Works (39)

Updated: August 16th, 2024 13:38

2014 journal article

Elevated cholesteryl ester transfer protein (CETP) activity, a major determinant of the atherogenic dyslipidemia, and atherosclerotic cardiovascular disease in South Asians

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 22(4), 468–477.

By: S. Rashid*, A. Sniderman*, M. Melone*, P. Brown*, J. Otvos n, A. Mente*, K. Schulze*, M. McQueen*, S. Anand*, S. Yusuf*

author keywords: Cholesteryl ester transfer protein (CETP); HDL; LDL; atherogenic dyslipoproteinemia; atherosclerotic cardiovascular diseases; South Asians
MeSH headings : Adult; Aged; Asia / ethnology; Asian People; Atherosclerosis / blood; Atherosclerosis / diagnosis; Atherosclerosis / ethnology; Biomarkers / blood; Canada / epidemiology; Cholesterol Ester Transfer Proteins / blood; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Cross-Sectional Studies; Dyslipidemias / blood; Dyslipidemias / diagnosis; Dyslipidemias / ethnology; Europe / ethnology; Female; Health Status Disparities; Humans; Male; Middle Aged; Risk Factors; Severity of Illness Index; Triglycerides / blood; Up-Regulation; White People
TL;DR: Novel associations are identified between elevated CETP activity and the triad of quantitative and qualitative lipoprotein abnormalities in the atherogenic dyslipidemia in South Asia, a major contributor of increased atherosclerotic cardiovascular diseases in South Asians. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness

Diabetic Medicine: A Journal of the British Diabetic Association, 23(9), 955–966.

James Otvos

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise

ATHEROSCLEROSIS, 188(1), 126–133.

By: R. Seip*, J. Otvos n, C. Bilbie*, G. Tsongalis*, M. Miles*, R. Zoeller*, P. Visich*, P. Gordon* ...

author keywords: apo E; lipoproteins; particle size; aerobic exercise; lipid metabolism
MeSH headings : Adolescent; Adult; Aged; Apolipoproteins E / genetics; Cohort Studies; Exercise; Female; Genotype; Humans; Lipoproteins, LDL / blood; Male; Middle Aged
TL;DR: APOE variants influence the serum LDL subpopulation response to exercise training in normolipidemic subjects, and subjects homozygous for APOE3 experienced the most beneficial lipid effects from exercise training. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training

ATHEROSCLEROSIS, 185(1), 65–69.

By: G. Ruano*, R. Seip*, A. Windemuth*, S. Zollner*, G. Tsongalis*, J. Ordovas*, J. Otvos n, C. Bilbie* ...

author keywords: apolipoprotein A1; single nucleotide polymorphism; high density lipoprotein; subtraction; aerobic exercise
MeSH headings : Adolescent; Adult; Aged; Apolipoprotein A-I / genetics; Biomarkers / blood; Cardiovascular Diseases / blood; Cardiovascular Diseases / genetics; Cholesterol, HDL / blood; DNA / genetics; Exercise / physiology; Follow-Up Studies; Genotype; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Polymorphism, Single Nucleotide; Reference Values
TL;DR: Results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size

ATHEROSCLEROSIS, 171(2), 311–319.

By: J. Kuivenhoven*, G. Hovingh*, A. Tol*, M. Jauhiainen*, C. Ehnholm*, J. Fruchart*, E. Brinton*, J. Otvos n ...

author keywords: HDL; LCAT; CETP; PLTP; ABCA1
MeSH headings : ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters / genetics; Analysis of Variance; Apolipoproteins / analysis; Apolipoproteins / metabolism; Case-Control Studies; Codon, Nonsense; Cohort Studies; Female; Follow-Up Studies; Heterozygote; Humans; Hyperlipoproteinemia Type II / epidemiology; Hyperlipoproteinemia Type II / genetics; Hyperlipoproteinemia Type II / metabolism; Lipoproteins / analysis; Lipoproteins / metabolism; Male; Multivariate Analysis; Mutation, Missense; Particle Size; Phosphatidylcholine-Sterol O-Acyltransferase / analysis; Phosphatidylcholine-Sterol O-Acyltransferase / metabolism; Probability; Reference Values; Risk Assessment
TL;DR: Heterozygosity for ABCA1 defects was associated with reduced LCAT activity in absence of effects on PLTP activity, and the effects of compromisedABCA1 function on HDL were more pronounced in women than in men. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Lipoproteins in the DCCT/EDIC cohort: Associations with diabetic nephropathy

KIDNEY INTERNATIONAL, 64(3), 817–828.

By: A. Jenkins*, T. Lyons, D. Zheng, J. Otvos*, D. Lackland, D. McGee, W. Garvey, R. Klein

author keywords: diabetes mellitus; nephropathy; lipoproteins; NMR
MeSH headings : Adolescent; Adult; Albuminuria; Child; Cholesterol, LDL / blood; Cohort Studies; Creatinine / blood; Cross-Sectional Studies; Diabetic Nephropathies / blood; Diabetic Nephropathies / urine; Female; Humans; Lipoproteins / blood; Lipoproteins, IDL; Lipoproteins, LDL / blood; Lipoproteins, VLDL / blood; Magnetic Resonance Spectroscopy; Male; Multivariate Analysis; Sex Characteristics; Triglycerides / blood
TL;DR: Potentially atherogenic lipoprotein profiles are associated with renal dysfunction in type 1 diabetes and further details are gained from NMR analysis. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 patent

Method of determining presence and concentration of lipoprotein X in blood plasma and serum

Washington, DC: U.S. Patent and Trademark Office.

By: J. Otvos, E. Jeyarajah & I. Shalaurova

Source: NC State University Libraries
Added: August 6, 2018

2003 patent

Methods and computer program products for determining risk of developing type 2 diabetes and other insulin resistance related disorders

Washington, DC: U.S. Patent and Trademark Office.

By: J. Otvos & D. Bennett

Source: NC State University Libraries
Added: August 6, 2018

2003 patent

Methods for providing personalized lipoprotein-based risk assessments

Washington, DC: U.S. Patent and Trademark Office.

By: J. Otvos

Source: NC State University Libraries
Added: August 6, 2018

2003 patent

Methods, systems, and computer program products for analyzing and presenting NMR lipoprotein-based risk assessment results

Washington, DC: U.S. Patent and Trademark Office.

By: J. Otvos

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort - Associations with gender and glycemia

DIABETES CARE, 26(3), 810–818.

By: A. Jenkins*, T. Lyons*, D. Zheng*, J. Otvos n, D. Lackland*, D. McGee*, W. Garvey*, R. Klein*

MeSH headings : Adult; Blood Glucose; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Cholesterol, VLDL / blood; Cohort Studies; Diabetes Mellitus, Type 1 / blood; Diabetes Mellitus, Type 1 / complications; Diabetes Mellitus, Type 1 / epidemiology; Female; Glycated Hemoglobin / analysis; Humans; Hyperglycemia / blood; Hyperglycemia / complications; Hyperglycemia / epidemiology; Lipoproteins / blood; Lipoproteins, LDL / metabolism; Magnetic Resonance Spectroscopy; Male; Middle Aged; Risk Factors; Sex Distribution; Triglycerides / blood
TL;DR: Male gender and poor glycemia are associated with a potentially more atherogenic NMR lipoprotein profile and LDL susceptibility to in vitro oxidation in type 1 diabetes. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 article

Cholesteryl ester transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency - Veterans Affairs HDL Cholesterol Intervention Trial

Brousseau, M. E., JJ O'Connor, Ordovas, J. M., Collins, D., Otvos, J. D., Massov, T., … Schaefer, E. J. (2002, July). ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol. 22, pp. 1148–1154.

By: M. Brousseau n, . JJ O'Connor, J. Ordovas n, D. Collins n, J. Otvos n, T. Massov n, . McNamara n, H. Rubins, S. Robins n, E. Schaefer n

author keywords: cholesteryl ester transfer protein; coronary heart disease; high density lipoproteins; polymorphism; Veterans Affairs HDL-C Intervention Trial
MeSH headings : Alleles; Apolipoproteins / blood; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cholesterol Ester Transfer Proteins; Cholesterol, HDL / blood; Cholesterol, HDL / deficiency; Cholesterol, HDL / genetics; Cholesterol, HDL / metabolism; Coronary Disease / etiology; Coronary Disease / genetics; Coronary Disease / prevention & control; Fasting / blood; Gemfibrozil / pharmacology; Gemfibrozil / therapeutic use; Genetic Markers / genetics; Genotype; Glycoproteins; Humans; Hypolipidemic Agents / pharmacology; Hypolipidemic Agents / therapeutic use; Lipid Metabolism; Lipid Metabolism, Inborn Errors / blood; Lipid Metabolism, Inborn Errors / complications; Lipid Metabolism, Inborn Errors / drug therapy; Lipid Metabolism, Inborn Errors / genetics; Lipids / blood; Lipoproteins, LDL / blood; Male; Middle Aged; Molecular Weight; Risk Factors; United States; United States Department of Veterans Affairs
TL;DR: The data demonstrate that in men with CHD and HDL deficiency, the CETP Taq I B2B2 genotype is significantly reduced and associated with higher levels of plasma HDL-C and lower CHD risk, and support the concept that increased LDL-C levels, resulting from reduced CETP activity, are associated with decreasedCHD risk. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Effects of pravastatin treatment on lipoprotein subclass profiles and particle size in the PLAC-I trial

ATHEROSCLEROSIS, 160(1), 41–48.

author keywords: lipoprotein subclasses; small LDL; HMG-CoA reductase inhibitors; CHD risk
MeSH headings : Aged; Arteriosclerosis / drug therapy; Dose-Response Relationship, Drug; Double-Blind Method; Endpoint Determination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Lipids / blood; Lipoproteins, HDL / blood; Lipoproteins, HDL / drug effects; Lipoproteins, LDL / blood; Lipoproteins, LDL / drug effects; Male; Middle Aged; Pravastatin / therapeutic use
TL;DR: High-risk CHD subjects with small LDL particles gain at least as much pharmacological benefit from pravastatin as those with large LDL, as evidenced by reductions in the numbers of total andSmall LDL particles, and increases in average LDL and HDL particle size. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Loci for CETP, LPL, LIPC, and APOC3 affect plasma lipoprotein size and subpopulation distribution in Hispanic and non- Hispanic white subjects: the Columbia University BioMarkers Study

Nutrition, Metabolism, and Cardiovascular Diseases, 12(4), 163–172.

By: S. Humphries, L. Berglund, C. Isasi, J. Otvos, D. Kaluski, R. Deckelbaum, S. Shea, P. Talmud

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the pravastatin limitation of atherosclerosis in the coronary arteries (PLAC-I) trial

AMERICAN JOURNAL OF CARDIOLOGY, 90(2), 89–94.

By: R. Rosenson*, J. Otvos n & D. Freedman*

MeSH headings : Anticholesteremic Agents / pharmacology; Cholesterol / blood; Coronary Angiography; Coronary Artery Disease / blood; Coronary Artery Disease / diagnostic imaging; Coronary Artery Disease / drug therapy; Coronary Vessels / drug effects; Disease Progression; Female; Humans; Lipoproteins / blood; Lipoproteins / classification; Lipoproteins / drug effects; Lipoproteins, LDL / blood; Lipoproteins, LDL / drug effects; Male; Middle Aged; Particle Size; Pravastatin / pharmacology; Treatment Outcome
TL;DR: Results indicate that levels of various lipoprotein subclasses may provide useful information on CAD risk even if levels of traditional risk factors are known. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Association of the A/T54 polymorphism in the intestinal fatty acid binding protein with variations in plasma lipids in The Framingham Offspring Study

ATHEROSCLEROSIS, 159(2), 417–424.

By: . Galluzzi*, L. Cupples*, J. Otvos n, P. Wilson*, E. Schaefer* & J. Ordovas*

author keywords: FABP2; cholesterol; polymorphism; Framingham
MeSH headings : Age Distribution; Aged; Alleles; Apolipoproteins / blood; Carrier Proteins / genetics; Cohort Studies; Coronary Artery Disease / epidemiology; Coronary Artery Disease / genetics; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Fatty Acids / metabolism; Female; Genetic Predisposition to Disease / epidemiology; Genetic Variation; Humans; Incidence; Lipids / blood; Lipoproteins / blood; Male; Middle Aged; Neoplasm Proteins; Polymorphism, Genetic; Probability; Prospective Studies; Risk Factors; Sex Distribution; Tumor Suppressor Proteins
TL;DR: The data are consistent with the T54 IFABP increasing the flux of lipids through the enterocyte leading to an increase in chylomicron secretion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study

ATHEROSCLEROSIS, 158(1), 173–181.

By: G. Russo*, J. Meigs*, L. Cupples n, S. Demissie n, J. Otvos n, P. Wilson*, C. Lahoz*, D. Cucinotta* ...

author keywords: apoC3; triglycerides; polymorphisms; lipoprotein particle size; insulin resistance
MeSH headings : Alleles; Apolipoprotein C-III; Apolipoproteins C / genetics; Chromosomes, Human, Pair 11; Coronary Disease / blood; Coronary Disease / genetics; Female; Humans; Lipids / blood; Lipoproteins / blood; Male; Middle Aged; Polymorphism, Genetic
TL;DR: Despite the described associations with lipid and glucose metabolism related risk factors, the Framingham Offspring Study did not find any significant increase in CHD risk associated with the S2 allele in this population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Distribution and correlates of high-density lipoprotein subclasses among children and adolescents

METABOLISM-CLINICAL AND EXPERIMENTAL, 50(3), 370–376.

By: D. Freedman n, B. Bowman n, . Srinivasan n, G. Berenson n & J. Otvos n

MeSH headings : Adolescent; Black People; Child; Cross-Sectional Studies; Female; Humans; Lipoproteins, HDL / blood; Lipoproteins, HDL / classification; Male; Particle Size; Sex Characteristics; White People
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Effectiveness of high doses of Simvastatin as monotherapy in mixed hyperlipidemia

AMERICAN JOURNAL OF CARDIOLOGY, 87(2), 232-+.

By: M. Miller*, C. Dolinar*, W. Cromwell & J. Otvos n

MeSH headings : Drug Administration Schedule; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Hyperlipidemias / drug therapy; Hypolipidemic Agents / administration & dosage; Hypolipidemic Agents / therapeutic use; Lipids / blood; Magnetic Resonance Spectroscopy; Simvastatin / administration & dosage; Simvastatin / therapeutic use
TL;DR: Twenty subjects with mixed hyperlipidemia participated in a 3-arm crossover trial to evaluate the effectiveness of high-dose simvastatin as monotherapy, and significant reductions were observed in atherogenic lipids and lipoproteins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Oral 17 beta-estradiol and medroxyprogesterone acetate therapy in postmenopausal women increases HDL particle size

ATHEROSCLEROSIS, 155(2), 425–430.

By: C. Tangney*, L. Mosca*, J. Otvos n & R. Rosenson*

author keywords: HDL particle size; hormone replacement therapy; menopause
MeSH headings : Administration, Oral; Animals; Estradiol / administration & dosage; Estradiol / pharmacology; Estradiol / therapeutic use; Estrogen Replacement Therapy; Estrogens, Conjugated (USP) / administration & dosage; Estrogens, Conjugated (USP) / pharmacology; Estrogens, Conjugated (USP) / therapeutic use; Female; Hormone Replacement Therapy; Horses; Humans; Lipoproteins, HDL / blood; Lipoproteins, HDL / chemistry; Magnetic Resonance Spectroscopy; Medroxyprogesterone Acetate / administration & dosage; Medroxyprogesterone Acetate / pharmacology; Medroxyprogesterone Acetate / therapeutic use; Middle Aged; Particle Size; Postmenopause / blood
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Oxidative dimerization in metallothionein is a result of intermolecular disulphide bonds between cysteines in the alpha- domain

Biochemical Journal (London, England : 1984), 359(2001 Oct 15), 353–360.

By: K. Zangger, G. Shen, G. Oz, J. Otvos & I. Armitage

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study

ATHEROSCLEROSIS, 148(2), 337–343.

By: P. Couture*, J. Otvos n, L. Cupples*, P. Wilson*, E. Schaefer* & J. Ordovas*

author keywords: microsomal triglyceride transfer protein; LDL-cholesterol; lipoprotein subfractions
MeSH headings : Adult; Apolipoproteins / blood; Cardiovascular Diseases / genetics; Carrier Proteins / genetics; Cholesterol Ester Transfer Proteins; Female; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glycoproteins; Humans; Lipids / blood; Lipoproteins / blood; Lipoproteins / classification; Male; Middle Aged; Polymorphism, Genetic / physiology; Promoter Regions, Genetic / genetics; Prospective Studies
TL;DR: The results suggest that the G-493T mutation in the MTP promoter is unlikely to have significant implications for cardiovascular disease in men and women. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Apolipoprotein epsilon 2 allele is associated with an anti-atherogenic lipoprotein profile in children: The Columbia University BioMarkers Study

PEDIATRICS, 106(3), 568–575.

By: C. Isasi, S. Shea, R. Deckelbaum*, S. Couch*, T. Starc*, J. Otvos n, L. Berglund

author keywords: apolipoprotein epsilon; children; cholesterol
MeSH headings : Adolescent; Adult; Alleles; Apolipoproteins E / genetics; Arteriosclerosis / genetics; Child; Child, Preschool; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Female; Genotype; Hispanic or Latino / genetics; Humans; Linear Models; Male; Phenotype; White People / genetics
TL;DR: The apo epsilon2 allele is associated with an anti-atherogenic lipid pattern in children and was independently predictive of higher levels of HDL cholesterol and the large HDL subpopulation and of lower level of LDL cholesterol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk - The Framingham study

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(5), 1323–1329.

author keywords: cholesteryl ester transfer protein; coronary heart disease; lipoproteins; gene polymorphisms
MeSH headings : Adult; Alcohol Drinking; Apolipoproteins B / blood; Blood Glucose / metabolism; Body Mass Index; Carrier Proteins / blood; Carrier Proteins / genetics; Cholesterol Ester Transfer Proteins; Cholesterol, LDL / blood; Coronary Disease / genetics; Deoxyribonucleases, Type II Site-Specific; Female; Genotype; Glycoproteins; Humans; Lipoproteins / blood; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Risk Factors; Triglycerides / blood
TL;DR: Variation at the CETP gene locus is a significant determinant of HDL-C levels, CETP activity, and lipoprotein size in this population, and these effects appear to translate into a lower CHD risk among those men with the B2 allele. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles - The Framingham Offspring Study

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20(3), 815–822.

author keywords: hepatic lipase; HDL; gene polymorphisms; lipoprotein particle size
MeSH headings : Adult; Aged; Apolipoprotein A-I / blood; Cholesterol, HDL / blood; Coronary Disease / enzymology; Coronary Disease / epidemiology; Coronary Disease / genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Lipase / genetics; Liver / enzymology; Male; Middle Aged; Particle Size; Polymorphism, Single Nucleotide; Risk Factors
TL;DR: The results show that the C-514T polymorphism in the hepatic lipase gene is associated with significant variations in the lipoprotein profile in men and women. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Levels and correlates of LDL and VLDF, particle sizes among children: the Bogalusa heart study

ATHEROSCLEROSIS, 152(2), 441–449.

By: D. Freedman*, B. Bowman*, J. Otvos n, . Srinivasan* & G. Berenson*

author keywords: nuclear magnetic resonance spectroscopy; lipids; lipoproteins; VLDL; LDL; lipoprotein subfractions; children; blacks
MeSH headings : Adolescent; Black or African American; Child; Coronary Disease / blood; Female; Humans; Insulin / blood; Lipids / blood; Lipoproteins, LDL / blood; Lipoproteins, VLDL / blood; Magnetic Resonance Spectroscopy; Male; Particle Size; Risk Factors; Rural Health; Sex Factors; White People
TL;DR: The analysis of lipoprotein subclasses may provide a better understanding of the role of various risk factors in the development of coronary heart disease, and levels of triglycerides, insulin, and relative weight were associated with the size of VLDL (positive) and LDL (negative) particles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Acute changes in serum lipids and lipoprotein subclasses in triathletes as assessed by proton nuclear magnetic resonance spectroscopy

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 19(8), 1945–1949.

By: H. Yu n, G. Ginsburg n, . ML O'Toole, J. Otvos n, P. Douglas n & N. Rifai n

author keywords: cholesterol; exercise; NMR; subclass
MeSH headings : Adult; Bicycling; Body Mass Index; Female; Humans; Lipids / blood; Lipoproteins / classification; Magnetic Resonance Spectroscopy; Male; Middle Aged; Physical Endurance / physiology; Running; Swimming; Triglycerides / blood
TL;DR: Exercise not only acutely induces changes in lipoprotein concentrations among the standard species in a manner that favorably affects CHD risk, but also induces favorable changes in specific lipop protein subclass size distribution that also may alterCHD risk independently of the total lipop Protein serum concentration. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Association of the A-204C polymorphism in the cholesterol 7 alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study

Journal of Lipid Research, 40(10), 1883–1889.

By: P. Couture, J. Otvos, L. Cupples, P. Wilson, E. Schaefer & J. Ordovas

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Hepatic lipase activity influences high density lipoprotein subclass distribution in normotriglyceridemic men: genetic and pharmacological evidence

Journal of Lipid Research, 40(2), 229–234.

By: S. Grundy, G. Vega, J. Otvos, D. Rainwater & J. Cohen

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Measurement of triglyceride-rich lipoproteins by nuclear magnetic resonance spectroscopy

Clinical Cardiology (Los Altos, Calif.), 22(6 Suppl.), II 21–27.

By: J. Otvos n

MeSH headings : Coronary Disease / diagnosis; Coronary Disease / metabolism; Humans; Lipoproteins, HDL / analysis; Lipoproteins, HDL / metabolism; Magnetic Resonance Spectroscopy; Sensitivity and Specificity; Triglycerides / analysis; Triglycerides / metabolism
TL;DR: Nuclear magnetic resonance spectroscopy measures lipoprotein subclasses directly and efficiently, and produces information that may improve the assessment and management of cardiovascular disease risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Three-dimensional solution structure of mouse [Cd-7]-metallothionein-1 by homonuclear and heteronuclear NMR spectroscopy

PROTEIN SCIENCE, 8(12), 2630–2638.

By: K. Zangger*, G. Oz*, J. Otvos n & I. Armitage

author keywords: Cd-113; 2D NMR; accordion-HMQC; mouse metallothionein-1; nuclear magnetic resonance; structure
MeSH headings : Amino Acid Sequence; Animals; Cadmium / chemistry; Magnetic Resonance Spectroscopy; Metallothionein / chemistry; Mice; Models, Molecular; Molecular Sequence Data; Protein Isoforms / chemistry; Protein Structure, Tertiary; Rats; Solutions
TL;DR: Structural comparison with rat liver MT2 showed high similarity, with the β‐domain structure in mouse MT1 showing evidence of increased flexibility compared to the same domain in MT2, and the latter was reflected by the presence of fewer interresidue NOEs, no slowly exchanging backbone amide protons, and enhanced cadmium‐cadmium exchange rates found in theβ‐domain of MT1. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Biphasic kinetics of Zn2+ removal from Zn metallothionein by nitrilotriacetate are associated with differential reactivity of the two metal clusters

JOURNAL OF INORGANIC BIOCHEMISTRY, 70(3-4), 187–194.

By: H. Li n & J. Otvos n

author keywords: metallothionein; ligand-exchange kinetics; NTA
MeSH headings : Animals; Cadmium / chemistry; Cadmium / metabolism; Circular Dichroism; Kinetics; Magnetic Resonance Spectroscopy / methods; Metallothionein / chemistry; Metallothionein / metabolism; Models, Chemical; Models, Molecular; Nitrilotriacetic Acid / analogs & derivatives; Nitrilotriacetic Acid / chemistry; Protons; Rabbits; Zinc / chemistry; Zinc / metabolism
TL;DR: The results indicate that the biphasic reactivity of Zn7MT stems from differential susceptibility of the metal in the two metal-thiolate clusters to removal by competing ligands, with Zn2+ in the more stable alpha- domain cluster reacting faster than that in the less stable beta-domain cluster. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Effects of oral combined hormone replacement therapy on plasma lipids and lipoproteins

METABOLISM-CLINICAL AND EXPERIMENTAL, 47(10), 1222–1226.

By: S. Vadlamudi n, P. Maclean n, R. Israel n, R. Marks n, M. Hickey n, J. Otvos n, H. Barakat n

MeSH headings : Administration, Oral; Cardiovascular Diseases / etiology; Cross-Sectional Studies; Estrogen Replacement Therapy; Female; Humans; Lipids / blood; Lipoproteins / blood; Middle Aged; Risk Factors
TL;DR: The results indicate that the combined estrogen and progesterone treatment leads to beneficial effects on plasma lipoproteins, including increases in HDL-cholesterol and predominance of HDL2, and no adverse effects on LDL subpopulation distribution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Lipid and lipoprotein responses to oral combined hormonereplacement therapy in normolipemic obese women with controlledtype 2 diabetes mellitus

Journal of Clinical Pharmacology, 38(12), 1107–1115.

By: S. Lilley, J. Spivey, S. Vadlamudi, J. Otvos, D. Cummings & H. Barakat

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men

ATHEROSCLEROSIS, 137(2), 359–366.

By: S. Giri*, P. Thompson*, P. Taxel*, J. Contois*, J. Otvos n, R. Allen*, G. Ens*, A. Wu*, D. Waters*

author keywords: I7 beta-estradiol; lipoproteins; thrombotic markers; homocysteine
MeSH headings : Administration, Oral; Aged; Antithrombin III / drug effects; Antithrombin III / metabolism; Cholesterol, HDL / blood; Cholesterol, HDL / drug effects; Cholesterol, LDL / blood; Cholesterol, LDL / drug effects; Cholesterol, VLDL / blood; Cholesterol, VLDL / drug effects; Estradiol / administration & dosage; Estradiol / therapeutic use; Fibrinogen / drug effects; Fibrinogen / metabolism; Fibrinolysis / drug effects; Follow-Up Studies; Homocysteine / blood; Homocysteine / drug effects; Humans; Lipids / blood; Lipoprotein(a) / blood; Lipoprotein(a) / drug effects; Male; Peptide Fragments / drug effects; Peptide Fragments / metabolism; Peptide Hydrolases / drug effects; Peptide Hydrolases / metabolism; Plasminogen Activator Inhibitor 1 / blood; Prothrombin / drug effects; Prothrombin / metabolism; Risk Factors; Thrombosis / blood; Thrombosis / prevention & control
TL;DR: It is concluded that oral estrogen in men reduces homocysteine, fibrinogen, and PAI-1 concentrations and favorably influences VLDL, LDL and HDL subclass levels without increasing markers of thrombotic risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men (vol. 137, pg. 359, 1998)

Atherosclerosis, 138(2), 403.

By: S. Giri, P. Thompson, P. Taxel, J. Contois, J. Otvos, R. Allen, G. Ens, A. Wu, D. Waters

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Relation of lipoprotein subclasses as measured by proton nuclear magnetic resonance spectroscopy to coronary artery disease

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 18(7), 1046–1053.

By: D. Freedman*, J. Otvos*, E. Jeyarajah*, J. Barboriak*, A. Anderson* & J. Walker*

author keywords: nuclear magnetic resonance spectroscopy; coronary disease; angiography; lipoproteins; lipoprotein subfractions
MeSH headings : Adult; Aged; Aged, 80 and over; Cholesterol, HDL / blood; Cholesterol, LDL / blood; Coronary Disease / blood; Humans; Lipoproteins / blood; Lipoproteins / classification; Lipoproteins, HDL / blood; Lipoproteins, LDL / blood; Lipoproteins, VLDL / blood; Magnetic Resonance Spectroscopy; Male; Middle Aged; Particle Size
TL;DR: It is found that a global measure of CAD severity was positively associated with levels of large VLDL and small HDL particles and inversely associated with intermediate size HDL particles; these associations were independent of age and standard lipid measurements. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Asparaginase associated lipid abnormalities in children with acute lymphoblastic leukemia

Blood, 89(6), 1886–1895.

By: S. Parsons, S. Skapek, E. Neufeld, C. Kuhlman, M. Young, M. Donnelly, J. Brunzell, J. Otvos, S. Sallan, N. Rifai

Source: NC State University Libraries
Added: August 6, 2018

1994 patent

Method and apparatus for measuring classes and subclasses of lipoproteins

Washington, DC: U.S. Patent and Trademark Office.

By: J. Otvos

Source: NC State University Libraries
Added: August 6, 2018

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