozoites from C. felis-infected ticks that can be used to infect naïve cats and has the potential to expand resources to study C.Felis and further advance research in this field. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2022 journal article

Direct injection of Amblyomma americanum ticks with Cytauxzoon felis

TICKS AND TICK-BORNE DISEASES, 13(1).

By: T. Yang  n, M. Reichard *, H. Marr n, L. Cohn*, L. Nafe*, N. Whitehurst n, A. Birkenheuer n 

author keywords: Cytauxzoon felis; Direct injection; Tick; In situ hybridization
MeSH headings : Amblyomma; Animals; Cat Diseases / epidemiology; Cats; Felis; Ixodidae / parasitology; Protozoan Infections, Animal / parasitology; Ticks
TL;DR: The results suggest that injected C. felis remained alive in ticks but was unable to progress to infective sporozoites after injection, and the potential of using ticks as an alternative model to study C.Felis is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 23, 2021

2020 journal article

Cytauxzoon felis cytochrome b gene mutation associated with atovaquone and azithromycin treatment

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(6), 2432–2437.

By: A. Hartley n, H. Marr n & A. Birkenheuer n 

author keywords: anemia; apicomplexan; cytauxzoonosis; feline; mitochondrial; resistance
MeSH headings : Animals; Atovaquone / therapeutic use; Azithromycin / therapeutic use; Cat Diseases / drug therapy; Cats; Cytochromes b / genetics; Felis; Mutation; Protozoan Infections, Animal
TL;DR: Parasites with mutations of cytb M128 can be selected and impart resistance to A&A treatment even with higher atovaquone dosing, according to this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2020 journal article

Novel Rickettsia Species Infecting Dogs, United States

EMERGING INFECTIOUS DISEASES, 26(12), 3011–3015.

By: J. Wilson n, E. Breitschwerdt n , N. Juhasz n, H. Marr n, J. Galvao n, C. Pratt n, B. Qurollo n 

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Phylogeny; Rickettsia / genetics; Rickettsia Infections / epidemiology; Rickettsia Infections / veterinary; United States / epidemiology
TL;DR: Multilocus phylogenetic analysis showed the dogs were infected with a novel Rickettsia species related to humanRickettsia pathogens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2020 journal article

Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs

JOURNAL OF CLINICAL MICROBIOLOGY, 58(4).

By: P. Neupane n, S. Sevala n, N. Balakrishnan*, H. Marr n, J. Wilson n, R. Maggi n , A. Birkenheuer n , M. Lappin *, B. Chomel*, E. Breitschwerdt n 

author keywords: serology; zoonosis; vector borne; Western blotting; antigen; Bartonella henselae
MeSH headings : Animals; Antibodies, Bacterial; Bartonella; Bartonella Infections / diagnosis; Bartonella Infections / veterinary; Bartonella henselae; Blotting, Western; Dog Diseases / diagnosis; Dogs; Serologic Tests
TL;DR: This study characterized WB immunodominant proteins that could be used to confirm a serodiagnosis of canine bartonelloses using agar-grown Bartonella henselae San Antonio type 2 (SA2) whole-cell proteins, and found a strong but variable recognition of these proteins among 81% of group II dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020

2019 journal article

Clinical, morphological, and molecular characterization of an undetermined Babesia species in a maned wolf (Chrysocyon brachyurus)

TICKS AND TICK-BORNE DISEASES, 10(1), 124–126.

By: A. Naor*, D. Lindemann *, M. Schreeg n, H. Marr n, A. Birkenheuer n , J. Carpenter *, J. Ryseff*

author keywords: Babesia; Maned wolf; Chrysocyon brachyurus; PCR; Blood smear; Raccoon
MeSH headings : Animals; Animals, Zoo; Anti-Infective Agents / therapeutic use; Babesia / classification; Babesia / cytology; Babesia / genetics; Babesia / isolation & purification; Babesiosis / drug therapy; Babesiosis / microbiology; Canidae; Female; Treatment Outcome
TL;DR: Clinical, morphological and molecular characterization of a possible novel Babesia species infection of a maned wolf with infection by an undetermined species suggested a unique Babesian species that is most closely related to a BabesIA species that has been found to infect raccoons in North America. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2019

2018 journal article

Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory

Journal of Veterinary Internal Medicine, 32(6), 1965–1969.

By: A. Birkenheuer n , H. Marr n, J. Wilson n, E. Breitschwerdt n  & B. Qurollo n 

author keywords: atovaquone; mitochondrial; pharmacogenomics; resistance
MeSH headings : Animals; Babesia / genetics; Babesiosis / blood; Babesiosis / epidemiology; Babesiosis / parasitology; Cytochromes b / genetics; Dog Diseases / blood; Dog Diseases / epidemiology; Dog Diseases / parasitology; Dogs; Mutation / genetics; Pathology, Veterinary / statistics & numerical data; Prevalence; Real-Time Polymerase Chain Reaction / veterinary; United States / epidemiology
TL;DR: The study reaffirms that B. gibsoni infection is widespread and most commonly detected in American Staffordshire Terrier/American Pit Bull Terrier dogs and that the prevalence of cytb mutations does not warrant pretreatment genotyping. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 31, 2018

2018 journal article

Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs

Journal of Veterinary Internal Medicine, 32(6), 1958–1964.

By: P. Neupane n, B. Hegarty n, H. Marr n, R. Maggi n , A. Birkenheuer n  & E. Breitschwerdt n 

author keywords: bacteria; BAPGM; serology; vector-borne; zoonosis
MeSH headings : Animals; Antigens, Bacterial / immunology; Bartonella / immunology; Bartonella Infections / diagnosis; Bartonella Infections / veterinary; Bartonella henselae / immunology; Bartonella quintana / immunology; Cells, Cultured; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Fluorescent Antibody Technique / methods; Fluorescent Antibody Technique / veterinary; Polymerase Chain Reaction / veterinary; Sensitivity and Specificity; Serologic Tests / methods; Serologic Tests / veterinary; Trench Fever / diagnosis; Trench Fever / veterinary
TL;DR: Despite IFA testing of dogs against 8 different Bartonella isolates, IFA sensitivity remained poor, and specificity was only 85%. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 31, 2018

2018 journal article

Identification of Cytauxzoon felis antigens via protein microarray and assessment of expression library immunization against cytauxzoonosis

CLINICAL PROTEOMICS, 15(1).

By: M. Schreeg n, H. Marr n, J. Tarigo n, M. Sherrill*, H. Outi*, E. Scholl n, D. Bird n , A. Vigil* ...

Contributors: M. Schreeg n, H. Marr n, J. Tarigo n, M. Sherrill*, H. Outi*, E. Scholl n, D. Bird n , A. Vigil* ...

author keywords: Cytauxzoonosis; Cytauxzoon felis; Expression library immunization; Protein microarray; Piroplasmid; Vaccine
TL;DR: Protein microarray facilitated high-throughput identification of novel antigens, substantially increasing the pool of characterized C. felis Antigens and should be considered for development of C.Felis vaccines, diagnostics, and therapeutics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 14, 2019

2018 journal article

Molecular detection of vector-borne pathogens in Greek cats

TICKS AND TICK-BORNE DISEASES, 9(2), 171–175.

By: M. Mylonakis *, M. Schreeg n, M. Chatzis *, J. Pearce n, H. Marr n, M. Saridomichelakis *, A. Birkenheuer n 

author keywords: Vector-borne pathogens; Bartonella spp.; Haemoplasmas; Cat; Greece
MeSH headings : Animals; Bacteria / isolation & purification; Bacterial Infections / epidemiology; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cat Diseases / epidemiology; Cat Diseases / microbiology; Cat Diseases / parasitology; Cats; Greece / epidemiology; Piroplasmida / isolation & purification; Prevalence; Protozoan Infections, Animal / epidemiology; Protozoan Infections, Animal / parasitology
TL;DR: This study represents the first description of Bartonella koehlerae in Greek cats, and there was no significant difference in either haemoplasma or Bart onella infection rates when comparing healthy and sick cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Endothelial alterations in a canine model of immune thrombocytopenia

Platelets, 30(1), 88–97.

By: D. LeVine  n, R. Cianciolo*, K. Linder n, P. Bizikova n, A. Birkenheuer n , M. Brooks *, A. Salous*, S. Nordone n ...

author keywords: Dog; endothelium; ITP
MeSH headings : Animals; Biomarkers; Biopsy; Blood Coagulation; Blood Platelets / metabolism; Blood Platelets / ultrastructure; Disease Models, Animal; Dogs; Endothelium / metabolism; Endothelium / ultrastructure; Flow Cytometry; Lysophospholipids / blood; Male; Platelet Activation; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / drug therapy; Purpura, Thrombocytopenic, Idiopathic / etiology; Purpura, Thrombocytopenic, Idiopathic / metabolism; Sphingosine / analogs & derivatives; Sphingosine / blood; von Willebrand Factor / metabolism
TL;DR: The results indicate that endothelial damage occurs in the canine ITP model and variability in the degree of endothelialDamage may account for differences in the bleeding phenotype among patients with ITP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 18, 2019

2017 journal article

Improved molecular detection of Babesia infections in animals using a novel quantitative real-time PCR diagnostic assay targeting mitochondrial DNA

Parasites & Vectors, 10(1).

By: B. Qurollo n , N. Archer n, M. Schreeg n, H. Marr n, A. Birkenheuer n , K. Haney n, B. Thomas n, E. Breitschwerdt n 

author keywords: Canine babesiosis; Babesia; Mitochondrial DNA; Quantitative PCR
MeSH headings : Animals; Babesia / classification; Babesiosis / diagnosis; Babesiosis / parasitology; DNA, Mitochondrial / genetics; DNA, Protozoan / genetics; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / veterinary
TL;DR: A more sensitive qPCR assay with a more expansive range of Babesia spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny

PLOS ONE, 11(11).

By: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn*, D. Bird n , E. Scholl n, M. Levy n, B. Wiegmann n , A. Birkenheuer n 

Contributors: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn*, D. Bird n , E. Scholl n, M. Levy n, B. Wiegmann n , A. Birkenheuer n 

MeSH headings : DNA, Protozoan / genetics; Genome, Mitochondrial; Humans; Phylogeny; Piroplasmida / classification; Piroplasmida / genetics; Protozoan Infections / parasitology
TL;DR: Phylogenetic analysis of concatenated mitochondrial and 18S sequences as well as cox1 amino acid sequence identified five distinct Piroplasmida groups, each of which possesses a unique mitochondrial genome structure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

PCR amplification of a multi-copy mitochondrial gene (cox3) improves detection of Cytauxzoon felis infection as compared to a ribosomal gene (18S)

VETERINARY PARASITOLOGY, 225, 123–130.

By: M. Schreeg n, H. Marr n, E. Griffith n, J. Tarigo n, D. Bird n , M. Reichard *, L. Cohn*, M. Levy n, A. Birkenheuer n 

Contributors: M. Schreeg n, H. Marr n, E. Griffith n, J. Tarigo n, D. Bird n , M. Reichard *, L. Cohn*, M. Levy n, A. Birkenheuer n 

author keywords: Cytauxzoonosis; Cytochrome c oxidase; Piroplasmosis; Mitochondria; Feline; Molecular diagnostic assays
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; DNA, Protozoan / blood; DNA, Protozoan / genetics; Electron Transport Complex IV / genetics; Gene Dosage; Haemosporida / genetics; Polymerase Chain Reaction / standards; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; RNA, Ribosomal, 18S / genetics; Sensitivity and Specificity
TL;DR: A PCR assay targeting the C. felis mitochondrial gene cytochrome c oxidase subunit III (cox3) is designed and demonstrated that the cox3 PCR can detect as low as 1 copy of DNA target and can detect C.Felis during early infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Rapid High-Resolution Melt Analysis of Cytauxzoon felis Cytochrome b To Aid in the Prognosis of Cytauxzoonosis

JOURNAL OF CLINICAL MICROBIOLOGY, 53(8), 2517–2524.

By: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn*, M. Levy n & A. Birkenheuer n 

MeSH headings : Alleles; Animals; Antiprotozoal Agents / therapeutic use; Atovaquone / therapeutic use; Azithromycin / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Cytochromes b / genetics; Genotype; Genotyping Techniques / methods; Piroplasmida / drug effects; Piroplasmida / genetics; Piroplasmida / isolation & purification; Polymerase Chain Reaction / methods; Prognosis; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / drug therapy; Protozoan Infections, Animal / parasitology; Protozoan Proteins / genetics; Sensitivity and Specificity; Transition Temperature; Veterinary Medicine / methods
TL;DR: The purpose of this study was to design a PCR panel that could distinguish C. felis cytb1 from other cytochrome b genotypes, and this panel was predicted to distinguish cytb 1 from other cytb genotypes through the use of high-resolution melt analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Spironucleus meleagridis, an enteric diplomonad protozoan of cockatiels (Nymphicus hollandicus): Preliminary molecular characterization and association with clinical disease

VETERINARY PARASITOLOGY, 208(3-4), 169–173.

By: M. Levy n, L. Powers*, K. Gore n & H. Marr n

author keywords: Spironucleus meleagridis; Hexamita meleag-ridis; Spironucleosis; Cockatiel; Nymphicus hollandicus; Protozoan
MeSH headings : Animals; Bird Diseases / parasitology; Cockatoos / parasitology; Diplomonadida / genetics; Diplomonadida / isolation & purification; Feces / parasitology; Female; Male; Polymerase Chain Reaction / methods; Protozoan Infections, Animal / parasitology
TL;DR: Prevalence of infection and incidence of clinical disease, including factors that lead to clinical manifestation such as viral, bacterial, or mycotic coinfections, are not yet known and warrant further study, but spironucleosis is likely an under-recognized disease in cockatiels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

British Journal of Haematology, 167(1), 110–120.

By: D. LeVine n, A. Birkenheuer n , M. Brooks *, S. Nordone n, D. Bellinger*, S. Jones  n, T. Fischer *, S. Oglesbee* ...

author keywords: immune thrombocytopenia; canine; interleukin-8; animal model
MeSH headings : Animals; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / immunology; Blood Platelets / immunology; Blood Platelets / metabolism; Cytokines / blood; Cytokines / metabolism; Disease Models, Animal; Dogs; Hemorrhage / immunology; Phenotype; Platelet Count; Purpura, Thrombocytopenic, Idiopathic / blood; Purpura, Thrombocytopenic, Idiopathic / diagnosis; Purpura, Thrombocytopenic, Idiopathic / immunology
TL;DR: Evaluation of cytokine profiles led to the identification of platelets as a potential source of serum interleukin‐8 (IL8) in dogs, suggesting that platelet IL8 may be a previously unrecognized modulator of platelet‐neutrophil crosstalk in humans with ITP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Failure of efficacy and adverse events associated with dose-intense diminazene diaceturate treatment of chronic Cytauxzoon felis infection in five cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 157–163.

By: K. Lewis*, L. Cohn*, H. Marr n & A. Birkenheuer n 

MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / adverse effects; Antiprotozoal Agents / therapeutic use; Carrier State; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Chronic Disease; Diminazene / administration & dosage; Diminazene / adverse effects; Diminazene / analogs & derivatives; Diminazene / therapeutic use; Dose-Response Relationship, Drug; Female; Male; Parasitic Diseases, Animal / drug therapy; Treatment Failure
TL;DR: It is hypothesized that a dose-intensified regimen of diminazene could reduce or eliminate parasitemia from five domestic cats naturally infected with C felis and that Diminazene diaceturate cannot be recommended for elimination of the carrier state of C fel is infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Investigation of a Commercial ELISA for the Detection of Canine Procalcitonin

JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(2), 599–602.

By: A. Floras*, M. Holowaychuk *, D. Hodgins*, H. Marr n, A. Birkenheuer n , S. Sharif *, A. Bersenas*, D. Bienzle *

author keywords: Sepsis; Diagnostic test; Dog; Validation; Biomarker
MeSH headings : Animals; Biomarkers / blood; Calcitonin / blood; Dog Diseases / blood; Dogs / blood; Enzyme-Linked Immunosorbent Assay / veterinary; Protein Precursors / blood; Reproducibility of Results; Sepsis / blood; Sepsis / veterinary; Thyroid Neoplasms / blood; Thyroid Neoplasms / veterinary
TL;DR: The results of this investigation do not support the use of this ELISA for the detection of Procalcitonin (PCT) in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Pharmacogenomics of Cytauxzoon felis Cytochrome b: Implications for Atovaquone and Azithromycin Therapy in Domestic Cats with Cytauxzoonosis

JOURNAL OF CLINICAL MICROBIOLOGY, 51(9), 3066–3069.

By: M. Schreeg n, H. Marr n, J. Tarigo n, L. Cohn*, M. Levy n & A. Birkenheuer n 

MeSH headings : Animals; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / therapeutic use; Atovaquone / pharmacokinetics; Atovaquone / therapeutic use; Azithromycin / pharmacokinetics; Azithromycin / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Cytochromes b / genetics; Cytochromes b / metabolism; Pharmacogenetics; Piroplasmida / genetics; Piroplasmida / metabolism; Protozoan Infections / drug therapy; Protozoan Infections / parasitology
TL;DR: This work characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Hypocalcemia and Hypovitaminosis D in Dogs with Induced Endotoxemia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 244–251.

By: M. Holowaychuk *, A. Birkenheuer n , J. Li  n, H. Marr n, A. Boll n & S. Nordone n

author keywords: Animal model; Calcium; Magnesium; Parathyroid hormone; Sepsis; Vitamin D
MeSH headings : Animals; Blood Gas Analysis / veterinary; Blood Pressure; Body Temperature; Calcium / blood; Calcium / urine; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / metabolism; Dogs; Endotoxemia / blood; Endotoxemia / complications; Endotoxemia / metabolism; Endotoxemia / veterinary; Hypocalcemia / blood; Hypocalcemia / complications; Hypocalcemia / metabolism; Hypocalcemia / veterinary; Magnesium / blood; Magnesium / urine; Male; Parathyroid Hormone / blood; Vitamin D / analogs & derivatives; Vitamin D / blood
TL;DR: Hypocalcemia occurs during endotoxemia in dogs and is associated with hypovitaminosis D, and hypomagnesemia, hypoparathyroidism, alkalosis, and increased calciuresis are not associated with HypocalCEmia in endotoxemic dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin

VETERINARY PARASITOLOGY, 187(1-2), 23–27.

By: M. Di Cicco n, M. Downey n, E. Beeler*, H. Marr n, P. Cyrog, L. Kidd *, P. Diniz *, L. Cohn*, A. Birkenheuer n 

author keywords: Protozoal; Babesiosis; Piroplasm; Babesia gibsoni
MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / therapeutic use; Atovaquone / administration & dosage; Atovaquone / therapeutic use; Azithromycin / administration & dosage; Azithromycin / therapeutic use; Babesia / classification; Babesiosis / drug therapy; Babesiosis / epidemiology; Babesiosis / parasitology; Babesiosis / veterinary; California / epidemiology; Communicable Diseases, Emerging / epidemiology; Communicable Diseases, Emerging / parasitology; Communicable Diseases, Emerging / veterinary; Dog Diseases / drug therapy; Dog Diseases / epidemiology; Dog Diseases / genetics; Dog Diseases / parasitology; Dogs; Female; Male; Pedigree
TL;DR: Combination therapy with atovaquone and azithromycin appears to be effective for acute and chronic babesiosis caused by B. conradae. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils

Developmental & Comparative Immunology, 35(8), 872–880.

By: J. Li, A. Birkenheuer* , H. Marr*, M. Levy*, J. Yoder*  & S. Nordone

author keywords: TREM-1; TLR; Neutrophils; Sepsis; Canine
MeSH headings : Amino Acid Sequence; Animals; Cells, Cultured; Cloning, Molecular; Conserved Sequence; Cytokines / immunology; Cytokines / metabolism; Dogs / genetics; Dogs / immunology; Humans; Lipopolysaccharides / immunology; Lipopolysaccharides / pharmacology; Membrane Glycoproteins / genetics; Membrane Glycoproteins / immunology; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Neutrophils / immunology; Neutrophils / metabolism; Phylogeny; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Sequence Alignment; Teichoic Acids / immunology; Teichoic Acids / pharmacology; Toll-Like Receptors / agonists; Up-Regulation / drug effects
TL;DR: Functionally, canine TREM-1 synergistically enhances LPS-induced production of IL-8, TNF-α and a canine orthologue of CXCL1 and these data suggest that T REM-1 expression in dogs is an amplifier of pro-inflammatory responses to microbial products. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Babesia microti-like infections are prevalent in North American foxes

VETERINARY PARASITOLOGY, 172(3-4), 179–182.

By: A. Birkenheuer n , B. Horney*, M. Bailey  n, M. Scott*, B. Sherbert n, V. Catto n, H. Marr n, A. Camacho, A. Ballman n

author keywords: Babesia; Tick; Anemia; Azotemia; Piroplasmosis
MeSH headings : Animals; Babesia microti / genetics; Babesiosis / epidemiology; Babesiosis / parasitology; Coyotes / parasitology; Dog Diseases / epidemiology; Dog Diseases / parasitology; Dogs; Foxes / parasitology; Molecular Sequence Data; North America; Prevalence; Protozoan Infections, Animal / epidemiology; Protozoan Infections, Animal / parasitology; RNA, Ribosomal, 18S / genetics; Spain; Tubulin / genetics
TL;DR: Interestingly, partial beta-tubulin gene sequences characterized from the B. microti-like parasites of domestic dogs from Spain in this study were different from those previously reported from a Spanish domestic dog sample which is believed to be a pseudogene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Prevalence of Selected Vector-borne Organisms and Identification of Bartonella Species DNA in North American River Otters (Lontra canadensis)

Journal of Wildlife Diseases, 46(3), 947–950.

By: S. Chinnadurai n, A. Birkenheuer n , H. Blanton n, R. Maggi n , N. Belfiore*, H. Marr n, E. Breitschwerdt n , M. Stoskopf n

author keywords: Bartonella; disease; Ehrlichia; Lontra canadensis; Ricketisia; river otter
MeSH headings : Animals; Animals, Wild / microbiology; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / transmission; Bartonella Infections / veterinary; DNA, Bacterial / blood; Female; Male; North Carolina / epidemiology; Otters / virology; Polymerase Chain Reaction / veterinary; Prevalence; Rivers
TL;DR: Trapper-killed North American river otters in North Carolina, USA, were screened for multiple vector-borne bacteria known to be pathogenic to mammals and blood from one live otter captured in 2008 was found positive for this Bartonella sp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Bartonella DNA in the Blood and Lymph Nodes of Golden Retrievers with Lymphoma and in Healthy Controls

Journal of Veterinary Internal Medicine, 22(1), 89–95.

By: A. Duncan n, H. Marr n, A. Birkenheuer n , R. Maggi n , L. Williams n, M. Correa  n, E. Breitschwerdt n 

author keywords: bacteria; cancer; dog; tick; vector-borne
MeSH headings : Animals; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / complications; Bartonella Infections / veterinary; Case-Control Studies; DNA, Bacterial / analysis; DNA, Bacterial / blood; Disease Vectors; Dog Diseases / blood; Dog Diseases / microbiology; Dogs; Female; Lymph Nodes / microbiology; Lymphoma / microbiology; Lymphoma / veterinary; Male; Models, Statistical; Polymerase Chain Reaction / veterinary; Risk Factors; Surveys and Questionnaires
TL;DR: Bartonella DNA can be detected in blood and lymph nodes; importantly, in this report, Bartonella was detected in the same proportion of clinically healthy dogs and dogs with lymphoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Cytauxzoon felis infections are present in bobcats (Lynx rufus) in a region where cytauxzoonosis is not recognized in domestic cats

VETERINARY PARASITOLOGY, 153(1-2), 126–130.

By: A. Birkenheuer n , H. Marr n, C. Warren n, A. Acton n, E. Mucker *, J. Humphreys*, M. Tucker n

author keywords: cytauxzoonosis; piroplasmosis; Cytauxzoon felis; bobcats; PCR; tick
MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / parasitology; Cats; Eukaryota / classification; Eukaryota / isolation & purification; Lynx / parasitology; North Carolina / epidemiology; Pennsylvania / epidemiology; Protozoan Infections, Animal / epidemiology; Protozoan Infections, Animal / parasitology
TL;DR: This study indicates the potential for C. felis infections in domestic cats in the northeastern USA if the appropriate tick vectors are present and Veterinary practitioners in PA should be on alert for cytauxzoonosis in domestic Cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

Evaluation of four DNA extraction methods for the detection of Tritrichomonas foetus in feline stool specimens by polymerase chain reaction

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 20(5), 639–641.

By: S. Stauffer n, A. Birkenheuer n , M. Levy n, H. Marr n & J. Gookin n 

author keywords: Cats; feces; polymerase chain reaction; protozoa
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / economics; Cat Diseases / parasitology; Cats; Costs and Cost Analysis; DNA, Protozoan / genetics; DNA, Protozoan / isolation & purification; Feces / parasitology; North Carolina; Polymerase Chain Reaction / methods; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 16S / isolation & purification; Trichomonas / genetics; Trichomonas Infections / diagnosis; Trichomonas Infections / economics; Trichomonas Infections / veterinary
TL;DR: In the present study, 4 commercially available DNA extraction methods were examined for their influence on the sensitivity of PCR for the detection of Tritrichomonas foetus in feline stool and the ZR Fecal DNA kit was identified as affording the greatest analytical sensitivity and reproducibility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Failure to identify an association between serologic or molecular evidence ofBartonellainfection and idiopathic rhinitis in dogs

Journal of the American Veterinary Medical Association, 233(4), 597–599.

By: E. Hawkins n , L. Johnson, L. Guptill*, H. Marr n, E. Breitschwerdt n  & A. Birkenheuer n 

MeSH headings : Animals; Antibodies, Bacterial / blood; Bartonella / immunology; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella henselae / immunology; Bartonella henselae / isolation & purification; Case-Control Studies; DNA, Bacterial / analysis; Dog Diseases / diagnosis; Dog Diseases / microbiology; Dogs; Female; Fluorescent Antibody Technique, Indirect / methods; Fluorescent Antibody Technique, Indirect / veterinary; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Rhinitis / diagnosis; Rhinitis / microbiology; Rhinitis / veterinary
TL;DR: The failure to find any evidence of exposure to or infection with Bartonella spp in dogs with idiopathic nasal discharge suggested that Bart onella infection was not a common cause of the disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Molecular evidence of prevalent dual piroplasma infections in North American raccoons (Procyon lotor)

PARASITOLOGY, 135(1), 33–37.

By: A. Birkenheuer n , H. Marr n, N. Hladio n & A. Acton n

author keywords: Babesia; piroplasmosis; babesiosis
MeSH headings : Animals; Babesia / genetics; Babesia / isolation & purification; Babesia microti / genetics; Babesia microti / isolation & purification; Babesiosis / parasitology; Babesiosis / veterinary; DNA Primers / chemistry; DNA, Protozoan / analysis; DNA, Protozoan / blood; Genotype; North Carolina; Parasitic Diseases, Animal / parasitology; Polymerase Chain Reaction / veterinary; RNA, Ribosomal, 18S / genetics; Raccoons / parasitology; Sequence Homology, Nucleic Acid
TL;DR: This study highlights the need for molecular assays for the accurate identification of piroplasma and performs a molecular survey of raccoons using polymerase chain reaction assays specific for each genotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Bartonella DNA in Loggerhead Sea Turtles

Emerging Infectious Diseases, 13(6), 949–950.

By: K. Valentine n, C. Harms n , M. Cadenas n, A. Birkenheuer n , H. Marr n, J. Braun-McNeill*, R. Maggi n , E. Breitschwerdt n 

MeSH headings : Animals; Atlantic Ocean; Bartonella / genetics; Bartonella / isolation & purification; Bartonella / pathogenicity; Bartonella Infections / blood; Bartonella Infections / genetics; Bartonella Infections / veterinary; DNA, Bacterial / classification; North Carolina; Polymerase Chain Reaction; Turtles / blood; Turtles / microbiology
TL;DR: Pathogenic bacteria are an important threat in terrestrial and marine environments, and in the case of B. henselae, reservoir hosts may be more diverse than currently recognized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2007 journal article

Quantification of mucin gene expression in tracheobronchial epithelium of healthy dogs and dogs with chronic bronchitis

AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(4), 435–440.

By: E. Hawkins n , A. Birkenheuer n , H. Marr n, A. Rogala n, E. Large n & K. Adler n

MeSH headings : Animals; Bronchitis, Chronic / metabolism; Bronchitis, Chronic / veterinary; DNA Primers; Dog Diseases / metabolism; Dogs; Evaluation Studies as Topic; Mucins / metabolism; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Messenger / metabolism
TL;DR: The ability to measure mucin gene expression from tracheobronchial brushing specimens collected from client-owned dogs during routine bronchoscopy should prove to be a useful tool for the study of bronchitis in dogs and expand the usefulness of airway inflammation in dogs as a model for bronchritis in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

The detection of Cytauxzoon felis in apparently healthy free-roaming cats in the USA

VETERINARY PARASITOLOGY, 146(3-4), 316–320.

By: M. Haber n, M. Tucker n, H. Marr n, J. Levy*, J. Burgess*, M. Lappin *, A. Birkenheuer n 

author keywords: Cytauxzoonosis; PCR; free-roaming; survival; hyperendemic
MeSH headings : Animals; Carrier State; Cat Diseases / epidemiology; Cat Diseases / parasitology; Cats; Female; Male; Piroplasmida; Protozoan Infections, Animal / epidemiology; Protozoan Infections, Animal / parasitology; United States / epidemiology
TL;DR: Despite the low prevalence rate, the presence of apparently healthy infected free-roaming cats suggests that they may have the capacity to serve as an additional reservoir host for C. felis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

The identification of a genetically unique piroplasma in North American river otters (Lontra canadensis)

PARASITOLOGY, 134(5), 631–635.

By: A. Birkenheuer n , C. Harms n , J. Neel n , H. Marr n, M. Tucker n, A. Acton n, A. Tuttle n, M. Stoskopf n

Contributors: A. Birkenheuer n , C. Harms n , J. Neel n , H. Marr n, M. Tucker n, A. Acton n, A. Tuttle n, M. Stoskopf n

author keywords: Babesia; North American river otter; PCR; phylogenetics
MeSH headings : Animals; Babesia / genetics; Babesia / isolation & purification; Base Sequence; Molecular Sequence Data; North America; Otters / parasitology; Phylogeny; RNA, Protozoan / genetics; RNA, Ribosomal, 18S / genetics; Rivers
TL;DR: It is indicated that the prevalence of piroplasma in North Carolina otters is quite high and the pathogenic potential of this organism for otters or other species remains unknown. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

Development and evaluation of a PCR assay for the detection of Cytauxzoon felis DNA in feline blood samples

VETERINARY PARASITOLOGY, 137(1-2), 144–149.

By: A. Birkenheuer n , H. Marr n, A. Alleman*, M. Levy n & E. Breitschwerdt n 

author keywords: cytauxzoonosis; piroplasmosis; pancytopenia
MeSH headings : Animals; Blood / parasitology; Cat Diseases / blood; Cat Diseases / diagnosis; Cat Diseases / mortality; Cat Diseases / parasitology; Cats; DNA, Protozoan / analysis; Ixodidae / parasitology; Piroplasmida / genetics; Piroplasmida / isolation & purification; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / blood; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / mortality; Protozoan Infections, Animal / parasitology; RNA, Ribosomal, 18S / analysis; Sensitivity and Specificity
TL;DR: This work has developed and evaluated the sensitivity and specificity of a polymerase chain reaction (PCR) based assay and can be used for the rapid clinical diagnosis of cytauxzoonosis and for epidemiological studies that will better define the geographic distribution of C. felis infection in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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