Joseph Anthony Ryan

Works (5)

Updated: July 5th, 2023 21:21

2008 patent

Nanoparticle delivery vehicle

Washington, DC: U.S. Patent and Trademark Office.

By: S. Franzen , D. Feldheim, A. Tkachenko, M. Godek, J. Ryan & M. Anderson

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Cellular Uptake of Gold Nanoparticles Passivated with BSA−SV40 Large T Antigen Conjugates

Ryan, J. A., Overton, K. W., Speight, M. E., Oldenburg, C. N., Loo, L. N., Robarge, W., … Feldheim, D. L. (2007, October 31). Analytical Chemistry, Vol. 79, pp. 9150–9159.

By: J. Ryan n, K. Overton n, M. Speight n, C. Oldenburg n, L. Loo n, W. Robarge n, S. Franzen n , D. Feldheim n

MeSH headings : Antigens, Polyomavirus Transforming / metabolism; Cell Nucleus / metabolism; Gold / chemistry; HeLa Cells; Humans; Metal Nanoparticles; Reproducibility of Results; Serum Albumin, Bovine / metabolism; Subcellular Fractions / metabolism
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery
TL;DR: The ICP-OES and nuclear fractionation techniques reported here are valuable tools that can add important quantitative information to optical and electron imaging methods such as VEC-DIC and transmission electron microscopy regarding the fate of nanoparticles in cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Cellular Trajectories of Peptide-Modified Gold Particle Complexes:  Comparison of Nuclear Localization Signals and Peptide Transduction Domains

Tkachenko, A. G., Xie, H., Liu, Y., Coleman, D., Ryan, J., Glomm, W. R., … Feldheim, D. L. (2004, April 28). Bioconjugate Chemistry.

By: A. Tkachenko n, H. Xie n, Y. Liu n, D. Coleman n, J. Ryan n, W. Glomm n, M. Shipton n, S. Franzen n , D. Feldheim n

MeSH headings : 3T3 Cells; Animals; Biological Transport, Active / physiology; Cell Line, Tumor; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Gene Products, tat / chemistry; Gold / chemistry; Gold / pharmacokinetics; HeLa Cells; Humans; Macromolecular Substances; Mice; Nuclear Localization Signals / drug effects; Nuclear Localization Signals / metabolism; Peptides / chemistry; Peptides / pharmacokinetics; Protein Structure, Tertiary / physiology; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Temperature; Transduction, Genetic
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Immunotherapy and Immune Responses
TL;DR: Video-enhanced color differential interference contrast microscopy and transmission electron microscopy indicated that transport of nanoparticles into the cytoplasm and nucleus depends on peptide sequence and cell line, and cellular uptake of Tat PTD peptide-gold nanoparticle conjugates was temperature dependent, suggesting an endosomal pathway of uptake. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

Critical Flocculation Concentrations, Binding Isotherms, and Ligand Exchange Properties of Peptide-Modified Gold Nanoparticles Studied by UV−Visible, Fluorescence, and Time-Correlated Single Photon Counting Spectroscopies

Xie, H., Tkachenko, A. G., Glomm, W. R., Ryan, J. A., Brennaman, M. K., Papanikolas, J. M., … Feldheim, D. L. (2003, September 30). Analytical Chemistry.

By: H. Xie n, A. Tkachenko n, W. Glomm n, J. Ryan n, M. Brennaman  n, J. Papanikolas  n, S. Franzen n, D. Feldheim n

MeSH headings : 2,2'-Dipyridyl / analogs & derivatives; 2,2'-Dipyridyl / chemistry; Amino Acid Sequence; Animals; Binding, Competitive; Cattle; Coordination Complexes; Dithionitrobenzoic Acid / chemistry; Flocculation; Fluorescamine / chemistry; Glutathione / chemistry; Gold Colloid / chemistry; Gold Colloid / metabolism; Kinetics; Ligands; Nanotechnology / methods; Particle Size; Peptides / chemistry; Protein Binding; Rhodamines / chemistry; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Succinimides / chemistry; Sulfhydryl Compounds / chemistry
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Analytical chemistry methods development; Mass Spectrometry Techniques and Applications
TL;DR: Protocols for modifying gold nanoparticles with peptide-bovine serum albumin (BSA) conjugates are described within and TCSPC has proven to be a powerful technique for observing the microenvironment of protein-gold nanoparticle conjugacy. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Multifunctional Gold Nanoparticle−Peptide Complexes for Nuclear Targeting

Tkachenko, A. G., Xie, H., Coleman, D., Glomm, W., Ryan, J., Anderson, M. F., … Feldheim, D. L. (2003, March 29). Journal of the American Chemical Society, Vol. 125, pp. 4700–4701.

By: A. Tkachenko  n, H. Xie n, D. Coleman n, W. Glomm n, J. Ryan n, M. Anderson n, S. Franzen n , D. Feldheim n

MeSH headings : Amino Acid Sequence; Cell Nucleus / metabolism; Gold / chemistry; Gold / pharmacokinetics; Humans; Molecular Sequence Data; Nanotechnology / methods; Oligopeptides / chemistry; Oligopeptides / pharmacokinetics; Particle Size; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / pharmacokinetics; Tumor Cells, Cultured
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Quantum Dots Synthesis And Properties; Gold and Silver Nanoparticles Synthesis and Applications
TL;DR: The ability of peptide-modified gold nanoparticles to target the nucleus of HepG2 cells was explored and nuclear targeting was more efficient when the two signals were attached to nanoparticles as separate short pieces versus one long peptide. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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