Jonathan David Douros

Works (5)

Updated: July 5th, 2023 15:43

2020 article

Epinephrine and glucose regulation of leptin synthesis and secretion in a teleost fish, the tilapia (Oreochromis mossambicus)

Mankiewicz, J. L., Deck, C. A., Taylor, J. D., Douros, J. D., & Borski, R. J. (2020, November 23). General and Comparative Endocrinology, Vol. 302, p. 113669.

By: J. Mankiewicz n , C. Deck n, J. Taylor  n, J. Douros* & R. Borski n 

Contributors: J. Mankiewicz n , C. Deck n, J. Taylor  n, J. Douros* & R. Borski n 

author keywords: Epinephrine; Tilapia; Glucose; Leptin; Stress
MeSH headings : Animals; Epinephrine; Glucose; Leptin; Liver; Tilapia
topics (OpenAlex): Aquaculture disease management and microbiota; Regulation of Appetite and Obesity; Aquaculture Nutrition and Growth
TL;DR: The results of this study demonstrate LepA is negatively regulated by rises in extracellular glucose at the level of the hepatocyte but stimulated by hyperglycemia in vivo, and epinephrine increases LepA. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 8, 2021

2016 article

Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia ( Oreochromis mossambicus )

Douros, J. D., Baltzegar, D. A., Mankiewicz, J., Taylor, J., Yamaguchi, Y., Lerner, D. T., … Borski, R. J. (2016, July 20). General and Comparative Endocrinology, Vol. 240, pp. 227–237.

By: J. Douros n, D. Baltzegar n, J. Mankiewicz n , J. Taylor  n, Y. Yamaguchi *, D. Lerner*, A. Seale *, E. Grau*, J. Breves *, R. Borski n 

Contributors: J. Douros n, D. Baltzegar n, J. Mankiewicz n , J. Taylor  n, Y. Yamaguchi *, D. Lerner*, A. Seale *, E. Grau*, J. Breves *, R. Borski n 

author keywords: Leptin; Growth hormone; Insulin-like growth factors; Growth hormone receptor; Teleost fishes; Metabolic stress
MeSH headings : Animals; Body Weight / drug effects; Fasting; Feeding Behavior / drug effects; Gene Expression Regulation / drug effects; Growth Hormone / metabolism; Hepatocytes / drug effects; Hepatocytes / metabolism; Hypophysectomy; Insulin-Like Growth Factor I / metabolism; Insulin-Like Growth Factor II / metabolism; Leptin / metabolism; Liver / metabolism; Male; Pituitary Gland / drug effects; Pituitary Gland / metabolism; RNA, Messenger / genetics; Receptors, Somatotropin / genetics; Receptors, Somatotropin / metabolism; Tilapia / metabolism
topics (OpenAlex): Regulation of Appetite and Obesity; Adipose Tissue and Metabolism; Growth Hormone and Insulin-like Growth Factors
TL;DR: Findings indicate LepA gene expression and secretion increases with fasting, consistent with the hormones function in promoting energy expenditure during catabolic stress, and suggests for the first time in teleosts that GH may exert important regulatory effects on hepatic LepA production. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Leptin stimulates hepatic growth hormone receptor and insulin-like growth factor gene expression in a teleost fish, the hybrid striped bass

Won, E. T., Douros, J. D., Hurt, D. A., & Borski, R. J. (2016, February 4). General and Comparative Endocrinology, Vol. 229, pp. 84–91.

By: E. Won n, J. Douros n, D. Hurt n & R. Borski n 

author keywords: Leptin; Growth hormone receptor; GHR; Insulin-like growth factor; IGF; Growth; Teleost; Fish; Hepatocyte
MeSH headings : Animals; Bass / metabolism; Gene Expression Regulation / drug effects; Growth Hormone / metabolism; Leptin / metabolism; Liver / metabolism; Receptors, Somatotropin / genetics; Somatomedins / metabolism
topics (OpenAlex): Regulation of Appetite and Obesity; Adipose Tissue and Metabolism; Growth Hormone and Insulin-like Growth Factors
TL;DR: The studies suggest that stimulation of growth axis component transcripts by leptin may be an important mechanism for coordinating somatic growth with nutritional state in these and perhaps other fish or vertebrates, and represent the first evidence of leptin regulating GHRs in vertebrates. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: Studies utilizing a homologous Leptin A ELISA in the tilapia

Douros, J. D., Baltzegar, D. A., Breves, J. P., Lerner, D. T., Seale, A. P., Grau, E. G., & Borski, R. J. (2014, March 23). General and Comparative Endocrinology, Vol. 207, pp. 86–93.

By: J. Douros n, D. Baltzegar n, J. Breves *, D. Lerner*, A. Seale *, E. Grau*, R. Borski n 

author keywords: Leptin; Prolactin; Pituitary; Hepatocytes; Teleost fishes; Enzyme-linked immunosorbant assay
MeSH headings : Acclimatization; Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation / drug effects; Humans; Hypophysectomy; Leptin / antagonists & inhibitors; Leptin / genetics; Leptin / metabolism; Liver / drug effects; Liver / metabolism; Pituitary Gland / drug effects; Pituitary Gland / metabolism; Prolactin / pharmacology; RNA, Messenger / genetics; Rabbits; Real-Time Polymerase Chain Reaction; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tilapia / growth & development; Tilapia / metabolism
topics (OpenAlex): Regulation of Appetite and Obesity; Adipokines, Inflammation, and Metabolic Diseases; Biochemical Analysis and Sensing Techniques
TL;DR: Results demonstrate that LepA enhances pituitary prolactin synthesis and release, while PRL in turn inhibits hepatic leptin secretion and synthesis in teleosts, and postulate this regulatory interaction may be necessary for mobilizing energy reserves during acute hyperosmotic adaptation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Role for leptin in promoting glucose mobilization during acute hyperosmotic stress in teleost fishes

Baltzegar, D. A., Reading, B. J., Douros, J. D., & Borski, R. J. (2013, November 5). Journal of Endocrinology, Vol. 220, pp. 61–72.

By: D. Baltzegar n, B. Reading n , J. Douros n & R. Borski n 

author keywords: osmoregulation; leptin; hyperglycemia; teleost fishes
MeSH headings : Amino Acids / blood; Animals; Biological Transport / drug effects; Blood Glucose / metabolism; Gene Expression / drug effects; Glucose / metabolism; Glycogen Phosphorylase / genetics; Hydrocortisone / pharmacology; Lactates / blood; Leptin / genetics; Leptin / pharmacology; Lipoprotein Lipase / genetics; Liver / drug effects; Liver / metabolism; Liver Glycogen / metabolism; Male; Osmotic Pressure / physiology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Leptin / genetics; Reverse Transcriptase Polymerase Chain Reaction; Salinity; Stress, Physiological / physiology; Tilapia / blood; Tilapia / genetics; Tilapia / physiology
topics (OpenAlex): Physiological and biochemical adaptations; Aquaculture Nutrition and Growth; Aquaculture disease management and microbiota
TL;DR: This is the first study to report that teleost leptin A has actions that are functionally distinct from those described in mammals acting as a potent hyperglycemic factor during osmotic stress, possibly in synergism with cortisol. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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