Works (120)

Updated: July 19th, 2024 05:00

2024 journal article

Increased lipogenesis and lipidosis of gallbladder epithelium in dogs with gallbladder mucocele formation

PLOS ONE, 19(6).

By: J. Gookin, D. Jewell, K. Aicher, G. Seiler, J. Cullen & K. Mathews

Sources: Web Of Science, NC State University Libraries
Added: July 17, 2024

2023 journal article

Gallbladder microbiota in healthy dogs and dogs with mucocele formation

PLOS ONE, 18(2).

By: J. Gookin n, A. Hartley n, K. Aicher n, K. Mathews n, R. Cullen n, J. Cullen n, B. Callahan n, D. Stowe n ...

MeSH headings : Dogs; Animals; Gallbladder / pathology; Mucocele / veterinary; RNA, Ribosomal, 16S / genetics; Bile / microbiology; Gallbladder Diseases / veterinary; Microbiota / genetics; Bile Duct Diseases; Dog Diseases / diagnosis
TL;DR: Results of this study do not support existence of a core microbiome in the bile of healthy dogs or gallbladder mucus from dogs with mucocele formation, and document how contaminating sequences can significantly contribute to the results of sequencing analysis when performed on samples with low bacterial biomass. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023

2023 article

Histologic characterization of the major duodenal papilla and association with concurrent biliary, pancreatic, and intestinal pathology in cats

Schreeg, M. E., Cullen, J. M., Robertson, J., & Gookin, J. L. (2023, August 10). VETERINARY PATHOLOGY, Vol. 8.

By: M. Schreeg n, J. Cullen n, J. Robertson n & J. Gookin n

author keywords: ampulla of Vater; cat; cholangitis; enteritis; lymphoma; major duodenal papillitis; pancreatitis
TL;DR: Ass associations between MDP anatomy/disease and the presence of biliary, pancreatic, or intestinal inflammation or neoplasia are identified and suggest that anatomy, immune activation, and/or inflammation of the MDP may play a role in the pathogenesis of triaditis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

Microbiome analysis of bile from apparently healthy cats and cats with suspected hepatobiliary disease

Slead, T. S., Callahan, B. J., Schreeg, M. E., Seiler, G. S., Stowe, D. M., Azcarate-Peril, M. A., … Gookin, J. L. (2023, September 13). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 9.

By: T. Slead n, B. Callahan n, M. Schreeg n, G. Seiler n, D. Stowe n, M. Azcarate-Peril*, M. Jacob n, J. Gookin n

author keywords: cholangitis; feline; gallbladder; microbiota
TL;DR: Cat bile does not harbor a core microbiota composed of bacterial taxa common to many individuals and Uncultured bacteria may contribute to pathogenesis of hepatobiliary disease in cats with bile E. coli infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 14, 2023

2022 journal article

Randomized placebo-controlled trial of feline-origin Enterococcus hirae probiotic effects on preventative health and fecal microbiota composition of fostered shelter kittens

FRONTIERS IN VETERINARY SCIENCE, 9.

By: J. Gookin n, S. Strong*, J. Bruno-Barcena n, S. Stauffer n, S. Williams n, E. Wassack n, M. Azcarate-Peril*, M. Estrada ...

Contributors: J. Bruno-Bárcena n

author keywords: 16S rRNA gene amplicon sequencing; diarrheal pathogens; growth and survival; infection; polymerase chain reaction; shelter medicine
TL;DR: A rationale for use of E. hirae to foster kittens supports a rationale for disease prevention in this young population at high risk for intestinal disease though additional studies are warranted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 8, 2022

2021 journal article

Comparative Genomics of Atypical Enteropathogenic Escherichia coli from Kittens and Children Identifies Bacterial Factors Associated with Virulence in Kittens

INFECTION AND IMMUNITY, 89(3).

By: V. Watson n, T. Hazen*, D. Rasko*, M. Jacob n, J. Elfenbein n, S. Stauffer n, J. Gookin n

author keywords: enteropathogenic E. coli; EPEC; animal model; phylogenetic analysis
MeSH headings : Adolescent; Animals; Cats / genetics; Child; Child, Preschool; Enteropathogenic Escherichia coli / genetics; Escherichia coli Infections / genetics; Escherichia coli Infections / microbiology; Escherichia coli Proteins / genetics; Female; Genetic Variation; Genomics; Humans; Infant; Infant, Newborn; Male; Serogroup; Serotyping; Virulence / genetics
TL;DR: Kittens are identified as a host for aEPEC where intestinal epithelial colonization was associated with diarrheal disease and death and may provide a needed comparative animal model for the study of aEP EC pathogenesis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 journal article

Dysbiosis of fecal microbiota in cats with naturally occurring and experimentally induced Tritrichomonas foetus infection

PLOS ONE, 16(2).

By: M. Bierlein n, B. Hedgespeth n, M. Azcarate-Peril*, S. Stauffer n & J. Gookin n

MeSH headings : Animals; Cats; Disease Models, Animal; Dysbiosis / complications; Feces / microbiology; Mice; Microbiota; Protozoan Infections / complications; Protozoan Infections / microbiology; Tritrichomonas foetus / physiology
TL;DR: It is hypothesized that T. foetus promotes dysbiosis by competition for fermentable substrates used by these bacteria and that metabolic byproducts may contribute to the pathogenesis of colonic inflammation and diarrhea. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(2), 878–886.

By: C. Lindaberry n, S. Vaden n, K. Aicher n, G. Seiler n, J. Robertson n, R. Cianciolo*, C. Yang*, J. Gookin n

author keywords: canine; dipstick; glomerular disease; urinalysis
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dogs; Gallbladder; Mucocele / complications; Mucocele / veterinary; Proteinuria / veterinary; Retrospective Studies
TL;DR: Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021

2020 journal article

Association of fecal sample collection technique and treatment history with Tritrichomonas foetus polymerase chain reaction test results in 1717 cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 734–741.

By: B. Hedgespeth n, S. Stauffer n, J. Robertson n & J. Gookin n

author keywords: diarrhea; retrospective; risk factors; ronidazole
MeSH headings : Animals; Antiprotozoal Agents / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Feces / parasitology; Female; Male; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / drug therapy; Protozoan Infections, Animal / parasitology; Retrospective Studies; Ronidazole / therapeutic use; Specimen Handling / veterinary; Tritrichomonas foetus / isolation & purification; United States
TL;DR: Results of this study support that fecal samples collected by loop might be better for PCR diagnosis of T. foetus infection and Lack of association of ronidazole with PCR test results and a 21% all‐potential‐causes failure rate of rONidazoles in cats with preconfirmed infection are important limitations to use of this drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 27, 2020

2020 journal article

Perceptions and attitudes of Small Animal Internal Medicine specialists toward the publication requirement for board certification

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 574–580.

By: A. Birkenheuer n, K. Royal n, A. Cerreta n, D. Hemstreet n, K. Lunn n, J. Gookin n, S. McGarvey n

author keywords: board certification; credentials; education; residency training
MeSH headings : Authorship; Certification; Humans; Societies, Scientific / organization & administration; Societies, Scientific / standards; Specialization; Specialty Boards / standards; Veterinary Medicine / organization & administration; Veterinary Medicine / standards
TL;DR: A majority of SAIM Diplomates favored the retention of the publication requirement in some form, and publications submitted for credentialing purposes were cited at rates similar to control articles. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 17, 2020

2019 journal article

Influence of the intestinal microbiota on disease susceptibility in kittens with experimentally-induced carriage of atypical enteropathogenic Escherichia coli

Veterinary Microbiology, 231, 197–206.

By: V. Watson, M. Jacob n, J. Bruno-Bárcena n, S. Amirsultan, S. Stauffer, V. Píqueras*, R. Frias*, J. Gookin n

Contributors: V. Watson, M. Jacob n, J. Bruno-Bárcena n, S. Amirsultan, S. Stauffer, V. Píqueras*, R. Frias*, J. Gookin n

author keywords: aEPEC; Animal model; Feline; Probiotic; Enterococcus hirae
MeSH headings : Age Factors; Animals; Anti-Infective Agents / pharmacology; Asymptomatic Infections; Bacterial Shedding; Cats / microbiology; Diarrhea / microbiology; Disease Models, Animal; Disease Susceptibility / etiology; Disease Susceptibility / microbiology; Enteropathogenic Escherichia coli; Escherichia coli Infections / veterinary; Feces / microbiology; Gastrointestinal Microbiome; Polymerase Chain Reaction; Probiotics
TL;DR: Enrichment of the intestinal microbiota with a commensal member of the feline mucosa-associated microbiota, Enterococcus hirae, ameliorated the effects of aEPEC experimental infection on intestinal function and water loss and begin to unravel the mechanisms by which aEPec infection may be able to exploit susceptible hosts. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 15, 2019

2019 journal article

Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection

Cellular and Molecular Gastroenterology and Hepatology, 8(1), 1–20.

By: S. Ferguson n, D. Foster n, B. Sherry n, S. Magness n, D. Nielsen n & J. Gookin n

author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR: These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: July 15, 2019

2019 journal article

Interventions and observations associated with survival of orphaned shelter kittens undergoing treatment for diarrhea

Journal of Feline Medicine and Surgery, 3, 1098612X1984045.

By: S. Strong*, J. Gookin n, M. Correa n & R. Banks*

author keywords: Animal welfare; mortality; population medicine
MeSH headings : Animals; Animals, Newborn; Cat Diseases / epidemiology; Cat Diseases / therapy; Cats; Diarrhea / epidemiology; Diarrhea / therapy; Diarrhea / veterinary
TL;DR: Age ⩾4 weeks and treatment of diarrhea with a vitamin and mineral supplement favorably improves survival of orphaned kittens to adoption and application is likely to improve the health and welfare of this population and contribute to a refinement in use of shelter resources. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2019 journal article

Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation

PLOS ONE, 14(2), e0212638.

By: K. Aicher n, J. Cullen n, G. Seiler n, K. Lunn n, K. Mathews n & J. Gookin n

Ed(s): J. Loor

MeSH headings : Adrenal Glands / physiopathology; Adrenocortical Hyperfunction / epidemiology; Adrenocortical Hyperfunction / physiopathology; Adrenocortical Hyperfunction / veterinary; Animals; Autoantibodies / blood; Case-Control Studies; Dehydroepiandrosterone / blood; Dog Diseases / diagnosis; Dog Diseases / epidemiology; Dog Diseases / physiopathology; Dogs; Electronic Health Records; Female; Gallbladder / diagnostic imaging; Gallbladder Diseases / blood; Gallbladder Diseases / physiopathology; Gallbladder Diseases / veterinary; Hypothyroidism / epidemiology; Hypothyroidism / physiopathology; Hypothyroidism / veterinary; Male; Mucocele / blood; Mucocele / physiopathology; Mucocele / veterinary; Prevalence; Retrospective Studies; Thyroid Gland / physiopathology; Ultrasonography
TL;DR: It is suggested that dogs with gallbladder mucocele formation have a greater capacity for cortisol synthesis and pinpoint DHEAS elevations as a potential clue to the underlying pathogenesis of the disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2019 journal article

The effect of enterococci on feline Tritrichomonas foetus infection in vitro

VETERINARY PARASITOLOGY, 273, 90–96.

By: R. Dickson*, J. Vose*, D. Bemis*, M. Daves*, T. Cecere*, J. Gookin n, J. Steiner*, M. Tolbert*

author keywords: Cats; Enterococcus faecium; Enterococcus hirae; Probiotics
MeSH headings : Animals; Cat Diseases / microbiology; Cat Diseases / parasitology; Cats; Enterococcus / physiology; Fluorescent Antibody Technique, Indirect; Intestinal Mucosa / microbiology; Intestinal Mucosa / parasitology; Microscopy, Electron, Scanning; Probiotics / pharmacology; Protozoan Infections, Animal / microbiology; Protozoan Infections, Animal / parasitology; Tritrichomonas foetus
TL;DR: In vitro studies performed to evaluate the effect of a probiotic containing Enterococcus faecium and a novel probiotic on the inhibition of T. foetus growth, adhesion to, and cytotoxicity towards the intestinal epithelium support further study into the investigation of a possible benefit of enterococci-containing probiotic treatment for prevention of T., foetus infection in at-risk uninfected cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2019

2018 chapter

Antiprotozoal Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1128–1165). Hoboken, NJ: Wiley Blackwell Publishing.

By: J. Davis & J. Gookin

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: October 21, 2020

2018 chapter

Canine Biliary Mucocele

In J. D. Bonagura & D. Twedt (Eds.), Current Veterinary Therapy XVI (16th ed.). W.B. Saunder’s Co. Philadelphia.

By: J. Gookin, G. Seiler, K. Mathews & J. Cullen

Ed(s): J. Bonagura & D. Twedt

Source: NC State University Libraries
Added: September 8, 2022

2018 chapter

Protozoal Gastrointestinal Disease

In J. D. Bonagura & D. Twedt (Eds.), Current Veterinary Therapy XVI (16th ed.). Philadelphia: W.B. Saunder’s Co.

By: J. Gookin & M. Lappin

Ed(s): J. Bonagura & D. Twedt

Source: NC State University Libraries
Added: September 8, 2022

2018 journal article

Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation

PLOS ONE, 13(1).

By: J. Gookin n, K. Mathews n, J. Cullen n & G. Seiler n

MeSH headings : Animals; Bile / metabolism; Blood; Dogs; Female; Gallbladder Diseases / blood; Gallbladder Diseases / metabolism; Male; Metabolomics; Mucocele / blood; Mucocele / metabolism
TL;DR: The findings support the presence of significant metabolic disruption in dogs with mucocele formation and identify specific compounds as candidate biomarkers or treatment targets. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 chapter

Trichomonosis

In F. Beugnet, L. Halos, & J. Guillot (Eds.), Textbook of Clinical Parasitology in Dogs and Cats. Zaragoza: Grupo Asís Biomedia.

By: J. Gookin

Ed(s): F. Beugnet, L. Halos & J. Guillot

Source: NC State University Libraries
Added: October 21, 2020

2017 journal article

Association between Gallbladder Ultrasound Findings and Bacterial Culture of Bile in 70 Cats and 202 Dogs

Journal of Veterinary Internal Medicine, 31(5), 1451–1458.

By: R. Policelli Smith, J. Gookin n, W. Smolski n, M. Di Cicco n, M. Correa n & G. Seiler n

author keywords: Bile culture; Biliary; Cholecystocentesis; Ultrasonography
MeSH headings : Animals; Bile / microbiology; Cat Diseases / diagnosis; Cat Diseases / diagnostic imaging; Cat Diseases / microbiology; Cats; Cholecystitis / diagnosis; Cholecystitis / diagnostic imaging; Cholecystitis / microbiology; Cholecystitis / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / microbiology; Dogs; Female; Gallbladder / diagnostic imaging; Male; Ultrasonography / veterinary
TL;DR: Gallbladder US has a high negative predictive value for bile culture results in cats and this modality is less predictive of infection in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2017 journal article

Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens

Journal of Clinical Microbiology, 55(9), 2719–2735.

By: V. Watson n, M. Jacob n, J. Flowers n, S. Strong*, C. DebRoy* & J. Gookin n

Ed(s): B. Fenwick

author keywords: Escherichia coli enterocyte attaching and effacing (eae) gene; EPEC; animal models; histopathology; cat
MeSH headings : Animals; Cat Diseases / microbiology; Cats; Colon / microbiology; Diarrhea / microbiology; Diarrhea / mortality; Diarrhea / veterinary; Disease Models, Animal; Enteropathogenic Escherichia coli / genetics; Enteropathogenic Escherichia coli / isolation & purification; Enteropathogenic Escherichia coli / pathogenicity; Escherichia coli Infections / microbiology; Escherichia coli Infections / mortality; Escherichia coli Infections / veterinary; Intestine, Small / microbiology; Multiplex Polymerase Chain Reaction; Parenteral Nutrition / methods; Virulence / genetics
TL;DR: Findings identify aEPEC to be prevalent in kittens and a significant primary or contributing cause of intestinal inflammation, diarrhea, dehydration, and associated mortality in kittens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 review

The conundrum of feline trichomonosis: The more we learn the "trickier' it gets

[Review of ]. JOURNAL OF FELINE MEDICINE AND SURGERY, 19(3), 261–274.

By: J. Gookin n, K. Hanrahan n & M. Levy n

MeSH headings : Animals; Antiprotozoal Agents / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / drug therapy; Protozoan Infections, Animal / parasitology; Ronidazole / therapeutic use; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR: This review provides a comprehensive examination of what is currently known about feline trichomonosis and pinpoints areas, based on the authors’ opinion, where further research is needed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Cyniclomyces guttulatus Infection in Dogs: 19 Cases (2006-2013)

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 52(1), 42–51.

By: J. Winston n, I. Piperisova n, J. Neel n & J. Gookin n

Contributors: J. Winston n, I. Piperisova n, J. Neel n & J. Gookin n

TL;DR: It is suggested that additional studies to determine if C. guttulatus is a potential cause or consequence of gastrointestinal illness in dogs may be warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Evaluation of associations among Coxiella burnetii and reproductive abnormalities in cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 18(4), 344–347.

By: M. Fujishiro*, A. Scorza*, J. Gookin n & M. Lappin*

MeSH headings : Animals; Cat Diseases / microbiology; Cats; Coxiella burnetii / isolation & purification; Female; Infertility, Female / microbiology; Infertility, Female / veterinary; Polymerase Chain Reaction / veterinary; Prevalence; Q Fever / microbiology; Q Fever / veterinary
TL;DR: While C burnetii could not be confirmed by sequence analysis or immunohistochemistry, the PCR positive prevalence rate was similar to that published previously and biosafety precautions should be taken when working with cats that are aborting or parturient. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(5), 1715–1719.

By: K. Manning n, A. Birkenheuer n, J. Briley n, S. Montgomery n, J. Harris n, S. Vanone n, J. Gookin n

author keywords: Esophagostomy; Regurgitation
MeSH headings : Animals; Catheters, Indwelling; Dog Diseases / etiology; Dog Diseases / prevention & control; Dogs; Enteral Nutrition; Esophageal Achalasia / complications; Esophageal Achalasia / veterinary; Female; Male; Pneumonia, Aspiration / etiology; Pneumonia, Aspiration / prevention & control; Pneumonia, Aspiration / veterinary; Recurrence; Suction / methods; Survival Analysis
TL;DR: Use of intermittent esophageal suctioning in dogs with megaesophagus that continue to regurgitate despite gastrostomy tube feedings can reduce or abolish clinical episodes of aspiration pneumonia. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

Mechanisms of Tritrichomonas foetus Pathogenicity in Cats with Insights from Venereal Trichomonosis

Journal of Veterinary Internal Medicine, 30(2), 516–526.

By: M. Tolbert* & J. Gookin n

author keywords: Diarrhea; Protozoa; Trichomonas; Trichomonas vaginalis
MeSH headings : Animals; Cat Diseases / parasitology; Cat Diseases / pathology; Cats; Protozoan Infections, Animal / parasitology; Protozoan Infections, Animal / pathology; Sexually Transmitted Diseases / parasitology; Sexually Transmitted Diseases / pathology; Sexually Transmitted Diseases / veterinary; Tritrichomonas foetus
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(6), 1464–1472.

By: J. Gookin n, M. Correa n, A. Peters n, A. Malueg n, K. Mathews n, J. Cullen n, G. Seiler n

author keywords: Bile; Canine; Mucus; Xenobiotic
MeSH headings : Animals; Case-Control Studies; Cholinergic Agents / adverse effects; Dog Diseases / chemically induced; Dogs; Female; Gallbladder Diseases / chemically induced; Gallbladder Diseases / veterinary; Hypothyroidism / drug therapy; Imidazoles / adverse effects; Male; Mucocele / chemically induced; Mucocele / pathology; Mucocele / veterinary; Neonicotinoids; Nitro Compounds / adverse effects; Pituitary ACTH Hypersecretion / drug therapy; Pituitary ACTH Hypersecretion / veterinary; Risk Factors; Thyroxine / adverse effects
TL;DR: This study provides evidence for an association between selected drug use and GBM formation in dogs and exposure to imidacloprid in Shetland sheepdogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs

PLOS ONE, 10(9).

MeSH headings : Animals; Dogs; Epithelial Cells / pathology; Epithelial Cells / ultrastructure; Epithelium / pathology; Exocytosis; Gallbladder / diagnostic imaging; Gallbladder / pathology; Gallbladder / surgery; Gallbladder / ultrastructure; Gels / metabolism; Glycosylation; Immunity, Innate; Immunoblotting; Male; Mass Spectrometry; Mucin 5AC / metabolism; Mucin-5B / metabolism; Mucocele / diagnostic imaging; Mucocele / pathology; Mucocele / surgery; Mucous Membrane / pathology; Mucus / metabolism; Phenotype; Rupture; Ultrasonography
TL;DR: These findings provide an explanation for abnormal mucus behavior and based on similarity to mucus observed in the airways of people with cystic fibrosis, suggest that abnormal mechanisms for maintenance of gallbladder epithelial hydration may be an instigating factor for mucocele formation in dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Identification of Parabodo caudatus (class Kinetoplastea) in urine voided from a dog with hematuria

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 27(1), 117–120.

By: M. Vandersea n, A. Birkenheuer n, R. Litaker n, S. Vaden n, J. Renschler n & J. Gookin n

author keywords: Bodo urinarius; canine; flagellate; Parabodo caudatus; protozoa
MeSH headings : Animals; DNA, Protozoan / genetics; Dog Diseases / parasitology; Dog Diseases / urine; Dogs; Euglenozoa Infections / parasitology; Euglenozoa Infections / urine; Euglenozoa Infections / veterinary; Hematuria / parasitology; Hematuria / urine; Hematuria / veterinary; Kinetoplastida / genetics; Kinetoplastida / isolation & purification; Male; Polymerase Chain Reaction / veterinary; RNA, Ribosomal, 18S / genetics
TL;DR: A voided urine sample was observed to contain biflagellate protozoa 5 days following an episode of gross hematuria, and Parabodo caudatus organisms were unable to be demonstrated cytologically or by means of PCR in samples collected from the dog’s environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Recovery of normal esophageal function in a kitten with diffuse megaesophagus and an occult lower esophageal stricture

JOURNAL OF FELINE MEDICINE AND SURGERY, 17(6), 557–561.

By: J. Schneider n, M. Ames n, M. DiCicco n, M. Savage n, C. Atkins n, M. Wood n, J. Gookin n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Catheterization / veterinary; Cats; Endoscopy / veterinary; Esophageal Achalasia / complications; Esophageal Achalasia / veterinary; Esophageal Stenosis / complications; Esophageal Stenosis / veterinary; Male; Recovery of Function
TL;DR: Management of kittens with radiographic findings suggestive of congenital megaesophagus by means of gastrostomy tube feeding may be associated with a return of normal esophageal motility and widening of the esophagal stricture, and facilitate subsequent success of interventional dilation of the EsophageAL stricture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Trichomonosis

In F. Beugnet & L. Halos (Eds.), Parasitoses and Vector Borne Diseases of Cats. Lyon, France: Merial.

By: J. Gookin & M. Levy

Ed(s): F. Beugnet & L. Halos

Source: NC State University Libraries
Added: October 21, 2020

2014 journal article

Cysteine Protease Activity of Feline Tritrichomonas foetus Promotes Adhesion-Dependent Cytotoxicity to Intestinal Epithelial Cells

INFECTION AND IMMUNITY, 82(7), 2851–2859.

By: M. Tolbert*, S. Stauffer n, M. Brand* & J. Gookin n

MeSH headings : Animals; Apoptosis; Cell Adhesion; Cell Line; Cysteine Proteases / genetics; Cysteine Proteases / metabolism; Epithelial Cells / parasitology; Epithelial Cells / physiology; Gene Expression Regulation, Enzymologic; Intestinal Mucosa / cytology; Swine; Tritrichomonas foetus / enzymology
TL;DR: The present studies are the first to examine the cellular mechanisms of pathogenicity of T. foetus toward the intestinal epithelium and support further investigation of the cysteine proteases as virulence factors in vivo and as potential therapeutic targets for ameliorating the pathological effects of intestinal trichomonosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 chapter

Hooking up with some helminths

In E. A. Stone & C. Dewey (Eds.), Sick! Curious tales of pests and parasites we share with animals (pp. 162–166). Guelph, Ontario: Ontario Veterinary College, University of Guelph.

By: J. Gookin

Ed(s): E. Stone & C. Dewey

Source: NC State University Libraries
Added: October 21, 2020

2014 chapter

Update on treatment of T. foetus and Giardia infections

In J. D. Bonagura & D. C. Twedt (Eds.), Kirk's Current Veterinary Therapy XV (15th ed., p. 528). St. Louis, MO: Elsevier/Saunders.

By: J. Gookin & M. Lappin

Ed(s): J. Bonagura & D. Twedt

Source: NC State University Libraries
Added: October 21, 2020

2013 journal article

Feline Tritichomonas foetus adhere to the intestinal epithelium by receptor-ligand-dependent mechanisms

Veterinary Parasitology, 192(1-3), 75–82.

By: M. Tolbert*, S. Stauffer* & J. Gookin*

author keywords: Tritrichomonas foetus; Intestine; Epithelium; Adhesion; Protozoa; Diarrhea; Model
MeSH headings : Animals; Cat Diseases / parasitology; Cats; Cell Adhesion; Cell Line; Cell Proliferation; Diarrhea / parasitology; Diarrhea / veterinary; Epithelial Cells / parasitology; Intestinal Mucosa / parasitology; Ligands; Microscopy, Electron, Scanning; Models, Biological; Protozoan Infections, Animal / parasitology; Swine; Trichomonadida / metabolism; Trichomonadida / physiology; Tritium; Tritrichomonas foetus / metabolism; Tritrichomonas foetus / physiology; Trophozoites
TL;DR: Based on saturation and competition binding experiments, adherence of feline TF to the epithelium occurred via specific receptor-ligand interactions, and the developed model provides a valuable resource for assessing pathogenic mechanisms of f cat TF and developing novel pharmacologic therapies for blocking the adhesion. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 chapter

Infectious diseases of the large intestine

In R. J. Washabau & M. J. Day (Eds.), Canine and Feline Gastroenterology (1st ed., pp. 745–757). St. Louis, MO: Elsevier Saunders.

By: J. Gookin

Ed(s): R. Washabau & M. Day

Source: NC State University Libraries
Added: October 21, 2020

2013 journal article

Mortality in Kittens Is Associated with a Shift in Ileum Mucosa-Associated Enterococci from Enterococcus hirae to Biofilm-Forming Enterococcus faecalis and Adherent Escherichia coli

JOURNAL OF CLINICAL MICROBIOLOGY, 51(11), 3567–3578.

By: A. Ghosh*, L. Borst n, S. Stauffer n, M. Suyemoto n, P. Moisan*, L. Zurek*, J. Gookin n

MeSH headings : Animals; Animals, Newborn; Biofilms / growth & development; Biota; Cat Diseases / microbiology; Cat Diseases / mortality; Cats; Enteritis / microbiology; Enteritis / mortality; Enteritis / veterinary; Enterococcus / isolation & purification; Enterococcus / physiology; Escherichia coli / isolation & purification; Escherichia coli / physiology; Ileum / microbiology; Intestinal Mucosa / microbiology
TL;DR: A significant difference is identified in the species of enterococci cultured from the ileum mucosa of kittens with terminal illness compared to the species cultured from healthy kittens, which is identified as more common and extensive in healthy kittens than in sick kittens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Ronidazole pharmacokinetics in cats following delivery of a delayed-release guar gum formulation

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 399–407.

By: M. Papich n, D. LeVine n, J. Gookin n, G. Davidson n, W. Stagner* & R. Hayes n

MeSH headings : Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / blood; Antiprotozoal Agents / pharmacokinetics; Area Under Curve; Cats / blood; Cats / metabolism; Delayed-Action Preparations; Galactans / chemistry; Half-Life; Male; Mannans / chemistry; Plant Gums / chemistry; Ronidazole / administration & dosage; Ronidazole / blood; Ronidazole / pharmacokinetics; Tablets
TL;DR: Delayed release of ronidazole from guar gum-coated tablets indicates that release of RDZ may be delayed to deliver the medication to a targeted area of the intestine in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Sa1762 Cysteine Proteases of the Enteric Trichomonad Tritrichomonas Foetus Mediate Adhesion to Intestinal Epithelial Cells and Enterocyte Apoptosis

Gastroenterology, 144(5), S-301.

By: K. Tolbert, S. Stauffer & J. Gookin*

TL;DR: It is established that serine and cysteine proteases are the predominant mediators of feline TF proteolytic activity and identify the specific involvement of serine protease in TF survival and Cytopathogenicity to intestinal epithelial cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2013 journal article

Tu2013 Characterization of Epithelial Cell Loss Due to Cryptosporidium Parvum Infection in a Non-Transformed Porcine Jejunal Enterocyte (IPEC-J2) Cell Line

Gastroenterology, 144(5), S-904-S-905.

By: D. Foster*, S. Stauffer, S. Magness & J. Gookin*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2013 journal article

Twice-daily dosing of RDZ no longer recommended for treatment of intestinal Tritrichomonas foetus infection

Journal of Feline Medicine and Surgery, 16(2), 198–198.

By: D. LeVine*, J. Gookin n, M. Papich n & G. Davidson n

MeSH headings : Animals; Cat Diseases / parasitology; Intestinal Diseases, Parasitic / veterinary; Protozoan Infections, Animal / parasitology; Tritrichomonas foetus / isolation & purification
TL;DR: Based on the recent feline RDZ pharmacokinetic (PK) studies, it is no longer recommend twice-daily dosing of RDZ, and cats are not inadvertently overdosed and risk neurologic sequelae based on outdated recommendations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue

Journal of Veterinary Diagnostic Investigation, 24(5), 888–894.

By: R. Hutchins n, E. Breitschwerdt n, J. Cullen n, S. Bissett n & J. Gookin n

author keywords: Copper hepatopathy; dogs; fluorescent in situ hybridization; granulomatous hepatitis; polymerase chain reaction
MeSH headings : Animals; Bartonella / isolation & purification; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / veterinary; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Female; Formaldehyde; Granuloma / pathology; Granuloma / veterinary; Hepatitis, Animal / diagnosis; Hepatitis, Animal / pathology; Liver / pathology; Male; Paraffin Embedding; Retrospective Studies; Tissue Preservation / veterinary
TL;DR: It was concluded that investigation of infectious etiologies within FFPE liver specimens using these diagnostic approaches may be of low yield. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Mo1784 The In Vivo Transcriptional Response of Intestinal Epithelium to C. Parvum Infection is Dominated by Interferon-Alpha Signaling Pathways

Gastroenterology, 142(5), S-684.

By: D. Foster*, D. Nielsen, S. Stauffer & J. Gookin*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2012 journal article

Proteasome Inhibition of Pathologic Shedding of Enterocytes to Defend Barrier Function Requires X-Linked Inhibitor of Apoptosis Protein and Nuclear Factor κB

Gastroenterology, 143(1), 133–144.e4.

By: D. Foster n, S. Stauffer n, M. Stone n & J. Gookin n

author keywords: Protozoan; Intestine; Parasitic Infection; Cell Death
MeSH headings : Animals; Apoptosis; Caspase 3 / metabolism; Cryptosporidiosis / metabolism; Cryptosporidium parvum; Disease Models, Animal; Enterocytes / metabolism; Enterocytes / microbiology; Ileum / microbiology; Ileum / physiopathology; Intestinal Mucosa / metabolism; NF-kappa B / metabolism; Proteasome Endopeptidase Complex / metabolism; Signal Transduction; Swine; X-Linked Inhibitor of Apoptosis Protein / metabolism
TL;DR: A pathway by which villus epithelial cells are maintained during C parvum infection is identified, which might be used to promote clearance of minimally invasive enteropathogens, such as by increasing the rate of migration of epithelial Cells from the crypt to the villus tip. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2012 journal article

Species identification of trichomonads and associated coinfections in dogs with diarrhea and suspected trichomonosis

VETERINARY PARASITOLOGY, 187(1-2), 319–322.

By: M. Tolbert n, C. Leutenegger*, R. Lobetti*, J. Birrell & J. Gookin n

author keywords: Pentatrichomonas hominis; Tritrichomonas foetus; Polymerase chain reaction
MeSH headings : Animals; Coinfection / veterinary; Diarrhea / parasitology; Diarrhea / veterinary; Dog Diseases / parasitology; Dogs; Feces / parasitology; Female; Male; Trichomonas Infections / complications; Trichomonas Infections / parasitology; Trichomonas Infections / veterinary
TL;DR: Results suggest that P. hominis infection is more frequently identified than T. foetus infection in diarrheic dogs with trichomonosis and that concurrent enteropathogen infection is common in this population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 chapter

Trichomoniasis

In C. E. Green (Ed.), Infectious Diseases of the Dog and Cat (4th ed., pp. 797–801). St. Louis, MO: Elsevier Saunder.

By: J. Gookin

Ed(s): C. Green

Source: NC State University Libraries
Added: October 21, 2020

2012 journal article

Tu1855 Tritrichomonas Foetus ADHERE to Intestinal Epithelium by Sialic Acid and Cysteine Protease-Dependent Mechanisms

Gastroenterology, 142(5), S-861-S-862.

By: K. Tolbert & J. Gookin*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2012 journal article

Uropathogenic E. coli Promote a Paracellular Urothelial Barrier Defect Characterized by Altered Tight Junction Integrity, Epithelial Cell Sloughing and Cytokine Release

Journal of Comparative Pathology, 147(1), 11–19.

By: M. Wood n, E. Breitschwerdt n, S. Nordone n, K. Linder n & J. Gookin n

author keywords: cytokine; tight junction; urinary tract infection; urothelial permeability
MeSH headings : Animals; Cell Membrane Permeability / physiology; Cytokines / metabolism; Diffusion Chambers, Culture; Dogs; Electric Conductivity; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Epithelial Cells / pathology; Tight Junctions / pathology; Tight Junctions / ultrastructure; Tissue Culture Techniques; Urinary Bladder / metabolism; Urinary Bladder / microbiology; Urinary Bladder / pathology; Uropathogenic Escherichia coli / physiology; Urothelium / metabolism; Urothelium / microbiology; Urothelium / pathology
TL;DR: A potential role for IL-15 is pointed to in UTI-induced urothelial injury after changes in both tissue ultrastructure and TER indicated that uropathogenic E. coli infection promotes a paracellular permeability defect associated with the failure of umbrella cell tight junction formation and umbrella cell sloughing. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 21, 2019

2011 journal article

Acute necrotizing enterocolitis of preterm piglets is characterized by dysbiosis of ileal mucosa-associated bacteria

Gut Microbes, 2(4), 234–243.

By: M. Azcarate-Peril n, D. Foster n, M. Cadenas*, M. Stone n, S. Jacobi n, S. Stauffer n, A. Pease*, J. Gookin n

author keywords: microbiome; Clostridium spp.; animal model; NEC; necrotizing; intestine; profile
MeSH headings : Acute Disease; Animals; Animals, Newborn; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Disease Models, Animal; Enterocolitis, Necrotizing / microbiology; Female; Humans; Ileum / microbiology; Ileum / pathology; Infant; Infant, Newborn; Infant, Premature, Diseases / microbiology; Infant, Premature, Diseases / pathology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Metagenome; Phylogeny; Polymorphism, Restriction Fragment Length; Swine
TL;DR: Results provide strong support for ileal mucosa as a focus for investigation of specific dysbiosis associated with NEC and suggest a significant role for Clostridium spp. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2011 journal article

NFkB-Mediated Expression of XIAP Inhibits Caspase-3-Dependent Shedding of Intestinal Epithelial Cells in Defense of Barrier Function in Cryptosporidium Parvum Infection

Gastroenterology, 140(5), S-503.

By: D. Foster*, S. Stauffer, M. Stone & J. Gookin*

Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2011 journal article

Necrotizing Enterocolitis of Preterm Piglets is Characterized by a Unique Ileum Mucosa-Associated Microbiome

Gastroenterology, 140(5), S-666.

By: M. Azcarate-Peril, D. Foster*, M. Cadenas, M. Stone, S. Jacobi, S. Stauffer, A. Pease, J. Gookin*

Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2011 journal article

Ronidazole pharmacokinetics after intravenous and oral immediate-release capsule administration in healthy cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 13(4), 244–250.

By: D. LeVine n, M. Papich n, J. Gookin n, G. Davidson n, J. Davis n & R. Hayes n

MeSH headings : Administration, Oral; Animals; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / pharmacokinetics; Biological Availability; Cat Diseases / drug therapy; Cats / metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Metabolic Clearance Rate; Protozoan Infections, Animal / drug therapy; Random Allocation; Ronidazole / administration & dosage; Ronidazole / pharmacokinetics; Tritrichomonas foetus / drug effects
TL;DR: The high oral bioavailability of RDZ and slow elimination may predispose cats to neurotoxicity with twice-daily administration, and less frequent administration should be considered for further study of effective treatment of T foetus-infected cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Assessment of reproductive tract disease in cats at risk for Tritrichomonas foetus infection

AMERICAN JOURNAL OF VETERINARY RESEARCH, 71(1), 76–81.

By: S. Gray n, S. Hunter*, M. Stone* & J. Gookin*

MeSH headings : Animals; Antiprotozoal Agents / therapeutic use; Cat Diseases / parasitology; Cats; Female; Genital Diseases, Female / parasitology; Genital Diseases, Female / veterinary; Genital Diseases, Male / parasitology; Genital Diseases, Male / veterinary; Male; Protozoan Infections, Animal / parasitology; Ronidazole / therapeutic use; Tritrichomonas foetus
TL;DR: No evidence of reproductive tract colonization by T foetus was detected in this study, suggesting it is unlikely that reproductive tract infection with T foetal infection plays an important role in overall disease transmission. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Autocrine Effects of Interleukin-6 Mediate Acute-Phase Proinflammatory and Tissue-Reparative Transcriptional Responses of Canine Bladder Mucosa

Infection and Immunity, 79(2), 708–715.

By: M. Wood n, E. Breitschwerdt n & J. Gookin n

Ed(s): A. Bäumler

MeSH headings : Acute-Phase Reaction / metabolism; Animals; Dogs; Humans; Interleukin-6 / metabolism; Mucous Membrane / metabolism; Mucous Membrane / microbiology; Signal Transduction; Tissue Culture Techniques; Urinary Bladder / metabolism; Urinary Bladder / microbiology; Uropathogenic Escherichia coli; Urothelium / metabolism
TL;DR: It is demonstrated that uropathogenic Escherichia coli infection stimulates the synthesis of IL-6 by all urothelial cell layers, with the u rothelial cells alone representing the only site of unequivocal IL- 6 receptor expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Documentation of In Vivo and In Vitro Aerobic Resistance of Feline Tritrichomonas foetus Isolates to Ronidazole

JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(4), 1003–1007.

By: J. Gookin n, S. Stauffer n, D. Dybas & D. Cannon*

author keywords: 5-nitroimidazole; Feline; Resistance; Treatment; Trichomonas
MeSH headings : Aerobiosis; Animals; Antiprotozoal Agents / pharmacology; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Drug Resistance; Male; Metronidazole / pharmacology; Metronidazole / therapeutic use; Ronidazole / pharmacology; Tinidazole / pharmacology; Tinidazole / therapeutic use; Tritrichomonas foetus / drug effects
TL;DR: Clinical resistance to metronidazole, low efficacy of tinidrazole, and present documentation of in vivo and in vitro resistance to ronidazoles in some cats are consistent with a high level of cross resistance of feline T. foetus to 5-nitroimidazol drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Fluorescence in situ hybridization for identification of Tritrichomonas foetus in formalin-fixed and paraffin-embedded histological specimens of intestinal trichomonosis

VETERINARY PARASITOLOGY, 172(1-2), 139–143.

By: J. Gookin n, M. Stone*, M. Yaeger, D. Meyerholz & P. Moisan

author keywords: Trichomonas; Intestine; Identification; Paraffin; Fluorescence
MeSH headings : Animals; Cats; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; Histocytochemistry; In Situ Hybridization, Fluorescence / methods; Intestinal Diseases / diagnosis; Intestinal Diseases / parasitology; Microscopy, Fluorescence; Polymerase Chain Reaction; RNA, Ribosomal, 18S / chemistry; RNA, Ribosomal, 18S / genetics; Swine; Trichomonas Infections / diagnosis; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR: The FISH assay described here enables simultaneous location and molecular identification of T. foetus in formalin-fixed and paraffin-embedded histological specimens of intestinal trichomoniasis by means of fluorescence in situ hybridization (FISH). (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

In Situ Molecular Diagnosis and Histopathological Characterization of Enteroadherent Enterococcus hirae Infection in Pre-Weaning-Age Kittens

JOURNAL OF CLINICAL MICROBIOLOGY, 48(8), 2814–2820.

By: J. Nicklas n, P. Moisan*, M. Stone n & J. Gookin n

MeSH headings : Animals; Bacteriological Techniques / methods; Cat Diseases / diagnosis; Cat Diseases / microbiology; Cat Diseases / pathology; Cats; Enterococcus / classification; Enterococcus / genetics; Enterococcus / isolation & purification; Gram-Positive Bacterial Infections / diagnosis; Gram-Positive Bacterial Infections / microbiology; Gram-Positive Bacterial Infections / pathology; Gram-Positive Bacterial Infections / veterinary; Histocytochemistry; In Situ Hybridization, Fluorescence / methods; Intestinal Diseases / diagnosis; Intestinal Diseases / microbiology; Intestinal Diseases / pathology; Intestinal Diseases / veterinary; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Microscopy; Microscopy, Electron, Transmission; Polymerase Chain Reaction; Retrospective Studies
TL;DR: E. hirae may be a common cause of enteroadherent bacterial infection in pre-weaning-age kittens and should be considered in the differential diagnosis of bacterial disease in this population. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Lymphocytes and not IFN-gamma mediate expression of iNOS by intestinal epithelium in murine cryptosporidiosis

PARASITOLOGY RESEARCH, 106(6), 1507–1511.

By: S. Nordone n & J. Gookin n

MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum / immunology; Female; Interferon-gamma / deficiency; Interferon-gamma / immunology; Intestinal Mucosa / immunology; Intestinal Mucosa / parasitology; Lymphocytes / immunology; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; Nitric Oxide Synthase Type II / biosynthesis
TL;DR: It is hypothesized that unrecognized differences in epithelial expression of inducible nitric oxide synthase (iNOS), resulting from engineered immunodeficiency, could explain the contradictory findings of prior studies regarding the importance of nitrous oxide in murine models of Cryptosporidium parvum infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Outcome assessment of a computer-animated model for learning about the regulation of glomerular filtration rate

ADVANCES IN PHYSIOLOGY EDUCATION, 34(2), 97–105.

By: J. Gookin*, D. McWhorter n, S. Vaden* & L. Posner*

author keywords: medical education; veterinary; interactive; renal physiology
MeSH headings : Computer Simulation; Education, Veterinary / methods; Glomerular Filtration Rate / physiology; Humans; Physiology / education; Problem-Based Learning / methods
TL;DR: It is suggested that the animated model is a useful, effective, and well-received tool for learning and creating a visual memory of the regulatory mechanisms of GFR. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

An Animated Model of Reticulorumen Motility

JOURNAL OF VETERINARY MEDICAL EDUCATION, 36(4), 444–450.

By: J. Gookin n, D. Foster*, A. Harvey* & D. McWhorter*

author keywords: animated model; eructation; reticulorumen motility; rumination; student preference
MeSH headings : Animals; Attitude of Health Personnel; Computer Simulation; Computer-Assisted Instruction / methods; Education, Veterinary / methods; Educational Measurement; Gastrointestinal Motility / physiology; Humans; Models, Biological; Reticulum / physiology; Rumen / physiology; Ruminants / anatomy & histology; Ruminants / physiology; Students / psychology
TL;DR: An animated model of reticulorumen motility was developed and hypothesized that veterinary students would prefer use of the model over traditional instructional methods and would recommend the model to other veterinary students. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 chapter

Antiprotozoal Drugs

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 1145–1179). Ames, Iowa: Blackwell Publishing.

By: J. Davis & J. Gookin

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: October 21, 2020

2009 journal article

Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets in a Pomeranian Dog Caused by a Novel Mutation in the Vitamin D Receptor Gene

JOURNAL OF VETERINARY INTERNAL MEDICINE, 23(6), 1278–1283.

By: D. LeVine n, Y. Zhou*, R. Ghiloni*, E. Fields n, A. Birkenheuer n, J. Gookin n, I. Roberston n, P. Malloy*, D. Feldman*

MeSH headings : Animals; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genetic Predisposition to Disease; Hypocalcemia / veterinary; Receptors, Calcitriol / genetics; Rickets / drug therapy; Rickets / genetics; Rickets / veterinary; Vitamin D / analogs & derivatives; Vitamin D / pharmacology
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 journal article

Observed occurrence of Tritrichomonas foetus and other enteric parasites in Australian cattery and shelter cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 11(10), 803–807.

By: S. Bissett n, M. Stone n, R. Malik*, J. Norris*, C. O'Brien*, C. Mansfield*, J. Nicholls, A. Griffin, J. Gookin n

MeSH headings : Animal Husbandry / statistics & numerical data; Animals; Australia / epidemiology; Breeding / statistics & numerical data; Cat Diseases / epidemiology; Cat Diseases / parasitology; Cats; Cross-Sectional Studies; Feces / parasitology; Female; Giardia / isolation & purification; Isospora / isolation & purification; Male; Polymerase Chain Reaction; Prospective Studies; Protozoan Infections, Animal / epidemiology; Protozoan Infections, Animal / parasitology; Surveys and Questionnaires; Toxascaris / isolation & purification; Tritrichomonas foetus / isolation & purification
TL;DR: The results suggest the prevalence of T foetus in cattery-housed cats is currently much lower in Australia than in the USA, while Isospora and Giardia species infections are common. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 chapter

Tritrichomonas

In J. D. Bonagura, D. C. Twedt, & R. W. Kirk (Eds.), Kirk's current veterinary therapy. XIV (14th ed., pp. 509–512). St. Louis, MO: Elsevier Saunders.

By: J. Gookin

Ed(s): J. Bonagura, D. Twedt & R. Kirk

Source: NC State University Libraries
Added: October 21, 2020

2009 journal article

Tritrichomonas foetus: A new agent of feline diarrhea

Compendium-Continuing Education for Veterinarians, 31(8), 374-.

By: M. Tolbert & J. Gookin

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Evaluation of four DNA extraction methods for the detection of Tritrichomonas foetus in feline stool specimens by polymerase chain reaction

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 20(5), 639–641.

By: S. Stauffer n, A. Birkenheuer n, M. Levy n, H. Marr n & J. Gookin n

author keywords: Cats; feces; polymerase chain reaction; protozoa
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / economics; Cat Diseases / parasitology; Cats; Costs and Cost Analysis; DNA, Protozoan / genetics; DNA, Protozoan / isolation & purification; Feces / parasitology; North Carolina; Polymerase Chain Reaction / methods; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 16S / isolation & purification; Trichomonas / genetics; Trichomonas Infections / diagnosis; Trichomonas Infections / economics; Trichomonas Infections / veterinary
TL;DR: In the present study, 4 commercially available DNA extraction methods were examined for their influence on the sensitivity of PCR for the detection of Tritrichomonas foetus in feline stool and the ZR Fecal DNA kit was identified as affording the greatest analytical sensitivity and reproducibility. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Feline diarrhoea associated with Tritrichomonas cf. foetus and Giardia co-infection in an Australian cattery

AUSTRALIAN VETERINARY JOURNAL, 86(11), 440–443.

By: S. Bissett n, R. Gowan*, C. O'Brien*, M. Stone n & J. Gookin n

author keywords: diarrhoea; cat; cattery; Giardia spp; Tritrichomonas foetus; Trichomonas spp
MeSH headings : Animals; Animals, Newborn; Australia / epidemiology; Cat Diseases / epidemiology; Cats; Comorbidity; Diarrhea / epidemiology; Diarrhea / parasitology; Diarrhea / veterinary; Feces / parasitology; Female; Giardia; Giardiasis / epidemiology; Giardiasis / veterinary; Male; Prevalence; Protozoan Infections / epidemiology; Protozoan Infections, Animal; Risk Factors; Tritrichomonas foetus
TL;DR: This is the first report in Australia of feline trichomoniasis, which appears to be an emerging infectious disease of cats, and further diagnostic tests performed performed on faecal specimens confirmed infection with Tritrichomonas cf. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Induction of arginase II by intestinal epithelium promotes the uptake of L-arginine from the lumen of Cryptosporidium parvum-infected porcine ileum

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 47(4), 417–427.

By: J. Gookin n, S. Stauffer n & M. Stone n

author keywords: epithelial transport; nitric oxide; polyamines
MeSH headings : Animals; Animals, Newborn; Arginase / genetics; Arginase / metabolism; Arginine / metabolism; Atrophy; Biological Transport / genetics; Carrier Proteins / metabolism; Cationic Amino Acid Transporter 1 / genetics; Cationic Amino Acid Transporter 1 / metabolism; Cationic Amino Acid Transporter 2 / genetics; Cationic Amino Acid Transporter 2 / metabolism; Chromatography, High Pressure Liquid; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Ileum / metabolism; Ileum / parasitology; Ileum / physiopathology; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Swine
TL;DR: Intracellular catabolism by arginase II, the induction of which has not been described previously for intestinal epithelium, facilitates uptake of L-arginine by infected epithelia using transport systems that do not differ from those of uninfected cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Oral Delivery of L-arginine Stimulates Prostaglandin-dependent Secretory Diarrhea in Cryptosporidium parvum–infected Neonatal Piglets

Journal of Pediatric Gastroenterology and Nutrition, 46(2), 139–146.

By: J. Gookin n, D. Foster n, M. Coccaro n & S. Stauffer n

author keywords: barrier function; enteral nutrition; epithelial defense; nitric oxide
MeSH headings : Alanine / administration & dosage; Analysis of Variance; Animals; Animals, Newborn; Arginine / administration & dosage; Atrophy; Chlorides / metabolism; Cryptosporidiosis / parasitology; Cryptosporidiosis / physiopathology; Cryptosporidiosis / therapy; Cryptosporidium parvum / growth & development; Cyclooxygenase Inhibitors / pharmacology; Diarrhea / parasitology; Diarrhea / physiopathology; Diarrhea / therapy; Dietary Supplements; Disease Models, Animal; Enteral Nutrition; Ileum / parasitology; Ileum / pathology; Ileum / physiology; Indomethacin / pharmacology; Intestinal Mucosa / parasitology; Intestinal Mucosa / pathology; Nitric Oxide / biosynthesis; Oocysts / growth & development; Parasite Egg Count; Prostaglandins / biosynthesis; Random Allocation; Severity of Illness Index; Swine
TL;DR: These studies demonstrate that provision of additional NO substrate in the form of L-arginine incites prostaglandin-dependent secretory diarrhea and does not promote epithelial defense or barrier function of C parvum–infected neonatal ileum. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2008 journal article

T1250 Luminal Uptake of L-Arginine By C. Parvum Infected Porcine Ileum Is Promoted By Epithelial Induction of Arginase II and Stimulates Prostaglandin-Dependent Secretory Diarrhea

Gastroenterology, 134(4), A-515-A-516.

By: J. Gookin*, D. Foster*, S. Stauffer & M. Stone (Coccaro)

Sources: Crossref, NC State University Libraries
Added: February 12, 2020

2008 journal article

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

Journal of Cell Science, 121(3), 298–305.

By: C. Van Itallie*, J. Holmes*, A. Bridges*, J. Gookin n, M. Coccaro n, W. Proctor*, O. Colegio*, J. Anderson*

author keywords: claudin; tight junctions; paracellular permeability
MeSH headings : Animals; Biological Transport, Active; Caco-2 Cells; Cell Line; Claudin-4; Claudins; Dogs; Humans; LLC-PK1 Cells; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / genetics; Membrane Proteins / metabolism; Particle Size; Polyethylene Glycols / chemistry; Polyethylene Glycols / pharmacokinetics; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Swine; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Transfection
TL;DR: It is speculated that permeability of all small solutes is proportional to pore number but that small electrolytes are subject to further selectivity by the profile of claudins expressed, explaining the dissociation between the Papp for noncharged solutes and electrical resistance. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2007 journal article

Efficacy of tinidazole for treatment of cats experimentally infected with Tritrichomonas foetus

AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(10), 1085–1088.

By: J. Gookin n, S. Stauffer n, M. Coccaro n, M. Poore n, M. Levy n & M. Papich n

MeSH headings : Animals; Antitrichomonal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Dose-Response Relationship, Drug; Protozoan Infections / drug therapy; Tinidazole / therapeutic use; Tritrichomonas foetus / isolation & purification
TL;DR: Although tinidazole decreased the detection of T foetus and treated cats were resistant to later efforts to incite the infection, inability of tinidrazole to eradicate infection in many cats poses a serious impediment to the drug's effectiveness in practice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Identification of Pentatrichomonas hominis in feline fecal samples by polymerase chain reaction assay

VETERINARY PARASITOLOGY, 145(1-2), 11–15.

By: J. Gookin n, S. Stauffer n & M. Levy n

author keywords: Tritrichomonas foetus; Trichomonas; diarrhea; Pentatrichomonas hominis
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / parasitology; Cats / parasitology; Feces / parasitology; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; RNA, Protozoan / analysis; RNA, Protozoan / genetics; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 18S / genetics; Trichomonadida / genetics; Trichomonadida / isolation & purification; Trichomonas Infections / diagnosis; Trichomonas Infections / veterinary
TL;DR: PCR identification of P. hominis infection in the cat should facilitate future studies to determine the pathogenicity of this species and enable differentiation from other known or as-yet unidentified species of trichomonads that may infect cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Optimization of a species-specific polymerase chain reaction assay for identification of Pentatrichomonas hominis in canine fecal specimens

AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(7), 783–787.

By: J. Gookin n, S. Stauffer*, M. Coccaro*, M. Marcotte* & M. Levy*

MeSH headings : Animals; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; Diarrhea / diagnosis; Diarrhea / parasitology; Dog Diseases / diagnosis; Dog Diseases / parasitology; Dogs; Feces / parasitology; Female; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / parasitology; Species Specificity; Trichomonadida / genetics; Trichomonadida / isolation & purification
TL;DR: Molecular identification of P hominis in feces of 4 dogs with trichomonosis and diarrhea reported here validates the identity of this species in such infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Restoration of Barrier Function in Injured Intestinal Mucosa

Physiological Reviews, 87(2), 545–564.

By: A. Blikslager*, A. Moeser*, J. Gookin*, S. Jones* & J. Odle*

Contributors: A. Blikslager*, A. Moeser*, J. Gookin*, S. Jones* & J. Odle*

MeSH headings : Animals; Epithelial Cells / physiology; Humans; Inflammation / pathology; Intestinal Diseases / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Mucous Membrane / cytology; Mucous Membrane / physiology
TL;DR: Ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space, which underscores the critical role of tight junction closure in measures of barrier function such as transepithelial electrical resistance. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2006 article

Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 20, pp. 536–543.

By: J. Gookin*, C. Copple*, M. Papich*, M. Poore*, S. Stauffer*, A. Birkenheuer*, D. Twedt, M. Levy*

author keywords: colitis; diarrhea; metronidazole; nitroimidazole; tinidazole
TL;DR: Oral administration of RDZ at 30 to 50 mg/kg PO q12h for 14 days resolved diarrhea and eradicated infection in 1 naturally infected cat and 10 experimentally inoculated cats receiving a different isolate of T foetus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

NF-kappa B-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 290(1), G164–G174.

By: J. Gookin n, S. Chiang*, J. Allen*, M. Armstrong*, S. Stauffer*, C. Finnegan, M. Murtaugh

author keywords: nitric oxide; barrier function; diarrhea; cryptosporidiosis
MeSH headings : Animals; Animals, Newborn; Body Weight; Chlorides / metabolism; Cryptosporidiosis / enzymology; Cryptosporidiosis / metabolism; Cryptosporidium parvum / immunology; Epithelial Cells / metabolism; Gene Expression Regulation, Enzymologic; Ileum / cytology; Ileum / metabolism; Ileum / ultrastructure; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; NF-kappa B / metabolism; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Swine; Swine Diseases / enzymology; Swine Diseases / metabolism; Swine Diseases / parasitology
TL;DR: It is shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function, suggesting that induction of i NOS represents a nonspecific response of the epithelium that mediates enterocyte defense against C. parvum infection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets

INFECTION AND IMMUNITY, 74(10), 5497–5505.

By: L. Zadrozny*, S. Stauffer*, M. Armstrong*, S. Jones n & J. Gookin*

MeSH headings : Animals; Antibodies / pharmacology; CD18 Antigens / drug effects; Cryptosporidiosis / immunology; Cryptosporidiosis / pathology; Cryptosporidium parvum; Diarrhea / immunology; Diarrhea / microbiology; Disease Models, Animal; Ileum / immunology; Ileum / microbiology; Ileum / pathology; Immunoglobulin G / pharmacology; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Lipid Peroxidation; Neutrophils / enzymology; Neutrophils / immunology; Peroxidase / analysis; Peroxidase / metabolism; Peroxynitrous Acid / metabolism; Prostaglandins / metabolism; Superoxides / metabolism; Swine
TL;DR: These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 chapter

Trichomoniasis

In C. E. Green (Ed.), Infectious Diseases of the Dog and Cat (3rd ed., pp. 740–744). St. Louis, MO: Saunder/Elsevier.

By: J. Gookin

Ed(s): C. Green

Source: NC State University Libraries
Added: October 21, 2020

2005 journal article

Histologic features associated with Tritrichomonas foetus-induced colitis in domestic cats

VETERINARY PATHOLOGY, 42(6), 797–804.

By: M. Yaeger n & J. Gookin n

author keywords: colon; feline; histology; trichomonas
MeSH headings : Animals; Cat Diseases / parasitology; Cat Diseases / pathology; Cats; Colitis / parasitology; Colitis / pathology; Colitis / veterinary; Colon / parasitology; Colon / ultrastructure; Feces / parasitology; Immunohistochemistry / veterinary; Microscopy, Electron, Transmission / veterinary; Polymerase Chain Reaction / veterinary; Protozoan Infections / pathology; Protozoan Infections, Animal; Tritrichomonas foetus / genetics; Tritrichomonas foetus / ultrastructure
TL;DR: The aim of the study reported here was to characterize the histologic changes in the colon of seven cats with T. foetus infection and chronic diarrhea, and found that the presence of colonic trichomonads was the most diagnostic histologic feature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Local peroxynitrite formation contributes to early control of Cryptosporidium parvum infection

INFECTION AND IMMUNITY, 73(7), 3929–3936.

By: J. Gookin n, J. Allen n, S. Chiang n, L. Duckett n & M. Armstrong n

MeSH headings : Animals; Cryptosporidiosis / immunology; Cryptosporidium parvum; Female; Immunohistochemistry; Lipid Peroxidation; Nitric Oxide Synthase / analysis; Nitric Oxide Synthase Type II; Peroxynitrous Acid / biosynthesis; Swine; Tyrosine / metabolism
TL;DR: The present results are the first to demonstrate an in vivo role for peroxynitrite formation in acute mucosal defense against a noninvasive intestinal epithelial pathogen. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Molecular characterization of trichomonads from feces of dogs with diarrhea

JOURNAL OF PARASITOLOGY, 91(4), 939–943.

By: J. Gookin n, A. Birkenheuer*, V. St John n, M. Spector & M. Levy*

MeSH headings : Animals; Base Sequence; DNA, Protozoan / chemistry; DNA, Protozoan / isolation & purification; Diarrhea / parasitology; Diarrhea / veterinary; Dog Diseases / parasitology; Dogs; Electrophoresis, Agar Gel / veterinary; Feces / parasitology; Female; Molecular Sequence Data; Polymerase Chain Reaction / veterinary; Protozoan Infections / parasitology; Protozoan Infections, Animal; RNA, Ribosomal / genetics; Sequence Alignment / veterinary; Trichomonadida / classification; Trichomonadida / genetics; Trichomonadida / isolation & purification; Tritrichomonas foetus / classification; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR: The present study is the first to establish the molecular identity of trichomonads infecting dogs with diarrhea, and validate the longstanding assumption that canine trICHomoniasis may be attributed to P. hominis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2005 article

Urinary tract manifestations of protothecosis in dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 19, pp. 115–119.

By: B. Pressler*, J. Gookin*, J. Sykes, A. Wolf & S. Vaden*

author keywords: acute renal failure; algae; Prototheca wickerhaniii; Prototheca zopfii; urinary tract infection; urine culture
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism

Gut, 53(4), 514–522.

By: J. Rhoads, W. Chen, J. Gookin, G. Wu, Q. Fu, A. Blikslager, R. Rippe, R. Argenzio ...

Contributors: J. Rhoads, W. Chen, J. Gookin, G. Wu, Q. Fu, A. Blikslager, R. Rippe, R. Argenzio ...

MeSH headings : Animals; Arginine / pharmacology; Cell Movement / drug effects; Cells, Cultured; Dietary Supplements; Dose-Response Relationship, Drug; Enterocytes / drug effects; Enterocytes / physiology; Enzyme Inhibitors / pharmacology; Focal Adhesion Protein-Tyrosine Kinases; Nitric Oxide / metabolism; Ornithine Decarboxylase / physiology; Ornithine Decarboxylase Inhibitors; Phosphorylation / drug effects; Polyamines / pharmacology; Protein-Tyrosine Kinases / physiology; Swine; Transfection; Tyrosine / physiology
TL;DR: Results showed that l-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2004 journal article

Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C-parvum-infected porcine ileum

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 287(3), G571–G581.

By: J. Gookin n, L. Duckett, M. Armstrong*, S. Stauffer, C. Finnegan*, M. Murtaugh, R. Argenzio*

author keywords: Cryptosporidium parvum; permeability
MeSH headings : Animals; Animals, Newborn; Atrophy; Cryptosporidiosis / enzymology; Cryptosporidiosis / physiopathology; Cryptosporidium parvum; Diarrhea / microbiology; Diarrhea / pathology; Dinoprostone / biosynthesis; Eicosanoids / biosynthesis; Epoprostenol / biosynthesis; Ileum / physiopathology; Intestinal Mucosa / metabolism; Microscopy, Electron; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Prostaglandins / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Sodium / metabolism; Swine; Thromboxane A2 / biosynthesis
TL;DR: Using an entire intestinal mucosa, it is demonstrated for the first time that NO serves as a proximal mediator of PGE2 synthesis and barrier function in C. parvum infection. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Outcome of cats with diarrhea and Tritrichomonas foetus infection

Foster, D. M., Gookin, J. L., Poore, M. F., Stebbins, M. E., & Levy, M. G. (2004, September 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 225, pp. 888–892.

By: D. Foster n, J. Gookin*, M. Poore*, M. Stebbins* & M. Levy*

MeSH headings : Animals; Antiprotozoal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; DNA, Protozoan / analysis; DNA, Ribosomal / analysis; Diarrhea / drug therapy; Diarrhea / parasitology; Diarrhea / veterinary; Female; Male; Paromomycin / therapeutic use; Polymerase Chain Reaction / veterinary; Prospective Studies; Protozoan Infections / drug therapy; Protozoan Infections / parasitology; Protozoan Infections, Animal; Time Factors; Treatment Outcome; Tritrichomonas foetus / isolation & purification; Tritrichomonas foetus / pathogenicity
TL;DR: Results suggested chronic T. foetus-associated diarrhea in most cats is likely to resolve spontaneously within 2 years of onset, and attempts to treat cats with T.foetus infection may result in prolongation of time to resolution of diarrhea. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 journal article

Prevalence of and risk factors for feline Tritichomonas foetus and Giardia infection

JOURNAL OF CLINICAL MICROBIOLOGY, 42(6), 2707–2710.

By: J. Gookin*, M. Stebbins*, E. Hunt n, K. Burlone n, M. Fulton n, R. Hochel n, M. Talaat n, M. Poore*, M. Levy*

MeSH headings : Animals; Cat Diseases / epidemiology; Cat Diseases / etiology; Cats; Female; Giardiasis / epidemiology; Giardiasis / etiology; Giardiasis / veterinary; Male; Prevalence; Protozoan Infections / etiology; Protozoan Infections, Animal; Risk Factors; Tritrichomonas foetus
TL;DR: Catteries in which T. foetus was identified were more likely to have had a recent history of diarrhea, historical diagnosis of coccidia infection in adult cats, and a decreased number of square feet of facility per cat. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Cyclooxygenase blockade and exogenous glutamine enhance sodium absorption in infected bovine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(3), G516–G524.

By: J. Cole*, A. Blikslager*, E. Hunt n, J. Gookin* & R. Argenzio*

author keywords: Cryptosporidium parvum; Na/H exchanger 3; cyclooxygenase-2; diarrhea
MeSH headings : Animals; Biological Transport, Active; Blotting, Western; Cattle; Chlorine; Cryptosporidiosis / metabolism; Cryptosporidiosis / parasitology; Cryptosporidium parvum; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Glutamine / pharmacology; Ileum / metabolism; Ileum / parasitology; Ileum / pathology; Inflammation / pathology; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Isoenzymes / metabolism; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Radioisotopes; Sodium / metabolism; Sodium Radioisotopes; Tissue Fixation
TL;DR: It is shown that prostanoids inhibit electroneneutral sodium absorption in Cryptosporidium parvum-infected porcine ileum, whereas glutamine stimulates electroneutral sodium absorption via a cyclooxygenase (COX)-dependent pathway, and glutamine increases sodium uptake by an electrogenic mechanism in this same tissue. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2003 journal article

PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(5), G967–G979.

By: J. Gookin n, J. Galanko, A. Blikslager* & R. Argenzio*

author keywords: resistance; permeability; tight junction; deoxycholate
MeSH headings : Animals; Deoxycholic Acid / pharmacology; Detergents / pharmacology; Gastrointestinal Motility; Ileum / drug effects; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Microscopy, Electron; Microvilli; Permeability / drug effects; Prostaglandins / metabolism; Recovery of Function; Swine; Wound Healing
TL;DR: These studies are the first to clearly distinguish the relative contribution of paracellular resistance vs. restitution to acute recovery of epithelial barrier function and underlie barrier failure resulting from NSAID use in patients with underlying enteropathy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2003 journal article

Tritrichomonas foetus and not Pentatrichomonas hominis is the etiologic agent of feline trichomonal diarrhea

JOURNAL OF PARASITOLOGY, 89(1), 99–104.

By: M. Levy n, J. Gookin n, M. Poore n, A. Birkenheuer n, M. Dykstra n & R. Litaker n

TL;DR: The purpose of the present study was to determine the identity of this recently recognized flagellate by means of rRNA gene sequence analysis; restriction enzyme digest mapping; and light, transmission, and scanning electron microscopy (SEM). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 article

Use of a commercially available culture system for diagnosis of Tritrichomonas foetus infection in cats

Gookin, J. L., Foster, D. M., Poore, M. F., Stebbins, M. E., & Levy, M. G. (2003, May 15). JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 222, pp. 1376–1379.

By: J. Gookin n, D. Foster*, M. Poore*, M. Stebbins* & M. Levy*

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / parasitology; Cats; Feces / parasitology; Female; Prospective Studies; Protozoan Infections / diagnosis; Protozoan Infections / parasitology; Protozoan Infections, Animal; Sensitivity and Specificity; Temperature; Time Factors; Tritrichomonas foetus / isolation & purification
TL;DR: The culture system was sensitive and specific for culture of T. foetus in feces of cats and performance was optimal when test kits were inoculated with < or = 0.1 g of freshly voided feces and cultured at 25 degrees C. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2002 journal article

Endoscopy via a gastric cannula to monitor the development of ulcers in the pars esophagea in pigs after consumption of a finely ground feed combined with a period of withholding of feed

AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(8), 1076–1082.

By: J. Cole n, J. Gookin n, J. Gayle n, J. Eisemann n, R. Argenzio n & A. Blikslager n

MeSH headings : Animal Feed / adverse effects; Animals; Catheterization / veterinary; Endoscopy, Digestive System / instrumentation; Endoscopy, Digestive System / veterinary; Food Deprivation / physiology; Male; Particle Size; Stomach Ulcer / etiology; Stomach Ulcer / metabolism; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Swine; Swine Diseases / etiology; Swine Diseases / metabolism; Swine Diseases / pathology
TL;DR: Endoscopic examination via a gastric cannula was an effective means of monitoring ulcer development in the pars esophagea of pigs and direct visual examination during necropsy confirmed the accuracy of endoscopic examination. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 review

Host responses to Cryptosporidium infection

[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(1), 12–21.

By: J. Gookin n, S. Nordone n & R. Argenzio n

author keywords: cryptosporidiosis; diarrhea; immunity; intestinal epithelium; pathogenesis
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Inducible nitric oxide synthase mediates early epithelial repair of porcine ileum

Gookin, J. L., Rhoads, J. M., & Argenzio, R. A. (2002, July). AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol. 283, pp. G157–G168.

By: J. Gookin n, J. Rhoads* & R. Argenzio n

author keywords: restitution; epithelium; serum; deoxycholate
MeSH headings : Animals; Arginine / pharmacology; Deoxycholic Acid; Detergents; Enterocytes / physiology; Female; Ileum / enzymology; Ileum / physiopathology; Intestinal Diseases / chemically induced; Intestinal Diseases / physiopathology; Intestinal Mucosa / physiopathology; Microvilli / enzymology; Microvilli / physiology; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / physiology; Nitric Oxide Synthase Type II; Swine; Wound Healing
TL;DR: It is demonstrated that iNOS-derived NO is a key mediator of early villous reepithelialization following acute mucosal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Muscle cramps in two standard poodles with hypoadrenocorticism

Journal of the American Animal Hospital Association, 38(5), 437–443.

By: M. Saito n, N. Olby n, L. Obledo n & J. Gookin n

MeSH headings : Adrenal Insufficiency / complications; Adrenal Insufficiency / drug therapy; Adrenal Insufficiency / veterinary; Animals; Desoxycorticosterone / analogs & derivatives; Desoxycorticosterone / therapeutic use; Dog Diseases / drug therapy; Dogs; Extremities; Female; Male; Muscle Cramp / complications; Muscle Cramp / drug therapy; Muscle Cramp / veterinary
TL;DR: It is concluded that hypoadrenocorticism can be associated with episodes of painful muscle cramps in standard poodles and altering treatment to desoxycorticosterone pivalate resolved the electrolyte abnormalities and the episodes of muscle cramping in both dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2002 journal article

Single-Tube Nested PCR for Detection of Tritrichomonasfoetus in Feline Feces

Journal of Clinical Microbiology, 40(11), 4126–4130.

By: J. Gookin*, A. Birkenheuer*, E. Breitschwerdt* & M. Levy n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / parasitology; Cats; DNA Primers; DNA, Protozoan / analysis; DNA, Ribosomal / analysis; Feces / parasitology; Polymerase Chain Reaction / instrumentation; Polymerase Chain Reaction / methods; Protozoan Infections / diagnosis; Protozoan Infections / parasitology; Protozoan Infections, Animal; RNA, Ribosomal, 5.8S / genetics; Sensitivity and Specificity; Tritrichomonas foetus / genetics; Tritrichomonas foetus / isolation & purification
TL;DR: The results demonstrate that the single-tube nested PCR is ideally suited for diagnostic testing of feline fecal samples that are found negative by direct microscopy and culturing and definitive identification of microscopically observable or cultivated organisms. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2001 journal article

Adverse reactions to sulfonamide administration

Standards of Care in Emergency and Critical Care Medicine, 3, 5–12.

By: R. Hopwood, M. Papich & J. Gookin

Source: NC State University Libraries
Added: October 21, 2020

2001 journal article

Experimental infection of cats with Tritrichomonas foetus

American Journal of Veterinary Research, 62(11), 1690–1697.

By: J. Gookin*, M. Levy*, J. Law*, M. Papich*, M. Poore* & E. Breitschwerdt*

MeSH headings : Animals; Antigens, Protozoan / analysis; Antiprotozoal Agents / administration & dosage; Antiprotozoal Agents / therapeutic use; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Cryptosporidiosis / complications; Cryptosporidiosis / drug therapy; Cryptosporidiosis / veterinary; Cryptosporidium / growth & development; Diarrhea / drug therapy; Diarrhea / parasitology; Diarrhea / veterinary; Feces / parasitology; Female; Intestinal Diseases / drug therapy; Intestinal Diseases / parasitology; Intestinal Diseases / veterinary; Intestinal Mucosa / parasitology; Nitro Compounds; Parasite Egg Count / veterinary; Prednisolone / administration & dosage; Prednisolone / therapeutic use; Protozoan Infections / complications; Protozoan Infections / drug therapy; Protozoan Infections, Animal; Specific Pathogen-Free Organisms; Thiazoles / administration & dosage; Thiazoles / therapeutic use; Tritrichomonas foetus
TL;DR: After experimental inoculation in cats, T. foetus organisms colonize the ileum, cecum, and colon, reside in close contact with the epithelium, and are associated with transient diarrhea that is exacerbated by coexisting cryptosporidiosis but not treatment with prednisolone. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2001 journal article

Information on parasitic gastrointestinal tract infections in cats (Letter to the Editor)

Journal of the American Veterinary Medical Association, 218(2), 194–195.

By: M. Levy, J. Gookin, M. Poore, R. Litaker & M. Dykstra

Source: NC State University Libraries
Added: October 21, 2020

2000 article

Granulomatous disease associated with Bartonella infection in 2 dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 14, pp. 37–42.

By: B. Pappalardo n, T. Brown*, J. Gookin n, C. Morrill n & E. Breitschwerdt n

author keywords: canine; infectious; lymphadenopathy; pathology
TL;DR: This is the 1st report of granulomatous disease in dogs associated with Bartonella infection, and an 11-year-old mixed-breed dog was referred for evaluation of a 6-week history of serous nasal discharge. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 chapter

Indications for nephrectomy and nephrotomy

In Kirk's current veterinary therapy : small animal practice (13th Ed.) (p. 866). Philadelphia, PA : W.B. Saunders.

By: E. Stone & J. Gookin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Urinary incontinence on dogs and cats. I. Measurement of urethral pressure. A review / L'incontinenza urinaria nel cane e nel gatto. Parte I -- profilometria della pressione uretrale

Veterinaria, 14(2), 33.

By: J. Gookin, E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Urinary incontinence on dogs and cats. II. Diagnosis and treatment. A review / L'incontinenza urinaria nel cane e nel gatto. Parte II -- diagnosi e trattamento

Veterinaria, 14(2), 43.

By: J. Gookin, E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Acute renal failure in four cats treated with paromomycin

Journal of the American Veterinary Medical Association, 215(12), 1821–1823.

By: J. Gookin, J. Riviere, B. Gilger & M. Papich

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Clinical hypothyroidism associated with trimethoprim- sulfadiazine administration in a dog

Journal of the American Veterinary Medical Association, 214(7), 1028–1031.

By: J. Gookin, L. Trepanier & S. Bunch

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Diarrhea associated with trichomonosis in cats

Journal of the American Veterinary Medical Association, 215(10), 1450–1454.

By: J. Gookin, E. Breitschwerdt, M. Ley, R. Gager & J. Benrud

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Evaluation of the effect of pleural effusion on central venous pressure in cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 13, pp. 561–563.

By: J. Gookin n & C. Atkins n

author keywords: diagnosis; hemodynamic effect of pleural effusion; heart failure; hydrothorax
TL;DR: The threshold volume required to increase CVP approximated that suggested by clinical observation (22 mL/kg) and a positive linear relationship was observed between CVP and volume of PEF. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Diagnosis and surgical management of obstructive ureteral calculi in cats: 11 cases (1993-1996)

Journal of the American Veterinary Medical Association, 213(8), 1150–1156.

By: A. Kyles, E. Stone, J. Gookin, K. Spaulding, E. Clary, K. Wylie, G. Spodnick

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Evaluation of microcytosis in 18 Shibas

Journal of the American Veterinary Medical Association, 212(8), 1258–1259.

By: J. Gookin, S. Bunch, L. Rush & C. Grindem

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Systemic Plasmacytosis and Polyclonal Gammopathy in a Dog

Journal of Veterinary Internal Medicine, 12(6), 471–474.

By: J. Gookin n, R. Sellon n, K. McDorman n & F. Geoly n

MeSH headings : Alopecia / veterinary; Animals; Antineoplastic Agents, Alkylating / therapeutic use; Antineoplastic Agents, Hormonal / therapeutic use; Biopsy / veterinary; Cyclophosphamide / therapeutic use; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Edema / veterinary; Electrophoresis / veterinary; Hypergammaglobulinemia / diagnosis; Hypergammaglobulinemia / therapy; Hypergammaglobulinemia / veterinary; Hyperpigmentation / veterinary; Immunohistochemistry; Immunosuppressive Agents / therapeutic use; Lymph Nodes / pathology; Male; Melphalan / therapeutic use; Plasma Cells / pathology; Prednisone / therapeutic use; Skin / pathology; gamma-Globulins / analysis
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1997 journal article

Factor X deficiency in a cat

Journal of the American Veterinary Medical Association, 211(5), 576–579.

By: J. Gookin, M. Brooks, J. Catalfamo, S. Bunch & K. Munana

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Use of carbamylated hemoglobin concentration to differentiate acute from chronic renal failure in dogs

American Journal of Veterinary Research, 58(11), 1193–1196.

By: S. Vaden, J. Gookin, M. Trogdon, C. Langston, J. Levine & L. Cowgill

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Detrusor-striated sphincter dyssynergia in a dog

JOURNAL OF VETERINARY INTERNAL MEDICINE, 10(5), 339–344.

By: J. Gookin n & S. Bunch n

MeSH headings : Animals; Baclofen / therapeutic use; Cystostomy / methods; Cystostomy / veterinary; Dantrolene / therapeutic use; Dog Diseases; Dogs; Male; Muscle Relaxants, Central / therapeutic use; Muscular Diseases / physiopathology; Muscular Diseases / therapy; Muscular Diseases / veterinary; Orchiectomy; Prazosin / therapeutic use; Urethral Diseases / physiopathology; Urethral Diseases / therapy; Urethral Diseases / veterinary; Urinary Diversion / methods; Urinary Diversion / veterinary; Urinary Incontinence / etiology; Urinary Incontinence / veterinary
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1996 journal article

Unilateral nephrectomy in dogs with renal disease: 30 cases (1985-1994)

Journal of the American Veterinary Medical Association, 208(12), 2020.

By: J. Gookin, E. Stone, K. Spaulding & C. Berry

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Urinary incontinence in dogs and cats. Part I. Urethral pressure profilometry

Compendium on Continuing Education for the Practicing Veterinarian, 18(4), 407.

By: J. Gookin, E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Urinary incontinence in dogs and cats. Part II. Diagnosis and management

Compendium on Continuing Education for the Practicing Veterinarian, 18(5), 525.

By: J. Gookin, E. Stone & N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1995 chapter

Urodynamic studies

In S. J. Wheeler (Ed.), BSAVA manual of small animal neurology (2nd ed., pp. 53–57). Cheltenham, Gloucestershire, UK: British Small Animal Veterinary Association.

By: J. Gookin & N. Sharp

Ed(s): S. Wheeler

Source: NC State University Libraries
Added: October 21, 2020

1995 chapter

Visceral and bladder dysfunction; Dysautonomia

In S. J. Wheeler (Ed.), BSAVA manual of small animal neurology (2nd edition, pp. 179–188). Cheltenham, Gloucestershire, UKc: British Small Animal Veterinary Association.

By: N. Sharp & J. Gookin

Ed(s): S. Wheeler

Source: NC State University Libraries
Added: October 21, 2020

1989 journal article

Cranial effects of retinoic acid in the loop-tail (Lp) mutant mouse

Journal of Craniofacial Genetics and Developmental Biology, 10(1), 75–81.

By: D. Wilson, D. Wyatt & J. Gookin

Source: NC State University Libraries
Added: October 21, 2020

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