Imran Rizvi

Rickard, B. P., Sapienza‐Lundie, L. A., Overchuk, M., Tan, X., Bae‐Jump, V. L., Yates, M. S., … Rizvi, I. (2025). Photodynamic priming overcomes platinum resistance from short‐term exposure to select perfluoroalkyl substances in endometrial cancer cell lines. Photochemistry and Photobiology. https://doi.org/10.1111/php.14073

Zahid, M. U., Waguespack, M., Harman, R. C., Kercher, E. M., Nath, S., Hasan, T., … Enderling, H. (2024, September 11). Fractionated photoimmunotherapy stimulates an anti-tumour immune response: an integrated mathematical and in vitro study. BRITISH JOURNAL OF CANCER, Vol. 9. https://doi.org/10.1038/s41416-024-02844-y

Overchuk, M., Rickard, B. P., Tulino, J., Tan, X., Ligler, F. S., Huang, H.-C., & Rizvi, I. (2024, June 7). Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance. PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 6. https://doi.org/10.1111/php.13967

Ruhi, M. K., Rickard, B. P., Overchuk, M., Sinawang, P. D., Stanley, E., Mansi, M., … Rizvi, I. (2024, August 27). PpIX-enabled fluorescence-based detection and photodynamic priming of platinum-resistant ovarian cancer cells under fluid shear stress. PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 8. https://doi.org/10.1111/php.14014

Overchuk, M., Ruhi, M. K., Rickard, B., Ligler, F., & Rizvi, I. (2023). Development of a light emitting device for the treatment of peritoneal car- cinomatosis of ovarian origin by intracavitary photodynamic therapy. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 41. https://doi.org/10.1016/j.pdpdt.2023.103406

Rickard, B. P., Overchuk, M., Tulino, J., Tan, X., Ligler, F. S., Bae-Jump, V. L., … Rizvi, I. (2023). Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines. Environmental Health, 22(1). https://doi.org/10.1186/s12940-023-01034-2

Rickard, B. P., Overchuk, M., Chappell, V. A., Kemal Ruhi, M., Sinawang, P. D., Nguyen Hoang, T. T., … Rizvi, I. (2023). Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer. Cancers, 15(9), 2564. https://doi.org/10.3390/cancers15092564

Overchuk, M., Ruhi, M. K., Rickard, B., Ligler, F., & Rizvi, I. (2023). Targeted PDT Combinations to Overcome Fluid Shear Stress-induced Plat- inum Resistance in Ovarian Cancer. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 41. https://doi.org/10.1016/j.pdpdt.2023.103405

Sorrin, A. J., Zhou, K., May, K., Liu, C., McNaughton, K., Rahman, I., … Huang, H.-C. (2023). Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy. ISCIENCE, 26(8). https://doi.org/10.1016/j.isci.2023.107221

Kessel, D., Obaid, G., & Rizvi, I. (2022). Critical PDT theory II: Current concepts and indications. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 39. https://doi.org/10.1016/j.pdpdt.2022.102923

Conrad, C., Moore, K., Polacheck, W., Rizvi, I., & Scarcelli, G. (2022). Mechanical Modulation of Ovarian Cancer Tumor Nodules Under Flow. IEEE Transactions on Biomedical Engineering, 69(1), 294–301. https://doi.org/10.1109/TBME.2021.3092641

Rickard, B. P., Rizvi, I., & Fenton, S. E. (2022). Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease. Toxicology, 465, 153031. https://doi.org/10.1016/j.tox.2021.153031

Rickard, B. P., Overchuk, M., Obaid, G., Ruhi, M. K., Demirci, U., Fenton, S. E., … Rizvi, I. (2022). Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer<sup>†. Photochemistry and Photobiology, 99(2), 448–468. https://doi.org/10.1111/php.13723

Rickard, B. P., Tan, X., Fenton, S. E., & Rizvi, I. (2022). Photodynamic Priming Overcomes Per‐ and Polyfluoroalkyl Substance (<scp>PFAS. Photochemistry and Photobiology, 99(2), 793–813. https://doi.org/10.1111/php.13728

Karimnia, V., Stanley, M. E., Fitzgerald, C. T., Rizvi, I., Slack, F. J., & Celli, J. P. (2022, August 3). Photodynamic Stromal Depletion Enhances Therapeutic Nanoparticle Delivery in 3D Pancreatic Ductal Adenocarcinoma Tumor Models. PHOTOCHEMISTRY AND PHOTOBIOLOGY, Vol. 8. https://doi.org/10.1111/php.13663

Rickard, B. P., Tan, X., Fenton, S. E., & Rizvi, I. (2022). Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines. International Journal of Molecular Sciences, 23(9), 5176. https://doi.org/10.3390/ijms23095176

Conrad, C., Conway, J., Polacheck, W. J., Rizvi, I., & Scarcelli, G. (2022). Water transport regulates nucleus volume, cell density, Young's modulus, and E-cadherin expression in tumor spheroids. European Journal of Cell Biology. https://doi.org/10.1016/j.ejcb.2022.151278

Soto, F., Guimaraes, C. F., Reis, R. L., Franco, W., Rizvi, I., & Demirci, U. (2021). Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models. CANCER LETTERS, 504, 116–124. https://doi.org/10.1016/j.canlet.2021.01.023

Rickard, B. P., Conrad, C., Sorrin, A. J., Ruhi, M. K., Reader, J. C., Huang, S. A., … Rizvi, I. (2021). [Review of Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response]. CANCERS, 13(17). https://doi.org/10.3390/cancers13174318

Karimnia, V., Rizvi, I., Slack, F. J., & Celli, J. P. (2021). Photodestruction of Stromal Fibroblasts Enhances Tumor Response to PDT in 3D Pancreatic Cancer Coculture Models. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 97(2), 416–426. https://doi.org/10.1111/php.13339

Broekgaarden, M., Alkhateeb, A., Bano, S., Bulin, A.-L., Obaid, G., Rizvi, I., & Hasan, T. (2020). Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. Cancers. https://doi.org/10.3390/cancers12061401

Kercher, E. M., Nath, S., Rizvi, I., & Spring, B. Q. (2020). Cancer Cell‐targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Photochemistry and Photobiology. https://doi.org/10.1111/php.13153

Nath, S., Pigula, M., Khan, A. P., Hanna, W., Ruhi, M. K., Dehkordy, F. M. P., … Rizvi, I. (2020). Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress. Journal of Clinical Medicine. https://doi.org/10.3390/jcm9040924

Sorrin, A. J., Ruhi, M. K., Ferlic, N. A., Karimnia, V., Polacheck, W. J., Celli, J. P., … Rizvi, I. (2020). Photodynamic Therapy and the Biophysics of the Tumor Microenvironment. Photochemistry and Photobiology. https://doi.org/10.1111/php.13209

Anbil, S., Pigula, M., Huang, H.-C., Mallidi, S., Broekgaarden, M., Baglo, Y., … Hasan, T. (2020). Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy. MOLECULAR CANCER THERAPEUTICS, 19(6), 1308–1319. https://doi.org/10.1158/1535-7163.MCT-19-0791

Rizvi, I., Nath, S., Obaid, G., Ruhi, M. K., Moore, K., Bano, S., … Hasan, T. (2019). A Combination of Visudyne and a Lipid‐anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Photochemistry and Photobiology. https://doi.org/10.1111/php.13066

Spring, B. Q., Lang, R. T., Kercher, E. M., Rizvi, I., Wenham, R. M., Conejo-Garcia, J. R., … Enderling, H. (2019). Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies. FRONTIERS IN PHYSICS, 7. https://doi.org/10.3389/fphy.2019.00046

Conrad, C., Gray, K. M., Stroka, K. M., Rizvi, I., & Scarcelli, G. (2019). Mechanical Characterization of 3D Ovarian Cancer Nodules Using Brillouin Confocal Microscopy. CELLULAR AND MOLECULAR BIOENGINEERING, 12(3), 215–226. https://doi.org/10.1007/s12195-019-00570-7

Broekgaarden, M., Rizvi, I., Bulin, A.-L., Petrovic, L., Goldschmidt, R., Massodi, I., … Hasan, T. (2018). Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget. https://doi.org/10.18632/oncotarget.24425

Rizvi, I., Obaid, G., Bano, S., Hasan, T., & Kessel, D. (2018). Photodynamic therapy: Promoting in vitro efficacy of photodynamic therapy by liposomal formulations of a photosensitizing agent. Lasers in Surgery and Medicine. https://doi.org/10.1002/lsm.22813

Huang, H. C., Liu, J., Baglo, Y., Rizvi, I., Anbil, S., Pigula, M., & Hasan, T. (2017). Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.mct-17-0568

Huang, H. C., Rizvi, I., Liu, J., Anbil, S., Kalra, A., Lee, H., … Hasan, T. (2017). Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery. Cancer Research. https://doi.org/10.1158/0008-5472.can-17-1700

Mallidi, S., Mai, Z., Rizvi, I., Hempstead, J., Arnason, S., Celli, J., & Hasan, T. (2015). In vivo evaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints. Journal of Biomedical Optics. https://doi.org/10.1117/1.jbo.20.4.048003

Hempstead, J., Jones, D. P., Ziouche, A., Cramer, G. M., Rizvi, I., Arnason, S., … Celli, J. P. (2015). Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models. Scientific Reports. https://doi.org/10.1038/srep10093

Huang, H. C., Mallidi, S., Liu, J., Chiang, C.-T., Mai, Z., Goldschmidt, R., … Hasan, T. (2015). Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer. Cancer Research. https://doi.org/10.1158/0008-5472.can-15-0391

Spring, B. Q., Rizvi, I., Xu, N., & Hasan, T. (2015). The role of photodynamic therapy in overcoming cancer drug resistance. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology. https://doi.org/10.1039/c4pp00495g

Ghogare, A. A., Rizvi, I., Hasan, T., & Greer, A. (2014). "Pointsource" delivery of a photosensitizer drug and singlet oxygen: eradication of glioma cells in vitro. Photochemistry and Photobiology. https://doi.org/10.1111/php.12274

Celli, J. P., Rizvi, I., Blanden, A. R., Massodi, I., Pogue, B. W., & Hasan, T. (2014). An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Scientific Reports. https://doi.org/10.1038/srep03751

Spring, B. Q., Abu-Yousif, A. O., Palanisami, A., Rizvi, I., Zheng, X., Mai, Z., … Hasan, T. (2014). Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1319493111

Rizvi, I., Gurkan, U. A., Tasoglu, S., Alagic, N., Celli, J. P., Mensah, L. B., … Hasan, T. (2013). Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proceedings of the National Academy of Sciences of the United States of America, 110(22), E1974–E1983. https://doi.org/10.1073/pnas.1216989110

Anbil, S., Rizvi, I., Celli, J. P., Alagic, N., Pogue, B. W., & Hasan, T. (2013). Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer. Journal of Biomedical Optics, 18(9), 098004. https://doi.org/10.1117/1.jbo.18.9.098004

Rizvi, I., Anbil, S., Alagic, N., Celli, J. P., Zheng, L. Z., Palanisami, A., … Hasan, T. (2013). PDT dose parameters impact tumoricidal durability and cell death pathways in a 3D ovarian cancer model. Photochemistry and Photobiology, 89(4), 942–952. https://doi.org/10.1111/php.12065

Glidden, M. D., Celli, J. P., Massodi, I., Rizvi, I., Pogue, B. W., & Hasan, T. (2012). Image-Based Quantification of Benzoporphyrin Derivative Uptake, Localization, and Photobleaching in 3D Tumor Models, for Optimization of PDT Parameters. Theranostics, 2(9), 827–839. https://doi.org/10.7150/thno.4334

Rizvi, I., Dinh, T. A., Yu, W., Chang, Y., Sherwood, M. E., & Hasan, T. (2012). Photoimmunotherapy and Irradiance Modulation Reduce Chemotherapy Cycles and Toxicity in a Murine Model for Ovarian Carcinomatosis: Perspective and Results. Israel Journal of Chemistry, 52(8-9), 776–787. https://doi.org/10.1002/ijch.201200016

Xu, F., Celli, J., Rizvi, I., Moon, S., Hasan, T., & Demirci, U. (2011). A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnology Journal, 6(2), 204–212. https://doi.org/10.1002/biot.201000340

Evans, C. L., Abu-Yousif, A. O., Park, Y. J., Klein, O. J., Celli, J. P., Rizvi, I., … Hasan, T. (2011). Killing hypoxic cell populations in a 3D tumor model with EtNBS-PDT. PloS One, 6(8). https://doi.org/10.1371/journal.pone.0023434

Samkoe, K. S., Chen, A., Rizvi, I., OHara, J. A., Hoopes, P. J., Pereira, S. P., … Pogue, B. W. (2010). Imaging Tumor Variation in Response to Photodynamic Therapy in Pancreatic Cancer Xenograft Models. International Journal of Radiation Oncology Biology Physics, 76(1), 251–259. https://doi.org/10.1016/j.ijrobp.2009.08.041

Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., … Hasan, T. (2010). Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization. Chemical Reviews, 110(5), 2795–2838. https://doi.org/10.1021/cr900300p

Rahmanzadeh, R., Rai, P., Celli, J. P., Rizvi, I., Baron-Luehr, B., Gerdes, J., & Hasan, T. (2010). Ki-67 as a Molecular Target for Therapy in an In vitro Three-Dimensional Model for Ovarian Cancer. Cancer Research, 70(22), 9234–9242. https://doi.org/10.1158/0008-5472.can-10-1190

Celli, J. P., Rizvi, I., Evans, C. L., Abu-Yousif, A. O., & Hasan, T. (2010). Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model. Journal of Biomedical Optics, 15(5). https://doi.org/10.1117/1.3483903

Rizvi, I., Celli, J. P., Evans, C. L., Abu-Yousif, A. O., Muzikansky, A., Pogue, B. W., … Hasan, T. (2010). Synergistic Enhancement of Carboplatin Efficacy with Photodynamic Therapy in a Three-Dimensional Model for Micrometastatic Ovarian Cancer. Cancer Research, 70(22), 9319–9328. https://doi.org/10.1158/0008-5472.can-10-1783

Evans, C. L., Rizvi, I., Hasan, T., & Boer, J. F. (2009). In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging. Optics Express, 17(11), 8892–8906.

Zhong, W., Celli, J. P., Rizvi, I., Mai, Z., Spring, B. Q., Yun, S. H., & Hasan, T. (2009). In vivo high-resolution fluorescence microendoscopy for ovarian cancer detection and treatment monitoring. British Journal of Cancer, 101, 2015–2022. https://doi.org/10.1038/sj.bjc.6605436
10.1038/sj.bjc.6605436. Epub 2009 Nov 17.

Abu-Yousif, A. O., Rizvi, I., Evans, C. L., Celli, J. P., & Hasan, T. (2009). PuraMatrix encapsulation of cancer cells. Journal of Visualized Experiments : JoVE, (34). https://doi.org/10.3791/1692

Chang, S. K., Rizvi, I., Solban, N., & Hasan, T. (2008). In vivo optical molecular imaging of vascular endothelial growth factor for monitoring cancer treatment. Clinical Cancer Research, 14(13), 4146–4153. https://doi.org/10.1158/1078-0432.ccr-07-4536

Laubach, H.-J., Chang, S. K., Lee, S., Rizvi, I., Zurakowski, D., Davis, S. J., … Hasan, T. (2008). In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy. Journal of Biomedical Optics, 13(5). https://doi.org/10.1117/1.2981813

Kosharskyy, B., Solban, N., Chang, S. K., Rizvi, I., Chang, Y. C., & Hasan, T. (2006). A mechanism-based combination therapy reduces local tumor growth and metastasis in an orthotopic model of prostate cancer. Cancer Research, 66(22), 10953–10958. https://doi.org/10.1158/0008-5472.can-06-1793

Chang, S., Rizvi, I., Solban, N., & Hasan, T. (2006). In vivo Imaging of VEGF Expression for Monitoring Molecular Response to Cancer Therapy. Biomedical Optics, TuC4. https://doi.org/10.1364/bio.2006.tuc4

Solban, N., Rizvi, I., & Hasan, T. (2006). Targeted photodynamic therapy. Lasers in Surgery and Medicine, 38(5), 522–531. https://doi.org/10.1002/lsm.20345

Shah, S., Islam, N., Dakshanamurthy, S., Rizvi, I., Rao, M., Herrell, R., … Byers, S. W. (2006). The Molecular Basis of Vitamin D Receptor and β-Catenin Crossregulation. Molecular Cell, 21(6), 799–809. https://doi.org/10.1016/j.molcel.2006.01.037

Yelin, D., Rizvi, I., White, W. M., Motz, J. T., Hasan, T., Bouma, B. E., & Tearney, G. J. (2006). Three-dimensional miniature endoscopy. Nature, 443, 765. https://doi.org/10.1038/443765a

Carmen, M. G., Rizvi, I., Chang, Y. C., Moor, A. C. E., Oliva, E., Sherwood, M., … Hasan, T. (2005). Synergism of epidermal growth factor receptor-targeted immunotherapy with photodynamic treatment of ovarian cancer in vivo. Journal of the National Cancer Institute, 97(20), 1516–1524. https://doi.org/10.1093/jnci/dji314

Hamblin, M. R., Miller, J. L., Rizvi, I., Loew, H. G., & Hasan, T. (2003). Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacy. British Journal of Cancer, 89, 937–943. https://doi.org/10.1038/sj.bjc.6601210

Hamblin, M. R., Miller, J. L., Rizvi, I., & Ortel, B. (2002). Degree of substitution of chlorin e(6) on charged poly- L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells. Journal of X-Ray Science and Technology, 10(3-4), 139–152.

Hamblin, M. R., Miller, J. L., Rizvi, I., Ortel, B., Maytin, E. V., & Hasan, T. (2001). Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer. Cancer Research, 61, 7155–7162.

Hamblin, M. R., Del Governatore, M., Rizvi, I., & Hasan, T. (2000). Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer. British Journal of Cancer, 83, 1544–1551. https://doi.org/10.1054/bjoc.2000.1486

Del Governatore, M., Hamblin, M. R., Shea, C. R., Rizvi, I., Molpus, K. G., Tanabe, K. K., & Hasan, T. (2000). Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate. Cancer Research, 60, 4200–4205.

Molpus, K. L., Hamblin, M. R., Rizvi, I., & Hasan, T. (2000). Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates. Gynecologic Oncology, 76, 397–404. https://doi.org/10.1006/gyno.1999.5705

Hamblin, M. R., Miller, J. L., Rizvi, I., & Hasan, T. (1997). Pegylated poly-L-lysine chlorin-e6 conjugates as photosensitizers. Photochemistry and Photobiology, 65(SPEC. ISSUE), 8S.