Ilene Ellis

College of Veterinary Medicine

Works (2)

Updated: June 21st, 2023 22:23

2022 journal article

Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

Frontiers in Veterinary Science, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n 

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Diabetic Foot Ulcer Assessment and Management
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 12, 2022

2022 journal article

TGF-β2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

Stem Cell Research & Therapy, 13(1).

By: D. Koch n, L. Schnabel n , I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Periodontal Regeneration and Treatments
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 26, 2022

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