Jennifer Carlton Daiker

College of Sciences

Works (3)

Updated: March 9th, 2024 05:01

2024 article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Nie, M., Valdes-Pena, M. A., Frohock, B. H., Smits, E., Daiker, J. C., Gilbertie, J. M., … Pierce, J. G. (2024, February 1). BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 99.

By: M. Nie n, M. Valdes-Pena  n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. V. Schnabel  n, J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 7, 2024

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis

OPEN FORUM INFECTIOUS DISEASES, 9(5).

By: J. Gilbertie n, E. Ulloa *, J. Daiker n, K. Nguyen *, D. Smelter *, W. Rose *, M. Geriak *, L. Schnabel n, V. Nizet *, G. Sakoulas *

author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 10, 2022

2019 article

5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

CHEMBIOCHEM, Vol. 12.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n & J. Pierce n 

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

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