Janice A Dye

Works (10)

Updated: April 5th, 2024 05:45

2008 journal article

A Hyperlipidemic Rabbit Model Provides New Insights into Pulmonary Zinc Exposure Effects on Cardiovascular Health

CARDIOVASCULAR TOXICOLOGY, 8(4), 195–206.

By: A. LaGier*, N. Manzo n, A. Carll, R. Jaskot*, R. Slade*, J. Richards*, D. Winsett*, A. Farraj*, J. Dye*

author keywords: Zinc; Rabbit; Cardiovascular; Particulate matter; Hyperlipidemia
MeSH headings : Acetylglucosaminidase / analysis; Animals; Atherosclerosis / chemically induced; Atherosclerosis / metabolism; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Cholesterol / blood; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Disulfide / analysis; Heart Rate / drug effects; Heart Rate / physiology; Hyperlipidemias / chemically induced; Hyperlipidemias / metabolism; Inhalation Exposure; Intubation, Intratracheal; Leukocyte Count; Lung / drug effects; Lung / metabolism; Male; Nitrites / blood; Particulate Matter / toxicity; Rabbits; Zinc Oxide / toxicity; Zinc Sulfate / toxicity
TL;DR: The study elucidates mechanisms by which the zinc metal component of PM drives cardiovascular health effects, as well as the possible susceptibility induced by hyperlipidemia, and exemplifies the benefits of monitoring circulatory physiology during exposure as to after exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism

TOXICOLOGY AND APPLIED PHARMACOLOGY, 163(3), 221–230.

By: N. Jiang n, K. Dreher*, J. Dye*, Y. Li n, J. Richards*, L. Martin n, K. Adler n

author keywords: mucin; cytotoxicity; residual oil fly ash; oxidant
MeSH headings : Animals; Antioxidants / pharmacology; Carbon / toxicity; Cell Survival / drug effects; Cells, Cultured; Coal Ash; Dust / adverse effects; Epithelial Cells / drug effects; Gene Expression / drug effects; Guinea Pigs; Industrial Waste; Metals / toxicity; Mucins / biosynthesis; Mucins / genetics; Mucins / metabolism; Oxidants / pharmacology; Particulate Matter; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Trachea / cytology; Trachea / drug effects; Trachea / metabolism
TL;DR: ROFA enhances mucin secretion and generates toxicity in vitro to airway epithelium via a mechanism(s) involving generation of oxidant stress, perhaps related to depletion of cellular antioxidant capacity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 277(3), L498–L510.

By: J. Dye*, K. Adler n, J. Richards* & K. Dreher*

author keywords: particulate matter; airway epithelial cells; gene induction; oxidative stress
MeSH headings : Animals; Carbon / pharmacology; Cell Survival / drug effects; Cells, Cultured; Chemokine CXCL2; Coal Ash; Cytokines / genetics; Epithelial Cells / drug effects; Epithelial Cells / physiology; Gene Expression / drug effects; Interleukin-6 / genetics; Male; Metals / pharmacology; Monokines / genetics; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type II; Particulate Matter; Rats; Rats, Sprague-Dawley; Solubility; Trachea / drug effects; Trachea / pathology; Trachea / physiopathology
TL;DR: Generation of an oxidative stress was critical to induction of the ROFA- or vanadium-induced effects on airway epithelial gene expression, cytokine production, and cytotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 article

Exposure of differentiated rodent airway epithelial cells in vitro to particles of residual fly ash (ROFA) induces cytotoxicity and generation of reactive oxygen species.

Proceedings of the 10th International Colloquium on Lung Fibrosis, Vol. 10, p. 26.

By: K. Adler, N. Jiang, J. Dye & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Particles of Residual Oil Fly Ash (ROFA) induce toxicity and mucin hypersecretion in rodent airway epithelial cells in vitro via an oxidant-mediated mechanism.

Toxicology Letters, Vol. 95, p. 224.

By: K. Adler*, N. Jiang, J. Dye* & K. Dreher*

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Vanadium content and related oxidative stress appear to determine airway epithelial cell responses to emission source particulate matter.

FASEB Journal, Vol. 12, p. A337.

By: J. Dye, K. Adler, L. Rochelle & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1997 article

Airway epithelial cell responses to fly ash (ROFA) particles: contribution of soluble transition metals.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A197.

By: J. Dye, K. Adler, J. Richards & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Injury of rat tracheal epithelial cultures by exposure to residual oil fly ash (ROFA) involves generation of the hydroxyl radical.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A542.

By: J. Dye, K. Adler, J. Richards & K. Dreher

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Role or reactive oxygen and nitrogen species in the response of airway epithelium to particulates.

Proceedings of the 6th International Meeting of the Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles., Vol. 6, p. 139.

By: K. Adler, T. Krunkosky, B. Fischer, L. Rochelle, L. Martin, K. Dreher, N. Jiang, J. Dye

Source: NC State University Libraries
Added: August 6, 2018

1994 journal article

Effects of cigarette smoke on epithelial cells of the respiratory tract.

404nOtfound, 49, 825–834.

By: J. Dye n & K. Adler n

MeSH headings : Epithelium / metabolism; Epithelium / pathology; Humans; Mucociliary Clearance / physiology; Respiratory System / metabolism; Respiratory System / pathology; Smoking / adverse effects
TL;DR: Early events in the response to cigarette smoke or its components may be critical, and certainly an understanding of these events may help to elucidate the pathogenetic mechanisms of many chronic respiratory diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

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