Joshua Aaron Stern
Also known as: Josh Stern; JA Stern; Joshua Aaron Stern
Genetics, Cardiology, Pharmacogenetics, Translational Medicine, Veterinary Medicine
Works (141)
Updated: October 8th, 2024 06:35
2024 article
A novel <i>ITGA2B</i> double cytosine frameshift variant (c.1986_1987insCC) leads to Glanzmann's thrombasthenia in a cat
Rivas, V. N., Tan, A. W. K., Shaverdian, M., Nguyen, N. P., Wouters, J. R., Stern, J. A., & Li, R. H. L. (2024, March 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 3.
author keywords: congenital; feline; glycoprotein IIb/IIIa; macrothrombocytopenia; precision medicine; thrombopathia
TL;DR:
This study provides a small-volume, standardized, successful protocol for adequate platelet RNA isolation and subsequent molecular assessment of gene expression in cats and identified yet another variant that may be of utility for screening in the feline population.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 8, 2024
2024 journal article
Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy
SCIENTIFIC REPORTS, 14(1).
author keywords: Pharmacodynamics; Left ventricular outflow tract obstruction (LVOTO); Obstructive hypertrophic cardiomyopathy (oHCM); Cat; Myosin-inhibitor
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 1, 2024
2024 journal article
Evaluation of clopidogrel response in healthy cats using a novel viscoelastic test and thromboelastography
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: clopidogrel resistance; arterial thromboembolic event (ATE); monitoring; light-transmission aggregometry; hypertrophic cardiomyopathy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 17, 2024
2024 article
Platelet hyperresponsiveness and increased platelet-neutrophil aggregates in dogs with myxomatous mitral valve disease and pulmonary hypertension
Duler, L., Visser, L., Nguyen, N., Johnson, L. R., Stern, J. A., & Li, R. H. L. (2024, May 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 5.
author keywords: clinical pathology; hematology; immunothrombosis; platelet function; pulmonary thromboembolism; respiratory tract; serotonin
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 1, 2024
2024 article
Training the next generation of veterinary academic leaders
Stern, J. A. (2024, August). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 85.
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 14, 2024
2023 journal article
A variant in the 5'UTR of ERBB4 is associated with lifespan in Golden Retrievers
GeroScience, 10.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2023 journal article
Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism
Journal of Veterinary Internal Medicine, 37(2), 490–502.
TL;DR:
Neutrophil extracellualr traps, especially citH3, are increased in cats with HCM and CATE and may serve as a novel therapeutic target and biomarker of thrombosis in catswith HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2023 journal article
Delayed-release rapamycin halts progression of left ventricular hypertrophy in subclinical feline hypertrophic results of the RAPACAT trial
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(11), 1628–1637.
Contributors: J. Kaplan *, V. Rivas n , A. Walker*, L. Grubb, A. Farrell, S. Fitzgerald, S. Kennedy, C. Pjauregui
author keywords: HCM; sirolimus; occult; cat; mTOR
TL;DR:
It is demonstrated that DR rapamycin was well tolerated and may prevent or delay progressive LV hypertrophy in cats with subclinical HCM and no demographic, echocardiographic, or clinicopathologic values were significantly different between study groups at baseline, confirming successful randomization.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 6, 2024
2023 journal article
Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy
Scientific Reports, 13(1), 32.
Contributors: A. Sharpe*, M. Oldach*, V. Rivas* , J. Kaplan *, A. Walker*, S. Kovacs, D. Hwee *, P. Cremin*
TL;DR:
Promising beneficial effects of reduced systolic function warrant further studies of this next-in-class therapeutic to evaluate the benefit of long-term administration in this patient population of HCM-affected patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 6, 2024
2023 journal article
Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease
Scientific Reports, 13(1).
MeSH headings : Animals; Dogs; Arrhythmogenic Right Ventricular Dysplasia; Autoantibodies; Dog Diseases / metabolism; Heart Atria; Prospective Studies; Desmoglein 2 / immunology
TL;DR:
This prospective study is the first to evaluate dogs of various breeds and cardiac disease state for anti-desmoglein-2 antibodies and found correlation with some measures of disease severity requires further study with larger populations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 26, 2023
2023 article
Exciting Advancements and Compelling Future Directions in Companion Animal Cardiology
Stern, J. A. (2023, November). VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, Vol. 53.
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 4, 2024
2023 journal article
Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C
SCIENTIFIC REPORTS, 13(1).
Contributors: * , V. Rivas* , J. Kaplan *, Y. Ueda n , M. Oldach, E. Ontiveros*, K. Kooiker *, S. Dijk *, S. Harris *
TL;DR:
The occurrence of a more severe phenotype in later generations of cats, and the occasional occurrence of HCM in wildtype cats suggests the presence of at least one gene modifier or a second causal variant in this research colony that exacerbates the HCM phenotype when inherited in combination with the A31P mutation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 18, 2023
2023 journal article
Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study
ANIMALS, 13(20).
author keywords: mTOR (mammalian/mechanistic target of rapamycin); transcriptomics (RNA sequencing); proteomics (LCMS); sirolimus; autophagy; cat; translational; large animal model
TL;DR:
Following repeated weekly dosing, transcriptomic differences between the low- and high-dose groups support dose-responsive suppressive effects on myocardial hypertrophy and stimulatory effects on autophagy, and rapamycin treatment continues to show great mechanistic promise in addressing the pathophysiologic features of HCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 13, 2023
2023 journal article
Naturally occurring canine laminopathy leading to a dilated and fibrosing cardiomyopathy in the Nova Scotia Duck Tolling Retriever
Scientific Reports, 13(1), 19077.
TL;DR:
Pedigree analysis in the NSDTR and functional evaluation of heterozygotes is consistent with a predominantly recessive mode of inheritance and possibly low penetrance in heterozygotes in contrast to people, where most pathogenic LMNA variants are dominantly inherited.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2023 article
No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan-induced inhibition of platelet aggregation response
Reimann, M. J., Faisst, D. N., Knold, M., Meurs, K. M., Stern, J. A., Cremer, S. E., … Olsen, L. H. (2023, September 24). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.
author keywords: dogs; genetic variation; heart disease; light transmission aggregometry; pharmacogenetics; platelet inhibition
TL;DR:
Dogs with the PDE5A:E90K polymorphism did not appear to have altered platelet function or response to pimobendan treatment, and did not influence in vitro basal platelet aggregation response or the inhibitory effect of pimOBendan on platelets aggregation in CKCS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 23, 2023
2023 journal article
Nonhuman primate genetic models for the study of rare diseases
Orphanet Journal of Rare Diseases, 18(1), 20.
Source: ORCID
Added: June 22, 2024
2023 article
Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)
Rivas, V. N., Ueda, Y., & Stern, J. A. (2023, July 17). JOURNAL OF MEDICAL PRIMATOLOGY, Vol. 7.
author keywords: diastology; E/A; hemodynamics; HFpEF; IVRT; monkey
TL;DR:
Diastolic dysfunction in humans is an age‐related process with an overrepresentation in women, and in rhesus macaques (Macaca mulatta), the incidence and predictors have yet to be reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 21, 2023
2023 review
Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research
[Review of ]. CARDIOLOGY RESEARCH, 14(5), 319–333.
author keywords: Fixed subaortic stenosis; Discrete subaortic stenosis; Aortic valve; Left ventricular outflow tract; Congenital heart disease; Translational approach; Animal model
TL;DR:
Historical leaps in SAS research support a continued translational approach as the most promising method for achieving this goal, and canine SAS patients represent a critical translational model of human SAS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 20, 2023
2023 journal article
Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet‐dependent thrombin generation in cats
Journal of Veterinary Internal Medicine, 37(4), 1390–1400.
TL;DR:
Treatment combining clopidogrel and rivaroxaban (DAT) safely decreases platelet activation, platelet response to agonists, and thrombin generation in feline platelets more effectively than monotherapy with either clopIDogrel or rivroxaban.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2023 journal article
The Genetics of Canine Pulmonary Valve Stenosis.
The Veterinary Clinics of North America. Small Animal Practice, 53(6), 1379—1391.
Source: ORCID
Added: June 22, 2024
2023 article
The Role of Personalized Medicine in Companion Animal Cardiology
Rivas, V. N., Stern, J. A., & Ueda, Y. (2023, November). VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, Vol. 53, pp. 1255–1276.
author keywords: Hypertrophic cardiomyopathy (HCM); Dilated cardiomyopathy (DCM); Arrhythmogenic right ventricular cardiomyopathy (ARVC); Cats; Dogs; Pharmacogenetics; Pharmacogenomics; Genetics
TL;DR:
The need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 6, 2024
2022 journal article
Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Administration, Oral; Adrenergic beta-2 Receptor Agonists / administration & dosage; Animals; Arrhythmias, Cardiac / diagnosis; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / physiopathology; Arrhythmias, Cardiac / veterinary; Asymptomatic Diseases; Cardiomyopathy, Hypertrophic / diagnosis; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / physiopathology; Cardiomyopathy, Hypertrophic / veterinary; Case-Control Studies; Cat Diseases / diagnosis; Cat Diseases / genetics; Cat Diseases / physiopathology; Cats; Electrocardiography, Ambulatory / veterinary; Female; Genetic Predisposition to Disease; Heart Rate; Male; Mutation; Phenotype; Predictive Value of Tests; Sex Factors; Terbutaline / administration & dosage; Time Factors
TL;DR:
This prospective study used AECG to evaluate ectopy and HRV in subclinical HCM cats compared to healthy controls and is the first to implement a pharmacologic cardiac stress test.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 14, 2022
2022 journal article
Canine cardiomyopathies.
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2022 journal article
Closure of a patent ductus arteriosus in a 2-week-old llama cria using an Amplatz canine duct occluder
The Canadian Veterinary Journal = La Revue Veterinaire Canadienne, 63(7), 706—710. https://europepmc.org/articles/PMC9207981
Source: ORCID
Added: June 22, 2024
2022 journal article
Effect of standard-dose and high-dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease
Journal of Veterinary Internal Medicine, 36(6), 1892—1899.
Source: ORCID
Added: June 22, 2024
2022 journal article
Evaluation of a Fluoroscopic Angiography Protocol in Hispaniolan Amazon Parrots (<i>Amazona ventralis</i>)
Journal of Avian Medicine and Surgery, 36(2), 178—186.
Source: ORCID
Added: June 22, 2024
2022 journal article
Outcome and prognostic factors in infective endocarditis in dogs: 113 cases (2005-2020)
Journal of Veterinary Internal Medicine, 36(2), 429—440.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2022 journal article
Pharmacokinetics of a single dose of Aficamten (CK-274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model
Journal of Veterinary Pharmacology and Therapeutics, 46(1), 52—61.
Contributors: A. Sharpe*, M. Oldach*, J. Kaplan *, V. Rivas* , S. Kovacs, D. Hwee *, B. Morgan *, F. Malik *, S. Harris *, *
TL;DR:
The marked reduction in systolic function and reduced IVRT coupled with an increased heart rate in treated cats, suggest a lower dose may be optimal, and further studies to determine optimal dosing of aficamten are indicated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: February 6, 2024
2022 journal article
Platelet Priming and Activation in Naturally Occurring Thermal Burn Injuries and Wildfire Smoke Exposure Is Associated With Intracardiac Thrombosis and Spontaneous Echocardiographic Contrast in Feline Survivors
Frontiers in Veterinary Science, 9.
author keywords: hypercoagulability; primary hemostasis; particulate matter <2; 5 mu m (PM) 2.5; hypertrophic cardiomyopathy (HCM); thromboembolism
TL;DR:
This is the first study reporting the significant association between platelet priming and intracardiac thrombosis in domestic cats with naturally occurring wildfire-related injuries and smoke inhalation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: August 8, 2022
2022 journal article
Resolution, recurrence, and chyle redistribution after thoracic duct ligation with or without pericardiectomy in dogs with naturally occurring idiopathic chylothorax
Journal of the American Veterinary Medical Association, 261(5), 696—704.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2022 journal article
Retrospective evaluation of hypertrophic cardiomyopathy in 68 dogs
Journal of Veterinary Internal Medicine, 36(3), 865—876.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2022 journal article
The TNNT2:c.95-108G>A variant is common in Maine Coons and shows no association with hypertrophic cardiomyopathy
Animal Genetics, 53(4), 526—529.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2021 journal article
A genetic polymorphism in P2RY(1) impacts response to clopidogrel in cats with hypertrophic cardiomyopathy
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / pathology; Cardiomyopathy, Hypertrophic / veterinary; Cats; Clopidogrel / adverse effects; Clopidogrel / pharmacology; Genetic Predisposition to Disease; Genotype; Humans; Platelet Activation / drug effects; Platelet Aggregation / drug effects; Platelet Aggregation Inhibitors / adverse effects; Platelet Aggregation Inhibitors / pharmacology; Polymorphism, Single Nucleotide / genetics; Receptors, Purinergic P2Y1 / genetics
TL;DR:
It is demonstrated that a genetic polymorphism in the P2RY1 gene altered response to clopidogrel therapy and suggests that clinicians may consider alternative or additional thromboprophylactic therapy in cats with the P 2RY1:A236G variant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 19, 2021
2021 journal article
Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy
BMC VETERINARY RESEARCH, 17(1).
author keywords: Feline; Pharmacodynamics; HCM; Obstruction; Inotrope
MeSH headings : Animals; Blood Flow Velocity / drug effects; Blood Flow Velocity / veterinary; Blood Pressure; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / pharmacokinetics; Cardiotonic Agents / pharmacology; Cat Diseases / drug therapy; Cats; Echocardiography / veterinary; Female; Heart Rate / drug effects; Male; Prospective Studies; Pyridazines / pharmacokinetics; Pyridazines / pharmacology; Ventricular Function, Left
TL;DR:
In client-owned cats with HCM, pimobendan acutely increased left atrial function and mildly increased left ventricular systolic function and the findings of this prospective, acute-dosing study suggest that chronic dosing studies are safe and warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 15, 2021
2021 journal article
Aorto-left atrial fistula secondary to infective aortic endocarditis and endarteritis in a cat with valvular aortic stenosis
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 35, 101—107.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2021 journal article
Biopsy of an intracardiac paraganglioma in a dog using a fluoroscopically guided endovascular technique
Journal of Veterinary Internal Medicine, 35(3), 1536—1541.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2021 journal article
Combined Assessment of Pulmonary Ventilation and Perfusion with Single-Energy Computed Tomography and Image Processing.
Academic Radiology.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2021 journal article
Comparative Assessment of Heart Rate Variability Obtained via Ambulatory ECG and Polar Heart Rate Monitors in Healthy Cats: A Pilot Study
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: cat; physiological stress measures; heart rate; heart rate variability; Holter monitor; Polar H10
TL;DR:
This pilot study tested the feasibility of obtaining HRV data from unrestrained cats, using a commercially available cardiac monitoring system (Polar H10 with chest strap), compared with data from a traditional ambulatory electrocardiogram, and results do not support the use of Polar H10 heart rate monitors for studies of HRV in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 29, 2021
2021 journal article
Dual therapy with clopidogrel and rivaroxaban in cats with thromboembolic disease
Journal of Feline Medicine and Surgery, 24(4), 277–283.
TL;DR:
Dual antithrombotic therapy with clopidogrel and rivaroxaban resulted in a low reported incidence of adverse events and effective thromboprophylaxis was achieved in cats with intracardiac thrombi or SEC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2021 journal article
Genetics of canine subvalvular aortic stenosis (SAS)
Canine Medicine and Genetics, 8(1), 4.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2021 journal article
Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca Mulatta)
FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: left ventricular hypertrophy; mode of inheritance; pedigree analysis; cardiac disease; genetics
TL;DR:
The findings of the present study support conducting genetic investigations such as whole genome sequencing to identify the causative variants of inherited HCM in rhesus macaques.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 28, 2021
2021 journal article
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus)
Animal Genetics, 52(3), 321—332.
TL;DR:
Bioinformatic and molecular modeling analysis suggests that changes in the Ticked locus disrupt a key disulfide bond in the Dkk4 cysteine‐rich domain 1 or DKK4 signal peptide cleavage respectively.
(via Semantic Scholar)
Source: ORCID
Added: December 13, 2023
2021 journal article
Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits
Scientific Reports, 11(1).
MeSH headings : Amyloidogenic Proteins / metabolism; Amyloidosis, Familial / genetics; Amyloidosis, Familial / metabolism; Amyloidosis, Familial / veterinary; Animals; Cat Diseases / genetics; Cat Diseases / metabolism; Cats / genetics; Cats / metabolism; Genetic Variation / genetics; Kidney / metabolism; Kidney Diseases / genetics; Kidney Diseases / metabolism; Kidney Diseases / veterinary; MicroRNAs; Proteomics; Whole Genome Sequencing
TL;DR:
The general conclusions are that the familial amyloid renal form in Abyssinians is not a simple monogenic trait and is a mix of proteins codified by wild-type genes, and the form is biochemically classifiable as AA amyloidsosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: May 24, 2021
2021 journal article
Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study
Journal of Feline Medicine and Surgery, 24(6), 580–586.
TL;DR:
The variation in NET distribution within arterial thrombi may shed light on the pathogenesis of thrombus growth and may be due to possible neutrophil entrapment or variations in shear stress.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 10, 2023
2021 journal article
Prevalence of an angiotensin-converting enzyme gene variant in dogs
Canine Medicine and Genetics, 8(1), 6.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2020 journal article
ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats
Journal of Veterinary Internal Medicine, 34(3), 1062–1077.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2020 journal article
Assessment of <i>PDK4</i> and <i>TTN</i> gene variants in 48 Doberman Pinschers with dilated cardiomyopathy
Journal of the American Veterinary Medical Association, 257(10), 1041—1044.
Source: ORCID
Added: June 22, 2024
2020 journal article
Cats with thermal burn injuries from California wildfires show echocardiographic evidence of myocardial thickening and intracardiac thrombi
Scientific Reports, 10(1), 2648.
TL;DR:
The first time, cardiovascular and coagulation effects of thermal burn and smoke inhalation in cats are described for the first time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study
PLOS ONE, 15(5), e0233206.
Ed(s): F. Staffieri
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2020 journal article
Echocardiographic reference intervals with allometric scaling of 823 clinically healthy rhesus macaques (Macaca mulatta)
BMC VETERINARY RESEARCH, 16(1).
author keywords: Heart; Cardiac; Cardiovascular; Ultrasound; Non-human primate; Cardiomyopathy; Hypertrophic cardiomyopathy; Left ventricular hypertrophy
MeSH headings : Age Factors; Animals; Body Weight; Echocardiography / veterinary; Female; Heart Rate; Hypnotics and Sedatives / administration & dosage; Ketamine / administration & dosage; Macaca mulatta / physiology; Male; Reference Values
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 19, 2020
2020 journal article
Identifying Cardiac Diseases using Cardiac Biomarkers in Rhesus Macaques (<i>Macaca mulatta</i>)
Comparative Medicine, 70(5), 348—357.
Source: ORCID
Added: June 22, 2024
2020 journal article
Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study
FRONTIERS IN VETERINARY SCIENCE, 7.
author keywords: histamine; cardiac; chemotherapy; Adriamycin; Benadryl
TL;DR:
This study demonstrates that in these dogs with rigorous pretreatment cardiovascular screening, DOX infusion did not induce significant arrhythmias, and suggests that, with this screening approach, diphenhydramine may not alter the arrhythmia number or severity in canine DOX recipients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 17, 2020
2020 journal article
Lamotrigine Toxicosis Treated with Intravenous Lipid Emulsion Therapy in a Dog
Journal of the American Animal Hospital Association, 56(4), 226—230.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2020 journal article
Long-term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart-base tumours in dogs
Veterinary and Comparative Oncology, 19(1), 191—200.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2020 journal article
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy
The American Journal of Human Genetics, 106(6), 893–904.
TL;DR:
The genetic, cell-based, and in vivo modeling data delineate an autosomal-dominant syndromic retinal ciliopathy in humans and suggest that multiple KIF3B pathomechanisms can impair kinesin-driven ciliary transport in the photoreceptor.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
PEA15 loss of function and defective cerebral development in the domestic cat.
PLoS Genetics.
Source: ORCID
Added: June 22, 2024
2020 journal article
Precision medicine identifies a pathogenic variant of the <scp><i>ITGA2B</i></scp> gene responsible for Glanzmann's thrombasthenia in a cat
Journal of Veterinary Internal Medicine, 34(6), 2438–2446.
TL;DR:
This novel ITGA2B variant and the associated phenotype closely resemble Glanzmann's thrombasthenia, which has never been reported in cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2020 journal article
Reference intervals for radiographic, echocardiographic and N-terminal pro B-type natriuretic peptide values in healthy kittens
JOURNAL OF FELINE MEDICINE AND SURGERY, 23(4), 293–301.
author keywords: Vertebral heart score; cardiac thoracic ratio; biomarker; reference interval; radiography; echocardiography
MeSH headings : Animals; Biomarkers; Cats; Echocardiography / veterinary; Female; Heart Murmurs / veterinary; Natriuretic Peptide, Brain; Peptide Fragments; Reference Values
TL;DR:
This study establishes RIs for thoracic radiograph assessment, echocardiography and cardiac biomarkers in kittens, which fills a critical gap in the veterinary literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 7, 2020
2020 journal article
Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism
JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.
author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
TL;DR:
The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 16, 2020
2020 journal article
Unraveling the Genetics Behind Equid Cardiac Disease
The Veterinary Clinics of North America. Equine Practice, 36(2), 235—241.
Source: ORCID
Added: June 22, 2024
2020 journal article
Varying Expression of Mu and Kappa Opioid Receptors in Cockatiels (<i>Nymphicus hollandicus</i>) and Domestic Pigeons (<i>Columba livia domestica)</i>
Frontiers in Genetics, 11, 549558.
Source: ORCID
Added: June 22, 2024
2020 journal article
Vertebral Heart Score in Rhesus Macaques (Macaca mulatta): Generating Normal Reference Intervals and Assessing its Validity for Identifying Cardiac Disease
Journal of the American Association for Laboratory Animal Science : JAALAS, 4.
Source: ORCID
Added: June 22, 2024
2020 journal article
Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed
Genes, 11(6), 682.
TL;DR:
Comparison to the 99 Lives dataset of 194 non-lykoi cats suggested two variants in the cat homolog for Hairless (HR: lysine demethylase and nuclear receptor corepressor) as candidate causal variants, and four additional loss of function HR variants likely causing the highly similar phenotypic hair coat across the diverse cats were identified.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2019 journal article
Cardiac Effects of a Single Dose of Pimobendan in Cats With Hypertrophic Cardiomyopathy; A Randomized, Placebo-Controlled, Crossover Study.
Frontiers in Veterinary Science, 6, 15.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil
Journal of Veterinary Internal Medicine, 34(1), 65—73.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017
Frontiers in Veterinary Science, 6, 52.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
ECG of the Month
Journal of the American Veterinary Medical Association, 255(1), 60—62.
Source: ORCID
Added: June 22, 2024
2019 journal article
Echocardiographic assessment of right heart size and function in dogs with pulmonary valve stenosis
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 26, 19—28.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension
Scientific Reports, 9(1), 6899.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
Genetic heterogeneity and diversity of North American golden retrievers using a low density STR marker panel
PloS One, 14(2), e0212171.
Ed(s): T. Chiang
Source: ORCID
Added: June 22, 2024
2019 journal article
Heart Rate and Heart Rate Variability of Rhesus Macaques (Macaca mulatta) Affected by Left Ventricular Hypertrophy
Frontiers in Veterinary Science, 6, 1.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2019 journal article
Pedigree analysis of atrial fibrillation in Irish wolfhounds supports a high heritability with a dominant mode of inheritance
Canine Genetics and Epidemiology, 6, 11.
Source: ORCID
Added: June 22, 2024
2018 journal article
Aberrant migration and surgical removal of a heartworm (Dirofilaria immitis) from the femoral artery of a cat
Journal of Veterinary Internal Medicine, 32(2), 792—796.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias
Journal of Veterinary Internal Medicine, 32(4), 1299—1307.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Correction: Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
PloS One, 13(12), e0210233.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Diet-associated dilated cardiomyopathy in dogs: what do we know?
Journal of the American Veterinary Medical Association, 253(11), 1390—1394.
Source: ORCID
Added: June 22, 2024
2018 journal article
Echocardiographic evaluation of velocity ratio, velocity time integral ratio, and pulmonary valve area in dogs with pulmonary valve stenosis
Journal of Veterinary Internal Medicine, 32(5), 1570—1578.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
First genome-wide CNV mapping in FELIS CATUS using next generation sequencing data
BMC Genomics, 19(1), 895.
Source: ORCID
Added: June 22, 2024
2018 journal article
High-pressure balloon valvuloplasty for severe pulmonary valve stenosis: a prospective observational pilot study in 25 dogs
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 20(2), 115—122.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Inherited cardiomyopathies in veterinary medicine
Pflugers Archiv : European Journal of Physiology, 471(5), 745—753.
Source: ORCID
Added: June 22, 2024
2018 journal article
Multiple midline defects identified in a litter of golden retrievers following gestational administration of prednisone and doxycycline: a case series
BMC Veterinary Research, 14(1), 86.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Non-electrocardiographic-gated computed tomographic angiography can be used to diagnose coronary artery anomalies in Bulldogs with pulmonary valve stenosis
Veterinary Radiology &Amp; Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 60(1), 38—46.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Nonsynonymous single nucleotide polymorphisms in candidate genes <i>P2<scp>RY</scp>1</i>,<i> P2<scp>RY</scp>12</i> and <i><scp>CYP</scp>2C19</i> for clopidogrel efficacy in cats
Animal Genetics, 49(4), 356–357.
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2018 journal article
Precision medicine validation: identifying the MYBPC3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy
JOURNAL OF FELINE MEDICINE AND SURGERY, 21(12), 1086–1093.
author keywords: HCM; WGS; individualized medicine; next-generation sequencing
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cat Diseases / genetics; Cats; Genetic Predisposition to Disease; Mutation; Precision Medicine / instrumentation; Precision Medicine / methods; Precision Medicine / veterinary; Whole Genome Sequencing / veterinary
TL;DR:
This proof-of-concept experiment identified the previously reported MYBPC3 A31P Maine Coon variant in two HCM-affected cases and highlights the power of whole-genome sequencing for feline precision medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: December 16, 2019
2018 journal article
Prospective pre- and post-race evaluation of biochemical, electrophysiologic, and echocardiographic indices in 30 racing thoroughbred horses that received furosemide
BMC Veterinary Research, 14(1), 18.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2018 journal article
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets
PloS One, 13(12), e0209112.
Ed(s): J. Loor
Source: ORCID
Added: June 22, 2024
2018 journal article
Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds
PLoS Genetics, 14(12), e1007850.
Ed(s): T. Leeb
Source: ORCID
Added: June 22, 2024
2017 journal article
A One Health Approach to Hypertrophic Cardiomyopathy.
The Yale Journal of Biology and Medicine, 9. http://europepmc.org/abstract/med/28955182
Source: ORCID
Added: June 22, 2024
2017 journal article
Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).
author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR:
It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Angiotensin-converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease
Pharmacogenetics and Genomics, 28(2), 37–40.
author keywords: angiotensin-converting enzyme; angiotensin-converting enzyme inhibitor; dog; polymorphism; valve
TL;DR:
Dogs with the ACE variant had lower levels of ACE activity even in more advanced mitral valve disease than dogs without the variant, and the CKCS appears to have a high prevalence of theACE variant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 18, 2020
2017 journal article
Echocardiographic Assessment of Right Ventricular Size and Function in Cats With Hypertrophic Cardiomyopathy
Journal of Veterinary Internal Medicine, 31(3), 668—677.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2017 journal article
Echocardiographic Parameters of Clinically Normal Geriatric Rhesus Macaques (Macacamulatta).
Journal of the American Association for Laboratory Animal Science : JAALAS, 7. http://europepmc.org/abstract/med/28728613
Source: ORCID
Added: June 22, 2024
2017 journal article
Feasibility, safety, and tolerance of subcutaneous synthetic canine B-type natriuretic peptide (syncBNP) in healthy dogs and dogs with stage B1 mitral valve disease
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 19(3), 211—217.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2017 journal article
Feline Hypertrophic Cardiomyopathy: A Spontaneous Large Animal Model of Human HCM
Cardiology Research, 8(4), 139—142.
Source: ORCID
Added: June 22, 2024
2017 journal article
Infundibular Pulmonic Stenosis in a Moluccan Cockatoo (Cacatua moluccensis)
Journal of Avian Medicine and Surgery, 31(1), 53—61.
Source: ORCID
Added: June 22, 2024
2017 journal article
Precision Medicine in Cats: Novel Niemann-Pick Type C1 Diagnosed by Whole-Genome Sequencing
Journal of Veterinary Internal Medicine, 31(2), 539—544.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2016 journal article
A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.
Mammalian Genome : Official Journal of the International Mammalian Genome Society.
Source: ORCID
Added: June 22, 2024
2016 journal article
A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy
PloS One, 11(12), e0168407.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2016 journal article
Antemortem Screening for Left Ventricular Hypertrophy in Rhesus Macaques (Macaca mulatta).
Comparative Medicine. http://europepmc.org/abstract/med/27538864
Source: ORCID
Added: June 22, 2024
2016 journal article
Diagnostic Value of Right Pulmonary Artery Distensibility Index in Dogs with Pulmonary Hypertension: Comparison with Doppler Echocardiographic Estimates of Pulmonary Arterial Pressure
Journal of Veterinary Internal Medicine, 30(2), 543—552.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2016 journal article
ECG of the Month
Journal of the American Veterinary Medical Association, 248(5), 497—500.
Source: ORCID
Added: June 22, 2024
2016 journal article
ECG of the Month
Journal of the American Veterinary Medical Association, 249(10), 1138—1140.
Source: ORCID
Added: June 22, 2024
2016 journal article
Effects of 0.5% Timolol Maleate Ophthalmic Solution on Heart Rate and Selected Echocardiographic Indices in Apparently Healthy Cats
Journal of Veterinary Internal Medicine, 30(3), 733—740.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2016 journal article
Letter to the Editor
Journal of Veterinary Internal Medicine, 30(4), 926.
Source: ORCID
Added: June 22, 2024
2016 journal article
Platelet Activation and Clopidogrel Effects on ADP-Induced Platelet Activation in Cats with or without the A31P Mutation in MYBPC3
Journal of Veterinary Internal Medicine, 30(5), 1619–1629.
TL;DR:
Cats with A31P mutation had increased platelet activation relative to the variable response seen in wild‐type cats, and clopidogrel treatment attenuated ADP‐induced P‐selectin expression and platelet aggregation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 13, 2023
2016 journal article
Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model
Medical Physics, 43(7), 3998.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2016 journal article
Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps).
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology.
Source: ORCID
Added: June 22, 2024
2016 journal article
The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency
Archives of Biochemistry and Biophysics, 601, 133—140.
Source: ORCID
Added: June 22, 2024
2015 journal article
Acquired tricuspid valve stenosis due to intentionally redundant transvenous lead placement for VDD pacing in two small dogs
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 17(4), 298—303.
Source: ORCID
Added: June 22, 2024
2015 journal article
Atrial Fibrillation in Eight New World Camelids
Journal of Veterinary Internal Medicine, 30(1), 335—338.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2015 journal article
Identification of striatin, a desmosomal protein, in the canine corneal epithelium
RESEARCH IN VETERINARY SCIENCE, 102, 182–183.
author keywords: Hemidesmosome; Cornea; Striatin; Desmosome; Adhesion
MeSH headings : Animals; Calmodulin-Binding Proteins / metabolism; Desmosomes / metabolism; Dogs / metabolism; Epithelium, Corneal / metabolism
TL;DR:
It is hypothesized that striatin may be found in the cornea localized to regions of either hemidesmosomes and/or desmosomes, and the role of striatin in corneal disease warrants investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Impact of the canine double-deletion beta 1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a beta 1-selective beta-blocker
PHARMACOGENETICS AND GENOMICS, 25(9), 427–431.
author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
TL;DR:
The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 article
Polymorphisms in the canine and feline renin-angiotensin-aldosterone system genes
Meurs, K. M., Chdid, L., Reina-Doreste, Y., & Stern, J. A. (2015, April). ANIMAL GENETICS, Vol. 46, pp. 226–226.
MeSH headings : Animals; Cats; Dogs; Polymorphism, Genetic; Renin-Angiotensin System / genetics; Sequence Analysis, DNA
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Predicting development of subaortic stenosis in dogs
Journal of the American Veterinary Medical Association, 246(10), 1058.
Source: ORCID
Added: June 22, 2024
2015 journal article
Severity of Mitral Valve Degeneration Is Associated with Chromosome 15 Loci in Whippet Dogs
PloS One, 10(10), e0141234.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2015 journal article
Sudden Death Associated with QT Interval Prolongation and KCNQ1 Gene Mutation in a Family of English Springer Spaniels
JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(2), 561–568.
author keywords: Long QT Syndrome
MeSH headings : Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genetic Predisposition to Disease; KCNQ1 Potassium Channel / genetics; KCNQ1 Potassium Channel / metabolism; Long QT Syndrome / complications; Long QT Syndrome / genetics; Male; Mutation; Pedigree
TL;DR:
This family represents the first documentation in dogs of spontaneous familial QT prolongation, which was associated with a KCNQ1 gene mutation and sudden death, and their phenotypic manifestations of QT interval prolongation and abnormal ECG restitution suggested increased risk for sudden arrhythmic death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
The influence of clinical and genetic factors on left ventricular wall thickness in Ragdoll cats
Journal of Veterinary Cardiology, 17, S258–S267.
author keywords: Cardiomyopathy; Genetics; Modifier genes; Breed screening
MeSH headings : Animals; Body Weight; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cats / anatomy & histology; Cats / genetics; Female; Gene Expression Regulation; Genotype; Heart Ventricles / anatomy & histology; Male; Mutation; Polymorphism, Genetic; Sex Factors
TL;DR:
Evidence is provided that the MYBPC3:R820W mutation is independently associated with LV wall thickness in Ragdoll cats and body weight is not currently accounted for in HCM screening.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 16, 2019
2014 journal article
A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs
Human Genetics, 133(9), 1139–1148.
MeSH headings : Animals; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / pathology; Aortic Stenosis, Subvalvular / veterinary; Base Sequence; Case-Control Studies; Clathrin / antagonists & inhibitors; Clathrin / genetics; Codon / genetics; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Male; Molecular Sequence Data; Monomeric Clathrin Assembly Proteins / chemistry; Monomeric Clathrin Assembly Proteins / genetics; Monomeric Clathrin Assembly Proteins / metabolism; Mutagenesis, Insertional; Pedigree; Phosphatidylinositols / metabolism; Prospective Studies; Protein Conformation; Sequence Analysis, RNA; Sex Factors; Xenopus laevis / embryology
TL;DR:
A three-nucleotide exonic insertion in phosphatidylinositol-binding clathrin assembly protein (PICALM) that is associated with the development of SAS in Newfoundlands is identified and the role of PICALM in OFT development may aid in future molecular and genetic investigations into other congenital heart defects of various species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR:
The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Fungal pericarditis and endocarditis secondary to porcupine quill migration in a dog
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 16(4), 283—290.
Source: ORCID
Added: June 22, 2024
2014 journal article
Natural History of Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: A Prospective Study
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(4), 1214–1220.
author keywords: Boxer; Holter; Striatin; Sudden death; Ventricular premature complex
MeSH headings : Age Factors; Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Case-Control Studies; Death, Sudden / veterinary; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Genotype; Male; Prospective Studies; Ventricular Premature Complexes / physiopathology; Ventricular Premature Complexes / veterinary
TL;DR:
Arrhythmogenic right ventricular cardiomyopathy is a disease of middle age and frequently is associated with the striatin deletion, and the prognosis in many affected dogs is good.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.
author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR:
This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
ECG of the month. Multiple episodes of collapse in a cat
Journal of the American Veterinary Medical Association, 242(7), 926—928.
Source: ORCID
Added: June 22, 2024
2013 journal article
Effect of body position on electrocardiographic recordings in dogs
Australian Veterinary Journal, 91(7), 281—286.
Source: ORCID
Added: June 22, 2024
2013 journal article
Extent of linkage disequilibrium in large-breed dogs: chromosomal and breed variation
MAMMALIAN GENOME, 24(9-10), 409–415.
MeSH headings : Animals; Breeding; Chromosomes, Mammalian / genetics; Dogs / genetics; Female; Genetic Markers; Genome-Wide Association Study; Haplotypes; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide
TL;DR:
This is the first reported of SNP-based LD for Newfoundland dogs, the first report based on genome-wide SNPs for Rottweilers, and an almost tenfold improvement in marker density over previous genome- wide studies of LD in Golden Retrievers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat
JOURNAL OF VETERINARY CARDIOLOGY, 15(3), 205–210.
author keywords: Sinistrum; Pulmonary venous anomaly; Feline; Congenital heart disease; Dilatation
MeSH headings : Angioplasty, Balloon, Coronary / methods; Angioplasty, Balloon, Coronary / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Cor Triatriatum / diagnosis; Cor Triatriatum / therapy; Cor Triatriatum / veterinary; Echocardiography, Transesophageal / veterinary; Female
TL;DR:
Based upon the outcome of this case, balloon dilatation appears to be a viable treatment option for cats affected with cor triatriatum sinister.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2013 journal article
Identification of PDE5A:E90K: A Polymorphism in the Canine Phosphodiesterase 5A Gene Affecting Basal cGMP Concentrations of Healthy Dogs
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(1), 78–83.
author keywords: Individualized medicine; Pharmacogenomics; Pulmonary hypertension; Sildenafil citrate; Single nucleotide polymorphisms
MeSH headings : Amino Acid Sequence; Animals; Cyclic GMP / metabolism; Cyclic Nucleotide Phosphodiesterases, Type 5 / genetics; Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism; DNA / chemistry; DNA / genetics; Dogs / genetics; Dogs / metabolism; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Polymorphism, Single Nucleotide / genetics; Sequence Alignment; Sequence Analysis, DNA
TL;DR:
A polymorphism exists in the canine PDE5A gene that is associated with variable circulating cGMP concentrations in healthy dogs and warrants investigation in diseases such as pulmonary hypertension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Complete atrioventricular block secondary to cardiac lymphoma in a dog
Journal of Veterinary Cardiology, 14(4), 537–539.
author keywords: Lymphoma; Cardiac lymphoma; Tumor; Septal tumor
MeSH headings : Animals; Atrioventricular Block / etiology; Atrioventricular Block / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Heart Neoplasms / complications; Heart Neoplasms / pathology; Heart Neoplasms / veterinary; Lymphoma, Non-Hodgkin / complications; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Male
TL;DR:
Necropsy revealed multiple masses within the interventricular septum, ventricular free walls and atrial myocardium, and the final diagnosis was large cell (T-cell) lymphosarcoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref
Added: August 14, 2021
2012 journal article
Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings
Journal of Small Animal Practice, 53(4), 213–216.
MeSH headings : Animals; Aortic Stenosis, Subvalvular / diagnostic imaging; Aortic Stenosis, Subvalvular / genetics; Aortic Stenosis, Subvalvular / veterinary; Aortic Valve Insufficiency / diagnostic imaging; Aortic Valve Insufficiency / genetics; Aortic Valve Insufficiency / veterinary; Blood Flow Velocity / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Echocardiography / veterinary; Female; Genetic Predisposition to Disease; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / genetics; Hypertrophy, Left Ventricular / veterinary; Male; Severity of Illness Index
TL;DR:
Severity of stenosis correlates well with cumulative presence of echocardiographic characteristics (left ventricular hypertrophy, subvalvular ridge and aortic insufficiency), and appears familial.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Hypertrophic cardiomyopathy in the Sphynx cat: A retrospective evaluation of clinical presentation and heritable etiology
JOURNAL OF FELINE MEDICINE AND SURGERY, 14(4), 246–249.
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / genetics; Cats; Female; Male; Phenotype; Retrospective Studies; Species Specificity
TL;DR:
The observation that Sphynx and Ragdoll breeds may have different clinical presentations, as well as different genetic mutations, suggests that hypertrophic cardiomyopathy is a diverse disease in the cat.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Resolution of sustained narrow complex ventricular tachycardia and tachycardia-induced cardiomyopathy in a Quarter Horse following quinidine therapy.
Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology, 9(3), 445—451.
Contributors: n , Y. Doreste n, S. Barnett*, S. Lahmers*, R. Baumwart *, K. Seino*, J. Bonagura*
author keywords: Equine; Systolic dysfunction; Quinidine; Arrhythmia; Tachycardiomyopathy
MeSH headings : Animals; Anti-Arrhythmia Agents / therapeutic use; Horse Diseases / drug therapy; Horses; Male; Quinidine / therapeutic use; Tachycardia, Ventricular / classification; Tachycardia, Ventricular / drug therapy; Tachycardia, Ventricular / veterinary
TL;DR:
Sustained narrow-QRS tachycardia of three months duration and left ventricular systolic dysfunction and chamber dilatation were identified in a fifteen-year-old Quarter Horse and oral quinidine therapy converted the tachyarrhythmia to sinus rhythm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: October 24, 2019
2011 journal article
Cutaneous and systemic blastomycosis, hypercalcemia, and excess synthesis of calcitriol in a domestic shorthair cat
Journal of the American Animal Hospital Association, 47(6), e116—20.
Source: ORCID
Added: June 22, 2024
2011 journal article
ECG of the month. Hyperkalemia
Journal of the American Veterinary Medical Association, 238(8), 982—984.
Source: ORCID
Added: June 22, 2024
2011 journal article
Effects of treatment on respiratory rate, serum natriuretic peptide concentration, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure secondary to degenerative mitral valve disease and dilated cardiomyopathy
Journal of the American Veterinary Medical Association, 239(4), 468—479.
Contributors: K. Schober *, T. Hart*, * , X. Li *, V. Samii*, L. Zekas*, B. Scansen *, J. Bonagura*
MeSH headings : Animals; Cardiomyopathy, Dilated / complications; Cardiomyopathy, Dilated / veterinary; Cardiovascular Agents / therapeutic use; Cohort Studies; Dog Diseases / drug therapy; Dogs; Echocardiography, Doppler / veterinary; Heart Failure / drug therapy; Heart Failure / veterinary; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / veterinary; Natriuretic Peptides / blood; Respiration / drug effects
TL;DR:
Resolution of CHF was associated with predictable changes in respiratory rate, serum NT-proBNP concentration, and selected Doppler echocardiographic variables in dogs with DCM and MVD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 24, 2019
2010 journal article
Ambulatory electrocardiographic evaluation of clinically normal adult Boxers
Journal of the American Veterinary Medical Association, 236(4), 430–433.
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / diagnosis; Dogs; Electrocardiography, Ambulatory / veterinary; Female; Male; Ventricular Premature Complexes / veterinary
TL;DR:
Clinically normal adult Boxers generally had < 91 VPCs/24 h and an arrhythmia grade < 2 and may have represented dogs with arrhythmogenic right ventricular cardiomyopathy or other disease processes that could have resulted in the development of ventricular arrh rhythmias.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 16, 2019
2010 journal article
Detection of congestive heart failure in dogs by Doppler echocardiography
Journal of Veterinary Internal Medicine, 24(6), 1358—1368.
Contributors: K. Schober *, T. Hart*, * , X. Li*, V. Samii*, L. Zekas*, B. Scansen *, J. Bonagura*
author keywords: Canine; Degenerative mitral valve disease; Dilated cardiomyopathy; NT-proBNP; Respiration rate
MeSH headings : Animals; Diastole; Dog Diseases / blood; Dog Diseases / diagnostic imaging; Dogs; Echocardiography, Doppler / veterinary; Female; Heart Failure / blood; Heart Failure / diagnostic imaging; Heart Failure / veterinary; Male; Mitral Valve / physiology; Natriuretic Peptides / blood; Respiratory Rate
TL;DR:
Various DE variables can be used to predict CHF in dogs with MVD and DCM, whereas other variables including N-terminal pro-brain natriuretic peptide, E:Ea, and E:Vp were less useful.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 24, 2019
2008 journal article
Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency
Journal of Veterinary Cardiology, 10(1), 1–10.
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / etiology; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / metabolism; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Base Sequence; Blotting, Western / veterinary; Breeding; Calcium / metabolism; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Female; Male; Microarray Analysis / veterinary; Polymerase Chain Reaction / veterinary; RNA, Messenger / metabolism; Ryanodine Receptor Calcium Release Channel / genetics; Ryanodine Receptor Calcium Release Channel / metabolism; Tacrolimus Binding Proteins / deficiency; Tacrolimus Binding Proteins / genetics
TL;DR:
Calstabin2 deficiency is a potential mechanism of Ca(2+) leak-induced ventricular arrhythmias and heart disease in Boxer dogs with ARVC and was associated with a significantly increased open probability of single RyR2 channels indicating intracellular Ca( 2+) leak.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 16, 2019
2008 journal article
Estimation of left ventricular filling pressure by Doppler echocardiography in dogs with pacing-induced heart failure
Journal of Veterinary Internal Medicine, 22(3), 578—585.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 22, 2024
2008 journal article
Estimation of left ventricular filling pressure by use of Doppler echocardiography in healthy anesthetized dogs subjected to acute volume loading
American Journal of Veterinary Research, 69(8), 1034—1049.
Contributors: K. Schober *, J. Bonagura* , B. Scansen, * & N. Ponzio
MeSH headings : Anesthesia, General; Animals; Blood Volume / physiology; Cardiac Output / physiology; Dogs; Echocardiography, Doppler / methods; Echocardiography, Doppler / veterinary; Ventricular Function, Left / physiology
TL;DR:
Doppler echocardiography can be used to predict an increase in LVFP in healthy anesthetized dogs subjected to volume loading, and mean LAP was correlated with several DE variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: October 24, 2019
2007 journal article
Desmosomal gene evaluation in Boxers with arrhythmogenic right ventricular cardiomyopathy
American Journal of Veterinary Research, 68(12), 1338–1341.
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Base Sequence; Desmoglein 2 / genetics; Desmoplakins / genetics; Desmosomes / genetics; Dog Diseases / genetics; Dogs; Exons / genetics; Female; Genetic Predisposition to Disease; Male; Multigene Family; Plakophilins / genetics; RNA Splice Sites / genetics; gamma Catenin / genetics
Sources: ORCID, Crossref, NC State University Libraries
Added: December 16, 2019
2007 journal article
Diagnostic accuracy of electrocardiography and thoracic radiography in the assessment of left atrial size in cats: comparison with transthoracic 2-dimensional echocardiography.
Journal of Veterinary Internal Medicine.
Source: ORCID
Added: June 22, 2024
Employment
Updated: November 9th, 2023 20:04
2023 - present
College of Veterinary Medicine, North Carolina State University Raleigh, NC, US
Associate Dean for Research and Graduate Studies
Department of Clinical Sciences
2013 - 2023
University of California Davis Davis, CA, US
Professor
Department of Medicine & Epidemiology; School of Veterinary Medicine
Education
Updated: September 17th, 2018 17:35
2009 - 2013
Washington State University Pullman, Washington, US
PhD
2004 - 2008
The Ohio State University Columbus, Ohio, US
Doctor of Veterinary Medicine
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