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Works (9)
Updated: April 5th, 2024 17:10
2024 article
A novel <i>ITGA2B</i> double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat
Rivas, V. N., Tan, A. W. K., Shaverdian, M., Nguyen, N. P., Wouters, J. R., Stern, J. A., & Li, R. H. L. (2024, March 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.
author keywords: congenital; feline; glycoprotein IIb/IIIa; macrothrombocytopenia; precision medicine; thrombopathia
TL;DR:
This study provides a small-volume, standardized, successful protocol for adequate platelet RNA isolation and subsequent molecular assessment of gene expression in cats and identified yet another variant that may be of utility for screening in the feline population.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 8, 2024
2023 journal article
Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease
Scientific Reports, 13(1).
MeSH headings : Animals; Dogs; Arrhythmogenic Right Ventricular Dysplasia; Autoantibodies; Dog Diseases / metabolism; Heart Atria; Prospective Studies; Desmoglein 2 / immunology
TL;DR:
This prospective study is the first to evaluate dogs of various breeds and cardiac disease state for anti-desmoglein-2 antibodies and found correlation with some measures of disease severity requires further study with larger populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 26, 2023
2023 article
Exciting Advancements and Compelling Future Directions in Companion Animal Cardiology
Stern, J. A. (2023, November). VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, Vol. 53.
Source: Web Of Science
Added: March 4, 2024
2023 journal article
Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C
SCIENTIFIC REPORTS, 13(1).
Contributors: n, V. Rivas n , J. Kaplan *, Y. Ueda n , M. Oldach*, E. Ontiveros*, K. Kooiker *, S. Dijk*, S. Harris *
TL;DR:
The occurrence of a more severe phenotype in later generations of cats, and the occasional occurrence of HCM in wildtype cats suggests the presence of at least one gene modifier or a second causal variant in this research colony that exacerbates the HCM phenotype when inherited in combination with the A31P mutation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 18, 2023
2023 journal article
Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study
ANIMALS, 13(20).
author keywords: mTOR (mammalian/mechanistic target of rapamycin); transcriptomics (RNA sequencing); proteomics (LCMS); sirolimus; autophagy; cat; translational; large animal model
TL;DR:
Following repeated weekly dosing, transcriptomic differences between the low- and high-dose groups support dose-responsive suppressive effects on myocardial hypertrophy and stimulatory effects on autophagy, and rapamycin treatment continues to show great mechanistic promise in addressing the pathophysiologic features of HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 13, 2023
2023 article
No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response
Reimann, M. J., Faisst, D. N., Knold, M., Meurs, K. M., Stern, J. A., Cremer, S. E., … Olsen, L. H. (2023, September 24). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.
author keywords: dogs; genetic variation; heart disease; light transmission aggregometry; pharmacogenetics; platelet inhibition
TL;DR:
Dogs with the PDE5A:E90K polymorphism did not appear to have altered platelet function or response to pimobendan treatment, and did not influence in vitro basal platelet aggregation response or the inhibitory effect of pimOBendan on platelets aggregation in CKCS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 article
Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)
Rivas, V. N., Ueda, Y., & Stern, J. A. (2023, July 17). JOURNAL OF MEDICAL PRIMATOLOGY, Vol. 7.
author keywords: diastology; E/A; hemodynamics; HFpEF; IVRT; monkey
TL;DR:
Diastolic dysfunction in humans is an age‐related process with an overrepresentation in women, and in rhesus macaques (Macaca mulatta), the incidence and predictors have yet to be reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 21, 2023
2023 review
Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research
[Review of ]. CARDIOLOGY RESEARCH, 14(5), 319–333.
author keywords: Fixed subaortic stenosis; Discrete subaortic stenosis; Aortic valve; Left ventricular outflow tract; Congenital heart disease; Translational approach; Animal model
TL;DR:
Historical leaps in SAS research support a continued translational approach as the most promising method for achieving this goal, and canine SAS patients represent a critical translational model of human SAS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: November 20, 2023
2023 article
The Role of Personalized Medicine in Companion Animal Cardiology
Rivas, V. N., Stern, J. A., & Ueda, Y. (2023, November). VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, Vol. 53, pp. 1255–1276.
author keywords: Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy (DCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cats; Dogs; Pharmacogenetics; Pharmacogenomics; Genetics
TL;DR:
The need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 6, 2024
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