Jaime Anna Willett

Works (5)

Updated: April 15th, 2025 10:47

2019 article

Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and FemaleDrd1a-tdTomato Line 6 BAC Transgenic Mice

Willett, J. A., Cao, J., Dorris, D. M., Johnson, A. G., Ginnari, L. A., & Meitzen, J. (2019, March 1). ENeuro, Vol. 6.

By: J. Willett n, J. Cao*, D. Dorris*, A. Johnson *, L. Ginnari* & J. Meitzen n 

author keywords: caudate putamen; electrophysiology; intrinsic excitability; medium spiny neurons; rodent; sex differences
MeSH headings : Animals; Corpus Striatum / cytology; Corpus Striatum / physiology; Electrophysiology; Female; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / physiology; Organ Culture Techniques; Sex Characteristics; Synaptic Potentials / physiology
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Neurotransmitter Receptor Influence on Behavior; Neuroendocrine regulation and behavior; Neurogenesis and neuroplasticity mechanisms; Adipose Tissue and Metabolism
TL;DR: A comprehensive evaluation of mouse caudate-putamen MSN subtype electrophysiological properties across females and males is provided, both confirming and extending previous studies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019

2019 article

The estrous cycle modulates rat caudate–putamen medium spiny neuron physiology

Willett, J. A., Cao, J., Johnson, A., Patel, O. H., Dorris, D. M., & Meitzen, J. (2019, July 6). European Journal of Neuroscience.

By: J. Willett n, J. Cao n, A. Johnson n, O. Patel n, D. Dorris n & J. Meitzen n 

author keywords: caudate-putamen; electrophysiology; estrous cycle; excitability; medium spiny neuron; sex differences
MeSH headings : Action Potentials; Animals; Estrous Cycle; Female; Male; Neurons; Nucleus Accumbens; Putamen; Rats
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Neuroendocrine regulation and behavior; Neural dynamics and brain function
TL;DR: Recordings indicate that female caudate–putamen MSNs are sensitive to the estrous cycle, and the importance of considering neuroendocrine state in studies of neuron physiology is considered. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2018 article

Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation

Cao, J., Willett, J. A., Dorris, D. M., & Meitzen, J. (2018, April 18). Frontiers in Endocrinology, Vol. 9.

By: J. Cao n, J. Willett n, D. Dorris n & J. Meitzen n 

author keywords: sex; estradiol; hormones; striatum; medium spiny neuron; nucleus accumbens; caudate-putamen; electrophysiology
topics (OpenAlex): Hypothalamic control of reproductive hormones; Neuroendocrine regulation and behavior; Neuroscience and Neuropharmacology Research; Stress Responses and Cortisol
TL;DR: Sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions are reviewed, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 article

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons

Willett, J. A., Will, T., Hauser, C. A., Dorris, D. M., Cao, J., & Meitzen, J. (2016, January 1). ENeuro, Vol. 3.

By: J. Willett n, T. Will n, C. Hauser n, D. Dorris n, J. Cao n & J. Meitzen n 

author keywords: genetic sex; intrinsic electrophysiological properties; male and female rats; medium spiny neuron; mEPSC; striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Interneurons / physiology; Male; Membrane Potentials; Miniature Postsynaptic Potentials; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
topics (OpenAlex): Neurotransmitter Receptor Influence on Behavior; Neuroendocrine regulation and behavior; Neuroscience and Neuropharmacology Research
TL;DR: Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons

Dorris, D. M., Cao, J., Willett, J. A., Hauser, C. A., & Meitzen, J. (2014, November 7). Journal of Neurophysiology, Vol. 113, pp. 720–729.

By: D. Dorris n, J. Cao n, J. Willett n, C. Hauser n & J. Meitzen n 

author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
topics (OpenAlex): Neuroendocrine regulation and behavior; Hypothalamic control of reproductive hormones; Neurotransmitter Receptor Influence on Behavior
TL;DR: It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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