Jin Di

Works (9)

Updated: July 5th, 2023 21:17

2017 journal article

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Nano Research, 10(4), 1393–1402.

By: J. Di n, J. Yu n, Q. Wang *, S. Yao  n, D. Suo  n, Y. Ye n, M. Pless n, Y. Zhu n , Y. Jing n, Z. Gu*

Contributors: J. Di n, J. Yu n, Q. Wang *, S. Yao  n, D. Suo  n, Y. Ye n, M. Pless n, Y. Zhu n , Y. Jing n, Z. Gu*

author keywords: controlled drug delivery; focused ultrasound; diabetes; nanocapsule; microgel
TL;DR: It is demonstrated that this ultrasound-triggered insulin delivery system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

ACS NANO, 10(1), 1292–1299.

By: D. Shi *, X. Xu *, Y. Ye n, K. Song *, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles

CELLULAR AND MOLECULAR BIOENGINEERING, 8(3), 445–454.

By: J. Di n, J. Yu n, Y. Ye n, D. Ranson n, A. Jindal n & Z. Gu n

author keywords: Insulin delivery; Diabetes; Glucose responsive; Bio-inspired; Hyaluronic acid; Dextran
TL;DR: In vitro studies demonstrated that the insulin release rate associated with HA microgels was effectively regulated by changes in the glucose concentration, and validated that a single injection of the developed formulation stabilized the blood glucose levels in the normoglycemic state for over 1 week. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Spatiotemporal drug delivery using laser-generated-focused ultrasound system

Journal of Controlled Release, 220, 592–599.

By: J. Di n, J. Kim n, Q. Hu n, X. Jiang n  & Z. Gu n

Contributors: J. Di n, J. Kim n, Q. Hu n, X. Jiang n  & Z. Gu n

author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
TL;DR: This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots

ACS NANO, 9(9), 9407–9415.

By: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n , Y. Zhu n , Z. Gu n

Contributors: J. Di n, S. Yao n, Y. Ye n, Z. Cui n, J. Yu n, T. Ghosh n , Y. Zhu n , Z. Gu n

author keywords: drug delivery; wearable devices; stimuli-responsive; nanoparticles; microdepots
MeSH headings : Animals; Drug Delivery Systems; Drug Liberation; Elastomers / chemistry; Elastomers / pharmacology; Mice; Nanoparticles / chemistry; Polymers / chemistry; Polymers / pharmacology
TL;DR: This work demonstrated that the tensile strain, applied to the stretchable device, facilitated release of therapeutics from microdepots for anticancer and antibacterial treatments. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

Bio-lnspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin

BIOMACROMOLECULES, 15(10), 3495–3502.

By: W. Tai n, R. Mo n, J. Di n, V. Subramanian n, X. Gu n, J. Buse *, Z. Gu n

MeSH headings : Animals; Blood Glucose / drug effects; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Drug Delivery Systems / methods; Gluconates / chemistry; Glucose / administration & dosage; Glucose / chemistry; Glucose Oxidase / metabolism; Hydrogen-Ion Concentration; Insulin / administration & dosage; Insulin / chemistry; Male; Mice; Mice, Inbred C57BL; Polymers / administration & dosage; Polymers / chemistry
TL;DR: In vivo experiments demonstrate that a single injection of the developed nanovesicle facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 5 days. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 review

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

[Review of ]. CHEMICAL SOCIETY REVIEWS, 43(10), 3595–3629.

By: R. Mo n, T. Jiang n, J. Di n, W. Tai  n & Z. Gu n

MeSH headings : Diabetes Mellitus / drug therapy; Drug Delivery Systems; Equipment Design; Humans; Insulin / administration & dosage; Insulin / therapeutic use; Insulin Infusion Systems; Nanotechnology / instrumentation
TL;DR: This review outlines recent developments in the controlled delivery of insulin, including oral, nasal, pulmonary, transdermal, subcutaneous and closed-loop insulin delivery. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

Novel genipin-collagen immobilization of polylactic acid (PLA) fibers for use as tissue engineering scaffolds

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 103(6), 1188–1197.

By: N. Tambe n, J. Di n, Z. Zhang *, S. Bernacki n, A. El-Shafei n  & M. King n 

Contributors: N. Tambe n, J. Di n, Z. Zhang *, S. Bernacki n, A. El-Shafei n  & M. King n 

author keywords: collagen immobilization; genipin; scaffold; functionalization; surface modification; polylactic acid (PLA) fibers
MeSH headings : Cells, Cultured; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Iridoids / chemistry; Lactic Acid / chemistry; Materials Testing; Polyesters; Polymers / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR: The collagen was immobilized on the surface of functionalized PLA via a novel natural cross-linking moleculegenipin which resulted in improved cell proliferation of human dermal fibroblasts as compared to the PLA surface coated with collagen without genipin. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Ultrasound-Triggered Regulation of Blood Glucose Levels Using Injectable Nano-Network

Advanced Healthcare Materials, 3(6), 811–816.

By: J. Di n, J. Price n, X. Gu*, X. Jiang n , Y. Jing n & Z. Gu n

Contributors: J. Di n, J. Price n, X. Gu*, X. Jiang n , Y. Jing n & Z. Gu n

MeSH headings : Alginates / chemistry; Animals; Blood Glucose / analysis; Chitosan / chemistry; Diabetes Mellitus, Experimental / metabolism; Diabetes Mellitus, Experimental / pathology; Diabetes Mellitus, Experimental / therapy; Drug Carriers / chemistry; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Hypoglycemic Agents / administration & dosage; Hypoglycemic Agents / chemistry; Insulin / administration & dosage; Insulin / chemistry; Lactic Acid / chemistry; Male; Mice; Mice, Inbred C57BL; Nanostructures / chemistry; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Ultrasonic Therapy
TL;DR: The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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