James C Bonner
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Works (61)
Updated: April 3rd, 2024 17:07
2023 article
House dust mite extract forms a der p 2 corona on multi-walled carbon nanotubes: implications for allergic airway disease
Dominguez, J., Holmes, S. K., Bartone, R. D., Tisch, L. J., Tighe, R. M., Bonner, J. C., & Payne, C. K. (2023, December 15). ENVIRONMENTAL SCIENCE-NANO.
TL;DR:
It is found that the corona is dominated by der p 2, a protein associated with human allergic responses to house dust mites, which remains adsorbed on the surface of the MWCNTs following subsequent exposures to lung fluid proteins.
(via Semantic Scholar)
Source: Web Of Science
Added: January 2, 2024
2023 journal article
Role of the protease-activated receptor-2 (PAR2) in the exacerbation of house dust mite-induced murine allergic lung disease by multi-walled carbon nanotubes
PARTICLE AND FIBRE TOXICOLOGY, 20(1).
author keywords: Carbon nanotubes; Allergens; Protease-activated receptor 2; Lung; Inflammation; Fibrosis
TL;DR:
This study indicates that protease-activated receptor 2 (PAR2) mediates airway fibrosis but not eosinophilic lung inflammation induced by co-exposure to MWCNTs and HDM allergens.
(via Semantic Scholar)
particleandfibretoxicology.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 28, 2023
2022 article
Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation
Lee, H. Y., You, D. J., Taylor-Just, A. J., Linder, K. E., Atkins, H. M., Ralph, L. M., … Bonner, J. C. (2022, June 14). INHALATION TOXICOLOGY.
author keywords: Carbon black; nanoparticles; PFAS; lung; immunity
MeSH headings : Ammonium Compounds / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cell Proliferation; Cytokines / metabolism; Fluorocarbons / toxicity; Immunity, Innate; Ki-67 Antigen / metabolism; Lung; Male; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Nanoparticles / toxicity; Soot / toxicity
TL;DR:
Pulmonary exposure to GenX suppressed CBNP-induced innate immune response in the lungs of mice yet promoted the proliferation of macrophages and lung epithelial cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: June 27, 2022
2022 journal article
Synergistic induction of IL-6 production in human bronchial epithelial cells in vitro by nickel nanoparticles and lipopolysaccharide is mediated by eSTAT3 and C/EBP beta
TOXICOLOGY IN VITRO, 83.
author keywords: Nanoparticles; Nickel; Lipopolysaccharide; Cytokines; Cell signaling; Epithelial cells
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cell Line; Epithelial Cells; Female; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lipopolysaccharides / pharmacology; Male; Mice; Nanoparticles; Nickel; STAT3 Transcription Factor / metabolism
TL;DR:
The data suggest that LPS and NiNPs induce IL-6 via STAT3 and C/EBPβ in BEAS-2B cells, and that these cells do not appear to be suitable for studying the effect of sex hormones.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 15, 2022
2021 journal article
Femtosecond pulsed laser microscopy: a new tool to assess the in vitro delivered dose of carbon nanotubes in cell culture experiments
PARTICLE AND FIBRE TOXICOLOGY, 18(1).
author keywords: Particokinetics; Turbidity assay
MeSH headings : Cell Culture Techniques; Macrophages; Microscopy, Confocal; Monocytes; Nanotubes, Carbon
TL;DR:
A rapid and direct approach based on femtosecond pulsed laser microscopy (FPLM) was applied to assess the in vitro delivered dose of multi-walled CNTs (MWCNTs) and found the FPLM measurement can enrich experimental results, and may refine the understanding of their interactions with cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 8, 2021
2021 journal article
Osteopontin mRNA expression by rat mesothelial cells exposed to multi-walled carbon nanotubes as a potential biomarker of chronic neoplastic transformation in vitro
TOXICOLOGY IN VITRO, 73.
author keywords: Carbon nanotubes; Osteopontin; Mesothelial cells; Mesothelioma
MeSH headings : Animals; Biomarkers; Cell Line; Cell Transformation, Neoplastic / genetics; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Male; Mesothelioma / genetics; Nanotubes, Carbon / toxicity; Osteopontin / genetics; Pleura / cytology; RNA, Messenger; Rats, Inbred F344
TL;DR:
Data suggest that OPN is a potential biomarker that should be further investigated to screen the carcinogenicity of MWCNTs in vitro, and exposure of NRM2 cells to rMWC NT increased OPN mRNA that correlated with cellular transformation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 10, 2021
2021 journal article
STAT6-dependent exacerbation of house dust mite-induced allergic airway disease in mice by multi-walled carbon nanotubes
NANOIMPACT, 22.
author keywords: Carbon nanotubes; House dust mite; Allergens; STAT6; Asthma
MeSH headings : Animals; Antigens, Dermatophagoides / adverse effects; Asthma / chemically induced; Dermatophagoides pteronyssinus; Fibrosis; Hypersensitivity / metabolism; Immunoglobulin E; Lung; Male; Metaplasia / chemically induced; Mice; Mice, Knockout; Nanotubes, Carbon / adverse effects; Pulmonary Eosinophilia / chemically induced; Pulmonary Fibrosis / chemically induced; Respiration Disorders / chemically induced; STAT6 Transcription Factor / genetics
TL;DR:
Findings provide new mechanistic insight by demonstrating a requirement for STAT6 in MWCNT-induced exacerbation of allergic respiratory disease by demonstrating that airway fibrosis was significantly increased by the combination of HDM and M WCNTs in WT mice but not in Stat6 KO mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 21, 2021
2021 journal article
Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure
TOXICOLOGICAL SCIENCES, 183(1), 170–183.
author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
TL;DR:
Data indicate that O3 drives an increased pulmonary inflammatory and bioactive lipid mediator response in females, and ovariectomy increases susceptibility to O3-induced pulmonary inflammation and injury, as well as decreases pulmonary DHA concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 27, 2021
2020 book
Interaction of Nanomaterials with the Immune System
Ed(s): & J. Brown
TL;DR:
This chapter overviews the topics covered in this book and thereby sets the stage for understanding the complexity of immune responses to a diversity of emerging engineered nanomaterials.
(via Semantic Scholar)
Source: Crossref
Added: February 5, 2022
2020 article
Interaction of Nanomaterials with the Immune System Introduction
INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 1–14.
author keywords: Nanotechnology; Immune system; Immunotoxicity
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2020 article
Macrophages: First Innate Immune Responders to Nanomaterials
INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM, pp. 15–34.
author keywords: Macrophage; Nanomaterial; Toll-like receptors; Scavenger receptors; Reactive oxygen species; Inflammasome; Polarization
TL;DR:
The immune response of macrophages to ENMs, including inflammasome activation and alternative polarization, plays important roles in immune-mediated diseases such as fibrosis, asthma, and cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 16, 2021
2020 journal article
Sex differences in the acute and subchronic lung inflammatory responses of mice to nickel nanoparticles
NANOTOXICOLOGY, 14(8), 1058–1081.
author keywords: Nickel nanoparticles; inflammation; lung; sex; susceptibility
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Chemokine CXCL1 / metabolism; Female; Humans; Inhalation Exposure; Interleukin-6 / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Male; Metal Nanoparticles / toxicity; Mice; Mice, Inbred C57BL; Neutrophils / cytology; Neutrophils / drug effects; Nickel / toxicity; Pneumonia / chemically induced; Pneumonia / pathology; STAT Transcription Factors / metabolism; Sex Characteristics; Signal Transduction; Toxicity Tests, Acute; Toxicity Tests, Subchronic
TL;DR:
Sex differences in the lung inflammatory response of mice to NiNPs that has implications for human disease are demonstrated and indicate that susceptibility of males to acute lung inflammation involves enhanced neutrophilia with increased CXCL1 and IL-6/STAT3 signaling, whereas susceptibility to subchronic lunginflammation involves enhanced monocytic infiltration withIncreased CXcl1 and CCL2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 7, 2020
2020 review
Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials
[Review of ]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(19).
author keywords: engineered nanomaterials; susceptibility; chronic inflammation; lung inflammation
MeSH headings : Animals; Humans; Inflammation / chemically induced; Inflammation / complications; Inflammation / pathology; Inhalation Exposure; Lung / drug effects; Lung / pathology; Nanostructures / adverse effects; Nanostructures / therapeutic use; Pneumonia / complications; Pneumonia / drug therapy; Pneumonia / pathology
TL;DR:
This review will address evidence from experimental animal models that highlights some important issues of susceptibility to chronic lung inflammation and systemic immune dysfunction after pulmonary exposure to ENMs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method
PARTICLE AND FIBRE TOXICOLOGY, 17(1).
author keywords: Carbon nanotubes; Purification; Functionalization; Lung injury; Fibrosis
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / metabolism; Inhalation Exposure; Lung / drug effects; Lung Injury; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / toxicity; Transforming Growth Factor beta1 / metabolism
TL;DR:
The purification method is an important determinant of lung toxicity induced by carboxyl- and amine-functionalized MWCNTs, as indicated by Raman spectroscopy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 21, 2020
2019 journal article
Inhalation exposure to multi-walled carbon nanotubes alters the pulmonary allergic response of mice to house dust mite allergen
INHALATION TOXICOLOGY, 31(5), 192–202.
author keywords: Carbon nanotubes; house dust mite allergen; asthma; inhalation; atopy; nanoparticles
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Immunologic; Fibrosis; Hypersensitivity / physiopathology; Immunoglobulin E / blood; Inhalation Exposure / adverse effects; Interleukin-13 / analysis; Lung / physiology; Male; Mice; Nanotubes, Carbon / toxicity; Th2 Cells / immunology
TL;DR:
Inhalation pre-exposure to MWCNTs inhibited HDM-induced TH2 immune responses, yet this combined exposure resulted in vascular inflammation and airway fibrosis, indicating that M WCNT pre-Exposure alters the immune response to allergens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 19, 2019
2018 article
ICONS - Integrated testing strategy for mechanistically assessing the respiratory toxicity of functionalized MWCNTs - Comparative in vitro investigations
Ziemann, C., Reamon-Buettner, S. M., Lison, D., Bonner, J. C., Brule, S., Simon, S., & Creutzenberg, O. H. (2018, October 10). TOXICOLOGY LETTERS, Vol. 295, pp. S213–S213.
Source: Web Of Science
Added: January 7, 2019
2018 review
Mechanisms of carbon nanotube-induced pulmonary fibrosis: A physicochemical characteristic perspective
[Review of ]. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 10(3).
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes
NANOTOXICOLOGY, 12(9), 975–991.
author keywords: Caron nanotubes; immunotoxicology; cancer; granuloma; p53
MeSH headings : Animals; Dose-Response Relationship, Drug; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / genetics; Granuloma, Respiratory Tract / immunology; Inhalation Exposure; Lung / drug effects; Lung / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Surface Properties; Tertiary Lymphoid Structures / chemically induced; Tertiary Lymphoid Structures / genetics; Tertiary Lymphoid Structures / immunology; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / physiology
TL;DR:
Findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 4, 2019
2018 journal article
Signal transducer and activator of transcription 1 regulates multiwalled carbon nanotube-induced pulmonary fibrosis in mice via suppression of transforming growth factor-beta 1 production and signaling
Annals of the American Thoracic Society, 15, S129–130.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
The Toxicology of Engineered Nanomaterials in Asthma
Current Environmental Health Reports, 5(1), 100–109.
author keywords: Asthma; Allergy; Lung; Nanoparticles; Nanotubes; Nanomaterials
MeSH headings : Asthma / chemically induced; Humans; Lung / drug effects; Metal Nanoparticles / toxicity; Nanostructures / toxicity; Nanotubes, Carbon / toxicity
TL;DR:
Evidence is strong that ENMs can contribute to allergic airway disease; however, more work is required to determine their mechanisms, and more epidemiological studies are needed to validate results from animal models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2017 journal article
Mapping differential cellular protein response of mouse alveolar epithelial cells to multi-walled carbon nanotubes as a function of atomic layer deposition coating
NANOTOXICOLOGY, 11(3), 313–326.
author keywords: Carbon nanotube; label-free proteomics; pulmonary fibrosis; toxicoproteomics
MeSH headings : Aluminum Oxide / toxicity; Alveolar Epithelial Cells / chemistry; Alveolar Epithelial Cells / drug effects; Animals; Cells, Cultured; Mice; Nanotubes, Carbon / toxicity; Proteomics / methods; Pulmonary Fibrosis / etiology; Zinc Oxide / toxicity
TL;DR:
It is demonstrated that specific types of metal oxide thin film coatings applied by ALD produce distinct cellular and biochemical responses related to lung inflammation and fibrosis compared to uncoated MWCNT exposure in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 10(3), e1498.
MeSH headings : Animals; Cells, Cultured; Chemical Phenomena; Disease Models, Animal; Environmental Exposure; Epithelial-Mesenchymal Transition; Mice; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Nanotubes, Carbon / ultrastructure; Oxidative Stress; Pulmonary Fibrosis / chemically induced; Rats
TL;DR:
The current state of the literature on mechanisms of CNT-exposed pulmonary fibrosis in rodent models is covered with a focus on physicochemical characteristics as principal drivers of the mechanisms leading to pulmonary Fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: June 6, 2020
2017 journal article
STAT1-dependent and -independent pulmonary allergic and fibrogenic responses in mice after exposure to tangled versus rod-like multi-walled carbon nanotubes
PARTICLE AND FIBRE TOXICOLOGY, 14.
author keywords: Carbon nanotubes; Lung; Fibrosis; Growth factors; Transcription factors
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / chemistry; Cell Proliferation / drug effects; Cytokines / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Genetic Predisposition to Disease; Granuloma, Respiratory Tract / chemically induced; Granuloma, Respiratory Tract / metabolism; Granuloma, Respiratory Tract / pathology; Immunoglobulin E / blood; Lung / drug effects; Lung / metabolism; Lung / pathology; Male; Mice, Knockout; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Phenotype; Phosphorylation; Pneumonia / chemically induced; Pneumonia / metabolism; Pneumonia / pathology; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Respiratory Hypersensitivity / chemically induced; Respiratory Hypersensitivity / genetics; Respiratory Hypersensitivity / metabolism; Respiratory Hypersensitivity / pathology; Risk Assessment; STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / metabolism; Signal Transduction / drug effects; Smad2 Protein / metabolism; Smad3 Protein / metabolism; Time Factors; Transforming Growth Factor beta1 / metabolism
TL;DR:
Rigidity plays a key role in the toxicity of MWCNTs and results in increased inflammatory, immunologic, and fibrogenic effects in the lung, and both rigidity and genetic susceptibility should be major considerations for risk assessment of MMWNTs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Atomic layer deposition coating of carbon nanotubes with zinc oxide causes acute phase immune responses in human monocytes in vitro and in mice after pulmonary exposure
PARTICLE AND FIBRE TOXICOLOGY, 13.
Contributors: E. Dandley n, A. Taylor n, K. Duke n, M. Ihrie n, K. Shipkowski n, G. Parsons n , n
author keywords: Atomic layer deposition; Carbon nanotubes; Pulmonary fibrosis; Inflammation
MeSH headings : Acute-Phase Reaction / chemically induced; Acute-Phase Reaction / immunology; Acute-Phase Reaction / metabolism; Acute-Phase Reaction / pathology; Air Pollutants / chemistry; Air Pollutants / toxicity; Animals; Cell Line; Cytokines / agonists; Cytokines / genetics; Cytokines / metabolism; Disease Progression; Gene Expression Regulation / drug effects; Humans; Inhalation Exposure / adverse effects; Lung / drug effects; Lung / immunology; Lung / metabolism; Lung / pathology; Male; Mice, Inbred C57BL; Microscopy, Electron, Scanning Transmission; Monocytes / drug effects; Monocytes / immunology; Monocytes / metabolism; Monocytes / pathology; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Nanotubes, Carbon / ultrastructure; Pulmonary Fibrosis / etiology; RNA, Messenger / metabolism; Respiratory Mucosa / drug effects; Respiratory Mucosa / immunology; Respiratory Mucosa / pathology; Surface Properties; Zinc Oxide / chemistry; Zinc Oxide / toxicity
TL;DR:
It is hypothesized that surface functionalization of multi-walled carbon nanotubes with polycrystalline ZnO by ALD would alter pro-inflammatory cytokine expression by human monocytes in vitro and modulate the lung and systemic immune response following oropharyngeal aspiration in mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials
ARCHIVES OF TOXICOLOGY, 90(7), 1769–1783.
author keywords: Inhalation toxicity; Multi-walled carbon nanotubes; MWCNTs; In vitro testing strategies; Regulatory risk assessment; Pulmonary fibrosis
MeSH headings : Aerosols; Animal Use Alternatives; Animals; Cell Culture Techniques; Cells, Cultured; Equipment Design; Humans; Inhalation Exposure / adverse effects; Lung / cytology; Lung / drug effects; Models, Biological; Nanostructures / administration & dosage; Nanostructures / toxicity; Pulmonary Fibrosis / chemically induced; Toxicity Tests / instrumentation; Toxicity Tests / methods
TL;DR:
The workshop discussions provided the fundamental design components of an air–liquid interface in vitro test system that will be subsequently expanded to the development of an alternative testing strategy to predict pulmonary toxicity and to generate data that will enable effective risk assessment of NMs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Multiwalled Carbon Nanotube Functionalization with High Molecular Weight Hyaluronan Significantly Reduces Pulmonary Injury
ACS NANO, 10(8), 7675–7688.
author keywords: multiwalled carbon nanotubes; hyaluronan; lung; inflammation; fibrosis; mucous metaplasia; differentiated human bronchial epithelia
MeSH headings : Fibroblasts; Humans; Hyaluronic Acid; Lung; Lung Injury / prevention & control; Macrophages, Alveolar; Molecular Weight; Nanotubes, Carbon
TL;DR:
Results demonstrate the effectiveness of HA functionalization as a safer design approach to eliminate MWCNT-induced lung injury and suggest thatHA functionalization works by reducing MWC NT-induced epithelial injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
An allergic lung microenvironment suppresses carbon nanotube-induced inflammasome activation via STAT6-dependent inhibition of caspase-1
PLoS One, 10(6).
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Role of Signal Transducer and Activator of Transcription 1 in Murine Allergen-Induced Airway Remodeling and Exacerbation by Carbon Nanotubes
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 53(5), 625–636.
author keywords: asthma; allergen; nanomaterials; carbon nanotubes; airway remodeling
MeSH headings : Allergens / pharmacology; Animals; Bronchoalveolar Lavage Fluid / chemistry; Eosinophils / drug effects; Eosinophils / immunology; Eosinophils / pathology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Epithelial Cells / pathology; Gene Expression Regulation; Goblet Cells / drug effects; Goblet Cells / immunology; Goblet Cells / pathology; Interleukin-10 / genetics; Interleukin-10 / immunology; Interleukin-13 / genetics; Interleukin-13 / immunology; Male; Mice; Mice, Knockout; Nanotubes / adverse effects; Neutrophils / drug effects; Neutrophils / immunology; Neutrophils / pathology; Osteopontin / genetics; Osteopontin / immunology; Ovalbumin / immunology; Respiratory Hypersensitivity / etiology; Respiratory Hypersensitivity / genetics; Respiratory Hypersensitivity / immunology; Respiratory Hypersensitivity / pathology; STAT1 Transcription Factor / deficiency; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / immunology; Signal Transduction; T-Lymphocytes, Helper-Inducer / drug effects; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / pathology; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / immunology; Transforming Growth Factor beta1 / pharmacology; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
TL;DR:
A protective role for STAT1 is supported in chronic AAI and exacerbation of remodeling caused by MWCNTs and fibroblasts isolated from the lungs of Stat1(-/-) mice produced significantly more collagen mRNA and protein in response to transforming growth factor-β1 compared with WT lung fibro Blasts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Toxicoproteomic analysis of pulmonary carbon nanotube exposure using LC-MS/MS
TOXICOLOGY, 329, 80–87.
Contributors: G. Hilton n, A. Taylor n, C. McClure n, G. Parsons n , n & M. Bereman n
author keywords: Carbon nanotube; Label-free proteomics; Pulmonary fibrosis; Toxicoproteomics
MeSH headings : Acute-Phase Proteins / genetics; Acute-Phase Proteins / metabolism; Animals; Bronchoalveolar Lavage Fluid / chemistry; Chromatography, Liquid; Complement C3 / genetics; Complement C3 / metabolism; Complement C4b / genetics; Complement C4b / metabolism; Complement C9 / genetics; Complement C9 / metabolism; Histones / genetics; Histones / metabolism; Lactoferrin / genetics; Lactoferrin / metabolism; Lipocalin-2; Lipocalins / genetics; Lipocalins / metabolism; Lung / drug effects; Lung / metabolism; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Peroxidase / genetics; Peroxidase / metabolism; Proteome / metabolism; Pulmonary Surfactant-Associated Protein B / genetics; Pulmonary Surfactant-Associated Protein B / metabolism; Tandem Mass Spectrometry; Toxicity Tests
TL;DR:
The protein secretion profile in lung bronchoalveolar lavage fluid from mice exposed to non-functionalized multi-walled carbon nanotubes or MWCNTs functionalized by nanoscale Al2O3 coatings formed using atomic layer deposition (ALD) was compared.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Atomic Layer Deposition Coating of Carbon Nanotubes with Aluminum Oxide Alters Pro-Fibrogenic Cytokine Expression by Human Mononuclear Phagocytes In Vitro and Reduces Lung Fibrosis in Mice In Vivo
PLOS ONE, 9(9).
Contributors: A. Taylor n, C. McClure n, K. Shipkowski n, E. Thompson n, S. Hussain *, S. Garantziotis *, G. Parsons n , n
MeSH headings : Aluminum Oxide / pharmacology; Animals; Cell Death / drug effects; Cell Line; Cytokines / metabolism; Humans; Inflammation / pathology; Interleukin-1beta / biosynthesis; Interleukin-6 / metabolism; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Macrophages / drug effects; Macrophages / metabolism; Macrophages / ultrastructure; Mice, Inbred C57BL; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure; Osteopontin / metabolism; Phagocytes / drug effects; Phagocytes / metabolism; Pulmonary Fibrosis; Soot / pharmacology; Surface Properties; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Findings indicate that ALD thin film coating of MWCNTs with Al2O3 reduces fibrosis in mice and that in vitro phagocyte expression of IL-6, TNF-α, and OPN, but not IL-1β, predict M WCNT-induced fibrosisIn the lungs of mice in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2014 journal article
Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V2O5)
FASEB JOURNAL, 28(3), 1098–1112.
author keywords: lung injury; inflammation; collagen; haplotype; mapping
MeSH headings : Animals; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Real-Time Polymerase Chain Reaction; Transforming Growth Factor beta / metabolism; Vanadium Compounds / toxicity
TL;DR:
Pulmonary responses to V2O5, including dose‐dependent increases in lung permeability, inflammation, collagen content, and dysfunction, were significantly greater in DBA/2J mice compared to C57BL/6J mice, suggesting that V2 O5 may induce pulmonary fibrosis through mechanisms distinct from those in other models of pulmonary Fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts
Particle and Fibre Toxicology, 11.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Nickel Nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet)
Particle and Fibre Toxicology, 11.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 306(3), L269–L276.
author keywords: cigarette smoking; epithelial cells; antiprotease
MeSH headings : Adult; Animals; Epithelial Cells / metabolism; Female; Humans; Leukocyte Elastase / antagonists & inhibitors; Lung / metabolism; Male; Mice; Nasal Lavage Fluid; Nasal Mucosa / metabolism; STAT1 Transcription Factor / biosynthesis; Secretory Leukocyte Peptidase Inhibitor / biosynthesis; Smoking / genetics
TL;DR:
It is demonstrated that smoking enhances expression of SLPI in NECs in vitro and in vivo, and that this response is regulated by STAT1, and antiprotease activity against neutrophil elastase is enhanced in smokers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment
ACS Nano, 7(8), 6422–6433.
MeSH headings : Animals; Congresses as Topic; Humans; International Cooperation; Materials Testing; Mice; Nanostructures / chemistry; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Risk Assessment / methods; Safety; Toxicity Tests
TL;DR:
A workshop bringing together national and international leaders from government, industry, and academia was convened at the University of California, Los Angeles, to discuss the utility of ATS for decision-making analyses of ENMs, including a general view that ATS approaches for ENMs can significantly benefit chemical safety analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2013 journal article
A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment
ACS Nano, 7(8), 6422–6433.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered n nanomaterials: The NIEHS Nano GO Consortium
Environmental Health Perspectives, 121(6), 683–690.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: The NIEHS Nano GO Consortium
Environmental Health Perspectives, 121(6), 676–682.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Nanomaterials as a potential cause of lung disease
Toxicology Letters, 221, S5.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 14, 2021
2013 journal article
Role of Cyclooxygenase-2 in Exacerbation of Allergen-Induced Airway Remodeling by Multiwalled Carbon Nanotubes
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 49(4), 525–535.
author keywords: carbon nanotubes; nanoparticles; asthma; inflammation; COX-2
MeSH headings : Airway Remodeling / genetics; Airway Remodeling / immunology; Airway Remodeling / physiology; Allergens / immunology; Animals; Cyclooxygenase 1 / genetics; Cyclooxygenase 1 / immunology; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / immunology; Cyclooxygenase 2 / metabolism; Cytokines / immunology; Female; Inflammation / chemically induced; Inflammation / genetics; Inflammation / immunology; Inflammation / metabolism; Male; Membrane Proteins / genetics; Membrane Proteins / immunology; Membrane Proteins / metabolism; Metaplasia / genetics; Metaplasia / immunology; Metaplasia / metabolism; Mice; Mice, Inbred C57BL; Mucus / immunology; Mucus / metabolism; Nanotubes, Carbon; Ovalbumin / immunology; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / metabolism
TL;DR:
Exacerbations of allergen-induced airway inflammation and mucus-cell metaplasia by MWCNTs are enhanced by deficiencies in COX-2, and are associated with the activation of a mixed Th1/Th2/Th17 immune response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages
Particle and Fibre Toxicology, 9.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Nickel Nanoparticles Enhance Platelet-Derived Growth Factor-Induced Chemokine Expression by Mesothelial Cells via Prolonged Mitogen-Activated Protein Kinase Activation
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 47(4), 552–561.
author keywords: nanoparticles; metals; lung; pleura; chemokines
MeSH headings : Acetylcysteine / pharmacology; Analysis of Variance; Animals; Antioxidants / pharmacology; Cell Line; Chemokine CCL2 / genetics; Chemokine CCL2 / metabolism; Chemokine CXCL10 / genetics; Chemokine CXCL10 / metabolism; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / ultrastructure; Gene Expression / drug effects; Gene Expression Regulation / drug effects; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; MAP Kinase Signaling System; Metal Nanoparticles; Mitogen-Activated Protein Kinases / metabolism; Nickel / metabolism; Nickel / pharmacology; Phosphorylation; Platelet-Derived Growth Factor / physiology; Pleura / cytology; Protein Processing, Post-Translational; Rats; Receptors, Platelet-Derived Growth Factor / metabolism
TL;DR:
It is found that NiNPs enhance the activity of PDGF in regulating chemokine production in NRM2 cells through a mechanism involving reactive oxygen species generation and prolonged activation of ERK-1,2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro
TOXICOLOGY AND APPLIED PHARMACOLOGY, 265(1), 27–42.
author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
TL;DR:
The finding that HSulf-1 sensitizes these cancer cells and intensifies the injury induced by cadmium suggests that 6-O-sulfate groups on HSPGs may play important roles in protection against certain environmental toxicants, such as heavy metals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Dispersal State of Multiwalled Carbon Nanotubes Elicits Profibrogenic Cellular Responses That Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine Lung
ACS NANO, 5(12), 9772–9787.
author keywords: multiwalled carbon nanotubes (MWCNTs); dispersion; TGF-beta 1; PDGF-AA; IL-1 beta; collagen; lung fibrosis
MeSH headings : Animals; Biomarkers / metabolism; Cytokines / metabolism; Dose-Response Relationship, Drug; Lung / drug effects; Lung / metabolism; Mice; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / toxicity; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Tissue Distribution
TL;DR:
The results indicate that the dispersal state of MWCNTs affects profibrogenic cellular responses that correlate with the extent of pulmonary fibrosis and are of potential use to predict pulmonary toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 review
PULMONARY ENDPOINTS (LUNG CARCINOMAS AND ASBESTOSIS) FOLLOWING INHALATION EXPOSURE TO ASBESTOS
[Review of ]. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 14(1-4), 76–121.
MeSH headings : Animals; Asbestos / administration & dosage; Asbestos / chemistry; Asbestos / pharmacokinetics; Asbestos / toxicity; Asbestosis / metabolism; Biological Transport; Body Burden; Carcinogens, Environmental / administration & dosage; Carcinogens, Environmental / chemistry; Carcinogens, Environmental / pharmacokinetics; Carcinogens, Environmental / toxicity; Carcinoma / chemically induced; Carcinoma / genetics; Carcinoma / metabolism; Chemical Phenomena; Humans; Inhalation Exposure / adverse effects; Lung / drug effects; Lung / metabolism; Lung Neoplasms / chemically induced; Lung Neoplasms / genetics; Lung Neoplasms / metabolism; Mineral Fibers / analysis; Mineral Fibers / toxicity; Mutagens / administration & dosage; Mutagens / chemistry; Mutagens / pharmacokinetics; Mutagens / toxicity; Particulate Matter / administration & dosage; Particulate Matter / chemistry; Particulate Matter / pharmacokinetics; Particulate Matter / toxicity; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 43(2), 142–151.
author keywords: carbon nanotubes; inflammation; lipopolysaccharide; fibrosis; growth factors
MeSH headings : Animals; Bacteria / metabolism; Fibroblasts / metabolism; Fibrosis; Inflammation; Lipopolysaccharides / metabolism; Macrophages / metabolism; Male; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Platelet-Derived Growth Factor / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction; Soot / chemistry
TL;DR:
The data suggest that LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasingPDGF-Ralpha on pulmonary fibroblasts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Respiratory syncytial virus infection reduces lung inflammation and fibrosis in mice exposed to vanadium pentoxide
RESPIRATORY RESEARCH, 11.
MeSH headings : Animals; Cytokines / metabolism; Male; Mice; Mice, Inbred AKR; Pneumonia / chemically induced; Pneumonia / complications; Pneumonia / metabolism; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / complications; Pulmonary Fibrosis / metabolism; Respiratory Syncytial Virus Infections / complications; Respiratory Syncytial Virus Infections / metabolism; Vanadium Compounds
TL;DR:
It is suggested that RSV infection reduces the severity of V2O5-induced fibrosis by suppressing growth factors and collagen genes and suggests that viral infection also suppresses the innate immune response that normally serves to resolve V2 O5- induced fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in Murine Allergic Asthma
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(3), 349–358.
author keywords: carbon nanotubes; asthma; fibrosis; lung
MeSH headings : Administration, Inhalation; Aerosols; Animals; Asthma / chemically induced; Asthma / immunology; Asthma / pathology; Bronchoalveolar Lavage Fluid / cytology; Fibrosis / chemically induced; Fibrosis / immunology; Fibrosis / pathology; Humans; Interleukin-13 / immunology; Lung / cytology; Lung / immunology; Lung / pathology; Macrophages / cytology; Macrophages / metabolism; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Ovalbumin / immunology; Particle Size; Platelet-Derived Growth Factor / immunology; Random Allocation; Transforming Growth Factor beta1 / immunology
TL;DR:
It is indicated that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled multiwalled carbon nanotubes, and combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airways fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhaled carbon nanotubes reach the subpleural tissue in mice
NATURE NANOTECHNOLOGY, 4(11), 747–751.
MeSH headings : Aerosols / adverse effects; Animals; Immunity / drug effects; Inhalation Exposure / analysis; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Pleura / drug effects; Pleura / immunology; Pleura / ultrastructure; Pulmonary Fibrosis / chemically induced
TL;DR:
It is shown that multi-walled carbon nanotubes reach the sub-pleura in mice after a single inhalation exposure of 30 mg/m3 for 6 hours and it is suggested that minimizing inhalation of nanot tubes during handling is prudent until further long term assessments are conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 article
Nanoparticle-Mediated Drug Delivery and Pulmonary Hypertension
Bonner, J. C., Card, J. W., & Zeldin, D. C. (2009, May). HYPERTENSION, Vol. 53, pp. 751–753.
MeSH headings : Animals; Drug Delivery Systems; Hypertension, Pulmonary / drug therapy; NF-kappa B / antagonists & inhibitors; NF-kappa B / physiology; Nanoparticles / administration & dosage; Nanoparticles / toxicity; Nanotubes, Carbon; Oligodeoxyribonucleotides / administration & dosage; Rats
TL;DR:
It was speculated by the authors that cellular uptake of the NPs might slowly release encapsulated ODNs, and it was shown that NP-encapsulated NF-κB decoy reached the distal regions of the lungs and was present in alveolar macrophages and small pulmonary arteries for ≤14 days after a single instillation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Male sex hormones exacerbate lung function impairment after bleomycin-induced pulmonary fibrosis
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 39(1), 45–52.
author keywords: fibrosis; bleomycin; sex; respiratory mechanics
MeSH headings : Animals; Bleomycin / toxicity; Collagen / metabolism; Dihydrotestosterone / pharmacology; Estradiol / deficiency; Female; Inflammation / chemically induced; Inflammation / physiopathology; Lung Compliance / drug effects; Lung Compliance / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Orchiectomy; Ovariectomy; Polymerase Chain Reaction; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / physiopathology; RNA / genetics; Respiratory Function Tests; Sex Characteristics
TL;DR:
The data indicate that androgens play an exacerbating role in decreased lung function after bleomycin administration, and traditional measures of fibrosis may miss critical differences in lung function between the sexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 review
Pulmonary applications and toxicity of engineered nanoparticles
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 295(3), L400–L411.
author keywords: nanotechnology; nanomaterials; respiratory system; lung
MeSH headings : Animals; Drug Delivery Systems; Humans; Lung / drug effects; Lung / metabolism; Models, Biological; Nanoparticles / therapeutic use; Nanoparticles / toxicity; Nanotechnology; Tissue Distribution
TL;DR:
An overview of the potential usefulness of nanoparticles and nanotechnology in respiratory research and medicine is provided and important issues and recent data pertaining to nanoparticle-related pulmonary toxicity are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
STAT-1 signaling in human lung fibroblasts is induced by vanadium pentoxide through an IFN-beta autocrine loop
JOURNAL OF IMMUNOLOGY, 180(6), 4200–4207.
MeSH headings : Autocrine Communication / drug effects; Autocrine Communication / immunology; Cell Line; Culture Media, Conditioned; Enzyme Inhibitors / pharmacology; Fibroblasts / drug effects; Fibroblasts / enzymology; Fibroblasts / immunology; Fibroblasts / metabolism; Humans; Hydrogen Peroxide / metabolism; Interferon-beta / physiology; Intracellular Fluid / drug effects; Intracellular Fluid / immunology; Intracellular Fluid / metabolism; Lung / drug effects; Lung / enzymology; Lung / immunology; Lung / metabolism; NADPH Oxidases / antagonists & inhibitors; NADPH Oxidases / physiology; Phosphorylation; Reactive Oxygen Species / metabolism; STAT1 Transcription Factor / metabolism; STAT1 Transcription Factor / physiology; Signal Transduction / drug effects; Signal Transduction / immunology; Vanadium Compounds / pharmacology; Xanthine Oxidase / physiology
TL;DR:
Fibroblasts play a role in the innate immune response to vanadium-induced oxidative stress by synthesizing IFN-β and activating STAT-1 to cause growth arrest and increase levels of CXCL10, a potent antifibrotic factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Lung Fibrotic Responses to Particle Exposure
Toxicologic Pathology, 35(1), 148–153.
author keywords: metals; endotoxin; oxidants; cytokines; growth factors
MeSH headings : Air Pollutants / adverse effects; Animals; Carbon / adverse effects; Cities; Coal Ash; Humans; Inhalation Exposure; Lung / drug effects; Lung / pathology; Particle Size; Particulate Matter / adverse effects; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / pathology; Urban Health; Vehicle Emissions / toxicity
TL;DR:
Particles generated from numerous anthropogenic sources have the potential to cause or exacerbate lung diseases, including asthma, bronchitis, and COPD, and involve the progressive deposition of collagen by pulmonary fibroblasts.
(via Semantic Scholar)
Source: Crossref
Added: August 14, 2021
2005 journal article
Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis
The American Journal of Pathology, 167(5), 1221–1229.
MeSH headings : Animals; Bleomycin / toxicity; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen / analysis; Disease Models, Animal; Epidermal Growth Factor / pharmacology; Fibroblasts / pathology; Growth Inhibitors / pharmacology; Hydroxyproline / analysis; Interferon-gamma / pharmacology; Lung / drug effects; Lung / pathology; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation; Platelet-Derived Growth Factor / pharmacology; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / physiopathology; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / physiology; STAT3 Transcription Factor / metabolism; Thymidine / metabolism
TL;DR:
The findings indicate that Stat1-/- mice are more susceptible to bleomycin-induced lung fibrosis than wild-type mice due to 1) enhanced fibroblast proliferation in response to growth factors (EGF and PDGF), 2) stimulation of fibro Blast growth by a Stat 1-independent IFN-gamma signaling pathway, and 3) increased activation of Stat3.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Regulation of PDGF and its receptors in fibrotic diseases
Cytokine & Growth Factor Reviews, 15(4), 255–273.
author keywords: PDGF; fibrosis; lung; liver; kidney
MeSH headings : Animals; Fibroblasts / metabolism; Fibrosis / pathology; Gene Expression Regulation; Humans; Inflammation / pathology; Interleukin-1 / metabolism; Kidney / pathology; Liver / pathology; Lung / pathology; Models, Biological; Muscles / pathology; Platelet-Derived Growth Factor / metabolism; Platelet-Derived Growth Factor / physiology; Protein Isoforms; Receptor, Platelet-Derived Growth Factor alpha / metabolism; Receptor, Platelet-Derived Growth Factor beta / metabolism; Scleroderma, Systemic / pathology; Signal Transduction; Tissue Distribution; Transforming Growth Factor beta / metabolism; Transforming Growth Factor beta1
TL;DR:
This review summarizes the literature on the role of PDGF and its receptors in the development of fibrosis in a variety of organ systems, including lung, liver, kidney, and skin.
(via Semantic Scholar)
Source: Crossref
Added: August 14, 2021
2001 article
Autocrine production of TGFa mediates interleukin 13-induced proliferation of human airway epithelial cells during development of a mucous phenotype in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A738.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Interleukin-13 induced mucous cell hyperplasia in airway epithelium.
In Cilia and mucus: from development to respiratory disease. (pp. 253–263).
Source: NC State University Libraries
Added: August 6, 2018
2000 article
Induction of heparin-binding epidermal growth factor (HB-EGF) mRNA in normal human bronchial epithelial cells by metal-induced oxidative stress.
American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A149.
Source: NC State University Libraries
Added: August 6, 2018
2000 article
Interaction of TGF? and EGF receptor mediates IL-13 induced mucous cell hyperplasia in human airway epithelium in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A779.
Source: NC State University Libraries
Added: August 6, 2018
1999 article
Normal human bronchial epithelial cells produce heparin-binding epidermal growth factor (HB-EGF), a mitogen for human lung fibroblasts in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A508.
Source: NC State University Libraries
Added: August 6, 2018
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