Works (3)

Updated: July 5th, 2023 15:48

2015 journal article

Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation


By: N. Yi n, D. Newman n, H. Zhang n, H. Johansson n & P. Sannes n

author keywords: COX-2; heparin; LPS; lung; sulfation
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression / drug effects; Glycosaminoglycans / chemistry; Glycosaminoglycans / metabolism; Heparin / chemistry; Heparin / pharmacology; Humans; Interleukin-8 / genetics; Interleukin-8 / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Signaling System / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism
TL;DR: Heparin's anti-inflammatory effects result from its nonspecific suppression of signaling and gene expression and are determined by its sulfation, which may reflect the moderating role of GAG sulfation in lung injury and health. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro


By: H. Zhang n, D. Newman n, J. Bonner n & P. Sannes n

author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
TL;DR: The finding that HSulf-1 sensitizes these cancer cells and intensifies the injury induced by cadmium suggests that 6-O-sulfate groups on HSPGs may play important roles in protection against certain environmental toxicants, such as heavy metals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Temporal Changes in Expression of FoxA1 and Wnt7A in Isolated Adult Human Alveolar Epithelial Cells Enhanced by Heparin


By: K. Apparao n, D. Newman n, H. Zhang n, J. Khosla n, S. Randell* & P. Sannes n

author keywords: beta-catenin; differentiation; heparin; sulfated extracellular matrices
MeSH headings : Adult; Anticoagulants / physiology; Biomarkers / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cell Line; Cell Separation; Cells, Cultured; Heparin / physiology; Hepatocyte Nuclear Factor 3-alpha / biosynthesis; Hepatocyte Nuclear Factor 3-alpha / genetics; Humans; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Time Factors; Wnt Proteins / biosynthesis; Wnt Proteins / genetics; beta Catenin / biosynthesis; beta Catenin / genetics
Source: Web Of Science
Added: August 6, 2018

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