John Schneible

College of Engineering

Works (10)

Updated: July 5th, 2023 15:13

2021 review

Chitosan: A versatile bio-platform for breast cancer theranostics

[Review of ]. JOURNAL OF CONTROLLED RELEASE, 341, 733–752.

By: V. Madamsetty *, S. Tavakol *, S. Moghassemi *, A. Dadashzadeh *, J. Schneible n, I. Fatemi*, A. Shirvani*, A. Zarrabi * ...

author keywords: Chitosan; Breast cancer; Drug delivery; Nanoparticles; Phytochemicals; Anticancer drug
MeSH headings : Breast Neoplasms / diagnosis; Breast Neoplasms / drug therapy; Chitosan / chemistry; Drug Carriers / chemistry; Drug Delivery Systems; Female; Humans; Precision Medicine; United States
TL;DR: The present servey will discuss the application of chitosan as an anticancer drug carrier such as tamoxifen, doxorubicin, paclitaxel, docetaxe, etc and also, its role as a theranostics (i.e. photo-responsive and thermo-responsive) moieties. (via Semantic Scholar)
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Source: Web Of Science
Added: January 10, 2022

2021 journal article

Engineering Next Generation Cyclized Peptide Ligands for Light-Controlled Capture and Release of Therapeutic Proteins

ADVANCED FUNCTIONAL MATERIALS, 31(27).

By: R. Prodromou n, K. Day n, S. Saberi-Bosari n, J. Schneible n, M. Mabe  n, A. San Miguel n , M. Daniele n, V. Pozdin*, S. Menegatti n 

author keywords: azobenzene; cyclized peptide; light‐ controlled biorecognition; microfluidic devices; photochromic switch; photo‐ isomerization kinetics
TL;DR: A framework for prototyping photo‐affinity adsorbents comprising azobenzene‐cyclized peptides (ACPs) conjugated to translucent porous beads (ChemMatrix) and it is demonstrated that the isomerization at different light intensities is correlated to the cyclization geometry. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 24, 2021

2021 journal article

Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(4).

By: J. Bowen n, J. Schneible n, K. Bacon n, C. Labar n, S. Menegatti n  & B. Rao n 

Contributors: J. Bowen n, J. Schneible n, K. Bacon n, C. Labar n, S. Menegatti n  & B. Rao n 

author keywords: yeast display library; cyclic peptide; Yes Associated Protein (YAP) 65; WW domain; transglutaminase
MeSH headings : Adaptor Proteins, Signal Transducing / chemistry; Adaptor Proteins, Signal Transducing / metabolism; Albumins / metabolism; Binding Sites; Combinatorial Chemistry Techniques; Endoplasmic Reticulum / metabolism; Flow Cytometry; Ligands; Muramidase / metabolism; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / pharmacology; Protein Binding; Protein Engineering / methods; Transcription Factors / chemistry; Transcription Factors / metabolism; Transglutaminases / metabolism; YAP-Signaling Proteins; Yeasts / genetics; Yeasts / growth & development
TL;DR: The usefulness of yeast surface display for screening transglutaminase-cyclized peptide libraries, and efficient identification of cyclic peptide ligands, are demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

Advanced Therapeutics, 4(5).

By: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda n, J. Schneible n, M. Harp*, H. Deal n, M. Daniele n ...

author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
TL;DR: Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 5, 2021

2020 journal article

A multiscale coarse-grained model to predict the molecular architecture and drug transport properties of modified chitosan hydrogels

SOFT MATTER, 16(47).

By: A. Singhal *, J. Schneible n, R. Lilova  n, C. Hall n , S. Menegatti n  & A. Grafmueller

MeSH headings : Chitosan; Doxorubicin; Drug Liberation; Hydrogels; Polymers
TL;DR: A multiscale coarse-grained model is presented to investigate the structure of networks of chitosan chains modified with acetyl, butanoyl, or heptanoysl moieties, as well as the diffusion of drugs doxorubicin and gemcitabine through the resulting networks. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021

2020 journal article

Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids

PHARMACEUTICAL RESEARCH, 37(7).

By: J. Schneible n, A. Young n, M. Daniele n & S. Menegatti n 

MeSH headings : Acetylation; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Chitosan / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / chemistry; Deoxycytidine / pharmacology; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers; Drug Compounding; Drug Liberation; Drug Synergism; Female; Humans; Hydrogels; Kinetics; Spheroids, Cellular; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / pathology; Gemcitabine
TL;DR: The ACS hydrogel delivery system accomplishes drug release kinetics and molar ratio that affords strong therapeutically synergism and provides a strong pre-clinical demonstration of the potential of the proposed system for complementing surgical resection of aggressive solid tumors. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

JOURNAL OF MATERIALS CHEMISTRY B, 8(17), 3852–3868.

By: J. Schneible n, K. Shi n, A. Young n, S. Ramesh n, N. He*, C. Dowdey n, J. Dubnansky n, R. Libya ...

MeSH headings : Antibiotics, Antineoplastic / chemistry; Antibiotics, Antineoplastic / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Drug Screening Assays, Antitumor; Graphite / chemistry; Humans; Hydrogels / chemistry; Molecular Dynamics Simulation; Particle Size; Peptides / chemistry; Surface Properties; Tumor Cells, Cultured
TL;DR: A homogeneous composite comprising modified graphene oxide (GO) nanoparticles embedded in a Max8 peptide hydrogel, which provides controlled kinetics and molar ratios of release of doxorubicin (DOX) and gemcitabine (GEM) and is tested against a triple negative breast cancer cell line. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2020 journal article

Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics

JOURNAL OF CHROMATOGRAPHY A, 1635.

By: W. Chu n, R. Prodromou n, K. Day n, J. Schneible n, K. Bacon n, J. Bowen n, R. Kilgore n, C. Catella n ...

author keywords: Affinity ligands; peptides; peptoids; pseudopeptides; biotherapeutics
MeSH headings : Antibodies / isolation & purification; Biological Products / isolation & purification; Chemistry, Pharmaceutical / methods; Chromatography, Affinity; Family Characteristics; Humans; Ligands; Peptides / isolation & purification; Peptoids / chemistry; Proteins / isolation & purification
TL;DR: This work presents a comprehensive and systematic review of the literature on peptide-based ligands and their use in the affinity purification of established and upcoming biological drugs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021

2020 journal article

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427.

By: K. Day n, J. Schneible n, A. Young n, V. Pozdin*, G. Driessche  n, L. Gaffney n, R. Prodromou n, D. Freytes n ...

MeSH headings : Amino Acid Sequence; Azo Compounds / chemistry; Hydrogen-Ion Concentration; Isomerism; Osmolar Concentration; Peptides, Cyclic / chemistry; Photochemical Processes
TL;DR: This study demonstrates a general method to develop azobenzene-cyclized peptide ligands with light-controlled affinity for target proteins by designing photo-switchable peptides targeting vascular cell adhesion marker 1 (VCAM1), a cell marker implicated in stem cell function. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 14, 2020

2019 journal article

Tailoring the Chemical Modification of Chitosan Hydrogels to Fine-Tune the Release of a Synergistic Combination of Chemotherapeutics

BIOMACROMOLECULES, 20(8), 3126–3141.

By: J. Schneible n, A. Singhal *, R. Lilova  n, C. Hall n , A. Grafmueller & S. Menegatti n 

MeSH headings : Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Breast Neoplasms / drug therapy; Chitosan / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Doxorubicin / administration & dosage; Drug Carriers / chemistry; Drug Liberation; Drug Synergism; Female; Humans; Hydrogels / chemistry; Polymers / chemistry; Gemcitabine
TL;DR: A computational toolbox that models the migration of a drug pair through a hydrated network of polysaccharide chains modified with hydrophobic moieties is developed and the potential of this model in guiding the design of chemotherapeutic hydrogels to combat cancer is demonstrated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2019

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