@article{nakanishi_lascelles_allen_case_gearing_enomoto_2022, title={A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain}, volume={9}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2022.836709}, abstractNote={Tumor necrosis factor-α (TNF-α) is a potential target for osteoarthritis (OA) treatment. In several recent clinical studies in human OA, anti-TNF-α therapy showed promising results; however, these were open-label and based on patient-reported outcome measures. In this study, we developed a caninized TNF-α receptor-Fc (caTNFR-Fc) fusion protein and conducted a non-randomized, open-label, pilot study in dogs with OA using objectively measured ground reaction forces and activity. The aims of the study were to assess the efficacy of the intra-articular (IA) injection of the caTNFR-Fc fusion protein as a treatment for OA pain, and additionally to evaluate TNF concentrations in synovial fluid (SF) between joints with/without OA in dogs. Dogs (n = 12) with single-limb lameness due to single joint appendicular OA were recruited. All dogs received caTNFR-Fc fusion protein injection into the affected joint under sedation. Objective kinetic gait analysis using force plate was performed prior to (baseline), and at 14- and 28-days following treatment. Additionally, SF samples were collected from OA joints (n = 69) and non-OA joints (n = 79) in a different cohort of dogs and TNF-α were measured using enzyme-linked immunosorbent assay. No significant treatment effects on the limb use, activity, and the questionnaire were found. The concentration of TNF-α was significantly higher in OA joints than in healthy joints (p = 0.0019), but TNF-α was detected in only 10/69 OA samples. The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study. Although the SF concentration of TNF-α was significantly higher in OA joints, few OA joints had measurable TNF-α. Collectively, the data indicate TNF-α may not be a good therapeutic target in canine OA.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Nakanishi, Aoi and Lascelles, B. Duncan X. and Allen, Julie and Case, Beth and Gearing, David and Enomoto, Masataka}, year={2022}, month={Jun} }
 @article{schreeg_evans_allen_lewis_luckring_evola_richard_piner_thompson_adin_et al._2019, title={Cardiac Leiomyosarcoma in a Cat Presenting for Bilateral Renal Neoplasia}, volume={168}, ISSN={["1532-3129"]}, DOI={10.1016/j.jcpa.2019.02.005}, abstractNote={A 10-year-old neutered female domestic longhair cat was presented to a tertiary care veterinary hospital for evaluation of a right renal mass that was identified incidentally on abdominal radiographs and classified further as a sarcoma based on fine needle aspiration cytology. Further diagnostic workup, including ultrasound and cytology, identified a sarcoma in the left kidney. After approximately 1 month of conservative medical management, the clinical condition deteriorated and the cat was humanely destroyed. Post-mortem examination confirmed bilateral renal masses with multifocal infarction and extensive necrosis, and further identified a large mass at the apex of the heart as well as multiple pulmonary nodules. Microscopical examination of the masses identified a population of poorly-differentiated neoplastic spindle cells, consistent with sarcoma. Immunohistochemically, the neoplastic cells expressed smooth muscle actin and muscle-specific actin, but were negative for myoglobin and factor VIII. Phosphotungstic acid–haematoxylin staining was unable to identify cross-striations in the neoplastic cells. Based on these results and the pattern of lesion distribution, the cat was diagnosed with cardiac leiomyosarcoma with pulmonary and bilateral renal metastasis.}, journal={JOURNAL OF COMPARATIVE PATHOLOGY}, author={Schreeg, M. E. and Evans, B. J. and Allen, J. and Lewis, M. C. and Luckring, E. and Evola, M. and Richard, D. K. and Piner, K. and Thompson, E. M. and Adin, D. B. and et al.}, year={2019}, month={Apr}, pages={19–24} }
 @article{allen_hartley_neel_2018, title={What is your diagnosis? Splenic aspirate from a dog}, volume={47}, ISSN={["1939-165X"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85055144319&partnerID=MN8TOARS}, DOI={10.1111/vcp.12661}, abstractNote={Veterinary Clinical PathologyVolume 47, Issue 4 p. 674-675 WHAT IS YOUR DIAGNOSIS? What is your diagnosis? Splenic aspirate from a dog Julie Allen, Corresponding Author Julie Allen ja684@cornell.edu orcid.org/0000-0001-7167-0341 Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North Carolina Correspondence Julie Allen, Department of Population Health and Diagnostic Sciences, Cornell University, Ithaca, NY. Email: ja684@cornell.eduSearch for more papers by this authorAshley N. Hartley, Ashley N. Hartley Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorJennifer A. Neel, Jennifer A. Neel Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this author Julie Allen, Corresponding Author Julie Allen ja684@cornell.edu orcid.org/0000-0001-7167-0341 Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North Carolina Correspondence Julie Allen, Department of Population Health and Diagnostic Sciences, Cornell University, Ithaca, NY. Email: ja684@cornell.eduSearch for more papers by this authorAshley N. Hartley, Ashley N. Hartley Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorJennifer A. Neel, Jennifer A. Neel Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this author First published: 16 October 2018 https://doi.org/10.1111/vcp.12661Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume47, Issue4December 2018Pages 674-675 This article also appears in:What is your diagnosis? Virtual Issue RelatedInformation}, number={4}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Allen, Julie and Hartley, Ashley N. and Neel, Jennifer A.}, year={2018}, month={Dec}, pages={674–675} }
 @article{allen_talley_grindem_neel_2018, title={What is your diagnosis? Submandibular mass in a dog}, volume={47}, ISSN={["1939-165X"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85055524703&partnerID=MN8TOARS}, DOI={10.1111/vcp.12664}, abstractNote={Veterinary Clinical PathologyVolume 47, Issue 4 p. 676-678 WHAT IS YOUR DIAGNOSIS? What is your diagnosis? Submandibular mass in a dog Julie Allen, Corresponding Author Julie Allen ja684@cornell.edu orcid.org/0000-0001-7167-0341 Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North Carolina Correspondence J. Allen, Clinical Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY. Email: ja684@cornell.eduSearch for more papers by this authorAshley M. Talley, Ashley M. Talley Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorJennifer A. Neel, Jennifer A. Neel Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this author Julie Allen, Corresponding Author Julie Allen ja684@cornell.edu orcid.org/0000-0001-7167-0341 Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North Carolina Correspondence J. Allen, Clinical Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY. Email: ja684@cornell.eduSearch for more papers by this authorAshley M. Talley, Ashley M. Talley Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this authorJennifer A. Neel, Jennifer A. Neel Department of Population Health and Pathobiology, College of Veterinary Medicine, NC State University, Raleigh, North CarolinaSearch for more papers by this author First published: 22 October 2018 https://doi.org/10.1111/vcp.12664Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume47, Issue4December 2018Pages 676-678 This article also appears in:What is your diagnosis? Virtual Issue RelatedInformation}, number={4}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Allen, Julie and Talley, Ashley M. and Grindem, Carol B. and Neel, Jennifer A.}, year={2018}, month={Dec}, pages={676–678} }