Works (42)
Updated: August 29th, 2023 11:24
2021 journal article
Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31
JOURNAL OF NEUROVIROLOGY, 27(2), 302–324.
author keywords: Human immunodeficiency virus; Neurocognitive; Neurotrophin; Therapy; Behavior; Neuroprotection
MeSH headings : Animals; Cats; Cognition Disorders / virology; Feline Acquired Immunodeficiency Syndrome / complications; Immunodeficiency Virus, Feline; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Morpholines / pharmacology; Neuroprotective Agents / pharmacology; Receptor, Nerve Growth Factor / agonists
TL;DR:
The data indicate that LM11A-31 is likely to be a potent adjunctive treatment for the control of neurodegeneration in HIV infected individuals.
(via Semantic Scholar)
open access via doi.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021
2021 journal article
Modified-Live Feline Calicivirus Vaccination Elicits Cellular Immunity against a Current Feline Calicivirus Field Strain in an Experimental Feline Challenge Study
VIRUSES-BASEL, 13(9).
author keywords: crossneutralisation; crossimmunity; lymphocyte subsets; neutralising antibodies; cytokines; IFN-gamma; perforin; granzyme B; antiviral factor MX1; ELISpot
MeSH headings : Animals; Antibodies, Viral / blood; Calicivirus, Feline; Cat Diseases / prevention & control; Cats; Cytokines; Granzymes; Immunity, Cellular / immunology; Immunity, Humoral; Leukocytes, Mononuclear / immunology; Perforin; Specific Pathogen-Free Organisms; Vaccination / veterinary; Vaccines, Attenuated; Viral Vaccines / immunology
TL;DR:
Investigating the cellular and humoral immune response of specified pathogen-free (SPF) cats after modified-live FCV F9 vaccinations and two heterologous FCV challenges induced cellular but not humoral crossimmunity in SPF cats finds innate immune mechanisms, secretory and membranolytic pathways, and IFN-γ-releasing PBMCs seem to be important in the host immune defence against FCV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 4, 2021
2021 journal article
Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits
Scientific Reports, 11(1).
MeSH headings : Amyloidogenic Proteins / metabolism; Amyloidosis, Familial / genetics; Amyloidosis, Familial / metabolism; Amyloidosis, Familial / veterinary; Animals; Cat Diseases / genetics; Cat Diseases / metabolism; Cats / genetics; Cats / metabolism; Genetic Variation / genetics; Kidney / metabolism; Kidney Diseases / genetics; Kidney Diseases / metabolism; Kidney Diseases / veterinary; MicroRNAs; Proteomics; Whole Genome Sequencing
TL;DR:
The general conclusions are that the familial amyloid renal form in Abyssinians is not a simple monogenic trait and is a mix of proteins codified by wild-type genes, and the form is biochemically classifiable as AA amyloidsosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: May 24, 2021
2021 article
Retrospective and prospective assessment of butorphanol, azaperone and medetomidine (BAM (TM)) for immobilisation of feral horses (Equus ferus caballus)
Balko, J. A., Fogle, C., Stuska, S. J., Fogle, J. E., & Posner, L. P. (2021, July 26). EQUINE VETERINARY JOURNAL, Vol. 7.
author keywords: azaperone; BAM; butorphanol; castration; horse; immobilisation; medetomidine
MeSH headings : Animals; Azaperone / pharmacology; Butorphanol / pharmacology; Horses; Hypnotics and Sedatives / pharmacology; Immobilization / veterinary; Ketamine; Male; Medetomidine / pharmacology; Prospective Studies; Retrospective Studies
TL;DR:
Intramuscular BAM™ with IV ketamine provided chemical restraint suitable for field castration of feral horses with no mortality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 9, 2021
2021 journal article
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Frontiers in Immunology, 12.
author keywords: adaptive immunity; humoral immunity; neutralizing antibodies; IgA; IgG; porcine reproductive and respiratory syndrome virus
MeSH headings : Animals; Antibodies, Neutralizing / blood; Flow Cytometry / methods; Immunity, Humoral / immunology; Immunoglobulin A / analysis; Immunoglobulin A / immunology; Immunoglobulin G / blood; Nasal Mucosa / immunology; Nasal Mucosa / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Vaccination; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
TL;DR:
This study improves the understanding of the relationship between local and systemic infections and the humoral immune response induced by PRRSV-2 infection or MLV vaccination and provides novel insights into the timeline of the development of homologous and heterologous NA levels – by bothMLV vaccination or infection with two strains from the currently prevalent PRRSv-2 lineage 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 29, 2021
2020 journal article
Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study
EXPERIMENTAL EYE RESEARCH, 193.
author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
TL;DR:
Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent than matched healthy controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020
2020 journal article
Multicenter flow cytometry proficiency testing of canine blood and lymph node samples
Veterinary Clinical Pathology, 49(2), 249–257.
author keywords: assay performance; dog; external laboratory quality assessment; immunophenotyping
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Flow Cytometry / standards; Flow Cytometry / veterinary; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / pathology; Hematologic Neoplasms / veterinary; Immunophenotyping / veterinary; Laboratory Proficiency Testing / standards; Lymph Nodes / pathology; Lymphoproliferative Disorders / diagnosis; Lymphoproliferative Disorders / pathology; Lymphoproliferative Disorders / veterinary
TL;DR:
Lymphoproliferations were readily identified by FC, but identification of the categories of hematolymphoid neoplasia in fresh samples or archived files was variable, indicating a need for a more standardized approach to maximize the enormous potential of FC in veterinary medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 20, 2020
2019 journal article
ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats
JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(2), 313–334.
author keywords: comorbidity; Delphi survey; direct antiglobulin test; erythrocyte; evidence; flow cytometry; hemolysis; iceberg model; spherocyte; veterinary and comparative clinical immunology society
MeSH headings : Anemia, Hemolytic, Autoimmune / diagnosis; Anemia, Hemolytic, Autoimmune / etiology; Anemia, Hemolytic, Autoimmune / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / etiology; Cats; Comorbidity; Consensus; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Societies, Veterinary
TL;DR:
Clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats are provided, which should be implemented with consideration of animal, owner, and geographical factors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2019
2019 book
Juvenile polyarteritis
In Clinical Veterinary Advisor (4th ed.). Elsevier.
Source: NC State University Libraries
Added: September 8, 2019
2019 chapter
Neonatal Isoerythrolysis
In Clinical Veterinary Advisor (4th ed.). Elsevier.
Source: NC State University Libraries
Added: September 8, 2019
2018 journal article
Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats
Viruses, 10(7), 353.
author keywords: FIV; enrichment; welfare; feline; laboratory animal
MeSH headings : Animals; Animals, Laboratory; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology
TL;DR:
Cats used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection were used and it was found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenails conditioning object.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018
2018 review
Epigenetic Modulation of CD8(+) T Cell Function in Lentivirus Infections: A Review
[Review of ]. VIRUSES-BASEL, 10(5).
author keywords: CD8(+) T cells; T regulatory cells; CD8(+) T cell dysfunction; epigenetics; lentiviral infections; feline immunodeficiency virus; simian immunodeficiency virus; human immunodeficiency virus
MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Cytokines / immunology; Epigenesis, Genetic; HIV Infections / immunology; Humans; Immunodeficiency Virus, Feline; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Activation; Simian Immunodeficiency Virus; T-Lymphocytes, Regulatory / immunology; Viremia / veterinary
TL;DR:
Using the feline immunodeficiency virus (FIV) model for lentiviral persistence, it is demonstrated that CD8+ T cells exhibit epigenetic changes such as DNA demethylation during the course of infection as compared to uninfected cats and epigenetic modulation reduces Foxp3 binding to these promoter regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8(+) T Cells from Feline Immunodeficiency Virus-Infected Cats
VIRUSES-BASEL, 10(6).
author keywords: Feline Immunodeficiency Virus; CD8(+) T cells; CD8(+) T cell dysfunction; T regulatory cells; Treg suppression; Foxp3; IL-2 suppression; epigenetics; histone acetylation
MeSH headings : Acetylation; Anacardic Acids / pharmacology; Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Coculture Techniques; Epigenesis, Genetic; Feline Acquired Immunodeficiency Syndrome / immunology; Forkhead Transcription Factors / metabolism; Histones / metabolism; Immunodeficiency Virus, Feline; Interferon-gamma / immunology; Interleukin-2 / genetics; Promoter Regions, Genetic; T-Lymphocytes, Regulatory / immunology
TL;DR:
Using anacardic acid (AA), a known histone acetyl transferase (HAT) inhibitor, a reduction in Foxp3 binding to the IL-2 promoter in virus-specific CD8+ T cells co-cultured with autologous Treg cells is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Precision medicine validation: identifying the MYBPC3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy
JOURNAL OF FELINE MEDICINE AND SURGERY, 21(12), 1086–1093.
author keywords: HCM; WGS; individualized medicine; next-generation sequencing
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cat Diseases / genetics; Cats; Genetic Predisposition to Disease; Mutation; Precision Medicine / instrumentation; Precision Medicine / methods; Precision Medicine / veterinary; Whole Genome Sequencing / veterinary
TL;DR:
This proof-of-concept experiment identified the previously reported MYBPC3 A31P Maine Coon variant in two HCM-affected cases and highlights the power of whole-genome sequencing for feline precision medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 16, 2019
2017 journal article
Micro-RNA 10a Is Increased in Feline T Regulatory Cells and Increases Foxp3 Protein Expression Following In Vitro Transfection
Veterinary Sciences, 4(4), 12.
TL;DR:
It is demonstrated that CD4+CD25+ T cells from both feline immunodeficiency virus infected (FIV+) cats and uninfected control cats exhibit increased miRNA 10a and 21 levels compared to autologous CD4-CD25− T cells but there was no difference in the levels of these miRNAs when T Reg cells from FIV+ cats were compared to Treg cells from unin infected controls.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2017 journal article
T Regulatory Cell Induced Foxp3 Binds the IL2, IFNγ, and TNFα Promoters in Virus-Specific CD8+ T Cells from Feline Immunodeficiency Virus Infected Cats
AIDS Research and Human Retroviruses, 34(3), 269–276.
author keywords: animal models; T cell immunity; cell mediated immunity; T regulatory cell; polyfunctional T cell; CD8(+) T cell
MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / metabolism; Immunodeficiency Virus, Feline; Interferon-gamma / genetics; Interleukin-2 / genetics; Lymphocyte Activation; Promoter Regions, Genetic; T-Lymphocytes, Regulatory / immunology; Tumor Necrosis Factor-alpha / genetics; Viremia / immunology; Viremia / virology
TL;DR:
It is shown that Foxp3 inhibits IL2, TNFα, and IFNγ transcription by binding to their promoter regions in lentivirus-specific CD8+ T cells, the first description of this process during the course of AIDS lentiviral infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2016 journal article
Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function
Journal of Veterinary Internal Medicine, 30(4), 1167–1178.
author keywords: Bone tumor; Chemoreceptors; Chemotaxis; Immunoregulation
MeSH headings : Animals; Bone Neoplasms / blood; Bone Neoplasms / veterinary; Case-Control Studies; Chemotaxis; Cytokines / metabolism; Disease-Free Survival; Dog Diseases / blood; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation; Male; Monocytes / metabolism; Monocytes / physiology; Osteosarcoma / blood; Osteosarcoma / veterinary; RNA, Messenger / analysis
TL;DR:
Dogs with OSA have decreased monocyte chemokine receptor expression and monocytes chemotaxis, potential mechanisms by which OSA might evade the immune response, and reversal of monocyte dysfunction using immunotherapy could improve survival in dogs with Osa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Comparison of lipopolysaccharides and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses
Equine Veterinary Journal, 49(2), 155–159.
Contributors: n, M. Jacob n, A. Blikslager n , A. Edwards n, B. Wagner *, K. Dean n, C. Fogle n
author keywords: horse; soluble CD14; endotoxin; sepsis; inflammation; colic
MeSH headings : Animals; Biomarkers / blood; Endotoxemia / blood; Endotoxemia / veterinary; Horse Diseases / blood; Horse Diseases / diagnosis; Horses; Lipopolysaccharide Receptors / blood; Lipopolysaccharides
TL;DR:
It is suggested that sCD14 and LPS were poor predictors of clinical endotoxaemia for the horses in this study, and further investigation is warranted to assess the utility of s CD14 measurement as a clinically useful biomarker to identify endotox aemia in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression
VACCINE, 34(35), 4180–4187.
author keywords: MDV; Control; ILTV; Immunosuppression; Immune system; Vaccine
MeSH headings : Animals; Chickens; Female; Immune Tolerance; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / adverse effects; Neoplasms / virology; Poultry Diseases / prevention & control; Vaccination / methods; Vaccination / veterinary
TL;DR:
It is demonstrated that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index=100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late- MDv-IS even in complete absence of tumors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Expression of Apoptosis-regulating Proteins Bcl-2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma
JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(3), 819–826.
author keywords: Canine; Flow cytometry; Lymphosarcoma; Programmed cell death
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Apoptosis; Case-Control Studies; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / drug therapy; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / drug therapy; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Prospective Studies; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; Systole; Treatment Outcome; bcl-2-Associated X Protein / genetics; bcl-2-Associated X Protein / metabolism
TL;DR:
Whether Bcl‐2/Bax will be helpful to identify canine BCL and TCL with more aggressive and more indolent behavior, respectively, should be evaluated in larger prospective clinical studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B-cell lymphoma
Veterinary Clinical Pathology, 46(1), 64–71.
Contributors: K. Meichner *, B. Kraszeski n, J. Durrant n, C. Grindem n, B. Breuhaus n , P. Moore*, J. Neel n , K. Linder n
author keywords: Clonality; equine; leukemia; leukocytosis; lymphoid
MeSH headings : Animals; Female; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horses; Immunohistochemistry / veterinary; Lymphocytosis / diagnostic imaging; Lymphocytosis / pathology; Lymphocytosis / veterinary; Lymphoma, B-Cell / diagnostic imaging; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Microscopy, Electron, Transmission / veterinary; T-Lymphocytes / pathology
TL;DR:
An 11-year-old Haflinger mare presented to the North Carolina State University Veterinary Teaching Hospital with a 2-week history of lethargy and a 3-day duration of anorexia, pyrexia, tachycardia, and ventral edema was diagnosed with diffuse large B-cell lymphoma with a marked hematogenous component.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
CD45+ and CD45− lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage
Veterinary Immunology and Immunopathology, 168(3-4), 242–248.
author keywords: Lymphoma; PARR; Cytology; CD45; Flow cytometry
MeSH headings : Animals; B-Lymphocytes / metabolism; Dog Diseases / immunology; Dog Diseases / metabolism; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic / physiology; Leukocyte Common Antigens / genetics; Leukocyte Common Antigens / metabolism; Lymphoma / metabolism; Lymphoma / veterinary; Male; T-Lymphocytes / metabolism
TL;DR:
Comparing morphology and assess clonal origin between CD45+ and CD45- lymphocyte populations identified by flow cytometry in confirmed cases of canine B- and T-cell lymphoma suggests that theCD45- population identified in dogs with lymphoma represents a phenotypic variant of the CD 45+ population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2015 journal article
Monocyte-Derived Dendritic Cells from Feline Immunodeficiency Virus Positive Cats are Productively Infected and Maintain CD8+ T Cell Stimulatory Capacity
International Journal of Virology and AIDS, 2(1).
TL;DR:
The hypothesis that monocyte-derived dendritic cells from FIV+ chronically infected cats maintained the ability to stimulate CD8+ T cells in the absence of exogenous antigen is supported, and these results support the hypothesis that moDCs maintain the able to stimulateCD8- T cells during chronic lentiviral infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: September 9, 2019
2015 journal article
Probable primary polydipsia in a domestic shorthair cat
Journal of Feline Medicine and Surgery Open Reports, 1(2), 205511691561537.
TL;DR:
Findings provide strong evidence that primary polydipsia was the underlying etiology of the cat’s condition and exemplifies the challenges faced when a cat presents for polyuria and polyDipsia without an obvious cause identified on routine diagnostics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID
Added: July 20, 2019
2014 journal article
CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism
Virology Journal, 11(1), 7.
author keywords: FIV; HIV; AIDS; Lentivirus; Treg cells; mTGF beta; GARP
MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Membrane Proteins / metabolism; Signal Transduction; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR:
Th to Treg conversion may initiate a cascade of events that contributes to the maintenance of virus reservoirs, progressive Th cell immunosuppression, and the development of immunodeficiency, all of which are central to the pathogenesis of AIDS lentivirus infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Modulating DNA Methylation in Activated CD8+ T Cells Inhibits Regulatory T Cell–Induced Binding of Foxp3 to the CD8+ T Cell IL-2 Promoter
The Journal of Immunology, 194(3), 990–998.
MeSH headings : Animals; Base Sequence; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Cats; Chromatin Assembly and Disassembly; Coculture Techniques; DNA Methylation; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Expression Regulation; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / chemistry; Interleukin-2 / genetics; Lentivirus / immunology; Lymphocyte Activation; Models, Biological; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
TL;DR:
Using the FIV model for lentiviral persistence, these studies provide a framework for understanding how immune activation combined with Treg-mediated suppression may affect CD8+ T cell IL-2 transcription, maturation, and antiviral function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2013 journal article
Feline Glycoprotein A Repetitions Predominant Anchors Transforming Growth Factor Beta on the Surface of Activated CD4(+)CD25(+) Regulatory T Cells and Mediates AIDS Lentivirus-Induced T Cell Immunodeficiency
AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(4), 641–651.
MeSH headings : Amino Acid Sequence; Animals; Cats; Feline Acquired Immunodeficiency Syndrome / etiology; Feline Acquired Immunodeficiency Syndrome / immunology; Glycoproteins / genetics; Glycoproteins / immunology; Glycoproteins / metabolism; Humans; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / pathogenicity; Membrane Proteins / genetics; Membrane Proteins / immunology; Membrane Proteins / metabolism; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes / metabolism; Protein Conformation; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Species Specificity; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR:
It is demonstrated that the GARP(+) Treg cells from FIV-infected cats suppress T helper cells in vivo and that blocking GARP or TGFb eliminates this suppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Infection with Feline Immunodeficiency Virus Directly Activates CD4+ CD25+ T Regulatory Cells
Journal of Virology, 87(16), 9373–9378.
MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Cells, Cultured; Gene Expression Profiling; Immunodeficiency Virus, Feline / immunology; Immunosuppression Therapy; Interleukin-2 Receptor alpha Subunit / analysis; T-Lymphocyte Subsets / chemistry; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology
TL;DR:
In vitro feline immunodeficiency virus (FIV) infection, but not UV-inactivated virus, activates Treg cells as measured by immunosuppressive function and upregulation of GARP, FoxP3, and membrane-bound transforming growth factor β (TGF-β).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2013 journal article
Lentivirus-Activated T Regulatory Cells Suppress T Helper Cell Interleukin-2 Production by Inhibiting Nuclear Factor of Activated T Cells 2 Binding to the Interleukin-2 Promoter
AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(1), 58–66.
MeSH headings : Amino Acid Sequence; Animals; Cats; Cell Proliferation; Cells, Cultured; Coculture Techniques; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / genetics; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lentivirus Infections / virology; Lymph Nodes / cytology; Lymph Nodes / virology; Lymphocyte Activation / immunology; Molecular Sequence Data; NFATC Transcription Factors / antagonists & inhibitors; NFATC Transcription Factors / genetics; Promoter Regions, Genetic / immunology; Protein Binding / immunology; RNA, Messenger / biosynthesis; Receptors, Transforming Growth Factor beta / biosynthesis; Sequence Alignment; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / virology; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / pharmacology; Up-Regulation
TL;DR:
Data suggest that TGF-β-mediated Treg cell suppression of IL-2 transcription is modulated through alterations in NFAT2 binding to the IL-1 promoter in suppressed Th cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Lymphoma Immunophenotype of Dogs Determined by Immunohistochemistry, Flow Cytometry, and Polymerase Chain Reaction for Antigen Receptor Rearrangements
Journal of Veterinary Internal Medicine, 27(6), 1509–1516.
author keywords: Cancer; Flow cytometry; Lineage; Lymph nodes; Specificity
MeSH headings : Animals; Area Under Curve; DNA / chemistry; DNA / genetics; Dog Diseases / immunology; Dogs; Female; Flow Cytometry / veterinary; Immunohistochemistry / veterinary; Immunophenotyping / methods; Immunophenotyping / veterinary; Lymph Nodes / immunology; Lymphoma / genetics; Lymphoma / immunology; Male; Polymerase Chain Reaction / veterinary; Receptors, Antigen / genetics; Receptors, Antigen / immunology; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity
TL;DR:
Flow cytometry is superior to PARR in correctly predicting immunophenotypes when evaluating lymph nodes from dogs already diagnosed with B- or T-cell LSA and if fresh samples are not available for FC, PARR is an acceptable assay for determination of immunophenotype given its high specificity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection
Viruses, 4(6), 954–962.
author keywords: acquired immunodeficiency syndrome; lentivirus; FIV; antiretroviral therapy (ART); Zidovudine; Fozivudine
MeSH headings : Animals; Anti-HIV Agents / administration & dosage; CD4-CD8 Ratio; Cat Diseases / drug therapy; Cats; Feline Acquired Immunodeficiency Syndrome / drug therapy; Feline Acquired Immunodeficiency Syndrome / virology; Lipids / administration & dosage; Lymphocyte Count; Treatment Outcome; Viral Load; Viremia / virology; Zidovudine / administration & dosage; Zidovudine / analogs & derivatives
TL;DR:
It is suggested that treatment with a single agent anti-retroviral drug during acute lentivirus infection does not significantly alter viral load and immune function during the chronic, asymptomatic stage of infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2012 journal article
CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection
Veterinary Immunology and Immunopathology, 152(3-4), 200–208.
author keywords: FIV; AIDS; CTL; CD8(+) clonality; PARR
MeSH headings : Animals; CD8 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Clonal Selection, Antigen-Mediated / genetics; Cytokines / genetics; Gene Rearrangement, T-Lymphocyte; Immunodeficiency Virus, Feline; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Male; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcriptome; Viremia / genetics; Viremia / immunology; Viremia / veterinary
TL;DR:
Using PARR to assess changes in CD8(+) clonality during the progression from acute to chronic FIV infection may help to better characterize the factors which contribute to CD8 (+) anergy and lentiviral persistence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 151(3-4), 229–234.
author keywords: Fc gamma receptor; CD16; CD32; Intravenous immunoglobulin
MeSH headings : Animals; Antibodies, Blocking / metabolism; Antibodies, Heterophile / metabolism; Antigen-Antibody Complex / metabolism; Antigen-Antibody Reactions; Cell Line; Dogs / immunology; Humans; Immunoglobulins, Intravenous / metabolism; Monocytes / immunology; Receptors, IgG / antagonists & inhibitors; Receptors, IgG / metabolism
TL;DR:
This is the first report to demonstrate Fc(γ) receptors CD16 and CD32 expression on canine monocytes and in vitro CD32 binding by human IgG, which may represent one of the immunomodulatory mechanisms of hIVIG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Fozivudine Tidoxil as Single-Agent Therapy Decreases Plasma and Cell-Associated Viremia during Acute Feline Immunodeficiency Virus Infection
JOURNAL OF VETERINARY INTERNAL MEDICINE, 25(3), 413–418.
author keywords: Acquired immunodeficiency syndrome; Antiretroviral therapy; Lentivirus; Zidovudine
MeSH headings : Animals; Antiviral Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / virology; Cats; Immunodeficiency Virus, Feline / drug effects; Lentivirus Infections / drug therapy; Lipids / therapeutic use; Male; Specific Pathogen-Free Organisms; Viremia / drug therapy; Viremia / veterinary; Zidovudine / analogs & derivatives; Zidovudine / therapeutic use
TL;DR:
Treatment of cats with FZD during the acute stage of FIV infection decreased plasma and cell-associated viremia during the first 2 weeks of infection, but was not protective against FIV, as all cats were infected by 6 weeks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
CD4(+)CD25(+) T Regulatory Cells Inhibit CD8(+) IFN-gamma Production During Acute and Chronic FIV Infection Utilizing a Membrane TGF-beta-Dependent Mechanism
AIDS RESEARCH AND HUMAN RETROVIRUSES, 26(2), 201–216.
MeSH headings : Animals; CD4 Antigens / analysis; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / immunology; Cat Diseases / virology; Cats; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interferon-gamma / antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit / analysis; Lentivirus Infections / veterinary; Lentivirus Infections / virology; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology
TL;DR:
The results demonstrate the suppressive effect CD4(+)CD25(+) Treg cells have on the CD8(+) immune response during the acute and chronic stages of FIV infection and suggest that the mechanism of suppression may be mediated by mTGF-beta.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
CD4(+)CD25(+) T regulatory cells from FIV+ cats induce a unique anergic profile in CD8(+) lymphocyte targets
RETROVIROLOGY, 7.
MeSH headings : Animals; CD4 Antigens / immunology; CD8-Positive T-Lymphocytes / cytology; CD8-Positive T-Lymphocytes / metabolism; Cats; Cell Cycle / immunology; Clonal Anergy; Coculture Techniques; Down-Regulation; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline; Interleukin-2 Receptor alpha Subunit / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR:
It is suggested that CD4+CD25+ Treg cells from FIV+ cats induce CD8+ anergy by disruption of normal G1 to S cell cycle progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263–272.
author keywords: FIV; HIV; Regulatory T cells; Acute infection
MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary
TL;DR:
The hypothesis that early activation of Treg immunosuppressor function may limit an effective anti-FIV response is supported, contributing to the establishment of chronic infection and the immunodeficiency caused by this virus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 chapter
CD4+CD25+ Regulatory T Cells in Viral Infections
In Regulatory T Cells and Clinical Application (pp. 407–422).
TL;DR:
It is clear from the studies described herein that chronic viral infections are characterized by an early and sustained activation of immunosuppressiveCD4+CD25+ Treg cells capable of inhibiting anti-viral CD4+ and CD8+ immune responses, which allows for the establishment of long-term infection.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2007 journal article
In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats
JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.
author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR:
It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Mucosal immunity and chronic idiopathic enteropathies in dogs
Compendium on Continuing Education for the Practicing Veterinarian, 29(5), 290–302.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Cholangiohepatitis in Cats
Standards of Care- Emergency and Critical Care Medicine, 7(4).
Source: NC State University Libraries
Added: December 28, 2020
2004 journal article
Pit Viper Envenomation in Dogs
Standards of Care- Emergency and Critical Care Medicine, 6(8).
Source: NC State University Libraries
Added: December 28, 2020
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