Works (24)

Updated: April 4th, 2024 08:28

2023 article

Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast

Bellingham-Johnstun, K., Thorn, A., Belmonte, J., & Laplante, C. (2023, February 1).

TL;DR: This work underlines how intrinsic properties of microtubules differently impact nuclear positioning according to microtubule network organization and cell size. (via Semantic Scholar)
Source: ORCID
Added: February 2, 2023

2023 journal article

β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis

JOURNAL OF CELL BIOLOGY, 222(1).

MeSH headings : Actin Cytoskeleton; Actins; Actomyosin; Animals; Caenorhabditis elegans / cytology; Caenorhabditis elegans Proteins / metabolism; Cytokinesis; Formins; Membrane Glycoproteins / metabolism; Membrane Proteins / metabolism; Microfilament Proteins / metabolism; Spectrin / metabolism
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: September 21, 2022

2021 journal article

A mechanical model of early somite segmentation

ISCIENCE, 24(4).

Contributors: P. Adhyapok*, A. Piatkowska*, M. Norman n, S. Clendenon*, C. Stern*, J. Glazier*, J. Belmonte n

TL;DR: A corresponding mechanical model of epithelial segmentation in early somitogenesis is developed in which a wave of apical constriction leads to increasing tension and periodic failure of adhesion junctions within the dorsal epithelial layer of the PSM, forming clefts which determine the eventual somite boundaries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: March 19, 2021

2021 journal article

Mechanical competition alters the cellular interpretation of an endogenous genetic program

JOURNAL OF CELL BIOLOGY, 220(11).

MeSH headings : Actin Cytoskeleton / genetics; Actins / genetics; Actomyosin / genetics; Animals; Cell Shape / genetics; Cytoskeleton / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Gastrulation / genetics; Mesoderm / physiology
TL;DR: This paper shows that adjacent cells with similar genetic capabilities to change their own shape enter a tug of war that determines which cell shrinks and which expands. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: October 26, 2021

2021 journal article

Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis

CURRENT BIOLOGY, 31(24), 5415-+.

MeSH headings : Actins / metabolism; Actomyosin / metabolism; Animals; Caenorhabditis elegans / metabolism; Cytokinesis; Membrane Glycoproteins; Microfilament Proteins; Spectrin / genetics
TL;DR: These findings provide the first evidence that spectrin contributes to cytokinesis and highlight the importance of crosslinker interplay for actomyosin network integrity. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: October 19, 2021

2020 article

Cellular mechanisms of chick limb bud morphogenesis

Lesnicar-Pucko, G., Belmonte, J. M., Musy, M., Glazier, J. A., & Sharpe, J. (2020, September 11). (Vol. 9). Vol. 9.

By: G. Lesnicar-Pucko*, J. Belmonte n, M. Musy*, J. Glazier* & J. Sharpe*

Contributors: G. Lesnicar-Pucko*, J. Belmonte n, M. Musy*, J. Glazier* & J. Sharpe*

TL;DR: It is argued that this less-organised region of mesenchyme is necessary to prevent PD-oriented intercalation events in the distal tip that would otherwise inhibit outgrowth. (via Semantic Scholar)
Source: ORCID
Added: September 13, 2020

2020 journal article

CompuCell3D Simulations Reproduce Mesenchymal Cell Migration on Flat Substrates

BIOPHYSICAL JOURNAL, 118(11), 2801–2815.

By: I. Fortuna*, G. Perrone*, M. Krug*, E. Susin*, J. Belmonte n, G. Thomas*, J. Glazier*, R. Almeida*

MeSH headings : Cell Movement; Computer Simulation; Diffusion; Models, Biological; Motion
TL;DR: A computationally tractable 3D model (implemented as a simulation in the CompuCell3D simulation environment) of mesenchymal cells crawling on a two-dimensional substrate suggests its future application in more complex situations, including chemotaxis, migration through complex 3D matrices, and collective cell motion. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: June 22, 2020

2020 article

Mechanical competition alters the cellular interpretation of an endogenous genetic programme

Bhide, S., Gombalova, D., Mönke, G., Stegmaier, J., Zinchenko, V., Kreshuk, A., … Leptin, M. (2020, October 15). (Vol. 10). Vol. 10.

TL;DR: It is shown here that tissue-wide interactions force these cells to expand even when an otherwise sufficient amount of apical, active actomyosin is present, and models show that this behaviour is a general emergent property of actomyOSin networks [in a supracellular context, in accordance with experimental observations of actin reorganisation within stretching cells. (via Semantic Scholar)
Source: ORCID
Added: October 16, 2020

2020 journal article

Parameterizing cell movement when the instantaneous cell migration velocity is ill-defined

Physica A: Statistical Mechanics and Its Applications.

Contributors: J. Belmonte n

author keywords: Cell migration; Furth equation
UN Sustainable Development Goal Categories
Source: ORCID
Added: May 4, 2020

2019 article

A Mechanical Model of Early Somite Segmentation

(2019, October 13).

Contributors: P. Adhyapok*, A. Piatkowska, M. Norman n, S. Clendenon*, C. Stern, J. Glazier*, J. Belmonte n

Source: ORCID
Added: March 1, 2022

2019 journal article

Polarity sorting drives remodeling of actin-myosin networks

Journal of Cell Science.

author keywords: Actin cytoskeleton; Actin-myosin contraction; Active gel; Cell cortex; Myosin end-dwelling; Polarity sorting
MeSH headings : Actin Cytoskeleton / chemistry; Actins / physiology; Actomyosin / physiology; Cell Movement / physiology; Computer Simulation; Cytoskeletal Proteins / physiology; Cytoskeleton / physiology; Models, Biological; Muscle Contraction / physiology; Myosins / physiology
TL;DR: Experiments combined with simulations show that myosin-2 motors drive actin network contraction via a polarity-sorting mechanism that relies on dwelling of myosins at the plus end of actin filaments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: February 7, 2019

2018 journal article

A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

ELife, 7.

MeSH headings : Actins / metabolism; Animals; Biological Transport; Chromosomes / metabolism; Computer Simulation; Meiosis; Models, Biological; Oocytes / physiology; Starfish
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: ORCID
Added: February 7, 2019

2018 journal article

Fibroblast state switching orchestrates dermal maturation and wound healing

Molecular Systems Biology, 14(8).

Contributors: null

author keywords: dermis development; fibroblast states; mathematical modelling; tissue architecture; wound healing
MeSH headings : Animals; Cell Lineage / genetics; Cell Movement / genetics; Cell Proliferation / genetics; Cells, Cultured; Dermis / growth & development; Dermis / metabolism; Extracellular Matrix / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Mice; Skin / growth & development; Skin / metabolism; Wound Healing / genetics
TL;DR: A mathematical model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture is proposed, which faithfully recapitulates dermal maturation and shows that tissue-scale coordination is driven by the interdependence of cell proliferation and ECM deposition. (via Semantic Scholar)
Source: ORCID
Added: July 29, 2021

2017 journal article

A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

Molecular Systems Biology, 13(4), 927.

By: K. Chen*, T. Srinivasan*, K. Tung*, J. Belmonte*, L. Wang*, P. Murthy*, J. Choi*, N. Rakhilin* ...

Contributors: K. Chen*, T. Srinivasan*, K. Tung*, J. Belmonte*, L. Wang*, P. Murthy*, J. Choi*, . al.

author keywords: gene editing; intestine stem cell; Notch signaling; organoid; positive feedback
MeSH headings : Animals; Binding Sites; Cell Self Renewal; Feedback, Physiological; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Mice; Mutation; Organoids / metabolism; Receptor, Notch1 / chemistry; Receptor, Notch1 / genetics; Receptors, G-Protein-Coupled / metabolism; Signal Transduction; Stem Cell Niche; Stochastic Processes; Systems Biology / methods
TL;DR: Dynamical system analysis and agent‐based multiscale stochastic modeling suggest that the positive feedback enhances the robustness of Notch‐mediated niche patterning and highlights the importance of feedback mechanisms in spatiotemporal control of the stem cell niche. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2017 journal article

A theory that predicts behaviors of disordered cytoskeletal networks

Molecular Systems Biology, 13(9), 941.

Contributors: J. Belmonte*, M. Leptin*, F. Nédélec*, J. Belmonte & N. François

author keywords: actin; active gel; cell cortex; contractility; morphogenesis
MeSH headings : Actomyosin / chemistry; Algorithms; Animals; Cytoskeleton / chemistry; Cytoskeleton / metabolism; Models, Biological; Systems Biology / methods
TL;DR: A theory that predicts whether an isotropic network will contract, expand, or conserve its dimensions is described and it is suggested that pulsatility is an intrinsic behavior of contractile networks if the filaments are not stable but turn over. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: ORCID
Added: February 7, 2019

2016 journal article

A Liver-Centric Multiscale Modeling Framework for Xenobiotics

PLOS ONE, 11(9), e0162428.

By: J. Sluka*, X. Fu*, M. Swat*, J. Belmonte*, A. Cosmanescu*, S. Clendenon*, J. Wambaugh*, J. Glazier*

Contributors: J. Belmonte*

Ed(s): E. Schmidt

MeSH headings : Acetaminophen / pharmacology; Liver / drug effects; Liver / metabolism; Models, Theoretical; Programming Languages; Xenobiotics
TL;DR: This work describes a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism and uses the Systems Biology Markup Language (SBML) to create both the whole-body and sub-cellular scales. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2016 journal article

Filopodial-Tension Model of Convergent-Extension of Tissues

PLOS Computational Biology, 12(6), e1004952.

Contributors: J. Belmonte*

Ed(s): T. Tusscher

MeSH headings : Animals; Cell Adhesion / physiology; Cell Polarity / physiology; Computer Simulation; Elastic Modulus / physiology; Embryonic Development / physiology; Feedback, Physiological / physiology; Humans; Mechanotransduction, Cellular / physiology; Models, Biological; Pseudopodia / physiology; Stress, Mechanical; Tensile Strength / physiology
TL;DR: A cell-based CE model based on asymmetric filopodial tension forces between cells is proposed and addition of a simple mechanical feedback between cells fully rescues and even improves CE of tissues with high levels of polarity misalignments. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2016 journal article

Large-scale microtubule networks contract quite well

Elife, 5.

MeSH headings : Actins; Dyneins; Microtubules
TL;DR: The quantitative investigation of how networks of microtubules contract can boost the understanding of actin biology and help clarify the role of “spatially aggregating particles” in actinogenesis. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2016 journal article

Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease

Molecular Biology of the Cell, 27(22), 3673–3685.

By: J. Belmonte*, S. Clendenon*, G. Oliveira*, M. Swat*, E. Greene*, S. Jeyaraman*, J. Glazier*, R. Bacallao*

Contributors: J. Belmonte*, S. Clendenon*, G. Oliveira*, M. Swat*, E. Greene*, S. Jeyaraman*, J. Glazier*, R. Bacallao*

MeSH headings : Animals; Cadherins / metabolism; Cell Adhesion / physiology; Cell Culture Techniques; Cell Proliferation / physiology; Computer Simulation / statistics & numerical data; Cysts / metabolism; Humans; Kidney / metabolism; Mutation; Polycystic Kidney, Autosomal Dominant / metabolism; Signal Transduction
TL;DR: Virtual-tissue modeling is used to model emergent cyst growth in polycystic kidney disease and shows that decreased cell adhesion is necessary to produce stalk cysts and loss of contact inhibition causes saccular cysts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 7, 2019

2015 journal article

3D simulations of wet foam coarsening evidence a self similar growth regime

Colloids and Surfaces a-Physicochemical and Engineering Aspects, 473, 109–114.

author keywords: Liquid foams; Foam coarsening; Potts model simulations
TL;DR: All simulations eventually reach a self-similar growth regime, with the distribution functions time independent and the number of bubbles decreasing with time as a power law whose exponent depends on the wetness. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2014 journal article

Somites Without a Clock

Science, 343(6172), 791–795.

By: A. Dias*, I. Almeida*, J. Belmonte*, J. Glazier* & C. Stern*

Contributors: A. Dias*, I. Almeida*, J. Belmonte*, J. Glazier* & C. Stern*

MeSH headings : Animals; Bone Morphogenetic Proteins / antagonists & inhibitors; CLOCK Proteins / genetics; Carrier Proteins / pharmacology; Cell Communication; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / physiology; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Metabolic Networks and Pathways; Quail; Receptors, Notch / metabolism; Somites / cytology; Somites / drug effects; Somites / growth & development
TL;DR: It is shown that it is possible to generate somites of normal size, shape, and identity without either a clock or a wavefront and the findings suggest that somite size and shape are regulated by local cell-cell interactions. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2012 journal article

Multi-Scale Modeling of Tissues Using CompuCell3D

Computational Methods in Cell Biology, 110, 325–366.

By: M. Swat*, G. Thomas*, J. Belmonte*, A. Shirinifard*, D. Hmeljak*, J. Glazier*, A. Asthagiri, A. Arkin

Contributors: M. Swat*, G. Thomas*, J. Belmonte*, A. Shirinifard*, D. Hmeljak*, J. Glazier*, A. Asthagiri, A. Arkin

MeSH headings : Algorithms; Cell Adhesion; Cell Death; Cell Movement; Cell Proliferation; Chemotaxis; Computer Simulation; Human Umbilical Vein Endothelial Cells / cytology; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Models, Biological; Monte Carlo Method; Neoplasms, Vascular Tissue / blood supply; Neoplasms, Vascular Tissue / pathology; Neovascularization, Pathologic; Software; Thermodynamics; Tissue Engineering; Vascular Endothelial Growth Factor A / metabolism
TL;DR: This tutorial introduces the lattice-based Glazier-Graner-Hogeweg (GGH) Monte Carlo multi-cell modeling and the open-source GGH-based CompuCell3D simulation environment that allows rapid and intuitive modeling and simulation of cellular and multi- cellular behaviors in the context of tissue formation and subsequent dynamics. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2011 journal article

A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation

Plos Computational Biology, 7(10).

By: S. Hester*, J. Belmonte*, J. Gens*, S. Clendenon* & J. Glazier*

Contributors: S. Hester*, J. Belmonte*, J. Gens*, S. Clendenon* & J. Glazier*

MeSH headings : Animals; Biological Clocks; Body Patterning; Cell Adhesion; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Cell Division; Cell Movement; Computational Biology; Fibroblast Growth Factor 8 / genetics; Fibroblast Growth Factor 8 / metabolism; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mesoderm / cytology; Mesoderm / embryology; Mesoderm / metabolism; Models, Biological; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Notch / genetics; Receptors, Notch / metabolism; Signal Transduction; Somites / cytology; Somites / embryology; Somites / metabolism; Wnt3A Protein / genetics; Wnt3A Protein / metabolism
TL;DR: An integrated clock-and-wavefront model is built including submodels of the intracellular segmentation clock, intercellular segmentation-clock coupling via Delta/Notch signaling, an FGF8 determination front, delayed differentiation, clock- wavefront readout, and differential-cell- cell-adhesion-driven cell sorting to test the consistency, integrability and combined explanatory power of current prevailing hypotheses. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

2008 journal article

Self-propelled particle model for cell-sorting phenomena

Physical Review Letters, 100(24).

Contributors: J. Belmonte*, G. Thomas*, L. Brunnet*, R. Almeida* & H. Chate*

MeSH headings : Animals; Cell Adhesion / physiology; Cell Movement / physiology; Hydra / cytology; Hydra / physiology; Models, Biological; Regeneration / physiology
TL;DR: It is found that the tendency of cells to actively follow their neighbors greatly reduces segregation time scales, and clear algebraic growth laws as in physical phase-ordering processes are revealed, albeit with unusual scaling exponents. (via Semantic Scholar)
Source: ORCID
Added: February 7, 2019

Employment

Updated: October 13th, 2019 17:06

2018 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Physics

2014 - 2018

European Molecular Biology Laboratory Heidelberg, Baden-Württemberg, DE
Postdoc

Education

Updated: January 4th, 2016 04:22

Indiana University Bloomington Bloomington, IN, US
PhD Physics

Universidade Federal do Rio Grande do Sul Porto Alegre, RS, BR
Master Physics

Universidade Federal do Rio Grande do Sul Porto Alegre, RS, BR
Bachelor Physics

Funding History

Funding history based on the linked ORCID record. Updated: January 4th, 2016 04:30

salary-award January 1, 2015
Embryo-scale characterization and modeling of tissue dynamics during Drosophila gastrulation
EMBL Interdisciplinary Postdoc (EIPOD) Fellowship

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