Joshua Pierce

Nie, M., Valdes-Pena, M. A., Frohock, B. H., Smits, E., Daiker, J. C., Gilbertie, J. M., … Pierce, J. G. (2024, February 1). Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 99. https://doi.org/10.1016/j.bmcl.2024.129609

Breunig, J. L., Valdes-Pena, M. A., Ratchford, A. W., & Pierce, J. G. (2024, January 12). Total Synthesis and Microbiological Evaluation of Leopolic Acid A and Analogues. ACS BIO & MED CHEM AU, Vol. 1. https://doi.org/10.1021/acsbiomedchemau.3c00068

Massaro, N. P., & Pierce, J. G. (2023). 3-Component Approach to 1,5-Dihydro-2<i>H</i>-pyrrol-2-one Heterocycles. ORGANIC SYNTHESES, 100, 418-+. https://doi.org/10.15227/orgsyn.100.0418

Guerra, A. W., & Pierce, J. G. (2023). Photoredox Catalyzed C(sp<SUP>3</SUP>)-C(sp<SUP>3</SUP>) Coupling of α-Bromoesters and Triethylamine. JOURNAL OF ORGANIC CHEMISTRY, 89(1), 810–814. https://doi.org/10.1021/acs.joc.3c02394

Piedrahita, J., & Pierce, J. (2023, August 4). Using Stem Mini-Organs to Find New Cures. https://doi.org/10.52750/572466

Pierce, J. (2022, June 22). Chemistry Drives Solutions to Our Planet’s Largest Problems: COVID-19 and Beyond. https://doi.org/10.52750/565310

Moody, C. T., Brown, A. E., Massaro, N. P., Patel, A. S., Agarwalla, P. A., Simpson, A. M., … Brudno, Y. (2022). Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture. ACTA BIOMATERIALIA, 138, 208–217. https://doi.org/10.1016/j.actbio.2021.10.046

Onuska, N. P. R., & Pierce, J. G. (2022, June 30). Synthesis provides insight into a traditional medicine. NATURE, Vol. 606, pp. 869–870. https://doi.org/10.1038/d41586-022-01740-w

Pandit, S., Palvai, S., Massaro, N. P., Pierce, J. G., & Brudno, Y. (2022). Tissue-reactive drugs enable materials-free local depots. JOURNAL OF CONTROLLED RELEASE, 343, 142–151. https://doi.org/10.1016/j.jconrel.2022.01.023

Pierce, J. G., & Qiu, X. (2022, July 5). Total Synthesis of Bipolamine I. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 7. https://doi.org/10.1021/jacs.2c06015

Natalia Gonzalez, S., Mills, J. J., Maugeri, D., Olaya, C., Laguera, B. L., Enders, J. R., … Edward L. D'Antonio. (2021). Design, synthesis, and evaluation of substrate - analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 32. https://doi.org/10.1016/j.bmcl.2020.127723

Valdes-Pena, M. A., Massaro, N. P., Lin, Y.-C., & Pierce, J. G. (2021). [Review of Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence]. ACCOUNTS OF CHEMICAL RESEARCH, 54(8), 1866–1877. https://doi.org/10.1021/acs.accounts.1c00007

Massaro, N. P., & Pierce, J. G. (2021). Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach. TETRAHEDRON LETTERS, 75. https://doi.org/10.1016/j.tetlet.2021.153201

Liang, Z., Lin, Y.-C., & Pierce, J. G. (2021). Stereoselective Synthesis of the Spirocyclic gamma-Lactam Core of the Ansalactams. ORGANIC LETTERS, 23(24), 9559–9562. https://doi.org/10.1021/acs.orglett.1c03782

Lin, Y.-C., Martinez-Brokaw, C., & Pierce, J. G. (2020). 1,4-Oxazines and their Benzo Derivatives. In Comprehensive Heterocyclic Chemistry IV. https://doi.org/10.1016/b978-008044992-0.00706-9

Lin, Y.-C., Ribaucourt, A., Moazami, Y., & Pierce, J. G. (2020). Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142(21), 9850–9857. https://doi.org/10.1021/jacs.0c04091

Frohock, B. H., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. G. (2020). Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020). ChemBioChem. https://doi.org/10.1002/cbic.202000168

Griewisch, K. F., Pierce, J. G., & Elfenbein, J. R. (2020). Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog. Applied and Environmental Microbiology, 86(20). https://doi.org/10.1128/aem.01120-20

Luckring, E. J., Parker, P. D., Hani, H., Grace, M. H., Lila, M. A., Pierce, J. G., & Adin, C. A. (2020). In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation. Cell Transplantation, 29, 096368972090641. https://doi.org/10.1177/0963689720906417

Cholewczynski, A. E., Williams, P. C., & Pierce, J. G. (2020). Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition. Organic Letters, 22(2), 714–717. https://doi.org/10.1021/acs.orglett.9b04546

Massaro, N. P., & Pierce, J. G. (2020). Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds. ORGANIC LETTERS, 22(13), 5079–5084. https://doi.org/10.1021/acs.orglett.0c01650

Frohock, B. H., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. G. (2019). 5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms. CHEMBIOCHEM, Vol. 12. https://doi.org/10.1002/cbic.201900633

Frohock, B., Gilbertie, J. M., Daiker, J. C., Schnabel, L. V., & Pierce, J. (2019). 5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms [Preprint]. 9. https://doi.org/10.26434/chemrxiv.9759302.v1

Martinez-Brokaw, C. D., Radke, J. B., Pierce, J. G., Ehlers, A., Ekins, S., Wood, K. E., … Krasowski, M. D. (2019). Accidental intoxications in toddlers: lack of cross-reactivity of vilazodone and its urinary metabolite M17 with drug of abuse screening immunoassays. BMC CLINICAL PATHOLOGY, 19. https://doi.org/10.1186/s12907-019-0084-9

Pierce, J., & Lin, Y.-C. (2019, October 3). Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D (Vol. 10). Vol. 10. https://doi.org/10.26434/chemrxiv.9924692.v1

Lin, Y.-C., Ribaucourt, A., Moazami, Y., & Pierce, J. (2019, October 4). Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D. https://doi.org/10.26434/chemrxiv.9924692.v2

Robinson, K. R., Mills, J. J., & Pierce, J. G. (2019). Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics. ACS MEDICINAL CHEMISTRY LETTERS, 10(3), 374-+. https://doi.org/10.1021/acsmedchemlett.9b00015

Pierce, J., Cholewczynski, A., & Williams, P. (2019). Stereocontrolled Synthesis of Melokhanine E via an Intramolecular Formal [3+2] Cycloaddition [Preprint]. 10. https://doi.org/10.26434/chemrxiv.10022858.v1

Cusumano, A. Q., & Pierce, J. G. (2018). 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones as novel antibacterial scaffolds against methicillin-resistant Staphylococcus aureus. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28(16), 2732–2735. https://doi.org/10.1016/j.bmcl.2018.02.047

Parker, P. D., Ge, Y., & Pierce, J. G. (2018). Coupling of thioamides with 4-bromocrotonate esters and subsequent conjugate addition for the rapid one-pot synthesis of functionalized thiazolines. Tetrahedron Letters, 59(3), 277–279. https://doi.org/10.1016/J.TETLET.2017.12.043

Gulledge, T. V., Collette, N. M., Mackey, E., Johnstone, S. E., Moazami, Y., Todd, D. A., … Laster, S. M. (2018). Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide. Journal of Ethnopharmacology, 212, 166–174. https://doi.org/10.1016/J.JEP.2017.10.012

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018). Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A. Angewandte Chemie, 130(28), 8818–8822. https://doi.org/10.1002/ange.201805078

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018, April 9). Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A. https://doi.org/10.26434/chemrxiv.6103607.v1

Mills, J. J., Robinson, K. R., Zehnder, T. E., & Pierce, J. G. (2018). Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A. Angewandte Chemie International Edition, 57(28), 8682–8686. https://doi.org/10.1002/anie.201805078

Parker, P. D., Lemercier, B. C., & Pierce, J. G. (2018). Synthesis of Quaternary-Substituted Thiazolines via Halocyclization of S-Allyl Thioimidate Salts. The Journal of Organic Chemistry, 83(1), 12–22. https://doi.org/10.1021/ACS.JOC.7B02299

Edwards, G. A., Shymanska, N. V., & Pierce, J. G. (2017). 5-Benzylidene-4-oxazolidinones potently inhibit biofilm formation in Methicillin-resistant Staphylococcus aureus. Chemical Communications, 53(53), 7353–7356. https://doi.org/10.1039/C7CC03626D

Cusumano, A. Q., Boudreau, M. W., & Pierce, J. G. (2017). Direct Access to Highly Functionalized Heterocycles through the Condensation of Cyclic Imines and alpha-Oxoesters. JOURNAL OF ORGANIC CHEMISTRY, 82(24), 13714–13721. https://doi.org/10.1021/acs.joc.7b02572

Pierce, J. G. (2017). How Cancer Cells Become Resistant to Cationic Lytic Peptides: It’s the Sugar! Cell Chemical Biology, 24(2), 121–122. https://doi.org/10.1016/J.CHEMBIOL.2017.01.009

Shymanska, N. V., & Pierce, J. G. (2017). Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and beta-Amino Acids. ORGANIC LETTERS, 19(11), 2961–2964. https://doi.org/10.1021/acs.orglett.7b01185

Shi, Y., Moazami, Y., & Pierce, J. G. (2017). Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids. Bioorganic & Medicinal Chemistry, 25(11), 2817–2824. https://doi.org/10.1016/J.BMC.2017.03.015

Parker, J., Oh, Y., Moazami, Y., Pierce, J. G., Loziuk, P. L., Dean, R. A., & Muddiman, D. C. (2016). Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein. ANALYTICAL BIOCHEMISTRY, 512, 114–119. https://doi.org/10.1016/j.ab.2016.08.017

Shi, Y., & Pierce, J. G. (2016). Stereocontrolled Synthesis of (+)-Plagiogyrin A. Organic Letters, 18(20), 5308–5311. https://doi.org/10.1021/ACS.ORGLETT.6B02629

Pierce, J., & Parker, P. (2016). Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes. Synthesis, 48(12), 1902–1909. https://doi.org/10.1055/S-0035-1561597

Lemercier, B. C., & Pierce, J. G. (2016). Thiohydroximic acids: Versatile reagents for organic synthesis. Synlett, 27(2), 181–189.

Pierce, J. G., Shymanska, N. V., & Edwards, G. A. (2015). Marine natural products synthesis as a driving force for chemical and biological discovery. Planta Medica, 81(11). https://doi.org/10.1055/S-0035-1556104

Shymanska, N. V., An, I. H., Guevara-Zuluaga, S., & Pierce, J. G. (2015). Rapid synthesis and antimicrobial activity of novel 4-oxazolidinone heterocycles. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4887–4889. https://doi.org/10.1016/j.bmcl.2015.06.003

Moazami, Y., Gulledge, T. V., Laster, S. M., & Pierce, J. G. (2015). Synthesis and biological evaluation of a series of fatty acid amides from Echinacea. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094. https://doi.org/10.1016/j.bmcl.2015.06.024

Lemercier, B. C., & Pierce, J. G. (2015). Synthesis of 1,4,2-Oxathiazoles via Oxidative Cyclization of Thiohydroximic Acids. ORGANIC LETTERS, 17(18), 4542–4545. https://doi.org/10.1021/acs.orglett.5b02256

Pierce, J., & Moazami, Y. (2015). Synthesis of 2,3-Dihydro-1,3-oxazin-4-ones via a Mild Formal [4+2] Cycloaddition of Acylketenes with Aldimines. Synthesis, 47(21), 3363–3370. https://doi.org/10.1055/S-0034-1378788

Shi, Y., & Pierce, J. G. (2015). Synthesis of the 5,6-Dihydroxymorpholin-3-one Fragment of Monanchocidin A. ORGANIC LETTERS, 17(4), 968–971. https://doi.org/10.1021/acs.orglett.5b00069

Pierce, J., & Lemercier, B. (2015). Thiohydroximic Acids: Versatile Reagents for Organic Synthesis. Synlett, 27(02), 181–189. https://doi.org/10.1055/S-0035-1560700

Shymanska, N. V., An, I. H., & Pierce, J. G. (2014). A Rapid Synthesis of 4-Oxazolidinones: Total Synthesis of Synoxazolidinones A and B**. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(21), 5401–5404. https://doi.org/10.1002/anie.201402310

Lemercier, B. C., & Pierce, J. G. (2014). Synthesis of Thiazolines by Copper Catalyzed Aminobromination of Thiohydroximic Acids. ORGANIC LETTERS, 16(7), 2074–2076. https://doi.org/10.1021/ol500588v

Lemercier, B. C., & Pierce, J. G. (2014). Synthesis of Thiohydroxamic Acids and Thiohydroximic Acid Derivatives. JOURNAL OF ORGANIC CHEMISTRY, 79(5), 2321–2330. https://doi.org/10.1021/jo500080x

James, R. C., Pierce, J. G., Okano, A., Xie, J., & Boger, D. L. (2012). Redesign of Glycopeptide Antibiotics: Back to the Future. ACS Chemical Biology, 7(5), 797–804. https://doi.org/10.1021/cb300007j

Okano, A., James, R. C., Pierce, J. G., Xie, J., & Boger, D. L. (2012). Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands. Journal of the American Chemical Society, 134(21), 8790–8793. https://doi.org/10.1021/ja302808p

Miller, B., Mao, S., Rosenker, K. M. G., Pierce, J. G., & Wipf, P. (2012). Synthesis of a library of tricyclic azepinoisoindolinones. Beilstein Journal of Organic Chemistry, 8, 1091–1097. https://doi.org/10.3762/bjoc.8.120

Xie, J., Okano, A., Pierce, J. G., James, R. C., Stamm, S., Crane, C. M., & Boger, D. L. (2012). Total Synthesis of [Ψ[C(═S)NH]Tpg4]Vancomycin Aglycon, [Ψ[C(═NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding. Journal of the American Chemical Society, 134(2), 1284–1297. https://doi.org/10.1021/ja209937s

Xie, J., Pierce, J. G., James, R. C., Okano, A., & Boger, D. L. (2011). A Redesigned Vancomycin Engineered for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding Exhibits Potent Antimicrobial Activity Against Vancomycin-Resistant Bacteria. Journal of the American Chemical Society, 133(35), 13946–13949. https://doi.org/10.1021/ja207142h

Frantz Marie-Céline, Pierce, J. G., Pierce, J. M., Kangying, L., Qingwei, W., Johnson, M., & Wipf, P. (2011). Large-Scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs. Organic Letters, 13(9), 2318–2321. https://doi.org/10.1021/ol200567p

Crane, C. M., Pierce, J. G., Leung, S. S. F., Tirado-Rives, J., Jorgensen, W. L., & Boger, D. L. (2010). Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon. Journal of Medicinal Chemistry, 53(19), 7229–7235. https://doi.org/10.1021/jm100946e

Rajagopalan, M. S., Gupta, K., Epperly, M. W., Franicola, D., Zhang, X., Wang, H., … Greenberger, J. S. (2009). The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair. In Vivo, 23(5), 717–726.

Pierce, J. G., Kasi, D., Fushimi, M., Cuzzupe, A., & Wipf, P. (2008). Synthesis of Hydroxylated Bicyclic Amino Acids from l-Tyrosine: Octahydro-1 H-indole Carboxylates. The Journal of Organic Chemistry, 73(19), 7807–7810. https://doi.org/10.1021/jo801552j

Epperly, M. W., Pierce, J. G., Dixon, T., Franicola, D., Wipf, P., & Greenberger, J. S. (2008). The Mitochondrial Targeted GS-Nitroxide JP4-039 is Radioprotective In Vitro and In Vivo. International Journal of Radiation Oncology*Biology*Physics, 72(1), S82. https://doi.org/10.1016/j.ijrobp.2008.06.952

Pierce, J. G., Waller, D. L., & Wipf, P. (2007). Synthesis of functionalized isoindolinones: Addition of in situ generated organoalanes to acyliminium ions. Journal of Organometallic Chemistry, 692(21), 4618–4629. https://doi.org/10.1016/j.jorganchem.2007.05.035

Wipf, P., & Pierce, J. G. (2006). Expedient Synthesis of the α-C-Glycoside Analogue of the Immunostimulant Galactosylceramide (KRN7000). Organic Letters, 8(15), 3375–3378. https://doi.org/10.1021/ol0613057

Motoyama, Y., Itonaga, C., Ishida, T., Takasaki, M., & Nagazhima, H. (2005). Catalytic Reduction of Amides to Amines with Hydrosilanes Using a Triruthenium Carbonyl Cluster as the Catalyst​. Organic Syntheses, 82, 188. https://doi.org/10.15227/orgsyn.082.0188

Marshall, J. A., & Chobanian, H. (2005). Lipase-Catalyzed Resolution of 4-Trimethylsilyl-3-Butyn-2-ol and Conversion of the (R)-Enantiomer to (R)-3-Butyn-2-yl Mesylate and (P)-1-Tributylstannyl-1,2-Butadiene. Organic Syntheses, 4, 43–55. https://doi.org/10.1002/0471264229.os082.07

Wipf, P., Pierce, J. G., & Zhuang, N. (2005). Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides. Organic Letters, 7(3), 483–485. https://doi.org/10.1021/ol0475414

Wipf, P., & Pierce, J. G. (2005). Synthesis of Homoallylic Amines by Hydrozirconation−Imine Addition of Allenes. Organic Letters, 7(16), 3537–3540. https://doi.org/10.1021/ol051266j

Wipf, P., Pierce, J. G., & Wang, X. (2003). Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions. Tetrahedron: Asymmetry, 14(22), 3605–3611. https://doi.org/10.1016/j.tetasy.2003.07.022