Ultrasound-Stimulated Phase-Change Contrast Agents for Transepithelial Delivery of Macromolecules, Toward Gastrointestinal Drug Delivery
Fix, S. M., Koppolu, B. P., Novell, A., Hopkins, J., Kierski, T. M., Zaharoff, D. A., … Papadopoulou, V. (2019, April 16). Ultrasound in Medicine & Biology.
author keywords: Ultrasound; Transepithelial delivery; Acoustic droplet vaporization; Phase-change contrast agents; Nanodroplet
MeSH headings : Cells, Cultured; Contrast Media; Dextrans / administration & dosage; Drug Delivery Systems / methods; Fluorescein-5-isothiocyanate / administration & dosage; Fluorescein-5-isothiocyanate / analogs & derivatives; Gastrointestinal Agents / administration & dosage; Humans; Image Enhancement / methods; In Vitro Techniques; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Ultrasound and Cavitation Phenomena; Advancements in Transdermal Drug Delivery
TL;DR:
It is demonstrated that ultrasound-stimulated phase change contrast agents (PCCAs) can transiently disrupt confluent colorectal adenocarcinoma monolayers and improve the transepithelial transport of a macromolecular model drug.
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7. Affordable and Clean Energy
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