Joyce Allene Goldstein
Works (9)
Updated: July 5th, 2023 16:03
2002 journal article
In vitro human metabolism and interactions of repellent N,N-diethyl-M-toluamide
DRUG METABOLISM AND DISPOSITION, 30(3), 289–294.
MeSH headings : Animals; Biotransformation; Chlorpyrifos / metabolism; Chlorpyrifos / pharmacology; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DEET / analogs & derivatives; DEET / metabolism; DEET / pharmacokinetics; Drug Interactions; Enzyme Induction / drug effects; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Female; Humans; In Vitro Techniques; Insect Repellents / metabolism; Insect Repellents / pharmacokinetics; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Oxidation-Reduction; Permethrin / metabolism; Permethrin / pharmacology; Pyridostigmine Bromide / metabolism; Pyridostigmine Bromide / pharmacology; Rats; Rats, Long-Evans; Spectrometry, Fluorescence
TL;DR:
Use of phenotyped HLMs demonstrated that individuals with high levels of CYP2B6, 3A4, 2C19, and 2A6 have the greatest potential to metabolize DEET.
(via Semantic Scholar)
dmd.aspetjournals.org (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
Journal of Pharmacology and Experimental Therapeutics, 299(3), 825–831.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Cloning of canine cytochrome P450 2E1 CDNA: identification and characterization of two variant alleles
Drug Metabolism and Disposition, 28(8), 981–986.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 13(6), 289–295.
author keywords: CYP2C8 gene structure; human CYP2C mRNA expression; extrahepatic tissues
TL;DR:
Extrahepatic tissue distribution of the mRNAs for the four human CYP2Cs was examined in kidney, testes, adrenal gland, prostate, brain, uterus, mammary gland, ovary, lung, and duodenum, finding neither a barbiturate‐responsive regulatory sequence nor a phenobarbital‐responsive enhancer module (PBREM) was found within the upstream region analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Behavioral response of Podisus maculiventris (Hemiptera : Pentatomidae) to its synthetic pheromone
JOURNAL OF ENTOMOLOGICAL SCIENCE, 33(1), 72–81.
author keywords: Podisus maculiventris; pheromone; anemotaxis; wind tunnel; behavior
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 357(1), 45–57.
author keywords: cytochrome P450; CYP2Cs; mouse; cDNA cloning; cDNA expression; arachidonic acid metabolism; liver; extrahepatic; mRNA expression
MeSH headings : Amino Acid Sequence; Animals; Arachidonic Acid / metabolism; Aryl Hydrocarbon Hydroxylases; Base Sequence; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Enzyme Activation; Female; Humans; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Male; Mice; Microsomes, Liver / enzymology; Molecular Sequence Data; Organ Specificity / genetics; Polymerase Chain Reaction; RNA, Messenger / biosynthesis; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / biosynthesis; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism
TL;DR:
Five murine cytochrome P450 (CYP) 2C cDNAs were cloned and characterized, including four new members of this subfamily, and the presence of CYP2C29 mRNA in liver as well as in extrahepatic tissues including brain, kidney, lung, heart, and intestine was demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 357(2), 240–248.
author keywords: cytochrome P450; CYP2C9; CYP2C19; site-directed mutagenesis; cDNA expression system; diclofenac; ibuprofen; tolbutamide; sulfaphenazole; substrate binding sites
MeSH headings : Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Diclofenac / metabolism; Enzyme Activation / drug effects; Enzyme Activation / genetics; Escherichia coli / genetics; Humans; Hydroxylation; Ibuprofen / metabolism; Mixed Function Oxygenases / genetics; Mutagenesis, Site-Directed; Protein Binding / drug effects; Protein Binding / genetics; Recombinant Fusion Proteins / genetics; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / antagonists & inhibitors; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism; Substrate Specificity / genetics; Tolbutamide / metabolism
TL;DR:
R residues 286 and 289 of CYP2C9 are important in conferring specificity for diclofenac and ibuprofen and tolbutamide activity was inhibited by a specific CYP1C9 inhibitor, sulfaphenazole.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Isolation of a new canine cytochrome P450 cDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression
Drug Metabolism and Disposition, 26(3), 278–283.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
The role of the CYP2C9-Leu(359) allelic variant in the tolbutamide polymorphism
PHARMACOGENETICS, 6(4), 341–349.
author keywords: CYP2C9; tolbutamide; polymorphism
MeSH headings : Alleles; Aryl Hydrocarbon Hydroxylases; Asian People / genetics; Black People / genetics; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Heterozygote; Homozygote; Humans; Leucine / genetics; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases / genetics; Steroid Hydroxylases / metabolism; Tolbutamide / metabolism; White People / genetics
TL;DR:
The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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