Jennifer Carlton Daiker

College of Sciences

Works (3)

Updated: March 9th, 2024 05:01

2024 journal article

Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity

Bioorganic & Medicinal Chemistry Letters, 99, 129609.

By: M. Nie n, M. Alejandro Valdes-Pena n, B. Frohock n, E. Smits n, J. Daiker n, J. Gilbertie n, L. Schnabel n , J. Pierce n 

author keywords: Natural products; Antibiotics; Antimicrobial resistance; Biofilms; 2 3-pyrrolidinedione
MeSH headings : Anti-Bacterial Agents / pharmacology; Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus; Methicillin Resistance; Biofilms; Microbial Sensitivity Tests
topics (OpenAlex): Antimicrobial Peptides and Activities; Chemical Synthesis and Analysis; Phenothiazines and Benzothiazines Synthesis and Activities
TL;DR: A new library of 2,3-pyrrolidinedione analogues is reported that expands on the previous report on the antimicrobial studies of this heterocyclic scaffold and displayed antibiofilm properties and represent intriguing scaffolds for further optimization and development. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 7, 2024

2022 journal article

Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis

Open Forum Infectious Diseases, 9(5).

By: J. Gilbertie n, E. Ulloa *, J. Daiker n, K. Nguyen *, D. Smelter *, W. Rose *, M. Geriak *, L. Schnabel n , V. Nizet *, G. Sakoulas *

author keywords: cefazolin; ertapenem; endocarditis; Staphylococcus aureus
topics (OpenAlex): Infective Endocarditis Diagnosis and Management; Antimicrobial Resistance in Staphylococcus; Bacterial Identification and Susceptibility Testing
TL;DR: Ertapenem reduces CZ concentrations required to eradicate MSSA biofilms to those achievable in vivo by standard dosing, translating into shorter bacteremia duration in patients with MSSA endocarditis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 10, 2022

2019 article

5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms

Frohock, B. H., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. G. (2019, November 5). ChemBioChem, Vol. 21, pp. 933–937.

By: B. Frohock n, J. Gilbertie n, J. Daiker n, L. Schnabel n  & J. Pierce n 

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Benzylidene Compounds / pharmacology; Biofilms / drug effects; Drug Synergism; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxazolidinones / pharmacology; Staphylococcus aureus / physiology; Structure-Activity Relationship
topics (OpenAlex): Synthesis and Catalytic Reactions; Click Chemistry and Applications; Chemical Synthesis and Analysis
TL;DR: An expanded set of 5‐benzylidene‐4‐oxazolidinones is reported that is able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilm, and are able to significantly reduce the bacterial load in a robust collagen‐matrix model of biofilm infection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

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