Works (20)

Updated: July 7th, 2023 21:21

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n, Z. Li n, D. Shen n, D. Zhu n, K. Huang n, T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 6, 2021

2021 journal article

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair

ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.

By: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

Contributors: X. Wang*, S. Hu n, J. Li n, D. Zhu n, Z. Wang n, J. Cores n, K. Cheng n, G. Liu*, K. Huang

author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 21, 2022

2021 journal article

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

NANO TODAY, 39.

By: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

Contributors: S. Hu n, X. Wang n, Z. Li n, D. Zhu n, J. Cores n, Z. Wang n, J. Li n, X. Mei n ...

author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR: It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 7, 2021

2020 journal article

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.

By: T. Su n, K. Huang n, K. Mathews n, V. Scharf n, S. Hu n, Z. Li n, B. Frame*, J. Cores n ...

author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
TL;DR: It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 11, 2020

2020 journal article

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling

SCIENCE ADVANCES, 6(30).

By: S. Hu n, Z. Li n, H. Lutz n, K. Huang n, T. Su n, J. Cores n, P. Dinh n, K. Cheng n

MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR: Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 10, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 23, 2020

2020 journal article

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair

SCIENCE ADVANCES, 6(6).

By: Z. Li n, S. Hu n, K. Huang n, T. Su n, J. Cores n & K. Cheng n

MeSH headings : Animals; Apoptosis; Blood Platelets / metabolism; Cell-Derived Microparticles / metabolism; Cytokines / metabolism; Disease Models, Animal; Humans; Immunohistochemistry; Inflammation Mediators / metabolism; Interleukin-1beta / antagonists & inhibitors; Mice; Models, Biological; Myocardial Infarction / etiology; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocytes, Cardiac / metabolism; Protein Binding; Ventricular Remodeling
TL;DR: IL1-PM is a promising cardiac detoxification agent that removes cytotoxic IL-1β during AMI and induces therapeutic cardiac repair and protects the cardiomyocytes from apoptosis by neutralizing IL–1β and decreasing IL- 1β–driven caspase-3 activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 2, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

By: L. Qiao n, S. Hu n, K. Huang n, T. Su n, Z. Li n, A. Vandergriff n, J. Cores n, P. Dinh n ...

author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR: It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2019 journal article

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging

ACS NANO, 13(10), 11273–11282.

By: S. Hu n, Z. Li n, J. Cores n, K. Huang n, T. Su n, P. Dinh n, K. Cheng n

author keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA
MeSH headings : Animals; Biopolymers / metabolism; Cell Proliferation / radiation effects; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Exosomes / metabolism; Fibroblasts / metabolism; Humans; Mice; Mice, Nude; Skin / cytology; Skin / radiation effects; Skin Aging / radiation effects; Spheroids, Cellular / cytology; Spheroids, Cellular / radiation effects; Tissue Inhibitor of Metalloproteinase-1 / metabolism; Transforming Growth Factor beta / metabolism; Tumor Necrosis Factor-alpha / metabolism; Ultraviolet Rays; Wound Healing / radiation effects
TL;DR: Results indicate that exosomes from 3D cultured HDF spheroids have anti-skin-aging properties and the potential to prevent and treat cutaneous aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 11, 2019

2019 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n, H. Ma*, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2019 journal article

The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)

CELL ADHESION & MIGRATION, 13(1), 63–75.

By: K. Gasior n, N. Wagner n, J. Cores n, R. Caspar n, A. Wilson n, S. Bhattacharya*, M. Hauck n

author keywords: EMT; TGF-; cellular adhesion; epithelial; mesenchymal; breast carcinoma; colon carcinoma
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Adhesion; Cell Movement; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Epithelial-Mesenchymal Transition / drug effects; Female; Humans; Signal Transduction; Transforming Growth Factor beta / pharmacology; Tumor Cells, Cultured
TL;DR: Examination of the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells highlights that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019

2019 journal article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.

By: L. Qiao*, S. Hu n, S. Liu*, H. Zhang*, H. Ma*, K. Huang n, Z. Li n, T. Su n ...

MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
TL;DR: The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 journal article

Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Stem Cells Translational Medicine, 7(4), 354–359.

By: J. Tang n, J. Cores n, K. Huang n, X. Cui*, L. Luo*, J. Zhang n, T. Li*, L. Qian*, K. Cheng n

author keywords: Myocardial injury; Stem cell therapy; Synthetic stem cells; Biomaterials
MeSH headings : Animals; Cell- and Tissue-Based Therapy / methods; Heart / physiology; Heart Diseases / therapy; Humans; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / cytology
TL;DR: This concise review provides a brief introduction into stem cell therapies for ischemic heart disease, and summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

TL;DR: The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart

Tissue Engineering Part C: Methods, 23(3), 146–155.

author keywords: cardiac patch; platelet fibrin gel; myocardial infarction; regeneration
MeSH headings : Animals; Biocompatible Materials / chemistry; Blood Platelets / metabolism; Fibrin / metabolism; Heart / physiology; Male; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocytes, Cardiac / cytology; Paintings; Rats; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR: The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue, and promoted cardiac repair and attenuated cardiac dysfunction after MI. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis

STEM CELLS Translational Medicine, 6(10), 1905–1916.

By: J. Cores n, M. Hensley n, K. Kinlaw n, S. Rikard n, P. Dinh n, D. Paudel n, J. Tang n, A. Vandergriff n ...

author keywords: Fibrosis; Pulmonary; Syngeneic; Allogeneic; Stem cells
MeSH headings : Animals; Bleomycin / toxicity; Cells, Cultured; Female; Lung / cytology; Pulmonary Fibrosis / etiology; Pulmonary Fibrosis / therapy; Rats; Rats, Wistar; Spheroids, Cellular / transplantation; Stem Cell Transplantation / adverse effects; Stem Cell Transplantation / methods; Transplantation, Homologous / adverse effects; Transplantation, Homologous / methods
TL;DR: It is found that infusion of allogeneic LSCs reduces the progression of inflammation and fibrotic manifestation and preserves epithelial and endothelial health without eliciting significant immune rejection. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Nature Communications, 8(1).

By: J. Tang*, D. Shen*, T. Caranasos*, Z. Wang*, A. Vandergriff n, T. Allen n, M. Hensley n, P. Dinh n ...

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / metabolism; Biomimetic Materials / pharmacology; Cell Fractionation; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / transplantation; Cell-Derived Microparticles / chemistry; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Culture Media, Conditioned / chemistry; Culture Media, Conditioned / isolation & purification; Disease Models, Animal; Gene Expression; Hepatocyte Growth Factor / genetics; Hepatocyte Growth Factor / metabolism; Humans; Injections, Intralesional; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Male; Mice; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Paracrine Communication; Recovery of Function / drug effects; Stem Cells / cytology; Stem Cells / metabolism; Vascular Endothelial Growth Factor A / genetics; Vascular Endothelial Growth Factor A / metabolism
TL;DR: A synthetic cell-mimicking microparticle that recapitulates stem cell functions in tissue repair and acts as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 journal article

Angiopellosis as an Alternative Mechanism of Cell Extravasation

STEM CELLS, 35(1), 170–180.

By: T. Allen n, D. Gracieux n, M. Talib n, D. Tokarz n, M. Hensley n, J. Cores n, A. Vandergriff n, J. Tang n ...

author keywords: Extravasation; Angiopellosis; Transmigration; Stem cell infusion; Diapedesis
MeSH headings : Animals; Blood Vessels / physiology; CD11 Antigens / metabolism; Cell Aggregation; Cell Membrane / metabolism; Cell Shape; Dogs; Extravasation of Diagnostic and Therapeutic Materials / pathology; Female; Humans; Injections; Intravital Microscopy; Male; Mesenchymal Stem Cells; Microspheres; Myocytes, Cardiac / cytology; Polymers / chemistry; Rats; Time Factors; Transendothelial and Transepithelial Migration; Zebrafish / metabolism
TL;DR: In injected cardiac and mesenchymal stem cells, the vascular wall undergoes an extensive remodeling to allow the cell to exit the lumen, while the injected cell remains distinctively passive in activity. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis

STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274.

By: E. Henry n, J. Cores n, M. Hensley n, S. Anthony n, A. Vandergriff n, J. Andrade n, T. Allen n, T. Caranasos*, L. Lobo*, K. Cheng n

author keywords: Adult lung stem cells; Mesenchymal stem cells; Pulmonary fibrosis; Spheroid cell culture
MeSH headings : Adult; Animals; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / pharmacology; Bleomycin / adverse effects; Bleomycin / pharmacology; Female; Heterografts; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / pathology; Mice; Mice, SCID; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / therapy; Regeneration; Spheroids, Cellular / metabolism; Spheroids, Cellular / transplantation
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips

PLOS ONE, 10(11).

By: J. Andrade n, J. Tang n, M. Hensley n, A. Vandergriff n, J. Cores n, E. Henry n, T. Allen n, T. Caranasos* ...

MeSH headings : Animals; Coronary Vessels / surgery; Disease Models, Animal; Ligation; Mice; Myocardial Infarction / etiology; Myocardial Infarction / mortality; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Surgical Instruments; Suture Techniques; Vascular Surgical Procedures
TL;DR: This new method, taking only less than 3 minutes to complete, represents an efficient myocardial infarction model in rodents and improved post-MI survival rate. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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