Works (3)

Updated: July 5th, 2023 15:32

2019 journal article

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model


By: B. Zwarycz*, A. Gracz*, K. Rivera n, I. Williamson n, L. Samsa*, J. Starmer*, M. Daniele n, L. Salter-Cid*, Q. Zhao*, S. Magness n

author keywords: Intestinal Stem Cells; Interleukin-22; Inflammatory Bowel Disease
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage / drug effects; Cell Proliferation / drug effects; Cell Self Renewal / drug effects; Cellular Microenvironment / drug effects; Computer Simulation; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ileum / cytology; Inflammatory Bowel Diseases / pathology; Interleukins / pharmacology; Mice, Inbred C57BL; Models, Biological; Organoids / cytology; Organoids / drug effects; Organoids / metabolism; Receptors, Interleukin / metabolism; Serum / metabolism; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / metabolism
TL;DR: Increased IL22 limits ISC expansion in favor of increased TA progenitor cell expansion, and chronically increased IL22 levels, similar to predicted microenvironment levels, showed increases in proliferative cells in the TA zone with no increase in ISCs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 14, 2019

2017 journal article

Self-renewing monolayer of primary colonic or rectal epithelial cells

Cellular and Molecular Gastroenterology and Hepatology, 4(1), 165-.

By: Y. Wang, M. DiSalvo, D. Gunasekara, J. Dutton, A. Proctor, M. Lebhar, I. Williamson, J. Speer ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

In vitro polarization of colonoids to create an intestinal stem cell compartment

PLoS One, 11(4).

By: P. Attayek, A. Ahmad, Y. Wang, I. Williamson, C. Sims, S. Magness, N. Allbritton

Source: NC State University Libraries
Added: August 6, 2018

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