Jaime Anna Willett

Works (5)

Updated: August 17th, 2023 21:15

2019 journal article

Electrophysiological Properties of Medium Spiny Neuron Subtypes in the Caudate-Putamen of Prepubertal Male and Female Drd1a-tdTomato Line 6 BAC Transgenic Mice

ENEURO, 6(2).

By: J. Willett n, J. Cao*, D. Dorris*, A. Johnson *, L. Ginnari* & J. Meitzen n 

author keywords: caudate putamen; electrophysiology; intrinsic excitability; medium spiny neurons; rodent; sex differences
MeSH headings : Animals; Corpus Striatum / cytology; Corpus Striatum / physiology; Electrophysiology; Female; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / physiology; Organ Culture Techniques; Sex Characteristics; Synaptic Potentials / physiology
TL;DR: A comprehensive evaluation of mouse caudate-putamen MSN subtype electrophysiological properties across females and males is provided, both confirming and extending previous studies. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019

2019 journal article

The estrous cycle modulates rat caudate-putamen medium spiny neuron physiology

EUROPEAN JOURNAL OF NEUROSCIENCE, 52(1), 2737–2755.

By: J. Willett n, J. Cao n, A. Johnson  n, O. Patel n, D. Dorris n & J. Meitzen n 

author keywords: caudate-putamen; electrophysiology; estrous cycle; excitability; medium spiny neuron; sex differences
MeSH headings : Action Potentials; Animals; Estrous Cycle; Female; Male; Neurons; Nucleus Accumbens; Putamen; Rats
TL;DR: Recordings indicate that female caudate–putamen MSNs are sensitive to the estrous cycle, and the importance of considering neuroendocrine state in studies of neuron physiology is considered. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019

2018 review

Sex Differences in Medium Spiny neuron excitability and Glutamatergic Synaptic input: Heterogeneity Across Striatal Regions and evidence for Estradiol-Dependent Sexual Differentiation

[Review of ]. FRONTIERS IN ENDOCRINOLOGY, 9.

By: J. Cao n, J. Willett n, D. Dorris n & J. Meitzen n 

author keywords: sex; estradiol; hormones; striatum; medium spiny neuron; nucleus accumbens; caudate-putamen; electrophysiology
TL;DR: Sex differences in rat MSN glutamatergic synaptic input and intrinsic excitability across striatal regions are reviewed, including evidence for estradiol-mediated sexual differentiation in the nucleus AcbC. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

No Evidence for Sex Differences in the Electrophysiological Properties and Excitatory Synaptic Input onto Nucleus Accumbens Shell Medium Spiny Neurons

ENEURO, 3(1).

By: J. Willett n, T. Will n, C. Hauser n, D. Dorris n, J. Cao n & J. Meitzen n 

author keywords: genetic sex; intrinsic electrophysiological properties; male and female rats; medium spiny neuron; mEPSC; striatum
MeSH headings : Action Potentials; Animals; Excitatory Postsynaptic Potentials; Female; Interneurons / physiology; Male; Membrane Potentials; Miniature Postsynaptic Potentials; Nucleus Accumbens / physiology; Rats; Rats, Sprague-Dawley; Sex Characteristics
TL;DR: Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons

JOURNAL OF NEUROPHYSIOLOGY, 113(3), 720–729.

By: D. Dorris n, J. Cao n, J. Willett n, C. Hauser n & J. Meitzen n 

author keywords: intrinsic excitability; sex differences; medium spiny neuron; dorsal striatum; mEPSC
MeSH headings : Action Potentials; Animals; Corpus Striatum / cytology; Corpus Striatum / growth & development; Corpus Striatum / physiology; Female; Male; Neurons / physiology; Rats; Rats, Sprague-Dawley; Sex Factors
TL;DR: It is indicated that MSN excitability is increased in prepubertal females compared with males, providing a new mechanism that potentially contributes to generating sex differences in striatal-mediated processes. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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