Works (9)
Updated: July 5th, 2023 21:17
2017 journal article
Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules
Nano Research, 10(4), 1393–1402.
author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
topics (OpenAlex): Diabetes Management and Research; Spectroscopy Techniques in Biomedical and Chemical Research; Advancements in Transdermal Drug Delivery
TL;DR:
It is demonstrated that this ultrasound-triggered insulin delivery system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration
ACS NANO, 10(1), 1292–1299.
author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Proteoglycans and glycosaminoglycans research; Silk-based biomaterials and applications
TL;DR:
The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles
CELLULAR AND MOLECULAR BIOENGINEERING, 8(3), 445–454.
author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
topics (OpenAlex): Pancreatic function and diabetes; Diabetes Management and Research; Advanced Drug Delivery Systems
TL;DR:
In vitro studies demonstrated that the insulin release rate associated with HA microgels was effectively regulated by changes in the glucose concentration, and validated that a single injection of the developed formulation stabilized the blood glucose levels in the normoglycemic state for over 1 week.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Novel genipin-collagen immobilization of polylactic acid (PLA) fibers for use as tissue engineering scaffolds
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 103(6), 1188–1197.
Contributors: N. Tambe n, n, Z. Zhang *, S. Bernacki n, A. El-Shafei n & M. King n
author keywords: collagen immobilization; genipin; scaffold; functionalization; surface modification; polylactic acid (PLA) fibers
MeSH headings : Cells, Cultured; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Iridoids / chemistry; Lactic Acid / chemistry; Materials Testing; Polyesters; Polymers / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Collagen: Extraction and Characterization
TL;DR:
The collagen was immobilized on the surface of functionalized PLA via a novel natural cross-linking moleculegenipin which resulted in improved cell proliferation of human dermal fibroblasts as compared to the PLA surface coated with collagen without genipin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 journal article
Spatiotemporal drug delivery using laser-generated-focused ultrasound system
Journal of Controlled Release, 220, 592–599.
author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Nanoplatforms for cancer theranostics; Photoacoustic and Ultrasonic Imaging
TL;DR:
This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots
ACS NANO, 9(9), 9407–9415.
author keywords: drug delivery; wearable devices; stimuli-responsive; nanoparticles; microdepots
MeSH headings : Animals; Drug Delivery Systems; Drug Liberation; Elastomers / chemistry; Elastomers / pharmacology; Mice; Nanoparticles / chemistry; Polymers / chemistry; Polymers / pharmacology
topics (OpenAlex): Advanced Sensor and Energy Harvesting Materials; Advancements in Transdermal Drug Delivery; Hydrogels: synthesis, properties, applications
TL;DR:
This work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Bio-lnspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin
BIOMACROMOLECULES, 15(10), 3495–3502.
MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Drug Delivery Systems / methods; Gluconates / chemistry; Glucose / administration & dosage; Glucose / chemistry; Glucose Oxidase / metabolism; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Male; Mice; Mice, Inbred C57BL; Polymers / administration & dosage; Polymers / chemistry
topics (OpenAlex): Lipid Membrane Structure and Behavior; Electrochemical sensors and biosensors; Hydrogels: synthesis, properties, applications
TL;DR:
In vivo experiments demonstrate that a single injection of the developed nanovesicle facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 5 days.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 review
Emerging micro-and nanotechnology based synthetic approaches for insulin delivery
[Review of ]. CHEMICAL SOCIETY REVIEWS, 43(10), 3595–3629.
MeSH headings : Diabetes Mellitus / drug therapy; Drug Delivery Systems; Equipment Design; Humans; Insulin / administration & dosage; Insulin / therapeutic use; Insulin Infusion Systems; Nanotechnology / instrumentation
topics (OpenAlex): Advanced Drug Delivery Systems; Advancements in Transdermal Drug Delivery; Diabetes Management and Research
TL;DR:
This review outlines recent developments in the controlled delivery of insulin, including oral, nasal, pulmonary, transdermal, subcutaneous and closed-loop insulin delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network
Advanced Healthcare Materials, 3(6), 811–816.
MeSH headings : Alginates / chemistry; Animals; Blood Glucose / analysis; Chitosan / chemistry; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Diabetes Mellitus, Experimental / therapy; Drug Carriers / chemistry; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Insulin / administration & dosage; Insulin / chemistry; Lactic Acid / chemistry; Male; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Ultrasonic Therapy
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Vagus Nerve Stimulation Research; Diabetes Management and Research
TL;DR:
The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018