J. Christopher Luft

Works (4)

Updated: July 15th, 2023 21:17

2020 journal article

Pulmonary Delivery of Nanoparticle-Bound Toll-like Receptor 9 Agonist for the Treatment of Metastatic Lung Cancer

ACS NANO, 14(6), 7200–7215.

By: J. Perry *, S. Tian *, N. Sengottuvel *, E. Harrison *, B. Gorentla*, C. Kapadia *, N. Cheng *, J. Luft* ...

author keywords: nanoparticles; PRINT; CpG; immunotherapy; pulmonary delivery; lung cancer
MeSH headings : Animals; Carcinoma, Non-Small-Cell Lung; Lung; Lung Neoplasms / drug therapy; Mice; Mice, Inbred C57BL; Nanoparticles; Oligodeoxyribonucleotides; Toll-Like Receptor 9
TL;DR: Results demonstrate that PRINT-CpG is a potent nanoplatform for local treatment of lung cancer that has collateral therapeutic effects on systemic disease, an encouraging toxicity profile, and may have the potential to treat lung metastasis of other cancer types. (via Semantic Scholar)
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Source: Web Of Science
Added: July 20, 2020

2019 journal article

Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine

ACS OMEGA, 4(3), 5547–5555.

By: C. Kapadia *, S. Tian *, J. Perry *, J. Luft* & J. Desimone n

TL;DR: High antigen density NPs presented the highest p-MHC-I on the surface of BMDCs and induced higher proliferation of T cells, whereas NPs with low peptide density resulted in higher DC cell uptake and elevated frequency of IFN-γ producing CD8+ T cells in mice as compared to the medium- and high-density formulations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 22, 2019

2011 journal article

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(2), 586–591.

By: T. Merkel, S. Jones, K. Herlihy, F. Kersey*, A. Shields, M. Napier*, J. Luft*, H. Wu ...

author keywords: biomimetic; deformability; drug carriers; long circulating; red blood cell mimic
MeSH headings : Animals; Biocompatible Materials / chemistry; Biomimetics; Drug Carriers / chemistry; Equipment Design; Erythrocytes / cytology; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Kinetics; Materials Testing; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence / methods; Particle Size; Polymers / chemistry; Time Factors; Tissue Distribution
TL;DR: Lowering the modulus of hydrogel microparticles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventionalmicroparticles. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 journal article

The effect of particle design on cellular internalization pathways

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(33), 11613–11618.

By: S. Gratton*, P. Ropp*, P. Pohlhaus*, J. Luft*, V. Madden, M. Napier*, J. DeSimone n

author keywords: PRINT; shape; size; surface charge
MeSH headings : Cell Membrane / metabolism; Endocytosis; HeLa Cells; Humans; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles / ultrastructure; Particle Size
TL;DR: These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates. (via Semantic Scholar)
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Added: August 6, 2018

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