2019 journal article

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin


By: E. Quist*, G. Boorman*, J. Cullen n, R. Maronpot, A. Remick*, J. Swenberg*, L. Freshwater, J. Hardisty*

author keywords: permethrin; liver neoplasms; hepatocellular adenoma; hepatocellular carcinoma; Pathology Working Group
MeSH headings : Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens / toxicity; Dose-Response Relationship, Drug; Female; Liver Neoplasms / chemically induced; Liver Neoplasms / pathology; Liver Neoplasms, Experimental / chemically induced; Liver Neoplasms, Experimental / pathology; Male; Mice, Inbred Strains; Permethrin / toxicity; Sex Factors
TL;DR: An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review coded liver histology sections from male and female mice and to classify all liver neoplasms according to current nomenclature and diagnostic criteria guidelines, which indicate that permethrin induced a significant dose-dependent increase in the incidence of hepatocellular neoplasm in treated female mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 11, 2019

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