Works (91)

Updated: April 5th, 2024 02:31

2023 journal article

Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per- and polyfluoroalkyl substances (PFAS)

FOOD AND CHEMICAL TOXICOLOGY, 181.

author keywords: Per-and polyfluoroalkyl substances (PFAS); Chemical residue; Interactive generic physiologically based pharmacokinetic (igPBPK) modeling; Withdrawal interval; Food safety; Risk assessment
Source: Web Of Science
Added: November 20, 2023

2023 journal article

Development of machine learning algorithms to estimate maximum residue limits for veterinary medicines

FOOD AND CHEMICAL TOXICOLOGY, 179.

author keywords: Unestablished MRL; Veterinary drugs; Machine learning; International market and trade; Published commodity (animal organ); Data resampling techniques
TL;DR: This study demonstrates unestablished MRLs can be reliably predicted for under-represented food commodity groups using machine learning (ML) and provides the first study to apply ML algorithms in regulatory food animal medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: September 25, 2023

2022 journal article

A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens

FOOD AND CHEMICAL TOXICOLOGY, 168.

By: L. Yuan*, W. Chou*, E. Richards*, L. Tell*, R. Baynes n, J. Davis*, J. Riviere n, Z. Lin*

author keywords: Meloxicam; Food Animal Residue Avoidance Databank (FARAD); Physiologically based pharmacokinetic (PBPK) modeling; Broiler chicken; Laying hen; Food safety
MeSH headings : Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Eggs; Female; Internet; Meloxicam
TL;DR: The model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment. (via Semantic Scholar)
Source: Web Of Science
Added: December 12, 2022

2022 article

An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G

Chou, W.-C., Tell, L. A., Baynes, R. E., Davis, J. L., Maunsell, F. P., Riviere, J. E., & Lin, Z. (2022, June 1). TOXICOLOGICAL SCIENCES.

author keywords: drug residue; Food Animal Residue Avoidance Databank (FARAD); food safety; interactive generic physiologically based pharmacokinetic (igPBPK) model; withdrawal interval (WDI)
MeSH headings : Animals; Cattle; Clonixin / analogs & derivatives; Drug Residues / analysis; Drugs, Generic; Models, Biological; Penicillin G / pharmacokinetics; Swine; Thiamphenicol / analogs & derivatives
TL;DR: A user-friendly generic PBPK platform that can predict tissue residues and estimate WDIs for multiple drugs including flunixin, florfenicol, and penicillin G in cattle and swine is developed and provides a basis for extrapolating to other drugs and species. (via Semantic Scholar)
Source: Web Of Science
Added: June 20, 2022

2022 journal article

Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine

Journal of the American Veterinary Medical Association, 260(1), 50–55.

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Drug Residues; Penicillin G Procaine / therapeutic use; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2020 review

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine

[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 43(5), 385–420.

By: Z. Lin*, M. Li*, Y. Wang*, L. Tell*, R. Baynes n, J. Davis*, T. Vickroy*, J. Riviere n

author keywords: blood flow; food safety; organ weight; physiologically based pharmacokinetic model; withdrawal interval
MeSH headings : Animals; Cattle / physiology; Drug Residues; Models, Biological; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Swine / physiology
TL;DR: These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal‐derived food safety assessment and provide a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys. (via Semantic Scholar)
Source: Web Of Science
Added: August 31, 2020

2019 journal article

Comparison of analytical techniques to explain variability in stored drinking water quality and microbial hand contamination of female caregivers in Tanzania

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, 21(5), 893–903.

By: A. Harris n, A. Pickering*, A. Boehm*, M. Mrisho* & J. Davis*

MeSH headings : Caregivers; Colony Count, Microbial; Drinking Water / microbiology; Drinking Water / standards; Escherichia coli / isolation & purification; Female; Hand / microbiology; Housing / standards; Humans; Hygiene / standards; Logistic Models; Models, Statistical; Public Health; Specimen Handling / methods; Specimen Handling / statistics & numerical data; Surveys and Questionnaires; Tanzania; Water Microbiology / standards; Water Quality / standards
TL;DR: This investigation compares the explanatory variables identified in the three different modeling methods to explain hand and water contamination: ordinary least squares regression, logistic regression, and classification tree and suggests there are benefits to using multiple analysis methods to assess relationships in complex systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 17, 2019

2019 journal article

Impact of bovine respiratory disease on the pharmacokinetics of danofloxacin and tulathromycin in different ages of calves

PLOS ONE, 14(6).

By: D. Mzyk n, C. Bublitz n, M. Martinez*, J. Davis*, R. Baynes n & G. Smith n

Ed(s): D. Gladue

MeSH headings : Age Factors; Animals; Area Under Curve; Bronchoalveolar Lavage Fluid / chemistry; Cattle; Cattle Diseases / drug therapy; Disaccharides / administration & dosage; Disaccharides / pharmacokinetics; Extracellular Fluid / chemistry; Female; Fluoroquinolones / administration & dosage; Fluoroquinolones / pharmacokinetics; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / pharmacokinetics; Pasteurella Infections / drug therapy; Pasteurella Infections / veterinary; Pasteurella multocida / pathogenicity; Respiration Disorders / drug therapy; Respiration Disorders / veterinary
TL;DR: Age was determined to be a significant covariate for calves administered danofloxacin and tulathromycin for plasma PK parameters and potential reasons for age-related differences on plasma concentration–time profiles and the impact of disease on the partitioning of the drug from the blood to the lungs and ISF as a function of age are explored. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 30, 2019

2019 journal article

Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration

Archives of Toxicology, 93(7), 1865–1880.

author keywords: Flunixin; Interactive physiologically based pharmacokinetic (iPBPK) model; Food safety; Drug residues; Withdrawal intervals (WDIs); Food Animal Residue Avoidance Databank (FARAD)
MeSH headings : Animals; Animals, Domestic / metabolism; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Databases, Factual; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Contamination / prevention & control; Food Safety / methods; Models, Biological; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: A new PBPK model for both cattle and swine after administration of flunixin meglumine was developed and it can be applied to develop new models for other drugs in other food animal species, thereby facilitating the application of P BPK modeling in WDI estimation and food safety assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 12, 2019

2019 journal article

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology

EQUINE VETERINARY JOURNAL, 51(4), 537–543.

By: J. Gilbertie n, J. Davis*, G. Davidson n, A. McDonald n, J. Schirmer n & L. Schnabel n

author keywords: horse; reserpine; pharmacokinetics; tranquilisation; platelets; hypercoagulability
MeSH headings : Administration, Oral; Adrenergic Uptake Inhibitors / administration & dosage; Adrenergic Uptake Inhibitors / blood; Adrenergic Uptake Inhibitors / pharmacokinetics; Adrenergic Uptake Inhibitors / pharmacology; Animals; Area Under Curve; Blood Platelets / drug effects; Female; Half-Life; Horses / blood; Male; Reserpine / administration & dosage; Reserpine / blood; Reserpine / pharmacokinetics; Reserpine / pharmacology
TL;DR: Oral reserpine demonstrates low plasma concentrations and a prolonged half-life in horses and is likely due to serotonin release and re-uptake which primes platelets for activation and thromboxane B2 release. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Pharmacokinetics of Intrarectal Altrenogest in Horses

JOURNAL OF EQUINE VETERINARY SCIENCE, 72, 41–46.

By: K. Ellis n, R. Council-Troche*, K. Von Dollen n, T. Beachler n, C. Bailey n, J. Davis*, S. Lyle n

author keywords: Horse; Altrenogest; Pharmacokinetics; Intrarectal administration
MeSH headings : Administration, Rectal; Animals; Cross-Over Studies; Female; Horses / metabolism; Pregnancy; Pregnancy Maintenance / drug effects; Trenbolone Acetate / analogs & derivatives; Trenbolone Acetate / pharmacokinetics
TL;DR: Altrenogest is rapidly absorbed following PR administration in the horse and reaches therapeutic concentrations, making this a viable method of treatment in NPO mares, and the decreased bioavailability and shorter detection time suggest 0.088 mg/kg PR q 4–8 hours would be necessary to maintain therapeutic concentrations over a 24‐hour period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 7, 2019

2018 journal article

Effect of age on plasma protein binding of several veterinary drugs in dairy Check for calves 2

RESEARCH IN VETERINARY SCIENCE, 121, 59–64.

By: D. Mzyk n, C. Bublitz n, G. Hobgood n, M. Martinez*, J. Davis*, G. Smith n, R. Baynes n

author keywords: Protein binding; Calves; Alpha-1-acid glycoprotein; Albumin
MeSH headings : Age Factors; Animals; Blood Proteins / metabolism; Cattle / metabolism; Protein Binding; Veterinary Drugs / metabolism
TL;DR: Findings from these calves suggest that age is not an important factor in the binding of these drugs to plasma proteins, and statistically significant age-effects on plasma protein binding were not observed for any of the drugs evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2018 article

Extralabel drug use in small ruminants

Martin, K. L., Clapham, M. O., Davis, J. L., Baynes, R. E., Lin, Z., Vickroy, T. W., … Tell, L. A. (2018, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 253, pp. 1001–1009.

By: K. Martin*, M. Clapham*, J. Davis*, R. Baynes n, Z. Lin*, T. Vickroy*, J. Riviere n, L. Tell

MeSH headings : Animals; Drug Residues; Goat Diseases / drug therapy; Goats; Legislation, Drug; Off-Label Use; Sheep; Sheep Diseases / drug therapy; United States; United States Food and Drug Administration; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The purpose of this digest is to update a previous FARAD Digest2 concerning small ruminants and provide veterinarians with summary information regarding ELDU in smallRuminants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 16, 2018

2018 journal article

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

Chemical Communications, 54(55), 7617–7620.

By: K. Roth Stefaniak*, C. Epley*, J. Novak*, M. McAndrew*, H. Cornell*, J. Zhu*, D. McDaniel*, J. Davis* ...

MeSH headings : Adsorption; Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Azo Compounds / chemistry; Azo Compounds / radiation effects; Azo Compounds / toxicity; Blood Proteins / chemistry; Cattle; Drug Carriers / chemistry; Drug Carriers / radiation effects; Drug Carriers / toxicity; Fluorouracil / chemistry; Fluorouracil / pharmacology; Humans; MCF-7 Cells; Metal-Organic Frameworks / chemistry; Metal-Organic Frameworks / radiation effects; Metal-Organic Frameworks / toxicity; Mice; Nanoparticles / chemistry; Nanoparticles / radiation effects; Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethylene Glycols / toxicity; Porosity; Ultraviolet Rays
TL;DR: A nano metal-organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: November 24, 2020

2018 journal article

Treatment of carprofen overdose with therapeutic plasma exchange in a dog

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 28(4), 356–360.

By: A. Kjaergaard*, J. Davis n & M. Acierno*

author keywords: canine; kidney injury; NSAID toxicity; plasmapheresis
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / poisoning; Carbazoles / poisoning; Diagnosis, Differential; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Drug Overdose / diagnosis; Drug Overdose / therapy; Drug Overdose / veterinary; Female; Plasma Exchange / veterinary
TL;DR: Although recent studies suggest that this particular dog may not have received a toxic dose, a 51% reduction of plasma carprofen concentration was achieved over 180 minutes, and TPE may be beneficial for treatment of dogs that have ingested higher doses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Feasibility and safety of lumbosacral epiduroscopy in the standing horse

EQUINE VETERINARY JOURNAL, 49(3), 322–328.

By: B. Shrauner n, A. Blikslager n, J. Davis n, N. Campbell n, M. Law n, M. Lustgarten n, T. Prange n

Contributors: B. Shrauner n, A. Blikslager n, J. Davis n, N. Campbell n, M. Law n, M. Lustgarten n, T. Prange n

author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / surgery; Female; Horse Diseases / surgery; Horses; Lumbosacral Region / surgery; Male
TL;DR: Lumbosacral epiduroscopy can be performed safely in sedated standing horses and may become a valuable diagnostic tool in horses with caudal back or hindlimb pain of unknown origin. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 review

Nonsteroidal anti-inflammatory drug associated right dorsal colitis in the horse

[Review of ]. EQUINE VETERINARY EDUCATION, 29(2), 104–113.

By: J. Davis n

author keywords: horse; right dorsal colon; adverse drug reaction; protein losing enteropathy; nonsteroidal anti-inflammatory drug
TL;DR: Right dorsal colitis in horses is a disease characterised by mucosal ulceration and oedema that is localised to the right dorsal colon that is considered one of the more severe adverse effects associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly phenylbutazone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Nonsteroidal anti-inflammatory drug associated right dorsal colitis in the horse

Pferdeheilkunde, 33(4), 403–405.

By: J. Davis

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Treatment of ibuprofen intoxication in a dog via therapeutic plasma exchange

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(4), 451–457.

By: S. Walton*, K. Ryan*, J. Davis n & M. Acierno*

author keywords: NSAID; plasmapheresis; toxicity
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / poisoning; Dog Diseases / chemically induced; Dog Diseases / therapy; Dogs; Drug Overdose / therapy; Drug Overdose / veterinary; Humans; Ibuprofen / poisoning; Male; Plasma Exchange / veterinary
TL;DR: An 85% reduction in plasma ib uprofen concentration occurred and recovery from a potentially lethal ingestion of ibuprofen was achieved with TPE and supportive care and the use of TPE should be considered when presented with acute ibUprofen intoxication due to the rapid and efficacious nature of therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Treatment of meloxicam overdose in a dog via therapeutic plasma exchange

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(4), 444–450.

By: S. Walton*, K. Ryan*, J. Davis n & M. Acierno*

author keywords: NSAID; overdose; plasmapharesis
MeSH headings : Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / poisoning; Dog Diseases / chemically induced; Dog Diseases / therapy; Dogs; Drug Overdose / therapy; Drug Overdose / veterinary; Female; Injections, Intravenous / veterinary; Meloxicam; Ovariectomy; Plasma Exchange; Plasmapheresis / veterinary; Thiazines / administration & dosage; Thiazines / poisoning; Thiazoles / administration & dosage; Thiazoles / poisoning
TL;DR: This report describes the successful use of TPE adjunctively following an acute meloxicam overdose in a dog with therapeutic plasma exchange (TPE). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Haemoperitoneum in a pregnant mare with an ovarian haematoma

EQUINE VETERINARY EDUCATION, 28(7), 359–363.

By: T. Beachler n, C. Bailey n, K. McKelvey n, J. Davis n, A. Edwards n, M. Diaw n, J. Vasgaard n, M. Whitacre n

author keywords: horse; haemoperitoneum; pregnancy; ovary; haematoma
TL;DR: An unusual case of haemoperitoneum in a pregnant mare attributed to a unilateral ovarian haematoma during early gestation is described, where the mare maintained her pregnancy to term and delivered a live colt. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Health concerns and management of select veterinary drug residues

Food and Chemical Toxicology, 88, 112–122.

By: R. Baynes n, K. Dedonder*, L. Kissell n, D. Mzyk n, T. Marmulak*, G. Smith n, L. Tell*, R. Gehring*, J. Davis n, J. Riviere*

author keywords: Drug; Veterinary; Residue; Adverse; Livestock
MeSH headings : Animals; Carcinogens; Drug Residues / adverse effects; Humans; Veterinary Drugs / chemistry; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR: The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Pharmacokinetics of ceftiofur crystalline-free acid in clinically healthy dogs (Canis lupus familiaris)

Journal of the American Association for Laboratory Animal Science, 55(2), 224–229.

By: S. Hooper, S. Korte, S. Giguere, W. Fales, J. Davis & L. Dixon

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Opinions of clinical veterinarians at a US veterinary teaching hospital regarding antimicrobial use and antimicrobial-resistant infections

Journal of the American Veterinary Medical Association, 247(8), 938–944.

By: M. Jacob*, J. Hoppin*, N. Steers*, J. Davis*, G. Davidson*, B. Hansen, K. Lunn*, K. Murphy, M. Papich*

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Cross-Sectional Studies; Data Collection; Drug Resistance, Bacterial; Education, Veterinary; Female; Hospitals, Animal; Humans; Male; Professional Practice; Schools, Veterinary; United States; Veterinarians
TL;DR: Findings indicated that veterinarians at this teaching hospital were concerned about antimicrobial resistance, thought antimicrobials were overprescribed, and supported restricting use of certain antimicrobial classes in companion animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(2), 123–129.

By: B. Lopez*, S. Giguere*, L. Berghaus*, M. Mullins* & J. Davis n

MeSH headings : Animals; Area Under Curve; Biological Availability; Female; Fluoroquinolones / blood; Fluoroquinolones / chemistry; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Horses / blood; Injections, Intramuscular; Injections, Intravenous; Quinolones / blood; Quinolones / chemistry; Quinolones / metabolism; Quinolones / pharmacokinetics; Synovial Fluid / chemistry
TL;DR: Monte Carlo simulations indicated that danofloxacin would be predicted to be effective against bacteria with a minimum inhibitory concentration (MIC) ≤0.25 μg/mL for i.m. and i.v. administration and 0.12  μg/ mL for oral administration to maintain an area under the curve:MIC ratio ≥50. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Use of Alprazolam to Facilitate Mare-Foal Bonding in an Aggressive Postparturient Mare

Journal of Veterinary Internal Medicine, 29(1), 414–416.

By: D. Wong*, C. Alcott*, J. Davis n, K. Hepworth*, L. Wulf* & J. Coetzee*

author keywords: Behavior; Horse; Maternal; Milk; Neonate; Nursing; Xanax
MeSH headings : Aggression / drug effects; Alprazolam / pharmacology; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal / drug effects; Female; GABA Modulators / pharmacology; Horses / physiology; Male; Maternal Behavior / drug effects; Postpartum Period
TL;DR: A healthy 11-year old, 577 kg maiden Quarter Horse mare was examined at the Lloyd Veterinary Medical Center with a 4-day old colt because the mare would bite or kick the foal when thefoal attempted to suckle, and the m Mare consistently demonstrated aggressive behavior toward the foals. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

EQUINE VETERINARY JOURNAL, 46(6), 729–733.

By: J. Davis n, K. Kruger n, D. LaFevers n, B. Barlow n, J. Schirmer n & B. Breuhaus n

author keywords: horse; angiotensin converting enzyme; renin; mitral insufficiency
MeSH headings : Administration, Intravenous; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors / blood; Angiotensin-Converting Enzyme Inhibitors / metabolism; Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Area Under Curve; Gene Expression Regulation, Enzymologic; Half-Life; Horses / blood; Horses / metabolism; Peptidyl-Dipeptidase A / blood; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Quinapril; Renin / blood; Tetrahydroisoquinolines / blood; Tetrahydroisoquinolines / metabolism; Tetrahydroisoquinolines / pharmacokinetics; Tetrahydroisoquinolines / pharmacology
TL;DR: Results suggest that, despite low plasma concentrations, quinapril has sufficient oral absorption to produce inhibition of ACE in healthy horses and provides a potential treatment alternative for horses with cardiovascular and renal disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 249–256.

By: B. Holland n, C. Fogle n, A. Blikslager n, A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

Contributors: B. Holland n, C. Fogle n, A. Blikslager n, A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; 4-Butyrolactone / pharmacology; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cross-Over Studies; Dinoprostone / blood; Horses / metabolism; Injections, Intravenous / veterinary; Ointments; Sulfones / administration & dosage; Sulfones / blood; Sulfones / pharmacokinetics; Sulfones / pharmacology; Tablets; Thromboxane B2 / blood
TL;DR: This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses, as well as a higher Cmax, shorter Tmax, and greater AUC for the paste compared to the tablet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetics and physiologic effects of alprazolam after a single oral dose in healthy mares

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 301–304.

By: D. Wong*, J. Davis n, C. Alcott*, K. Hepworth-Warren*, N. Galow-Kersh*, S. Rice*, J. Coetzee*

MeSH headings : Administration, Oral; Alprazolam / administration & dosage; Alprazolam / analogs & derivatives; Alprazolam / blood; Alprazolam / pharmacokinetics; Alprazolam / pharmacology; Animals; Ataxia / chemically induced; Ataxia / veterinary; Conscious Sedation / methods; Conscious Sedation / veterinary; Female; Horses / metabolism; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Hypnotics and Sedatives / pharmacology
TL;DR: Oral alprazolam tablets were absorbed in adult horses and no clinically relevant adverse events were observed, and further evaluation of repeated dosing and safety of administration of alpazolam to horses is warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetics and safety of firocoxib after oral administration of repeated consecutive doses to neonatal foals

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(3), 243–251.

By: N. Hovanessian*, J. Davis n, H. McKenzie*, J. Hodgson*, D. Hodgson* & M. Crisman*

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / adverse effects; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Drug Administration Schedule; Horses / blood; Horses / metabolism; Sulfones / administration & dosage; Sulfones / adverse effects; Sulfones / blood; Sulfones / pharmacokinetics
TL;DR: It is demonstrated that firocoxib is absorbed in neonatal foals with no demonstrable adverse effects after repeated doses of 0.1 mg/kg. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Plasma and pulmonary pharmacokinetics of desfuroylceftiofur acetamide after weekly administration of ceftiofur crystalline free acid to adult horses

EQUINE VETERINARY JOURNAL, 46(2), 252–255.

By: L. Fultz*, S. Giguere*, L. Berghaus* & J. Davis n

author keywords: Excede; cephalosporin; horse; ceftiofur
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Administration Schedule; Female; Half-Life; Horses / blood; Horses / metabolism; Lung / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Septic funiculitis caused by Streptococcus equi subspecies equi infection with associated immune- mediated haemolytic anaemia

EQUINE VETERINARY EDUCATION, 26(5), 227–233.

By: C. Caniglia*, J. Davis n, H. Schott* & J. Brakenhoff

author keywords: horse; castration; septic funiculitis; immune-mediated haemolytic anaemia; azathioprine
TL;DR: A 2-year-old Quarter Horse gelding presented for anaemia, icterus, depression and intermittent colic 2 weeks after routine castration and a blood transfusion was required to facilitate general anaesthesia for surgical excision of the septic funiculitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Comparative pharmacokinetics of desfuroylceftiofur acetamide after intramuscular versus subcutaneous administration of ceftiofur crystalline free acid to adult horses

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(3), 309–312.

By: L. Fultz*, S. Giguere*, L. Berghaus* & J. Davis n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cephalosporins / administration & dosage; Cephalosporins / pharmacokinetics; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular / veterinary; Injections, Subcutaneous / veterinary; Statistics as Topic
TL;DR: This study hypothesized that SC administration of CCFA to adult horses will be well tolerated and result in therapeutic plasma concentrations, and sought to compare the size of visible injection site swellings after administration by the two routes of administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Management and complications associated with treatment of cervical oesophageal perforations in horses

EQUINE VETERINARY EDUCATION, 25(5), 247–255.

By: K. Kruger n & J. Davis n

author keywords: horse; oesophageal perforation; enteral nutrition
TL;DR: With surgical debridement and adequate supportive care, oesophageal perforation cases can have a fair to good long-term survival, although chronic complications can occur, therapy is prolonged, and a significant economic commitment is required. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Pharmacokinetics of a continuous rate infusion of ceftiofur sodium in normal foals

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(1), 99–101.

By: J. Wearn*, J. Davis n, D. Hodgson*, J. Raffetto* & M. Crisman*

MeSH headings : Animals; Animals, Newborn / blood; Animals, Newborn / metabolism; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / pharmacokinetics; Female; Horses / blood; Horses / metabolism; Infusions, Intravenous / veterinary; Male
TL;DR: Ceftiofur sodium, a third-generation cephalosporin antimicrobial, has in vitro efficacy against many bacterial organisms cultured from septicemic equine neonates and has a period of post-antibiotic effect and post-Antibiotic leukocyte enhancement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Pharmacokinetics of tobramycin following intravenous, intramuscular, and intra-articular administration in healthy horses

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(6), 532–541.

By: J. Newman n, T. Prange n, S. Jennings n, B. Barlow n & J. Davis n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Female; Half-Life; Horses / blood; Injections, Intra-Articular; Injections, Intramuscular; Injections, Intravenous; Microbial Sensitivity Tests; Tobramycin / administration & dosage; Tobramycin / blood; Tobramycin / pharmacokinetics
TL;DR: Tobramycin IA resulted in a mild chemical synovitis as evidenced by an increase in synovial fluid cell count and total protein, but appeared to be safe for administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 28(4), 359–368.

By: J. Davis n, N. Yi n, J. Salmon n, A. Charlton n, C. Colitz n & B. Gilger n

MeSH headings : Animals; Cataract Extraction; Celecoxib; Corneal Opacity / pathology; Corneal Opacity / prevention & control; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / pharmacokinetics; Cyclooxygenase 2 Inhibitors / therapeutic use; Delayed-Action Preparations; Dogs; Epithelial Cells / drug effects; Epithelium / drug effects; Epithelium / growth & development; In Vitro Techniques; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / growth & development; Lenses, Intraocular; Polymethyl Methacrylate; Posterior Capsule of the Lens / cytology; Posterior Capsule of the Lens / drug effects; Posterior Capsule of the Lens / pathology; Postoperative Complications / pathology; Postoperative Complications / prevention & control; Pyrazoles / administration & dosage; Pyrazoles / pharmacokinetics; Pyrazoles / therapeutic use; Sulfonamides / administration & dosage; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use
TL;DR: A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO and further studies are needed to determine whether C XB-incubated IOLs can effectively prevent the development of PCO in vivo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes

Veterinary Ophthalmology, 14(1), 41–47.

By: A. Clode n, J. Davis n, G. Davidson n, J. Salmon n, H. Lafevers n & B. Gilger n

author keywords: aqueous humor; equine; keratomycosis; terbinafine
MeSH headings : Absorption; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Cornea / metabolism; Female; Horses / metabolism; Male; Naphthalenes / administration & dosage; Naphthalenes / analysis; Naphthalenes / blood; Naphthalenes / pharmacokinetics; Ophthalmic Solutions; Terbinafine
TL;DR: Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Clinical and Immunomodulating Effects of Ketamine in Horses with Experimental Endotoxemia

JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(4), 934–943.

By: C. Alcott*, B. Sponseller*, D. Wong*, J. Davis n, A. Soliman*, C. Wang*, W. Hsu*

author keywords: Horses; Immunomodulation; Lipopolysaccharide; Subanesthetic ketamine; Thromboxane; Tumor necrosis factor-alpha
MeSH headings : Animals; Area Under Curve; Body Temperature / drug effects; Endotoxemia / drug therapy; Endotoxemia / immunology; Endotoxemia / veterinary; Female; Heart Rate / drug effects; Horse Diseases / drug therapy; Horse Diseases / immunology; Horses; Immunologic Factors / administration & dosage; Ketamine / administration & dosage; Lipopolysaccharides / administration & dosage; Random Allocation; Respiration / drug effects; Statistics, Nonparametric; Thromboxane B2 / blood; Thromboxane B2 / immunology; Tumor Necrosis Factor-alpha / blood; Tumor Necrosis Factor-alpha / immunology
TL;DR: A significant effect on the clinical or immunologic response to LPS administration, as assessed by clinical observation, hematological parameters, and TNF-α and TXB(2) production, was not identified in healthy horses with the subanesthetic dose of racemic ketamine utilized in this study. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Failure of nebulized irritant, acidic, or hypotonic solutions or external mechanical stimulation of the trachea to consistently induce coughing in healthy, awake dogs

Canadian Journal of Veterinary Research, 75(3), 228–232.

By: T. Boyle, E. Hawkins, J. Davis & I. Robertson

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site

VETERINARY ANAESTHESIA AND ANALGESIA, 38(4), 374–384.

By: K. Messenger n, J. Davis n, D. LaFevers n, B. Barlow n & L. Posner n

author keywords: analgesia; buprenorphine; equine; opioids; pharmacokinetics; sampling site
MeSH headings : Administration, Sublingual; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Blood Chemical Analysis / methods; Blood Chemical Analysis / veterinary; Buprenorphine / administration & dosage; Buprenorphine / analogs & derivatives; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Horses / metabolism; Injections, Intravenous / veterinary; Jugular Veins; Male; Prospective Studies
TL;DR: Buprenorphine has a long plasma half-life and results in plasma concentrations that are consistent with analgesia in other species for up to 4 hours following IV administration of this dose in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Motility of the equine gastrointestinal tract: Physiology and pharmacotherapy

EQUINE VETERINARY EDUCATION, 23(2), 88–100.

By: D. Wong n, J. Davis n & N. White n

author keywords: horse; intestine; colic; prokinetic; ileus
TL;DR: A brief review of the anatomy and physiology of the GI tract in the horse is provided and medications available to the equine veterinarian that may potentially promote intestinal motility are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Journal of Veterinary Pharmacology and Therapeutics, 35(1), 52–58.

By: J. Davis*, K. Messenger*, D. Lafevers*, B. Barlow n & L. Posner*

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR: Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pharmacokinetics of pioglitazone after multiple oral dose administration in horses

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(3), 252–258.

By: J. Wearn*, M. Crisman*, J. Davis n, R. Geor*, D. Hodgson*, J. Suagee*, M. Ashraf-Khorassani*, L. McCutcheon*

MeSH headings : Administration, Oral; Animals; Chromatography, High Pressure Liquid / veterinary; Drug Administration Schedule / veterinary; Female; Half-Life; Horses / metabolism; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / pharmacokinetics; Pioglitazone; Tablets; Tandem Mass Spectrometry / veterinary; Thiazolidinediones / administration & dosage; Thiazolidinediones / pharmacokinetics
TL;DR: It is shown that in healthy horses, pioglitazone administered at a daily oral dose of 1 mg/kg results in plasma concentrations and total drug exposure approximating, but slightly below, those considered therapeutic in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 13(4), 244–250.

By: D. LeVine n, M. Papich n, J. Gookin n, G. Davidson n, J. Davis n & R. Hayes n

MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / pharmacokinetics; Biological Availability; Cat Diseases / drug therapy; Cats / metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Metabolic Clearance Rate; Protozoan Infections, Animal / drug therapy; Random Allocation; Ronidazole / administration & dosage; Ronidazole / pharmacokinetics; Tritrichomonas foetus / drug effects
TL;DR: The high oral bioavailability of RDZ and slow elimination may predispose cats to neurotoxicity with twice-daily administration, and less frequent administration should be considered for further study of effective treatment of T foetus-infected cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses

Journal of Veterinary Pharmacology and Therapeutics, 34(1), 12–16.

By: J. Davis*, J. Marshall*, M. Papich n, A. Blikslager* & N. Campbell n

Contributors: J. Davis*, J. Marshall*, M. Papich n, A. Blikslager* & N. Campbell n

MeSH headings : Animals; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Horses / blood; Horses / metabolism; Sulfonamides / blood; Sulfonamides / pharmacokinetics; Sulfonamides / pharmacology
TL;DR: It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2010 journal article

Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses

American Journal of Veterinary Research, 71(5), 564–569.

By: A. Clode n, J. Davis*, J. Salmon*, H. LaFevers & B. Gilger*

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Aqueous Humor / metabolism; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Female; Fluoroquinolones; Horses / blood; Horses / metabolism; Male; Moxifloxacin; Orchiectomy / veterinary; Quinolines / administration & dosage; Quinolines / blood; Quinolines / metabolism
TL;DR: Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacIn, suggesting moxif loxac in might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Babesiosis Caused by a Large Babesia Species in 7 Immunocompromised Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(1), 127–131.

By: L. Sikorski*, A. Birkenheuer n, M. Holowaychuk n, A. McCleary-Wheeler n, J. Davis n & M. Littman*

author keywords: Anemia; Chemotherapy; Splenectomy; Thrombocytopenia
MeSH headings : Animals; Babesia / classification; Babesia / genetics; Babesiosis / parasitology; Babesiosis / veterinary; DNA, Protozoan / genetics; Dog Diseases / immunology; Dog Diseases / parasitology; Dogs; Immunocompromised Host; RNA, Ribosomal, 18S / genetics; Retrospective Studies
TL;DR: Dogs with pigmenturia, anemia, and thrombocytopenia should be tested for Babesia sp. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Differential heat stability of amphenicols characterized by structural degradation, mass spectrometry and antimicrobial activity

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 53(4), 869–877.

By: C. Franje*, S. Chang*, C. Shyu*, J. Davis n, Y. Lee*, R. Lee*, C. Chang*, C. Chou*

author keywords: Amphenicol; Capillary electrophoresis; Heat stability; GC-MS; Minimum inhibitory concentration
MeSH headings : Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Chloramphenicol / analysis; Chloramphenicol / chemistry; Chloramphenicol / pharmacology; Drug Stability; Electrophoresis, Capillary; Gas Chromatography-Mass Spectrometry / methods; Hot Temperature; Microbial Sensitivity Tests; Microwaves; Thiamphenicol / analogs & derivatives; Thiamphenicol / analysis; Thiamphenicol / chemistry; Thiamphenicol / pharmacology
TL;DR: Despite close similarity in structure; amphenicols exhibited differential behavior toward heating degradation in solutions and protein matrices, and heating treatment may generate product with antimicrobial activity (FF to TAP), therefore, heating of amphenicol residues in food cannot always be assumed safe. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Efficacy and Pharmacokinetics of Pantoprazole in Alpacas

JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(4), 949–955.

By: G. Smith n, J. Davis n, S. Smith n, M. Gerard n, N. Campbell n & D. Foster n

author keywords: Camelid; Gastrointestinal agents; Pharmacology; Physiology-gastrointestinal tract
MeSH headings : 2-Pyridinylmethylsulfinylbenzimidazoles / pharmacokinetics; 2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use; Animals; Anti-Ulcer Agents / pharmacokinetics; Anti-Ulcer Agents / therapeutic use; Camelids, New World; Hydrogen-Ion Concentration; Pantoprazole; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary
TL;DR: Based on the results of this study, pantoprazole represents a safe and effective drug for increasing 3rd compartment pH in camelids and either IV or SC administration is likely to be an effective treatment for gastric ulcers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Pharmacokinetics and tissue depletion of florfenicol in Leghorn and Taiwan Native chickens

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 33(5), 471–479.

By: S. Chang*, J. Davis n, C. Cheng*, R. Shien*, M. Hsieh*, B. Koh*, C. Chou*

MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Brain / metabolism; Chickens / genetics; Chickens / metabolism; Drug Residues / metabolism; Drug Residues / pharmacokinetics; Intestines / chemistry; Kidney / chemistry; Liver / chemistry; Muscle, Skeletal / metabolism; Myocardium / chemistry; Polysaccharides / chemistry; Spleen / chemistry; Thiamphenicol / analogs & derivatives; Thiamphenicol / chemistry; Thiamphenicol / pharmacokinetics
TL;DR: Results from this investigation demonstrate the practicality of using in vivo microdialysis in chickens for pharmacokinetic studies and reveal significant time-dependent differences in the free concentrations of Ff in leg and breast muscles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Pharmacokinetics/pharmacodynamics of Quinapril in horses

Journal of Equine Veterinary Science, 30(10), 537–537.

By: J. Davids

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses

American Journal of Veterinary Research, 70(10), 1259–1268.

By: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n

Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR: In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Effects of compounding and storage conditions on stability of pergolide mesylate

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 234(3), 385–389.

By: J. Davis n, L. Kirk, G. Davidson* & M. Papich*

MeSH headings : Administration, Oral; Animals; Dopamine Agonists / chemistry; Dopamine Agonists / standards; Dopamine Agonists / therapeutic use; Drug Compounding / methods; Drug Compounding / standards; Drug Compounding / veterinary; Drug Stability; Drug Storage / standards; Horse Diseases / drug therapy; Horses; Light; Pergolide / chemistry; Pergolide / standards; Pergolide / therapeutic use; Pharmaceutical Solutions / chemistry; Pharmaceutical Solutions / standards; Pharmaceutical Solutions / therapeutic use; Pituitary ACTH Hypersecretion / drug therapy; Pituitary ACTH Hypersecretion / veterinary; Temperature; Time Factors
TL;DR: Results indicated that pergolide mesylate was unstable after compounding in an aqueous vehicle and that storage conditions had an effect on stability of the compounded formulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle

Journal of the American Veterinary Medical Association, 234(2), 245–248.

By: G. Smith*, J. Davis*, R. Baynes*, J. Yeatts*, B. Barlow* & J. Riviere*

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR: Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2009 personal communication

Supports compounding standards response

By: J. Davis, L. Kirk, G. Davidson & M. Papich

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Third-compartment cannulation in alpacas using a polyurethane gastrostomy tube

AUSTRALIAN VETERINARY JOURNAL, 87(12), 487–491.

By: G. Smith n, M. Gerard n, N. Campbell n, D. Foster n, S. Smith n & J. Davis n

author keywords: alpacas; camelids; cannulation; nutritional support; third compartment
MeSH headings : Animals; Camelids, New World / surgery; Gastrostomy / instrumentation; Gastrostomy / methods; Gastrostomy / veterinary; Male; Polyurethanes; Prospective Studies; Surgery, Veterinary / instrumentation; Surgery, Veterinary / methods; Treatment Outcome
TL;DR: Surgical placement of polyurethane tubes designed for percutaneous endoscopic gastrostomy is a useful method of cannulating the third compartment in camelids and can be used for nutritional support and fluid therapy in sick camelids that might need long-term care. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 article

Update on drugs prohibited from extralabel use in food animals

Davis, J. L., Smith, G. W., Baynes, R. E., Tell, L. A., Webb, A. I., & Riviere, J. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 528–534.

By: J. Davis n, G. Smith n, R. Baynes n, L. Tell n, A. Webb n & J. Riviere n

MeSH headings : Animals; Animals, Domestic; Food / standards; Legislation, Drug; Legislation, Veterinary; United States; Veterinary Drugs
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine

Equine Veterinary Journal, 40(4), 353–357.

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2008 article

Comparison of two indirect techniques for local delivery of a high dose of an antimicrobial in the distal portion of forelimbs of horses

Errico, J. A., Trumble, T. N., Bueno, A. C. D., Davis, J. L., & Brown, M. P. (2008, March). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 69, pp. 334–342.

By: J. Errico*, T. Trumble, A. Bueno*, J. Davis n & M. Brown*

MeSH headings : Amikacin / administration & dosage; Amikacin / blood; Amikacin / pharmacokinetics; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Cross-Over Studies; Female; Forelimb / metabolism; Horses / blood; Horses / metabolism; Infusions, Intraosseous / veterinary; Injections, Intravenous / veterinary; Perfusion / veterinary; Synovial Fluid / metabolism; Tourniquets / veterinary
TL;DR: Both techniques reliably achieved synovial fluid concentrations of amikacin consistent with concentration-dependent killing for bacteria commonly encountered in horses with septic arthritis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Exposure to phenobarbital in a foal after nursing a mare treated with phenobarbital

JOURNAL OF VETERINARY INTERNAL MEDICINE, 22(1), 227–230.

By: D. Wong*, M. Papich n & J. Davis n

MeSH headings : Animals; Animals, Newborn / blood; Animals, Suckling; Anticonvulsants / adverse effects; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Anticonvulsants / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Milk / chemistry; Phenobarbital / adverse effects; Phenobarbital / blood; Phenobarbital / pharmacokinetics; Phenobarbital / therapeutic use; Pregnancy; Pregnancy Complications / drug therapy; Pregnancy Complications / veterinary; Prenatal Exposure Delayed Effects / veterinary; Seizures / drug therapy; Seizures / veterinary
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

FARAD digest - Extralabel use of nonsteroidal anti-inflammatory drugs in cattle

Journal of the American Veterinary Medical Association, 232(5), 697–701.

By: G. Smith, J. Davis, L. Tell, A. Webb & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes

Veterinary Ophthalmology, 11, 15–19.

By: N. Yi n, J. Davis n, J. Salmon n & B. Gilger n

author keywords: horses; intravitreal; pharmacokinetics; toxicity; triamcinolone acetonide
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / toxicity; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Electroretinography / veterinary; Horses / blood; Horses / metabolism; Injections / adverse effects; Injections / veterinary; Retina / drug effects; Tissue Distribution; Triamcinolone Acetonide / pharmacokinetics; Triamcinolone Acetonide / toxicity; Vitreous Body / chemistry
TL;DR: There was no evidence of overt toxicity from intravitreal TA in normal horses and a single intravItreal injection resulted in TA ocular levels for 21 days, however, the risk for bacterial infections with intrav itreal injection or anterior chamber aspirations in horses is high. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses

Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.

By: L. Douglas n, N. Yi n, J. Davis n, J. Salmon n & B. Gilger n

MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
TL;DR: Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Pharmacokinetics of voriconazole after oral administration of single and multiple doses in African grey parrots (Psittacus erithacus timneh)

American Journal of Veterinary Research, 69(1), 114–121.

By: K. Flammer n, J. Nettifee Osborne, D. Webb*, L. Foster*, S. Dillard* & J. Davis*

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Drug Administration Schedule; Psittaciformes / metabolism; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR: Oral administration of 12 to 18 mg of voriconazole/kg twice daily is a rational starting dose for treatment of African grey parrots infected with Aspergillus or other fungal organisms that have a minimal inhibitory concentration for vorIconazole < or = 0.4 microg/mL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

The use of antifungals

Veterinary Technician, 29(7), 428-.

By: J. Davis

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum

American Journal of Veterinary Research, 68(6), 614–624.

By: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager*

Contributors: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & A. Blikslager*

MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / veterinary; Ischemia / veterinary; Jejunum / injuries; Meloxicam; Thiazines / pharmacokinetics; Thiazines / therapeutic use; Thiazoles / pharmacokinetics; Thiazoles / therapeutic use
TL;DR: It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Gabapentin for the treatment of neuropathic pain in a pregnant horse

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 231(5), 755–758.

By: J. Davis*, L. Posner* & Y. Elce*

MeSH headings : Amines / adverse effects; Amines / therapeutic use; Analgesics / adverse effects; Analgesics / therapeutic use; Animals; Colic / surgery; Colic / veterinary; Cyclohexanecarboxylic Acids / adverse effects; Cyclohexanecarboxylic Acids / therapeutic use; Female; Gabapentin; Horses; Neuralgia / drug therapy; Neuralgia / etiology; Neuralgia / veterinary; Pain Measurement; Postoperative Complications / drug therapy; Postoperative Complications / veterinary; Pregnancy; Safety; Treatment Outcome; gamma-Aminobutyric Acid / adverse effects; gamma-Aminobutyric Acid / therapeutic use
TL;DR: Gabapentin appeared to be a safe, effective, and economical treatment for neuropathic pain in this horse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Nonsecretory multiple myeloma in a horse

EQUINE VETERINARY EDUCATION, 19(11), 564–568.

By: A. Morton*, J. Davis, W. Redding n & S. Jones n

author keywords: horse; myeloma; nuclear scintigraphy; lameness; neoplasia
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Pharmacokinetics and tissue distribution of enrofloxacin and its active metabolite ciprofloxacin in calves

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 30(6), 564–571.

By: J. Davis*, D. Foster* & M. Papich n

MeSH headings : Animals; Animals, Newborn / metabolism; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacology; Area Under Curve; Cattle / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / pharmacology; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / pharmacology; Injections, Subcutaneous / veterinary; Tissue Distribution
TL;DR: It is concluded that Cmax/MIC and AUC/MIC ratios for free drug concentrations in plasma and ISF would meet suggested ratios for a targeted MIC of 0.06 microg/mL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2007 journal article

Pharmacokinetics of etodolac in the horse following oral and intravenous administration

Journal of Veterinary Pharmacology and Therapeutics, 30(1), 43–48.

By: J. Davis*, M. Papich n, A. Morton*, J. Gayle*, A. Blikslager* & N. Campbell n

Contributors: J. Davis*, M. Papich n, A. Morton*, J. Gayle*, A. Blikslager* & N. Campbell n

MeSH headings : Administration, Oral; Animals; Area Under Curve; Cross-Over Studies; Cyclooxygenase 1 / drug effects; Cyclooxygenase 2 / drug effects; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Etodolac / administration & dosage; Etodolac / blood; Etodolac / pharmacokinetics; Etodolac / pharmacology; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR: It was showed that etodolac is well absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in thehorse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2006 journal article

Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses

American Journal of Veterinary Research, 67(2), 296–301.

By: A. Clode n, J. Davis*, J. Salmon*, T. Michau* & B. Gilger*

MeSH headings : Administration, Oral; Administration, Topical; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Dose-Response Relationship, Drug; Female; Horses / metabolism; Male; Pyrimidines / administration & dosage; Pyrimidines / adverse effects; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / adverse effects; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation

Journal of Veterinary Pharmacology and Therapeutics, 29(5), 379–385.

By: J. Davis*, D. Little n, A. Blikslager n & M. Papich*

Contributors: J. Davis*, D. Little n, A. Blikslager n & M. Papich*

MeSH headings : Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Biological Availability; Cephalexin / chemistry; Cephalexin / pharmacokinetics; Fluconazole / chemistry; Fluconazole / pharmacokinetics; Fluoroquinolones / chemistry; Fluoroquinolones / pharmacokinetics; Horses; Intestinal Mucosa / drug effects; Jejunum / metabolism; Linear Models; Metronidazole / chemistry; Metronidazole / pharmacokinetics; Permeability / drug effects; Quinolones / chemistry; Quinolones / pharmacokinetics; Solubility
TL;DR: The Ussing chamber is a promising method for determining mucosal permeability in the horse and the low permeability of cephalexin across the tissue may indicate a lack of active transporters that are found in other species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2006 journal article

Pharmacokinetics and tissue distribution of doxycycline after oral administration of single and multiple doses in horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(2), 310–316.

By: J. Davis*, J. Salmon* & M. Papich*

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / pharmacokinetics; Drug Administration Schedule; Female; Food Deprivation; Half-Life; Horses / metabolism; Male; Tissue Distribution
TL;DR: Results suggest that doxycycline administered at a dosage of 20 mg/kg, PO, every 24 hours will result in drug concentrations adequate for killing intracellular bacteria and bacteria with minimum inhibitory concentration < or = 0.25 microg/mL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Pharmacokinetics of voriconazole after oral and intravenous administration to horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(6), 1070–1075.

By: J. Davis n, J. Salmon* & M. Papich*

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Stability; Female; Horses / blood; Injections, Intravenous; Male; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR: It was concluded that administration of voriconazole at a dosage of 4 mg/kg, PO, every 24 hours will attain plasma concentrations adequate for treatment of horses with fungal infections for which the fungi have a minimum inhibitory concentration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(3), 191–197.

By: J. Davis n, M. Papich n & A. Weingarten

MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Ciprofloxacin / administration & dosage; Ciprofloxacin / analogs & derivatives; Ciprofloxacin / blood; Ciprofloxacin / pharmacokinetics; Cross-Over Studies; Drug Administration Schedule; Female; Horses / metabolism; Infusions, Intravenous / veterinary; Male; Protein Binding
TL;DR: This dose is suggested for further studies on the clinical efficacy of orbifloxacin for treatment of susceptible bacterial infections in the horse, an oral dose of approximately 5 mg/kg once daily will produce plasma concentrations within the suggested range. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Pharmacokinetics and tissue distribution of itraconazole after oral and intravenous administration to horses

Davis, J. L., Salmon, J. H., & Papich, M. G. (2005, October). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1694–1701.

By: J. Davis n, J. Salmon* & M. Papich*

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Horses / metabolism; Injections, Intravenous / veterinary; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Protein Binding
TL;DR: Itraconazole administered orally as a solution had higher, more consistent absorption than orally administered capsules and attained plasma concentrations that are inhibitory against fungi that infect horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Pharmacokinetics of oral omeprazole in llamas

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(6), 539–543.

By: K. Poulsen, G. Smith*, J. Davis n & M. Papich n

MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / blood; Anti-Ulcer Agents / pharmacokinetics; Area Under Curve; Camelids, New World / metabolism; Female; Omeprazole / administration & dosage; Omeprazole / blood; Omeprazole / pharmacokinetics
TL;DR: Oral omeprazole produced plasma drug concentrations which are not likely to be associated with clinical efficacy in camelids, and due to low absorption the oral dose was increased to 8 and 12 mg/kg and studies were repeated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(1), 57–60.

By: S. Gardner*, J. Davis*, S. Jones*, D. Lafevers*, M. Hoskins*, M. Mcarver*, M. Papich n

MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Novel approaches to ocular drug delivery

Current Opinion in Molecular Therapeutics, 6(2), 195–205.

By: J. Davis, B. Gilger & M. Robinson

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Quality of heart failure care in managed Medicare and Medicaid patients in North Carolina

The American Journal of Cardiology, 93(6), 714–718.

By: A. Bertoni*, V. Duren-Winfield*, W. Ambrosius*, J. McArdle, C. Sueta, M. Massing, S. Peacock, J. Davis*, J. Croft*, D. Goff*

MeSH headings : Adrenergic beta-Antagonists / therapeutic use; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Female; Guideline Adherence; Heart Failure / drug therapy; Heart Failure / epidemiology; Heart Failure / etiology; Humans; Male; Managed Care Programs / standards; Medicaid / standards; Medical Records; Medicare / standards; Middle Aged; North Carolina / epidemiology; Quality Assurance, Health Care; Retrospective Studies; Total Quality Management
TL;DR: Ventricular function assessment and ACE inhibitor prescription rates are higher than beta-blocker prescription rates among Medicare and Medicaid managed care patients in North Carolina. (via Semantic Scholar)
Source: Crossref
Added: January 2, 2021

2003 journal article

A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002)

JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 896–901.

By: J. Davis*, A. Blikslager*, K. Catto* & S. Jones*

author keywords: colic; duodenitis-proximal jejunitis; equine; gastric reflux; hepatopathy
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Equine primary immunodeficiencies

Compendium on Continuing Education for the Practicing Veterinarian, 25(7), 548–556.

By: J. Davis & S. Jones

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Suppurative cholangiohepatitis and enteritis in adult horses

JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(4), 583–587.

By: J. Davis n & S. Jones n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

The effect of topical administration of atropine sulfate on the normal equine pupil: influence of age, breed and gender

VETERINARY OPHTHALMOLOGY, 6(4), 329–332.

By: J. Davis n, T. Stewart*, E. Brazik n & B. Gilger n

author keywords: atropine; equine; mydriasis
MeSH headings : Administration, Topical; Animals; Atropine / administration & dosage; Atropine / pharmacology; Female; Horses / physiology; Male; Mydriatics / administration & dosage; Mydriatics / pharmacology; Ophthalmic Solutions; Pedigree; Pupil / drug effects; Pupil / physiology
TL;DR: Horses of the Arabian breed and female horses may be more sensitive to effects of cholinergic blockade in the eye following a single dose of 1% atropine sulfate ophthalmic solution in the normal equine eye. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Treatment of peritonitis

VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 19(3), 765-+.

By: J. Davis n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents / therapeutic use; Drainage / veterinary; Endotoxemia / etiology; Endotoxemia / therapy; Endotoxemia / veterinary; Fluid Therapy / veterinary; Horse Diseases / diagnosis; Horse Diseases / etiology; Horse Diseases / therapy; Horses; Peritonitis / etiology; Peritonitis / therapy; Peritonitis / veterinary; Prognosis; Therapeutic Irrigation / veterinary
TL;DR: In summary, peritonitis in the horse is a potentially life-threatening disease that must be treated promptly and aggressively and the prognosis is best determined by an early and quick response to aggressive treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Congestive heart failure in horses: 14 cases (1984-2001)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 220(10), 1512–1515.

By: J. Davis n, S. Gardner n, B. Schwabenton n & B. Breuhaus n

MeSH headings : Animals; Echocardiography / veterinary; Female; Heart Failure / diagnosis; Heart Failure / mortality; Heart Failure / therapy; Heart Failure / veterinary; Horse Diseases / diagnosis; Horse Diseases / mortality; Horse Diseases / therapy; Horses; Male; Prognosis; Retrospective Studies; Tachycardia / diagnosis; Tachycardia / therapy; Tachycardia / veterinary; Treatment Outcome
TL;DR: It is suggested that congestive heart failure is rare in horses and echocardiography was useful in determining the underlying cause in affected horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Nasal adenocarcinoma with diffuse metastases involving the orbit, cerebrum, and multiple cranial nerves in a horse

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(10), 1460–1463.

By: J. Davis*, B. Gilger*, K. Spaulding*, I. Robertson* & S. Jones*

MeSH headings : Adenocarcinoma / diagnosis; Adenocarcinoma / secondary; Adenocarcinoma / veterinary; Animals; Brain Neoplasms / diagnosis; Brain Neoplasms / secondary; Brain Neoplasms / veterinary; Cerebrospinal Fluid / chemistry; Cranial Nerve Neoplasms / diagnosis; Cranial Nerve Neoplasms / secondary; Cranial Nerve Neoplasms / veterinary; Diagnosis, Differential; Fatal Outcome; Horse Diseases / diagnosis; Horse Diseases / pathology; Horses; Male; Nose Neoplasms / diagnosis; Nose Neoplasms / pathology; Nose Neoplasms / veterinary; Orbital Neoplasms / diagnosis; Orbital Neoplasms / secondary; Orbital Neoplasms / veterinary; Prognosis; Tomography, X-Ray Computed / veterinary
TL;DR: A 9-year-old Trakehner gelding examined because of right exophthalmus found a lack of menace response in the right eye, reduced direct and consensual right pupillary light reflexes, ventrolateral strabismus of the rightEye, mild right-sided facial asymmetry, a head tilt to the left, and increased extensor tone in theright limbs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 journal article

Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 25(2), 99–104.

By: J. Davis n, S. Gardner n, S. Jones n, B. Schwabenton n & M. Papich n

MeSH headings : Actinomycetales Infections / drug therapy; Actinomycetales Infections / veterinary; Administration, Oral; Animals; Animals, Newborn; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Azithromycin / administration & dosage; Azithromycin / blood; Azithromycin / pharmacokinetics; Azithromycin / therapeutic use; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid / veterinary; Female; Horse Diseases / drug therapy; Horses / metabolism; Infusions, Intravenous / veterinary; Macrophages, Alveolar / metabolism; Male; Phagocytes / metabolism; Rhodococcus equi
TL;DR: The properties of azithromycin suggest that it may be an alternative to erythromycin for treatment of Rhodococcus equi pneumonia in foals and its disposition in plasma, polymorphonuclear leukocytes (PMN), and alveolar cells was examined to investigate this possibility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2001 journal article

Acute and chronic mineral oil pneumonitis in two horses

Equine Veterinary Education, 13(5), 230–234.

By: J. Davis n, S. Ramirez n, N. Campbell n & jones

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

review

Health concerns and management of select veterinary drug residues

Baynes, R. E., Dedonder, K., Kissell, L., Mzyk, D., Marmulak, T., Smith, G., … Riviere, J. E. [Review of ]. Food and Chemical Toxicology, 88, 112–122.

By: R. Baynes, K. Dedonder, L. Kissell, D. Mzyk, T. Marmulak, G. Smith, L. Tell, R. Gehring, J. Davis, J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

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