Jeremy A. Leonard

Works (4)

Updated: July 5th, 2023 15:42

2017 journal article

Extending the toxicity-testing paradigm for freshwater mussels: Assessing chronic reproductive effects of the synthetic estrogen 17 alpha-ethinylestradiol on the unionid mussel Elliptio complanata

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 191, 14–25.

By: J. Leonard n, W. Cope  n, E. Hammer*, M. Barnhart* & R. Bringolf*

author keywords: carbohydrate; Elliptio complanata; ethinylestradiol; glochidia; lipid; protein; Unionid; vitellogenin
MeSH headings : Alkaline Phosphatase / metabolism; Animals; Behavior, Animal / drug effects; Biomarkers / metabolism; Carbohydrate Metabolism / drug effects; Ethinyl Estradiol / toxicity; Female; Gonads / drug effects; Gonads / metabolism; Hemolymph / metabolism; Larva / drug effects; Larva / metabolism; Lipid Metabolism / drug effects; Male; Reproduction / drug effects; Seasons; Sex Factors; Time Factors; Toxicity Tests, Chronic; Unionidae / drug effects; Unionidae / embryology; Unionidae / metabolism; Vitellogenins / metabolism; Water Pollutants, Chemical / toxicity
TL;DR: Results indicate that the 180 d test approach, concurrent with the sequence of 28 d tests, enabled a more robust evaluation of mussel behavior and physiology than would have been possible with a single short-term (28 d) test. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Assessing toxicity of contaminants in riverine suspended sediments to freshwater mussels

Environmental Toxicology and Chemistry, 36(2), 395–407.

By: J. Archambault n, C. Bergeron n, W. Cope  n, P. Lazaro n, J. Leonard n & D. Shea n 

Contributors: J. Archambault n, C. Bergeron n, W. Cope n , P. Lazaro n, J. Leonard n & D. Shea n 

author keywords: Unionoida; Water quality; Ammonia; Metal; Polycyclic aromatic hydrocarbon
MeSH headings : Agriculture; Ammonia / analysis; Ammonia / toxicity; Animals; Environmental Monitoring / methods; Geologic Sediments / analysis; Geologic Sediments / chemistry; Metals, Heavy / analysis; Metals, Heavy / toxicity; Mining; Polycyclic Aromatic Hydrocarbons / analysis; Polycyclic Aromatic Hydrocarbons / toxicity; Rivers / chemistry; Tennessee; Unionidae / drug effects; Virginia; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR: It is found that sediments collected with sediment traps over relatively short deployment durations can help elucidate recent contaminant influx and its potential for inducing toxicity in benthic organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Metabolomic, behavioral, and reproductive effects of the aromatase inhibitor fadrozole hydrochloride on the unionid mussel Lampsilis fasciola

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 206, 213–226.

By: J. Leonard n, W. Cope  n, M. Barnhart* & R. Bringolf*

author keywords: Glochidia; Bivalve; Metabolomics; Aromatase inhibitor; Unionid
MeSH headings : Animals; Aromatase Inhibitors / pharmacology; Behavior, Animal / drug effects; Fadrozole / pharmacology; Female; Larva / drug effects; Male; Metabolome / drug effects; Reproduction / drug effects; Unionidae / drug effects; Unionidae / physiology
TL;DR: Both sexes revealed significant reductions in fadrozole-induced metabolic effects in gill tissue sampled after 12 Days, indicating time-dependent mechanisms of disruptions in metabolic pathways and homeostatic processes to compensate for such disruptions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Metabolomic, behavioral, and reproductive effects of the synthetic estrogen 17 alpha-ethinylestradiol on the unionid mussel Lampsilis fasciola

AQUATIC TOXICOLOGY, 150, 103–116.

By: J. Leonard n, W. Cope  n, M. Barnhart* & R. Bringolf*

author keywords: Endocrine disruption; Bivalve; Sublethal; Glochidia; Osmoregulation
MeSH headings : Animals; Behavior, Animal / drug effects; Bivalvia / drug effects; Ethinyl Estradiol / toxicity; Female; Male; Metabolome / drug effects; Reproduction / drug effects; Water Pollutants, Chemical / toxicity
TL;DR: The utility of metabolomics when used in conjunction with traditional physiological and behavioral toxicity test endpoints is demonstrated and the usefulness of this approach is established in determining possible underlying toxicological mechanisms of EE2 in exposed freshwater mussels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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