Ian Andrew Williamson

Works (17)

Updated: January 15th, 2026 16:15

2023 conference paper

Glycerate Production from Intestinal Fructose Metabolism is Exacerbated by Dietary Fat, Driving Glucose Intolerance

NIDDK Digestive Disease Research Centers Directors Meeting. Presented at the NIDDK Digestive Disease Research Centers Directors Meeting, Cincinnati, OH.

By: I. Williamson 

Event: NIDDK Digestive Disease Research Centers Directors Meeting at Cincinnati, OH

Source: NC State University Libraries
Added: July 3, 2025

2023 conference paper

Glycerate Production from Intestinal Fructose Metabolism is Exacerbated by Dietary Fat, Driving Glucose Intolerance

The Metabolic Physiology Meeting 2023. Presented at the The Metabolic Physiology Meeting 2023, Hilton Head, SC.

By: I. Williamson 

Event: The Metabolic Physiology Meeting 2023 at Hilton Head, SC

Source: NC State University Libraries
Added: July 3, 2025

2023 journal article

Gut Mucosal Cells Transfer α-Synuclein Pathology to the Vagus Nerve

Aligning Science Against Parkinson’s Disease Regional Conference. Presented at the Aligning Science Against Parkinson’s Disease Regional Conference, San Diego, CA.

By: I. Williamson 

Event: Aligning Science Against Parkinson’s Disease Regional Conference at San Diego, CA

Source: NC State University Libraries
Added: July 3, 2025

2023 conference paper

Measuring the Contributions of Enteric Metabolic Reprogramming to Disease

Texas Medical Center Digestive Diseases Center Research Forum. Presented at the Texas Medical Center Digestive Diseases Center Research Forum, Houston, TX.

By: I. Williamson 

Event: Texas Medical Center Digestive Diseases Center Research Forum at Houston, TX

Source: NC State University Libraries
Added: July 3, 2025

2022 journal article

Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance

Cell Metabolism, 34(7), 1042–1053.e6.

By: Y. Wu, C. Wong, E. Chiles, A. Mellinger n, H. Bae *, S. Jung *, T. Peterson*, J. Wang * ...

MeSH headings : Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat / adverse effects; Dietary Fats / pharmacology; Fructose / metabolism; Glucose / metabolism; Glucose Intolerance / metabolism; Humans; Insulin / metabolism; Islets of Langerhans / metabolism
topics (OpenAlex): Diet, Metabolism, and Disease; Liver Disease Diagnosis and Treatment; Diet and metabolism studies
TL;DR: It is reported that dietary fat enhances intestinal fructose metabolism, which releases glycerate into the blood, which provides a link between dietary fructose and diabetes that is modulated by dietary fat. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 8, 2022

2022 conference paper

Intestinal-Derived Glycerate Contributes to Pancreatic Islet Dysfunction

Don Fredrickson Lipid Research Conference. Presented at the Don Fredrickson Lipid Research Conference, Durham, NC.

By: I. Williamson 

Event: Don Fredrickson Lipid Research Conference at Durham, NC

Source: NC State University Libraries
Added: July 3, 2025

2022 conference paper

Intestinal-Derived Glycerate Contributes to Pancreatic Islet Dysfunction

FASEB Gastrointestinal Tract Conference XX. Presented at the FASEB Gastrointestinal Tract Conference XX, Steamboat Springs, CO.

By: I. Williamson 

Event: FASEB Gastrointestinal Tract Conference XX at Steamboat Springs, CO

Source: NC State University Libraries
Added: July 3, 2025

2022 journal article

Patient-derived micro-organospheres enable clinical precision oncology

Cell Stem Cell, 29(6), 905–917.e6.

By: S. Ding *, C. Hsu*, Z. Wang *, N. Natesh *, R. Millen *, M. Negrete *, N. Giroux *, G. Rivera * ...

MeSH headings : Colonic Neoplasms / pathology; Humans; Immunotherapy; Organoids / pathology; Precision Medicine
topics (OpenAlex): Cancer Cells and Metastasis; 3D Printing in Biomedical Research; Immunotherapy and Immune Responses
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 30, 2025

2021 conference paper

Glycerate Production from Intestinal Fructose Metabolism is Exacerbated by Dietary Fat, Driving Glucose Intolerance.

Digestive Disease Week. Presented at the Digestive Disease Week.

By: I. Williamson 

Event: Digestive Disease Week

Source: NC State University Libraries
Added: July 3, 2025

2018 journal article

A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology

Cellular and Molecular Gastroenterology and Hepatology, 6(3), 301–319.

By: I. Williamson n , J. Arnold *, L. Samsa  n, L. Gaynor*, M. DiSalvo  n, J. Cocchiaro *, I. Carroll *, M. Azcarate-Peril * ...

MeSH headings : Animals; Bifidobacterium adolescentis / genetics; Bifidobacterium adolescentis / growth & development; Bifidobacterium adolescentis / isolation & purification; Colon / anatomy & histology; Colon / cytology; Escherichia coli / genetics; Escherichia coli / growth & development; Feces / microbiology; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract / physiology; Humans; Male; Mice; Microinjections / methods; Organoids / anatomy & histology; Organoids / cytology; Single-Cell Analysis; Video Recording; Yersinia pseudotuberculosis / genetics; Yersinia pseudotuberculosis / growth & development
topics (OpenAlex): 3D Printing in Biomedical Research; Gut microbiota and health; Cancer Cells and Metastasis
Sources: Crossref, NC State University Libraries
Added: June 30, 2025

2018 journal article

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model

Cellular and Molecular Gastroenterology and Hepatology, 7(1), 1–17.

By: B. Zwarycz*, A. Gracz *, K. Rivera n, I. Williamson n , L. Samsa*, J. Starmer*, M. Daniele n , L. Salter-Cid *, Q. Zhao*, S. Magness n

Contributors: B. Zwarycz*, A. Gracz *, K. Rivera n, I. Williamson n , L. Samsa*, J. Starmer*, M. Daniele n , . al.

author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
topics (OpenAlex): Cancer Cells and Metastasis; IL-33, ST2, and ILC Pathways; Single-cell and spatial transcriptomics
TL;DR: Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: January 14, 2019

2018 journal article

Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations

Cellular and Molecular Gastroenterology and Hepatology, 6(1), 79–96.

By: N. Smith*, J. Swain *, P. Davies*, A. Gallagher *, M. Parappilly *, C. Beach *, P. Streeter*, I. Williamson* , S. Magness *, M. Wong *

topics (OpenAlex): Cancer Cells and Metastasis; Cellular Mechanics and Interactions; T-cell and B-cell Immunology
Sources: Crossref, NC State University Libraries
Added: June 30, 2025

2017 journal article

Self-renewing monolayer of primary colonic or rectal epithelial cells

Cellular and Molecular Gastroenterology and Hepatology, 4(1), 165-.

By: Y. Wang, M. DiSalvo, D. Gunasekara, J. Dutton, A. Proctor, M. Lebhar, I. Williamson , J. Speer ...

Source: NC State University Libraries
Added: August 6, 2018

2016 conference paper

A High-Throughput Organoid Microinjection Platform to Investigate ‘Unculturable’ Human Microbiota

Digestive Disease Week. Presented at the Digestive Disease Week, San Diego, CA.

By: I. Williamson 

Event: Digestive Disease Week at San Diego, CA

Source: NC State University Libraries
Added: July 21, 2025

2016 journal article

In vitro polarization of colonoids to create an intestinal stem cell compartment

PLoS One, 11(4).

By: P. Attayek, A. Ahmad, Y. Wang, I. Williamson , C. Sims, S. Magness, N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis

Nature Cell Biology, 17(3), 340–349.

By: A. Gracz *, I. Williamson* , K. Roche *, M. Johnston *, F. Wang *, Y. Wang *, P. Attayek *, J. Balowski* ...

MeSH headings : Animals; Cell Differentiation; Coculture Techniques; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Reporter; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; High-Throughput Screening Assays; Male; Mice; Mice, Transgenic; Paneth Cells / cytology; Paneth Cells / metabolism; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Signal Transduction; Single-Cell Analysis; Stem Cell Niche / genetics; Stem Cells / cytology; Stem Cells / metabolism; Tissue Array Analysis / instrumentation; Tissue Array Analysis / methods
topics (OpenAlex): Cancer Cells and Metastasis; 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies
Sources: ORCID, Crossref, NC State University Libraries
Added: June 26, 2025

2013 journal article

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration

PLoS ONE, 8(6), e66465.

By: L. Gonzalez  n, I. Williamson* , J. Piedrahita  n, A. Blikslager n  & S. Magness *

Contributors: L. Gonzalez  n, I. Williamson* , J. Piedrahita  n, A. Blikslager n  & S. Magness *

Ed(s): S. Singh* 

MeSH headings : Animals; Apoptosis; Biomarkers / metabolism; Cell Culture Techniques; Cell Cycle; Cell Differentiation; Cell Lineage; Cell Proliferation; Cells, Cultured; Epithelial Cells / physiology; Epithelial Cells / ultrastructure; Goblet Cells / physiology; Goblet Cells / ultrastructure; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Regeneration; Stem Cells / physiology; Sus scrofa
topics (OpenAlex): Cancer Cells and Metastasis; Digestive system and related health; 3D Printing in Biomedical Research
TL;DR: Biomarker characterization and development of IESC culture in the porcine model represents a foundation for translational studies of I ESC-driven regeneration of the intestinal epithelium in physiology and disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Crossref, NC State University Libraries
Added: July 27, 2019

Employment

Updated: February 15th, 2022 14:01

2021 - present

Duke University Durham, North Carolina, US
Research Specialist School of Medicine

2018 - 2021

Duke University Durham, NC, US
T32 Postdoctoral Fellow School of Medicine

Education

Updated: March 26th, 2019 08:45

2013 - 2018

University of North Carolina NC, NC, US
PhD Biomedical Engineering

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